Theranostics, Journal Year: 2025, Volume and Issue: 15(11), P. 5172 - 5219
Published: April 9, 2025
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Feb. 21, 2024
Abstract Inflammation-associated diseases encompass a range of infectious and non-infectious inflammatory diseases, which continuously pose one the most serious threats to human health, attributed factors such as emergence new pathogens, increasing drug resistance, changes in living environments lifestyles, aging population. Despite rapid advancements mechanistic research development for these current treatments often have limited efficacy notable side effects, necessitating more effective targeted anti-inflammatory therapies. In recent years, nanotechnology has provided crucial technological support prevention, treatment, detection inflammation-associated diseases. Various types nanoparticles (NPs) play significant roles, serving vaccine vehicles enhance immunogenicity carriers improve targeting bioavailability. NPs can also directly combat pathogens inflammation. addition, facilitated biosensors pathogen imaging techniques This review categorizes characterizes different NPs, summarizes their applications It discusses challenges associated with clinical translation this field explores latest developments prospects. conclusion, opens up possibilities comprehensive management
Language: Английский
Citations
147
Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(32), P. 17881 - 17891
Published: Aug. 2, 2023
Atherosclerotic plaque rupture is a significant cause of acute cardiovascular events such as heart attack and stroke, triggered by the decomposition fiber caps induced cysteine cathepsin. However, accurate measurement cathepsin B (CTB) activity in plaques challenging due to low specificity insufficient penetration depth available atherosclerosis-associated fluorescent probes, hampering reliable assessment vulnerability. To address these limitations, we added both lipophilic alkyl chain hydrophilic CTB substrate hemicyanine scaffold develop lipid-unlocked responsive probe (L-CRP) that uses lipids two keys unlock photoacoustic (PA) signals for measuring environments. Such properties allow L-CRP imaging specific activities foam cells atherosclerotic while keeping silence toward lipid-deficient environments, M1-type macrophages LPS-induced inflammatory lesions. Moreover, activatable PA exhibit deeper tissue ability (>1.0 cm) than current probes based on near-infrared (∼0.3 cm), suitable atherosclerosis living mice. In mice, dynamically reports intraplaque levels, which well-correlated with vulnerability characteristics cap thickness, macrophage recruitment, necrotic core size, thus enabling risk stratification mice complicated pneumonia. successfully identifies excised human artery tissues, promising auxiliary diagnosis clinical application.
Language: Английский
Citations
76
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(18)
Published: Jan. 15, 2024
Abstract Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad vital functions across diverse cellular processes. Dysfunctions within mitochondria serve catalysts for various diseases, prompting widespread demise. Mounting research on remedying damaged indicates that constitute valuable target therapeutic intervention against diseases. But less clinical practice and lower recovery rate imply limitation traditional drugs, which need further breakthrough. Nanotechnology has approached favorable regiospecific biodistribution high efficacy by capitalizing excellent nanomaterials targeting drug delivery. Mitochondria‐remedying nanodrugs achieved ideal effects. This review elucidates significance in cells organs, while also compiling mortality data related Correspondingly, nanodrug‐mediate strategies applicable mitochondria‐remedying disease are detailed, with full understanding roles dysfunction advantages nanodrugs. In addition, future challenges directions discussed. conclusion, this provides comprehensive insights into design development nanodrugs, aiming to help scientists who desire extend their fields engage interdisciplinary subject.
Language: Английский
Citations
30
Advanced Science, Journal Year: 2024, Volume and Issue: 11(17)
Published: Feb. 17, 2024
Abstract Atherosclerosis, a multifaceted chronic inflammatory disease, has profound impact on cardiovascular health. However, the critical limitations of atherosclerosis management include delayed detection advanced stages, intricate assessment plaque stability, and absence efficacious therapeutic strategies. Nanotheranostic based nanotechnology offers novel paradigm for addressing these challenges by amalgamating imaging capabilities with targeted interventions. Meanwhile, iron oxide nanoparticles have emerged as compelling candidates theranostic applications in due to their magnetic resonance capability biosafety. This review delineates current state prospects nanoparticle‐based nanotheranostics realm atherosclerosis, including pivotal aspects development, pertinent targeting strategies involved disease pathogenesis, diagnostic roles nanoparticles. Furthermore, this provides comprehensive overview nanomedicine approaches employing nanoparticles, encompassing chemical therapy, physical stimulation biological therapy. Finally, proposes discusses associated translating innovative into clinically viable anti‐atherosclerosis In conclusion, new insights future theranostic, showcasing remarkable potential oxide‐based versatile tools battle against atherosclerosis.
Language: Английский
Citations
19
Advanced Science, Journal Year: 2023, Volume and Issue: 10(36)
Published: Oct. 28, 2023
Abstract With the changing disease spectrum, atherosclerosis has become increasingly prevalent worldwide and associated diseases have emerged as leading cause of death. Due to their fascinating physical, chemical, biological characteristics, nanomaterials are regarded a promising tool tackle enormous challenges in medicine. The emerging discipline nanomedicine filled huge application gap atherosclerotic field, ushering new generation diagnosis treatment strategies. Herein, based on essential pathogenic contributors atherogenesis, well distinct composition/structural synthesis strategies, surface design nanoplatforms, three major branches (nanodiagnosis, nanotherapy, nanotheranostic) elaborated. Then, state‐of‐art studies containing sequence representative significant achievements summarized detail with an emphasis intrinsic interaction/relationship between nanomedicines atherosclerosis. Particularly, attention is paid biosafety nanomedicines, which aims pave way for future clinical translation this burgeoning field. Finally, comprehensive review concluded by proposing unresolved key scientific issues sharing vision expectation future, fully elucidating closed loop from atherogenesis paradigm advancing early achievement applications.
Language: Английский
Citations
40
Exploration, Journal Year: 2023, Volume and Issue: 4(3)
Published: Dec. 7, 2023
Abstract Atherosclerosis, a chronic disease associated with metabolism, poses significant risk to human well‐being. Currently, existing treatments for atherosclerosis lack sufficient efficiency, while the utilization of surface‐modified nanoparticles holds potential deliver highly effective therapeutic outcomes. These can target and bind specific receptors that are abnormally over‐expressed in atherosclerotic conditions. This paper reviews recent research (2018–present) advances various ligand‐modified nanoparticle systems targeting by specifically signature molecules hope precise treatment at molecular level concludes discussion challenges prospects this field. The intention review is inspire novel concepts design advancement targeted nanomedicines tailored atherosclerosis.
Language: Английский
Citations
27
ACS Nano, Journal Year: 2024, Volume and Issue: 18(3), P. 2195 - 2209
Published: Jan. 9, 2024
Nanocarrier-based cytoplasmic protein delivery offers opportunities to develop therapeutics; however, many systems are positively charged, causing severe toxic effects. For enhanced therapeutics, it is also of great importance design nanocarriers with intrinsic bioactivity that can be integrated drugs due the limited proteins alone for disease treatment. We report here a system based on anionic phosphite-terminated phosphorus dendrimers anti-inflammatory activity. A dendrimer termed AK-137 optimized activity was selected complex through various physical interactions. Model such as bovine serum albumin, ribonuclease A, ovalbumin, and fibronectin (FN) transfected into cells exert their respective functions, including cancer cell apoptosis, dendritic maturation, or macrophage immunomodulation. Particularly, constructed AK-137@FN nanocomplexes display powerful therapeutic effects in acute lung injury gout arthritis models by integrating both carrier protein. The developed may employed universal particularly utilized deliver fight different inflammatory diseases efficacy.
Language: Английский
Citations
16
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(16)
Published: April 2, 2024
Atherosclerotic plaque formation is considered the primary pathological mechanism underlying atherosclerotic cardiovascular diseases, leading to severe events such as stroke, acute coronary syndromes, and even sudden cardiac death. Early detection timely intervention of plaques are challenging due lack typical symptoms in initial stages. Therefore, precise early play a crucial role risk stratification achieving favorable post-interventional outcomes. The continuously advancing nanoplatforms have demonstrated numerous advantages including high signal-to-noise ratio, enhanced bioavailability, specific targeting capabilities for imaging agents therapeutic drugs, enabling effective visualization management plaques. Motivated by these superior properties, various noninvasive modalities recognition preliminary stage atherosclerosis comprehensively summarized. Additionally, several strategies proposed enhance efficacy treating Finally, existing challenges promising prospects accelerating clinical translation nanoplatform-based molecular therapy discussed. In conclusion, this review provides an insightful perspective on diagnosis
Language: Английский
Citations
13
Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: 765, P. 110316 - 110316
Published: Jan. 22, 2025
Language: Английский
Citations
1
Regenerative Biomaterials, Journal Year: 2023, Volume and Issue: 10
Published: Jan. 1, 2023
Abstract Atherosclerosis (AS) has emerged as one of the prevalent arterial vascular diseases characterized by plaque and inflammation, primarily causing disability mortality globally. Drug therapy remains main treatment for AS. However, a series obstacles hinder effective drug delivery. Nature, from natural micro-/nano-structural biological particles like cells extracellular vesicles to distinctions between normal pathological microenvironment, offers compelling solutions efficient Nature-inspired nanocarriers synthetic stimulus-responsive materials components, such lipids, proteins membrane structures, have promising candidates fulfilling delivery needs. These offer several advantages, including prolonged blood circulation, targeted delivery, specific controlled release at action site. In this review, we discuss nature-inspired which leverage properties or microenvironment improve atherosclerotic therapy. Finally, provide an overview challenges opportunities applying these innovative nanocarriers.
Language: Английский
Citations
18