Synergizing
nanomaterial
technology
with
advanced
3D
printing
techniques
creates
new
opportunities
for
developing
smart,
stimuli-responsive
materials
suitable
tissue
engineering
scaffolds.
By
incorporation
of
nanoparticles
into
extracellular
matrix
mimetics,
these
composites
gain
functional
elements
capable
replicating
dynamic
biological
processes
in
vitro.
Herein,
we
propose
combining
hybrid
multifunctional
inorganic-organic
the
emerging
volumetric
bioprinting
(VBP)
technique.
We
present
two
materials,
a
light
polymer-based
resin
and
biocompatible
porcine-derived
decellularized
(dECM)-based
bioresin,
thus
expanding
library
VBP.
Plasmonic
are
combined
thermoresponsive
polymeric
matrix,
formulating
plasmonic
resin,
while
dECM-based
bioresin
embedded
smooth
muscle
cells
(SMCs)
is
employed
to
include
component
system.
As
proof
concept
demonstrate
versatility
investigated
generation
highly
complex
structures,
including
multiwalled
channels,
using
sequential
Overall,
this
study
broadens
range
compatible
VBP,
thereby
enabling
use
smart
multicomponent
fabrication
dynamic,
vitro
models.
Aggregate,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
ABSTRACT
The
repair
and
functional
reconstruction
of
bone
defects
resulting
from
trauma,
surgical
resection,
degenerative
diseases,
congenital
malformations
are
major
clinical
challenges.
Bone
tissue
engineering
has
significant
advantages
in
the
treatment
severe
defects.
Vascularized
scaffolds
gradually
attracting
attention
development
because
their
excellent
biomimetic
properties
efficient
efficiency.
Three‐dimensional
(3D)
printing
technology,
which
can
be
used
to
fabricate
structures
at
different
scales
using
a
wide
range
materials,
been
production
vascularized
scaffolds.
This
review
discusses
research
progress
3D
for
Angiogenesis‐osteogenesis
coupling
regeneration
process
is
first
introduced,
followed
by
summary
technologies,
inks,
bioactive
factors
Notably,
this
focuses
on
structural
design
strategies
Finally,
application
medicine,
as
well
challenges
outlooks
future
development,
described.
Bioengineering,
Journal Year:
2025,
Volume and Issue:
12(2), P. 136 - 136
Published: Jan. 30, 2025
Whole-organ
decellularization
generates
scaffolds
containing
native
extracellular
matrix
(ECM)
components
with
preserved
tissue
microarchitecture,
providing
a
promising
advancement
in
engineering
and
regenerative
medicine.
Decellularization
retains
the
ECM
integrity
which
is
important
for
supporting
cell
attachment,
growth,
differentiation,
biological
function.
Although
there
are
consensus
guidelines
to
standardize
processes
characterization,
no
specific
criteria
or
standards
regarding
sterility
biosafety
have
been
established
so
far.
This
regulatory
gap
safety,
sterilization,
regulation
has
hampered
clinical
translation
of
decellularized
scaffolds.
In
this
review,
we
identify
essential
safe
use
products
from
both
human
animal
sources.
These
include
efficacy,
levels
chemical
residue,
preservation
composition
physical
characteristics,
aseptic
processing
assure
sterility.
Furthermore,
explore
key
considerations
advancing
into
practice,
focusing
on
frameworks
safety
requirements.
Addressing
these
challenges
crucial
minimizing
risks
adverse
reactions
infection
transmission,
thereby
accelerating
adoption
tissue-engineered
products.
review
aims
provide
foundation
establishing
robust
guidelines,
effective
integration
medicine
applications.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
Engineered
living
systems
(ELSs)
represent
purpose-driven
assemblies
of
components,
encompassing
cells,
biomaterials,
and
active
agents,
intricately
designed
to
fulfill
diverse
biomedical
applications.
Gelatin
its
derivatives
have
been
used
extensively
in
ELSs
owing
their
mature
translational
pathways,
favorable
biological
properties,
adjustable
physicochemical
characteristics.
This
review
explores
the
intersection
gelatin
with
fabrication
techniques,
offering
a
comprehensive
examination
synergistic
potential
creating
for
various
applications
biomedicine.
It
offers
deep
dive
into
gelatin,
including
structures
production,
sources,
processing,
properties.
Additionally,
techniques
employing
derivatives,
generic
microfluidics,
3D
printing
methods.
Furthermore,
it
discusses
based
on
regenerative
engineering
as
well
cell
therapies,
bioadhesives,
biorobots,
biosensors.
Future
directions
challenges
are
also
examined,
highlighting
emerging
trends
areas
improvements
innovations.
In
summary,
this
underscores
significance
gelatin-based
advancing
lays
groundwork
guiding
future
research
developments
within
field.
Engineering,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 1, 2024
Organ
damage
or
failure
arising
from
injury,
disease,
and
aging
poses
challenges
due
to
the
body's
limited
regenerative
capabilities.
transplantation
presents
issues
of
donor
shortages
immune
rejection
risks,
necessitating
innovative
solutions.
The
3D
bioprinting
organs
on
demand
offers
promise
in
tissue
engineering
medicine.
In
this
review,
we
explore
state-of-the-art
technologies,
with
a
focus
bioink
cell
type
selections.
We
follow
discussions
advances
solid
organs,
such
as
heart,
liver,
kidney,
pancreas,
highlighting
importance
vascularization
integration.
Finally,
provide
insights
into
key
future
directions
context
clinical
translation
bioprinted
their
large-scale
production.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(14), P. 8787 - 8822
Published: July 5, 2024
Harnessing
light
for
cross-linking
of
photoresponsive
materials
has
revolutionized
the
field
3D
printing.
A
wide
variety
techniques
leveraging
broad-spectrum
shaping
have
been
introduced
as
a
way
to
achieve
fast
and
high-resolution
printing,
with
applications
ranging
from
simple
prototypes
biomimetic
engineered
tissues
regenerative
medicine.
Conventional
light-based
printing
use
material
in
layer-by-layer
fashion
produce
complex
parts.
Only
recently,
new
emerged
which
deploy
multidirection,
tomographic,
light-sheet
or
filamented
image
projections
deep
into
volume
resin-filled
vat
photoinitiation
cross-linking.
These
Deep
Vat
(DVP)
approaches
alleviate
need
layer-wise
enable
unprecedented
fabrication
speeds
(within
few
seconds)
high
resolution
(>10
μm).
Here,
we
elucidate
physics
chemistry
these
processes,
their
commonalities
differences,
well
emerging
biomedical
non-biomedical
fields.
Importantly,
highlight
limitations,
future
scope
research
that
will
improve
scalability
applicability
DVP
engineering
medicine
applications.
iScience,
Journal Year:
2025,
Volume and Issue:
28(3), P. 111882 - 111882
Published: Jan. 23, 2025
Cardiac
tissue
lacks
regenerative
capacity,
making
heart
transplantation
the
primary
treatment
for
end-stage
failure.
Engineered
cardiac
tissues
developed
through
three-dimensional
bioprinting
(3DBP)
offer
a
promising
alternative.
However,
reproducing
native
structure,
cellular
diversity,
and
functionality
of
requires
advanced
bioinks.
Major
obstacles
in
CTE
(cardiac
engineering)
include
accurately
characterizing
bioink
properties,
replicating
microenvironment,
achieving
precise
spatial
organization.
Optimizing
properties
to
closely
mimic
extracellular
matrix
(ECM)
is
essential,
as
deviations
may
result
pathological
effects.
This
review
encompasses
rheological
electromechanical
bioinks
function
microenvironment
design
functional
constructs.
Furthermore,
it
focuses
on
improving
characteristics,
printability,
bioinks,
offering
valuable
perspectives
developing
new
especially
designed
CTE.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(20)
Published: April 22, 2024
Regenerative
medicine
has
evolved
with
the
rise
of
tissue
engineering
due
to
advancements
in
healthcare
and
technology.
In
recent
years,
bioprinting
been
an
upcoming
approach
traditional
practices,
through
fabrication
functional
by
its
layer-by-layer
deposition
process.
This
overcomes
challenges
such
as
irregular
cell
distribution
limited
density,
it
can
potentially
address
organ
shortages,
increasing
transplant
options.
Bioprinting
fully
organs
is
a
long
stretch
but
advancement
rapidly
growing
precision
compatibility
complex
geometries.
Computational
Fluid
Dynamics
(CFD),
carestone
computer-aided
engineering,
instrumental
assisting
research
development
cutting
costs
saving
time.
CFD
optimizes
testing
parameters
shear
stress,
diffusivity,
viability,
reducing
repetitive
experiments
aiding
material
selection
bioprinter
nozzle
design.
review
discusses
current
application
potential
enhance
technology
that
contribute
evolution
regenerative
medicine.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 5, 2024
Abstract
Reproductive
health
concerns
like
Mayer‐Rokitansky‐Küster‐Hauser
(MRKH)
syndrome
are
prevalent
in
today's
society.
MRKH
is
a
condition
that
severely
affects
women's
sexual
life,
fertility,
and
mental
has
high
prevalence
of
one
out
5000
female
births.
Vaginoplasty
the
primary
method
to
regain
patients’
reproductive
health.
However,
conventional
vaginoplasty
faces
various
challenges,
including
complex
non‐customized
treatment
procedures
causing
intense
pains
complications.
To
bring
new
advances
vaginoplasty,
3D‐printed
hydrogel
scaffold
developed
provide
satisfactory
mechanical
support
bioactivity
for
accelerating
defect
repair
after
surgery.
The
consisting
gelatin
methacryloyl
(gelMA)
carrageenan
(Car)
custom
using
an
ambient
temperature
printing
system.
Furthermore,
undergoes
dual‐crosslinking
through
chemical
crosslinking
gelMA
ionic
Car
with
magnesium
ions
(Mg
2+
).
This
strategy
substantially
improves
overall
properties
introduces
bioactive
Mg
.
sustained
release
plus
extracts
from
dual‐crosslinked
significantly
promotes
cell
proliferation,
migration
angiogenesis.
In
preclinical
rat
model
penetrating
genital
tract
defects
mimicking
implantation
repairs
wounds
near‐normal
levels
within
week,
showing
potential
as
alternative
better
regaining
