Layered double hydroxide-based nanomaterials for biomedical applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(14), P. 6126 - 6176

Published: Jan. 1, 2022

Against the backdrop of increased public health awareness, inorganic nanomaterials have been widely explored as promising nanoagents for various kinds biomedical applications. Layered double hydroxides (LDHs), with versatile physicochemical advantages including excellent biocompatibility, pH-sensitive biodegradability, highly tunable chemical composition and structure, ease composite formation other materials, shown great promise in In this review, we comprehensively summarize recent advances LDH-based Firstly, material categories are discussed. The preparation surface modification nanomaterials, pristine LDHs, nanocomposites LDH-derived then described. Thereafter, systematically describe potential LDHs applications drug/gene delivery, bioimaging diagnosis, cancer therapy, biosensing, tissue engineering, anti-bacteria. Finally, on basis current state art, conclude insights remaining challenges future prospects rapidly emerging field.

Language: Английский

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A MgFe‐LDH Nanosheet‐Incorporated Smart Thermo‐Responsive Hydrogel with Controllable Growth Factor Releasing Capability for Bone Regeneration

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(5)

Published: Nov. 25, 2022

Although growth factor (GF)-loaded hydrogels have been explored as promising materials in repairing bone defects, it still remains challenging to construct smart with excellent gelation/mechanical properties well controllable GF releasing capability. Herein, the incorporation of morphogenetic protein 2 (BMP-2)-functionalized MgFe-layered double hydroxide (LDH) nanosheets into chitosan/silk fibroin (CS) loaded platelet-derived factor-BB (PDGF-BB) a injectable thermo-responsive hydrogel (denoted CSP-LB), which can achieve burst release PDGF-BB and sustained BMP-2, for highly efficient regeneration is reported. The MgFe-LDH CS not only shortens gelation time decreases sol-gel transition temperature, but also enhances mechanical property hydrogel. Because sequential dual-GFs bioactive Mg2+ /Fe3+ ions, vitro experiments prove that CSP-LB exhibits angiogenic osteogenic compared In vivo further significantly enhance higher volume mineral density than This thermo-sensitive possesses capability properties, thus providing minimally invasive solution defect treatment.

Language: Английский

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Coupling Probiotics with 2D CoCuMo‐LDH Nanosheets as a Tumor‐Microenvironment‐Responsive Platform for Precise NIR‐II Photodynamic Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(23)

Published: March 13, 2023

Photodynamic therapy (PDT) has become a promising cancer treatment approach with superior advantages. However, it remains grand challenge to develop tumor microenvironment (TME)-responsive photosensitizers (PSs) for tumor-targeting precise PDT. Herein, the coupling Lactobacillus acidophilus (LA) probiotics 2D CoCuMo layered-double-hydroxide (LDH) nanosheets (LA&LDH) is reported as TME-responsive platform NIR-II The CoCuMo-LDH loaded on LA can be transformed from crystalline into amorphous through etching by LA-metabolite-enabled low pH and overexpressed glutathione. TME-induced in situ amorphization of boost its photodynamic activity singlet oxygen (1 O2 ) generation under 1270 nm laser irradiation relative 1 quantum yield 1.06, which highest among previously NIR-excited PSs. In vitro vivo assays prove that LA&LDH effectively achieve complete cell apoptosis eradication irradiation. This study proves used highly efficient

Language: Английский

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Boosting the Sonodynamic Cancer Therapy Performance of 2D Layered Double Hydroxide Nanosheet‐Based Sonosensitizers Via Crystalline‐to‐Amorphous Phase Transformation

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(17)

Published: Feb. 13, 2023

Abstract Sonodynamic therapy (SDT) has been a promising therapeutic modality for cancer because of its superior advantages compared with other strategies. However, the current sonosensitizers used SDT normally exhibit low activity ultrasound (US)‐induced reactive oxygen species (ROS) generation. Herein, crystalline‐to‐amorphous phase transformation is reported as simple but powerful strategy to engineer ultrathin 2D CoW‐LDH and NiW‐LDH nanosheets highly efficient SDT. The from polycrystalline amorphous ones achieved through acid etching treatment. Importantly, one, (a‐CoW‐LDH) possess higher ROS generation under US irradiation, which ≈17 times commercial TiO 2 sonosensitizer. results suggest that enhanced performance a‐CoW‐LDH US‐induced may be attributed transformation‐induced defect electronic structure changes. After polyethylene glycol modification, can serve high‐efficiency sonosensitizer achieve cell death in vitro tumor eradication vivo irradiation.

Language: Английский

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Doping Engineering to Modulate Lattice and Electronic Structure for Enhanced Piezocatalytic Therapy and Ferroptosis

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(38)

Published: July 12, 2023

Piezocatalytic therapy, which generates reactive oxygen species (ROS) under mechanical force, has garnered extensive attention for its use in cancer therapy owing to deep tissue penetration depth and less O2 -dependence. However, the piezocatalytic therapeutic efficiency is limited poor piezoresponse, low separation of electron-hole pairs, complicated tumor microenvironment (TME). Herein, a biodegradable, porous Mn-doped ZnO (Mn-ZnO) nanocluster with enhanced piezoelectric effect constructed via doping engineering. Mn-doping not only induces lattice distortion increase polarization but also creates rich vacancies (OV ) suppressing recombination leading high-efficiency generation ROS ultrasound irradiation. Moreover, shows TME-responsive multienzyme-mimicking activity glutathione (GSH) depletion ability mixed valence Mn (II/III), further aggravating oxidative stress. Density functional theory calculations show that can improve performance enzyme Mn-ZnO due presence OV . Benefiting from boosting GSH ability, significantly accelerate accumulation lipid peroxide inactivate peroxidase 4 (GPX4) induce ferroptosis. The work may provide new guidance exploring novel sonosensitizers therapy.

Language: Английский

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Facile synthesis of 2D Al-TCPP MOF nanosheets for efficient sonodynamic cancer therapy

Materials Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 7(8), P. 1684 - 1693

Published: Jan. 1, 2023

2D Al-TCPP MOF nanosheets were prepared via a simple solvothermal synthesis method without the need for any surfactants and found to be an effective sonosensitizer sonodynamic cancer therapy.

Language: Английский

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A restricted dynamic surface self-reconstruction toward high-performance of direct seawater oxidation

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 20, 2024

Abstract The development of highly efficient electrocatalysts for direct seawater splitting with bifunctionality inhibiting anodic oxidation reconstruction and selective oxygen evolution reactions is a major challenge. Herein, we report electrocatalyst that achieves long-term stability more than 1000 h at 600 mA/cm 2 @η high selectivity (Faraday efficiency 100%). This catalyst revolves an amorphous molybdenum oxide layer constructed on the beaded-like cobalt interface by atomic deposition technology. As demonstrated, new restricted dynamic surface self-reconstruction mechanism induced formation stable reconstructed Co-Mo double hydroxide phase layer. device assembled into two-electrode flow cell overall electrolysis maintained 1 A/cm @1.93 V 500 Faraday higher 95%. Hydrogen generation rate reaches 419.4 mL/cm /h, power consumption (4.62 KWh/m 3 H ) lower pure water (5.0 industrial current density.

Language: Английский

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Ultrathin Clay Nanoparticles‐Mediated Mutual Reinforcement of Ferroptosis and Cancer Immunotherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(9)

Published: Nov. 8, 2023

Ferroptosis-triggered immunogenic cell death (ICD) is widely adopted to potentiate the body's antitumor immunity by catalyzing production of toxic reactive oxygen species (ROS). However, efficacy ferroptosis and immunotherapy greatly restricted intracellular abundant glutathione (GSH) immunosuppressive tumor microenvironment (TME). Herein, a facile bottom-up method for solvent-free synthesis ultrathin manganese (Mn)-based layered double hydroxide nanosheets with high loading efficiency pro-inflammatory cytokine interferon (IFNγ) (IFNγ/uMn-LDHs) proposed mutually reinforce systemic immunity. The introduction ions significantly contributes GSH depletion hydroxyl radical generation, which can be further enhanced IFNγ delivery-induced SLC7A11 downregulation. ICD effect after cooperates intrinsic immunomodulatory property IFNγ/uMn-LDHs facilitate maturation dendritic cells (DCs) priming T cells. secretion from activated CD8

Language: Английский

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Unique electromagnetic wave absorber for three-dimensional framework engineering with copious heterostructures

Journal of Material Science and Technology, Journal Year: 2023, Volume and Issue: 170, P. 129 - 139

Published: July 21, 2023

Language: Английский

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Size engineering of 2D MOF nanosheets for enhanced photodynamic antimicrobial therapy

Chinese Chemical Letters, Journal Year: 2023, Volume and Issue: 34(9), P. 108140 - 108140

Published: Jan. 14, 2023

Language: Английский

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