Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: Sept. 12, 2022

Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving therapeutic potential various agents and bioactive molecules through enhanced permeability retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective tumor cells utilizing cell surface-specific receptors, vasculature antigens high accuracy affinity. Additionally, stimuli-responsive nanoplatforms also been as a promising strategy against tumors, these maintain their stealth feature under conditions, but upon homing cancerous lesions or microenvironment, are responsive release cargoes. In this review, we comprehensively summarize field active number studies context emerging nanoplatform development, discuss how knowledge contribute further improvements clinical practice.

Language: Английский

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Synergistic Reinforcing of Immunogenic Cell Death and Transforming Tumor‐Associated Macrophages Via a Multifunctional Cascade Bioreactor for Optimizing Cancer Immunotherapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(51)

Published: Oct. 17, 2022

Immunogenic cell death (ICD) has aroused widespread attention because it can reconstruct a tumor microenvironment and activate antitumor immunity. This study proposes two-way enhancement of ICD based on CaO2 @CuS-MnO2 @HA (CCMH) nanocomposite to overcome the insufficient damage-associated molecular patterns (DAMPs) conventional ICD-inducers. The near-infrared (NIR) irradiation (1064 nm) CuS nanoparticles generates 1 O2 through photodynamic therapy (PDT) trigger ICD, also damages Ca2+ buffer function mitochondria. Additionally, react with H2 O produce large amount , which respectively lead enhanced PDT overload during mitochondrial damage, thereby triggering robust activation. Moreover, oxidative-damaged DNA, induced by released from cells, reprograms immunosuppressive transforming tumor-associated macrophages M1 subphenotype. shows that CCMH NIR-II elicit adequate DAMPs an active tumor-immune for both 4T1 CT26 models. Combining this method immune checkpoint blockade realize improved immunotherapy efficacy long-term protection effect body.

Language: Английский

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Bioactive inorganic nanomaterials for cancer theranostics

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(6), P. 2031 - 2081

Published: Jan. 1, 2023

Bioactive materials are a special class of biomaterials that can react in vivo to induce biological response or regulate functions, thus achieving better curative effect than traditional inert biomaterials. For cancer theranostics, compared with organic polymer nanomaterials, inorganic nanomaterials possess unique physical and chemical properties, have stronger mechanical stability on the basis maintaining certain bioactivity, easy be compounded various carriers (polymer carriers, etc.), so as achieve specific antitumor efficacy. After entering nanoscale, due nano-size effect, high surface area nanostructures, exhibit effects, which significantly influence interaction organisms. Therefore, research applications bioactive theranostics attracted wide attention. In this review, we mainly summarize recent progress also introduce definition, synthesis modification strategies nanomaterials. Thereafter, tumor imaging therapy, including microenvironment (TME) regulation, catalytic gas regulatory cell death immunotherapy, discussed. Finally, biosafety challenges mentioned, their future development opportunities prospected. This review highlights bioapplication

Language: Английский

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Dual-Responsive Triple-Synergistic Fe-MOF for Tumor Theranostics

ACS Nano, Journal Year: 2023, Volume and Issue: 17(10), P. 9003 - 9013

Published: April 28, 2023

The intelligent responsive drug delivery system has great application potential in cancer precision therapy. Although many antitumor methods have been developed based on systems, most of them yet suffer from poor efficiency. In this project, a near-infrared and pH dual-response multimodal collaborative platform for diagnosis treatment (PCN-DOX@PDA) was constructed. We used PCN-600 as vehicle loaded with antineoplastic drugs polydopamine (PDA). Under 633 nm laser irradiation, the ligand tetrakis(4-carboxyphenyl)porphyrin (TCPP) can generate singlet oxygen (1O2) kill tumor cells. PDA is photothermal agent PTT. PCN-DOX@PDA achieves release by responding to weak acidity microenvironment thermal stimulation generated NIR irradiation. addition, since central ion PCN Fe3+, realizes tumors through magnetic resonance imaging-mediated chemotherapy photodynamic synergistic This triple strategy showed excellent biocompatibility ability vivo experiments 4T1 tumor-bearing mouse model, indicating that good development prospect field therapy diversified biomedical applications.

Language: Английский

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Advances in the application of metal oxide nanozymes in tumor detection and treatment

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 235, P. 113767 - 113767

Published: Jan. 24, 2024

Language: Английский

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Biomedical applications of MnO2 nanomaterials as nanozyme-based theranostics

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 163, P. 114833 - 114833

Published: May 8, 2023

Manganese dioxide (MnO2) nanoenzymes/nanozymes (MnO2-NEs) are 1-100 nm nanomaterials that mimic catalytic, oxidative, peroxidase, and superoxide dismutase activities. The oxidative-like activity of MnO2-NEs makes them suitable for developing effective low-cost colorimetric detection assays biomolecules. Interestingly, also demonstrate scavenging properties against reactive oxygen species (ROS) in various pathological conditions. In addition, due to the decomposition tumor microenvironment (TME) production Mn2+, they can act as a contrast agent improving clinical imaging diagnostics. use an situ system TME, thereby overcoming hypoxic conditions their consequences progression cancer. Furthermore, shell coating make nanosystems smart and, therefore, combination with other nanomaterials, be used intelligent nanocarrier delivering drugs, photosensitizers, sonosensitizers vivo. Moreover, these capabilities promising candidate treatment different human diseases such cancer, metabolic, infectious, inflammatory have ROS-scavenging anti-bacterial Gram-positive Gram-negative bacterial strains, which wound healing applications. Given importance potential applications biomedicine, this review aimed discuss biochemical theranostic roles recent advances biomolecules, diagnostic imaging, drug delivery, combinatorial therapy Finally, challenges biomedicine will discussed.

Language: Английский

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A Photo‐Therapeutic Nanocomposite with Bio‐Responsive Oxygen Self‐Supplying Combats Biofilm Infections and Inflammation from Drug‐Resistant Bacteria

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(37)

Published: May 25, 2023

Abstract The use of non‐antibiotic strategies to combat refractory drug‐resistant bacterial infections, especially biofilms and accompanying inflammation, has recently aroused widespread interest. Herein, a photo‐therapeutic nanocomposite with bio‐responsive oxygen (O 2 ) self‐supplying is introduced by integrating manganese dioxide (MnO nanozymes onto photosensitizer (indocyanine green, ICG)‐loaded mesoporous polydopamine nanoparticles (MPDA), namely MI‐MPDA NPs. can activate O generation in the infection microenvironment, thereby effectively alleviating biofilm hypoxia. Under near‐infrared light (NIR) irradiation, continuous supplying further boosts level singlet ( 1 ), enabling robust elimination through ‐potentiated photodynamic/photothermal therapy. Interestingly, down‐regulates factor expression inflammatory signaling pathways MnO ‐mediated reactive species scavenging, which ameliorates condition. Meanwhile, prevents M1‐phenotype switch macrophages from overexpression hypoxia‐inducible factor‐1 α (HIF‐1 prompting macrophage reprogramming toward pro‐regenerative M2‐phenotype. In mouse models subcutaneous implant‐associated caused methicillin‐resistant Staphylococcus aureus (MRSA) burn Pseudomonas aeruginosa biofilms, NIR‐irradiated not only eliminates formed but also alleviates oxidative stress drives cascade reaction immunomodulation‐wound healing. Overall, this strategy provides reliable tool for combating infections inflammation bacteria.

Language: Английский

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Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(16)

Published: Feb. 21, 2024

Abstract Cancer cells typically display redox imbalance compared with normal due to increased metabolic rate, accumulated mitochondrial dysfunction, elevated cell signaling, and accelerated peroxisomal activities. This may regulate gene expression, alter protein stability, modulate existing cellular programs, resulting in inefficient treatment modalities. Therapeutic strategies targeting intra‐ or extracellular states of cancer at varying state progression trigger programmed death if exceeded a certain threshold, enabling therapeutic selectivity overcoming resistance radiotherapy chemotherapy. Nanotechnology provides new opportunities for modulating their excellent designability high reactivity. Various nanomaterials are widely researched enhance highly reactive substances (free radicals) production, disrupt the endogenous antioxidant defense systems, both. Here, physiological features described challenges illustrated. Then, that classified elaborated upon based on ability target regulations. Finally, future perspectives this field proposed. It is hoped review guidance design nanomaterials‐based approaches involving therapy, especially cancers resistant chemotherapy, etc.

Language: Английский

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Single-atom nanozymes: Emerging talent for sensitive detection of heavy metals

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 242, P. 114093 - 114093

Published: July 14, 2024

Language: Английский

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Targeted Delivery of Active Sites by Oxygen Vacancy-Engineered Bimetal Silicate Nanozymes for Intratumoral Aggregation-Potentiated Catalytic Therapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(2), P. 1516 - 1530

Published: Jan. 3, 2024

Biodegradable silicate nanoconstructs have aroused tremendous interest in cancer therapeutics due to their variable framework composition and versatile functions. Nevertheless, low intratumoral retention still limits practical application. In this study, oxygen vacancy (OV)-enriched bimetallic nanozymes with Fe–Ca dual active sites via modification of oxidized sodium alginate gallic acid (GA) loading (OFeCaSA-V@GA) were developed for targeted aggregation-potentiated therapy. The band gap silica markedly decreased from 2.76 1.81 eV by codoping Fe3+ Ca2+, enabling its excitation a 650 nm laser generate reactive species. OV that occurred the hydrothermal synthetic stage OFeCaSA-V@GA can anchor metal ions form an atomic phase, offering massive fabrication method single-atom nanozymes. Density functional theory results reveal Ca promote adsorption H2O2, Fe accelerate dissociation thereby realizing synergetic catalytic effect. More importantly, delivery induce morphological transformation at tumor sites, leading high (the highest rate is 36.3%) theranostic components cells. Thus, finding may offer ingenious protocol designing engineering highly efficient long-retention nanodrugs.

Language: Английский

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