Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(35)
Published: Aug. 1, 2024
Bacterial-derived
micro-/nanomedicine
has
garnered
considerable
attention
in
anticancer
therapy,
owing
to
the
unique
natural
features
of
bacteria,
including
specific
targeting
ability,
immunogenic
benefits,
physicochemical
modifiability,
and
biotechnological
editability.
Besides,
bacterial
components
have
also
been
explored
as
promising
drug
delivery
vehicles.
Harnessing
these
features,
cutting-edge
biotechnologies
applied
attenuated
tumor-targeting
bacteria
with
properties
or
functions
for
potent
effective
cancer
treatment,
strategies
gene-editing
genetic
circuits.
Further,
advent
bacteria-inspired
micro-/nanorobots
mimicking
artificial
systems
furnished
fresh
perspectives
formulating
developing
highly
efficient
systems.
Focusing
on
advantages
this
review
delves
into
advances
bacteria-derived
treatment
recent
years,
which
experienced
a
process
from
living
entities
Meanwhile,
summary
relative
clinical
trials
is
provided
primary
challenges
impeding
their
application
are
discussed.
Furthermore,
future
directions
suggested
combat
cancer.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
unknown
Published: July 12, 2023
Abstract
Natural
living
materials
serving
as
biotherapeutics
exhibit
great
potential
for
treating
various
diseases
owing
to
their
immunoactivity,
tissue
targeting,
and
other
biological
activities.
In
this
review,
the
recent
developments
in
engineered
materials,
including
mammalian
cells,
bacteria,
viruses,
fungi,
microalgae,
plants,
active
derivatives
that
are
used
summarized.
Further,
future
perspectives
challenges
of
such
material‐based
discussed
provide
considerations
advances
biomedical
applications.
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(19)
Published: May 8, 2024
Lactic
acid
(LA)
accumulation
in
the
tumor
microenvironment
poses
notable
challenges
to
effective
immunotherapy.
Here,
an
intelligent
treatment
microrobot
based
on
unique
physiological
structure
and
metabolic
characteristics
of
Science Advances,
Journal Year:
2024,
Volume and Issue:
10(10)
Published: March 6, 2024
Synergistic
phototherapy
stands
for
superior
treatment
prospects
than
a
single
phototherapeutic
modality.
However,
the
combined
photosensitizers
often
suffer
from
incompatible
excitation
mode,
limited
irradiation
penetration
depth,
and
lack
of
specificity.
We
describe
development
upconversion
dual-photosensitizer-expressing
bacteria
(UDPB)
near-infrared
monochromatically
excitable
combination
phototherapy.
UDPB
are
prepared
by
integrating
genetic
engineering
surface
modification,
in
which
encoded
to
simultaneously
express
photothermal
melanin
phototoxic
KillerRed
protein
primary
amino
groups
derived
free
thiols
biorthogonal
conjugation
nanoparticles.
exhibit
monochromatic
irradiation-mediated
dual-activation
characteristic
as
conversion
can
be
initiated
directly,
while
photodynamic
effect
stimulated
indirectly
upconverted
visible
light
emission.
also
show
living
features
colonize
hypoxic
lesion
sites
inhibit
pathogens
via
bacterial
community
competition.
In
two
murine
models
solid
tumor
skin
wound
infection,
separately
induce
robust
antitumor
response
rapid
healing
effect.
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Journal Year:
2024,
Volume and Issue:
151, P. 106391 - 106391
Results in Physics,
Journal Year:
2024,
Volume and Issue:
58, P. 107441 - 107441
Published: Feb. 10, 2024
In
this
study,
the
gamma-photon,
neutron,
and
charged
particle
interaction
quantities
for
SiO2–P2O5–CaO–Na2O–CaF2
bioactive
glasses
were
evaluated
with
objective
of
estimating
effect
CaF2
on
physical
radiation
responses
involved.
The
features
(e.g.
glass
density)
increased
as
increases
in
samples.
gamma
mass-attenuation
coefficient
(μ/ρ)
was
estimated
photon
energies
0.015–15
MeV
using
XCOM
database
FLUKA
Monte
Carlo
simulation
procedure.
total
stopping
powers
(TSP)
range
particles
(electrons,
protons,
α-particles,
C6+
ions)
aid
ESTAR
(for
electrons
only)
SRIM
code
C6
+
ions).
addition,
fast
(ΣR)
thermal
(TN)
neutron
cross-sections
computed
standard
theoretical
models.
μ/ρ
values
SPCNCF
within
0.0216–8.7469,
0.0217–9.2151,
0.0219–10.0588
0.0222–11.1264
cm2/g
SPCNCF1,
SPCNCF2,
SPCNCF3
SPCNCF4,
respectively.
half-value
layers
had
minimum
0.02936,
0.02767,
0.02499,
0.02215
cm
SPCNCF3,
respectively,
at
0.015
MeV.
Analysis
parameters
showed
that
attenuation
prowess
improved
content.
same
trend
observed
particles.
TSP
is
maximum
12.82
SPCNCF1
12.76
12.71
SPCNCF4.
ΣR
equal
to
0.0896,
0.0897
0.0900
increase
weight
proportion
also
removal
capacities
glasses.
better
shielding
competence
compared
some
conventional
shields
such
RS
253
G18
commercial
glasses,
concrete
samples,
polymers.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(21)
Published: Feb. 24, 2024
Engineered
bacteria
are
widely
used
in
cancer
treatment
because
live
facultative/obligate
anaerobes
can
selectively
proliferate
at
tumor
sites
and
reach
hypoxic
regions,
thereby
causing
nutritional
competition,
enhancing
immune
responses,
producing
anticancer
microbial
agents
situ
to
suppress
growth.
Despite
the
unique
advantages
of
bacteria-based
biotherapy,
insufficient
efficiency
limits
its
application
complete
ablation
malignant
tumors.
The
combination
nanomedicine
engineered
has
attracted
increasing
attention
owing
their
striking
synergistic
effects
treatment.
that
function
as
natural
vehicles
effectively
deliver
nanomedicines
sites.
Moreover,
provide
an
opportunity
enhance
by
modulating
TME
substrates
support
nanomedicine-mediated
reactions.
Nanomedicine
exhibits
excellent
optical,
magnetic,
acoustic,
catalytic
properties,
plays
important
role
promoting
bacteria-mediated
biotherapies.
therapy
comprehensively
summarized
this
review.
Attention
is
paid
not
only
fabrication
nanobiohybrid
composites,
but
also
interpromotion
mechanism
between
therapy.
Additionally,
recent
advances
bacteria-synergized
multimodal
therapies
highlighted.
Chemical Engineering Journal,
Journal Year:
2024,
Volume and Issue:
492, P. 152295 - 152295
Published: May 16, 2024
The
relentless
advancement
of
cancer,
a
leading
cause
mortality
worldwide,
underscores
the
need
for
innovative
therapeutic
strategies.
Amorphous
metal–organic
frameworks
(aMOFs)
have
emerged
as
paradigm-shifting
solution
in
field
cancer
diagnostics
and
therapeutics,
distinguishing
themselves
from
their
crystalline
counterparts
through
superior
properties
functionalities.
This
comprehensive
review
explores
synthesis,
unique
properties,
multifaceted
applications
aMOFs
diagnosis
treatment.
Compared
with
counterparts,
display
including
enhanced
catalytic
performance,
exceptional
porosity,
elevated
thermal
conductivity.
These
underpin
extensive
use
sensitive
biochemical
detection
precision
drug
delivery,
tumor
ablation,
other
applications.
Their
inherent
chemical
tunability
further
enables
integration
multifunctional
anticancer
strategies,
ranging
multiple
biomedical
imaging
to
phototherapy
metal
ion-mediated
apoptosis,
positioning
versatile
theranostic
nanoplatforms.
article
delves
into
current
oncological
challenges
prospects
aMOFs,
underscoring
transformative
potential
advanced
diagnostics,
targeted
therapy,
development
next-generation
convergence
computational
simulations
interdisciplinary
research
is
anticipated
accelerate
clinical
translation
heralding
new
era
personalized
medicine.
Biological
carriers
have
emerged
as
significant
tools
to
deliver
radionuclides
in
nuclear
medicine,
providing
a
meaningful
perspective
for
tumor
imaging
and
treatment.
Various
radionuclide-labeled
biological
been
developed
meet
the
needs
of
biomedical
applications.
This
review
introduces
principles
radionuclide-mediated
therapy
selected
criteria
them,
well
comprehensive
description
characteristics
functions
representative
including
bacteria,
cells,
viruses,
their
derivatives,
emphasizing
labeled
strategies
combined
with
radionuclides.
Subsequently,
we
in-depth
introduce
application
treatment,
behaviors
vivo
metastasis
treatment
by
radionuclide
therapy,
plus
other
radiation-induced
photodynamic
therapy.
Finally,
challenges
prospects
are
discussed
improve
shortcomings
this
innovative
platform
promote
clinical
transformation
field
medical
imaging.
