Piezo‐Augmented and Photocatalytic Nanozyme Integrated Microneedles for Antibacterial and Anti‐Inflammatory Combination Therapy

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 33(10)

Published: Dec. 23, 2022

Abstract Wound infection is arguably the most common, and potentially devastating, complication of wound healing process. The ideal treatment strategy has to eliminate bacteria, alleviate inflammation, promote skin formation. Herein, a multifunctional heterostructure designed consisting ultrasmall platinum–ruthenium nanoalloys porous graphitic carbon nitride C 3 N 5 nanosheets (denoted as PtRu/C ), which concurrently possesses piezoelectric enhanced oxidase ‐mimic nanozyme activity photocatalytic hydrogen gas production capacity. Moreover, these hybrid nanotherapeutics are integrated in natural hyaluronic acid microneedles, exhibit almost 100% broad‐spectrum antibacterial efficacy against multiple bacterial strains vitro vivo within 10 min ultrasound treatment, effectively inhibit inflammation reactions after 1 h visible light irradiation, promising for accelerating cutaneous infected mice. This study highlights competitive development all‐in‐one anti‐inflammatory therapies.

Language: Английский

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Electrical stimulation system based on electroactive biomaterials for bone tissue engineering

Materials Today, Journal Year: 2023, Volume and Issue: 68, P. 177 - 203

Published: July 17, 2023

Language: Английский

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Piezoelectricity, Pyroelectricity, and Ferroelectricity in Biomaterials and Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(3)

Published: Oct. 16, 2023

Abstract Piezoelectric, pyroelectric, and ferroelectric materials are considered unique biomedical due to their dielectric crystals asymmetric centers that allow them directly convert various primary forms of energy in the environment, such as sunlight, mechanical energy, thermal into secondary electricity chemical energy. These possess exceptional conversion ability excellent catalytic properties, which have led widespread usage within fields. Numerous applications demonstrated great potential with these materials, including disease treatment, biosensors, tissue engineering. For example, piezoelectric used stimulate cell growth bone regeneration, while pyroelectric applied skin cancer detection imaging. Ferroelectric even found use neural implants record electrical activity brain. This paper reviews relationship between ferroelectric, piezoelectric, effects fundamental principles different reactions. It also highlights preparation methods three significant progress made applications. The review concludes by presenting key challenges future prospects for efficient catalysts based on nanomaterials

Language: Английский

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A Review on PVDF Nanofibers in Textiles for Flexible Piezoelectric Sensors

ACS Applied Nano Materials, Journal Year: 2023, Volume and Issue: 6(3), P. 1522 - 1540

Published: Jan. 20, 2023

Textiles are turning into a suitable next-generation sensing platform because of their good breathability, softness, and structural elasticity. Besides, research on self-powered piezoelectric sensors is hot topic in wearable applications; they can perform long-term monitoring. Therefore, this paper mainly reviews the development progress PVDF-based textiles flexible sensors. In paper, we first introduce principle effect classification materials; then summarize structure characteristics nanofiber mat-based, yarn-based, fabric-based approaches that employed to fabricate textile such as melt spinning, electrospinning, stretch forming processes, so on. At last, review applicability application electronic skin, human–computer interaction, healthcare, human movement monitoring demonstrate facing difficulties future directions

Language: Английский

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Bio-piezoelectricity: fundamentals and applications in tissue engineering and regenerative medicine

Biophysical Reviews, Journal Year: 2022, Volume and Issue: 14(3), P. 717 - 733

Published: June 1, 2022

Language: Английский

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Piezotronic and piezo‐phototronic effects on sonodynamic disease therapy

BMEMat, Journal Year: 2023, Volume and Issue: 1(1)

Published: Feb. 18, 2023

Abstract With the development of engineered nanomaterials and nanomedicines, utilization to generate excessive reactive oxygen species under exogenous ultrasound (US) irradiation for realizing disease therapy, namely sonodynamic therapy (SDT), has attracted widespread attention. Compared with traditional photodynamic US shows deeper tissue penetration reach deep‐seated location. However, high‐efficiency sonosensitizers remains one gravest challenges in current related research future clinical application. Latterly, benefiting from piezotronic piezo‐phototronic effects, novel based on piezoelectric semiconductor (PS) have exhibited inspiring application prospects SDT. In this review, we outline structures physicochemical properties PS that potential applications SDT, introduce presumed mechanisms Then, latest progress as cancer antibacterial are summarized. Finally, existing trends field prospected.

Language: Английский

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Biodegradable Piezoelectric Polymers: Recent Advancements in Materials and Applications

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(23)

Published: May 26, 2023

Recent materials, microfabrication, and biotechnology improvements have introduced numerous exciting bioelectronic devices based on piezoelectric materials. There is an intriguing evolution from conventional unrecyclable materials to biodegradable, green, biocompatible functional As a fundamental electromechanical coupling material in applications, novel with feature of degradability desired electrical mechanical properties are being developed for future wearable implantable bioelectronics. These bioelectronics can be easily integrated biological systems including sensing physiological signals, diagnosing medical problems, opening the blood-brain barrier, stimulating healing or tissue growth. Therefore, generation piezoelectricity natural synthetic bioresorbable polymers has drawn great attention research field. Herein, significant recent advancements biodegradable polymers, their principles, advanced challenges uses, reviewed thoroughly. The degradation methods these through vitro vivo studies also investigated. microsystems could enable new applications biomedical In end, potential opportunities regarding practical pointed out that might research.

Language: Английский

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Perspectives on recent advancements in energy harvesting, sensing and bio-medical applications of piezoelectric gels

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(17), P. 6191 - 6220

Published: Jan. 1, 2023

This review highlights the recent progress in piezoelectric gels (also known as PiezoGels) comprised of polymers, ceramic oxides and supramolecular materials used for energy harvesting, sensing wound dressing.

Language: Английский

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Bimetallic Organic Frameworks of High Piezovoltage for Sono‐Piezo Dynamic Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(41)

Published: July 11, 2023

Piezoelectric materials produce charges to directly act on cancer medium or promote the generation of reactive oxygen species (ROS) for novel tumor therapy triggered by sonography. Currently, piezoelectric sonosensitizers are mainly used catalyze ROS band-tilting effect sonodynamic therapy. However, it remains a challenge high piezovoltages overcome bandgap barrier direct charge generation. Herein, Mn-Ti bimetallic organic framework tetragonal nanosheets (MT-MOF TNS) designed sono-piezo (SP)-dynamic (SPDT) with remarkable antitumor efficacy in vitro and vivo. The MT-MOF TNS comprise non-centrosymmetric secondary building units Mn-Ti-oxo cyclic octamers heterogeneous components piezoelectricity. promotes strong sonocavitation induce SP voltage (2.9 V) situ, excite charges, which is validated SP-excited luminescence spectrometry. depolarize mitochondrial plasma membrane potentials cause overproduction serious cell damage. Importantly, can be decorated targeting molecules chemotherapeutics more severe regression combining SPDT chemodynamic chemotherapy. This report develops fascinating nano-semiconductor provides an efficient strategy treatment.

Language: Английский

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The fundamentals and applications of piezoelectric materials for tumor therapy: recent advances and outlook

Materials Horizons, Journal Year: 2023, Volume and Issue: 10(4), P. 1140 - 1184

Published: Jan. 1, 2023

Malignant tumors are one of the main diseases leading to death, and vigorous development nanotechnology has opened up new frontiers for antitumor therapy. Currently, researchers focused on solving biomedical challenges associated with traditional anti-tumor medical methods, promoting research nano-drug carriers nano-drugs, which brings great hope improving curative effect reducing toxic side effects. Among systems being investigated, piezoelectric nano biomaterials, including ferroelectrics, pyroelectric materials, have recently received extensive attention applications. By coupling force, light, magnetism or heat electricity, polarized charges generated in these materials microscopically, forming a piezo-potential establishing built-in electric field. Polarized can directly act tumor micro-environment also assist separation inhibit recombination based theory optoelectronic theory. Based this, convert various forms primary energy (such as light energy, mechanical thermal magnetic energy) from surrounding environment into secondary electrical chemical energy). Herein, we review basic principles ferroelectric nanomedicine. Then, summarize types reported date their wide applications treatment, imaging, device construction probe detection treatment fields. discuss relevant characteristics post-processing strategies biomaterials obtain maximum response. Finally, present key future prospects ferroelectric, nanomaterial-based nanoagents efficient harvesting conversion desirable therapeutic outcomes.

Language: Английский

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