Customized materials-assisted microorganisms in tumor therapeutics

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(22), P. 12576 - 12615

Published: Jan. 1, 2021

This review provides a comprehensive introduction to microorganisms-based biohybrid systems, namely MAMO, for application in tumor therapeutics.

Language: Английский

---

Walking Dead Tumor Cells for Targeted Drug Delivery Against Lung Metastasis of Triple‐Negative Breast Cancer

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(33)

Published: June 27, 2022

Lung metastasis is challenging in patients with triple-negative breast cancer (TNBC). Surgery always not available due to the dissemination of metastatic foci and most drugs are powerless because poor retention at sites. TNBC cells generate an inflamed microenvironment overexpress adhesive molecules promote invasion colonization. Herein, "walking dead" developed through conjugating anti-PD-1 (programmed death protein 1 inhibitor) doxorubicin (DOX)-loaded liposomes onto cell corpses for temporal chemo-immunotherapy against lung metastasis. The walking dead maintain plenary tumor antigens conduct vaccination effects. Anti-PD-1 antibodies conjugated via reduction-activated linker, DOX-loaded attached by maleimide-thiol coupling. This anchor strategy enables rapid release upon reduction conditions while long-lasting DOX improve pulmonary accumulation local drugs, reprogram damage-associated molecular patterns (DAMPs) PD-1 blockade, prolong overall survival 4T1 EMT6-bearing mice. Taking advantage preferred delivery chemotherapeutics checkpoint inhibitors, this study suggests alternative treatment option augment efficacy

Language: Английский

---

Bacterial extracellular vesicles-based therapeutic strategies for bone and soft tissue tumors therapy

Theranostics, Journal Year: 2022, Volume and Issue: 12(15), P. 6576 - 6594

Published: Jan. 1, 2022

Bone and soft tissue tumors are complex mesenchymal neoplasms that seriously endanger human health. Over the past decade, relationship between microorganisms health diseases is getting more attention. The extracellular vesicles derived from bacteria have been shown to regulate bacterial-host cell communication by transferring their contents, including nucleic acids, proteins, metabolites, lipopolysaccharides, peptidoglycans. Bacteria (BEVs) promising lipid-bilayer nanocarriers for treatment of many due low toxicity, drug loading capacity, ease modification industrialization. Specially, BEVs-based cancer therapy has attracted much attention because ability effectively stimulate immune responses. In this review, we provide an overview biogenesis, composition, isolation, classification, internalization BEVs. We then comprehensively summarize sources BEVs in BEVs-related strategies. further highlight great potential bone tumors. Finally, conclude major advantages challenges therapy. believe comprehensive understanding field will generate innovative solutions achieve clinical applications.

Language: Английский

---

Dressing Bacteria With a Hybrid Immunoactive Nanosurface to Elicit Dual Anticancer and Antiviral Immunity

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(11)

Published: Dec. 24, 2022

Approaches capable of simultaneously treating cancer and protecting susceptible patients from lethal infections such as coronavirus disease 2019, are highly desirable but prove to be difficult. Here, dressing bacteria with a hybrid immunoactive nanosurface is reported elicit dual anticancer antiviral immunity. A combination checkpoint blocking antibody virus-specific antigen covalently conjugated polydopamine nanoparticles, which can anchored onto bacterial surface, by one-step in situ polymerization dopamine under cell-friendly condition. By virtue the ability colonize penetrate deep tumor tissue, dressed enable sustained release expanded exposure carried immunoactivators stimulate immune cells. In addition carrier role, able further provoke innate immunity due native immunogenicity pathogen-associated molecular patterns. Immunization promotes maturation, activation antigen-presenting cells, induces robust humoral cellular responses tumor-bearing mice. As evidenced efficient production viral-antigen-specific immunoglobulin G serum significantly suppressed growth different models, paves an avenue prepare next-generation therapeutics for synergistic treatment prevention.

Language: Английский

---

A Platelet Intelligent Vehicle with Navigation for Cancer Photothermal-Chemotherapy

ACS Nano, Journal Year: 2022, Volume and Issue: 16(4), P. 6359 - 6371

Published: March 24, 2022

Controllable and visible delivery of therapeutic agents is critical for tumor precise therapy. Tumor targeting deep penetration are still challenging issues controllable delivery. Visible drug with imaging navigation can optimize the treatment window personalized medicine. Herein, a biomimetic platelet intelligent vehicle (IRDNP-PLT) was developed to achieve system, driving loading system. The platelets acted as engines repositories exert target functions. fluorescent photothermal agent IR-820 introduced in platform offer an addition nanodrug-loaded enabled efficient controlled release payload by encapsulating photothermal-/pH-sensitive chemotherapeutic nanoparticles (PDA@Dox NPs). In vivo experiments on 4T1 tumor-bearing mice models, IRDNP-PLT performed well showed excellent efficacy recurrence prevention ability. achieved functions penetration, fluorescence guidance, photocontrolled release, chemo-photothermal combination therapy, suggesting advancement

Language: Английский

---

Dual-source powered nanomotor with integrated functions for cancer photo-theranostics

Biomaterials, Journal Year: 2022, Volume and Issue: 288, P. 121744 - 121744

Published: Aug. 15, 2022

Language: Английский

---

Bacteria-based bioactive materials for cancer imaging and therapy

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 193, P. 114696 - 114696

Published: Jan. 9, 2023

Language: Английский

---

Nano‐biotechnology in tumour and cancerous disease: A perspective review

Journal of Cellular and Molecular Medicine, Journal Year: 2023, Volume and Issue: 27(6), P. 737 - 762

Published: Feb. 24, 2023

Abstract In recent years, drug manufacturers and researchers have begun to consider the nanobiotechnology approach improve delivery system for tumour cancer diseases. this article, we review current strategies delivery, which mainly focuses on sustaining biocompatibility, biodistribution, active targeting. The conventional therapy using cornerstone drugs such as fludarabine, cisplatin etoposide, paclitaxel has its own challenges especially not being able discriminate between versus normal cells eventually led toxicity side effects in patients. contrast approach, nanoparticle‐based provides target‐specific controlled release of drug, a better therapeutic window treatment options by focusing eradication diseased via targeting sparing passive Additionally, tumours associated with brain is hampered impermeability blood–brain barriers drugs, poor survival Nanoparticle‐based offers superior target breaching barriers. Herein, provide an overview properties nanoparticles that are crucial nanotechnology applications. We address potential future applications specific or desired areas. particular, use nanomaterials, biostructures, methods targeted explored.

Language: Английский

---

Harnessing Engineered Immune Cells and Bacteria as Drug Carriers for Cancer Immunotherapy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(2), P. 843 - 884

Published: Jan. 4, 2023

Immunotherapy continues to be in the spotlight of oncology therapy research past few years and has been proven a promising option modulate one's innate adaptive immune systems for cancer treatment. However, poor delivery efficiency agents, potential off-target toxicity, nonimmunogenic tumors significantly limit its effectiveness extensive application. Recently, emerging biomaterial-based drug carriers, including but not limited cells bacteria, are expected candidates break dilemma immunotherapy, with their excellent natures intrinsic tumor tropism immunomodulatory activity. More than that, tiny vesicles physiological components derived from them have similar functions source due inheritance various surface signal molecules proteins. Herein, we presented representative examples about latest advances employed cells, derivatives. Simultaneously, opportunities challenges bacteria-based carriers discussed provide reference future application immunotherapy.

Language: Английский

---

Engineered Living Bacteriophage-Enabled Self-Adjuvanting Hydrogel for Remodeling Tumor Microenvironment and Cancer Therapy

Nano Letters, Journal Year: 2023, Volume and Issue: 23(4), P. 1219 - 1228

Published: Feb. 2, 2023

Due to the complexity and heterogeneity in tumor microenvironment, efficacy of breast cancer treatment has been significantly impeded. Here, we established a living system using an engineered M13 bacteriophage through chemical cross-linking biomineralization remodel microenvironment. Chemically gel (M13 Gel) could situ synthesize photothermal palladium nanoparticles (PdNPs) on pVIII capsid protein obtain M13@Pd Gel. In addition, NLG919 was further loaded into form (M13@Pd/NLG gel) for down-regulating expression tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1). Both vitro vivo studies showed that served not only as cargo-loaded device but also self-immune adjuvant, which induced immunogenic death cells effectively down-regulated IDO1 expression. Such bioactive constructed by natural materials reverse immunosuppression improve anti-breast response.

Language: Английский

---