Beilstein Journal of Nanotechnology,
Journal Year:
2021,
Volume and Issue:
12, P. 1140 - 1150
Published: Oct. 12, 2021
Biomolecules,
such
as
proteins
and
peptides,
can
be
self-assembled.
They
are
widely
distributed,
easy
to
obtain,
biocompatible.
However,
the
self-assembly
of
peptides
has
disadvantages,
difficulty
in
obtaining
high
quantities
materials,
cost,
polydispersity,
purification
limitations.
The
difficulties
using
functional
materials
make
it
more
complicate
arrange
assembled
nanostructures
at
both
microscopic
macroscopic
scales.
Amino
acids,
smallest
constituent
bottom-up
approach,
building
blocks
that
single
amino
acids
advantages
low
synthesis
simple
modeling,
excellent
biocompatibility
biodegradability
vivo.
In
addition,
with
other
components
meet
multiple
scientific
needs.
these
design
attractive
remains
a
challenge
due
simplicity
acids.
Most
review
articles
about
focus
on
large
molecules,
proteins.
preparation
complicated
by
not
yet
been
evaluated.
Therefore,
is
great
significance
systematically
summarize
literature
acid
self-assembly.
This
article
reviews
recent
advances
regarding
self-assembly,
coordination
regulatory
molecule
Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
31(32)
Published: May 13, 2021
Abstract
Tissue
engineering
requires
not
only
tissue‐specific
functionality
but
also
a
realistic
scale.
Decellularized
extracellular
matrix
(dECM)
is
presently
applied
to
the
extrusion‐based
3D
printing
technology.
It
has
demonstrated
excellent
efficiency
as
bioscaffolds
that
allow
of
living
constructs
with
elaborate
microarchitectures
well
biochemical
milieu
target
tissues
and
organs.
However,
dECM
bioinks
have
poor
printability
physical
properties,
resulting
in
limited
shape
fidelity
scalability.
In
this
study,
new
light‐activated
ruthenium/sodium
persulfate
(dERS)
are
introduced.
The
materials
can
be
polymerized
via
dityrosine‐based
cross‐linking
system
rapid
reaction
kinetics
improved
mechanical
properties.
Complicated
high
aspect
ratios
fabricated
similar
geometry
desired
increased
versatility
using
dERS.
Furthermore,
tissue
safely
regenerative
capacity
identical
pure
dECM.
dERS
may
serve
platform
for
wider
biofabrication
window
through
building
complex
centimeter‐scale
supporting
performances
encapsulated
cells.
This
capability
opens
avenues
upscaling
production
hydrogel‐based
without
additional
processes,
applicable
medicine.
Materials Today,
Journal Year:
2023,
Volume and Issue:
65, P. 244 - 259
Published: April 20, 2023
The
ability
to
reverse
engineer
the
silkworm
fiber
has
led
tremendous
advancements
in
field
of
silk
materials
over
last
several
decades,
with
fibroin
applied
biomedical,
food,
and
high
technology
industries.
This
progress
is
largely
due
process
into
a
regenerated
solution
that
can
be
engineered
variety
material
formats
stabilized
by
reintroduction
non-covalent
native
β-sheet
protein
structure.
next
revolution
involves
stabilizing
through
covalent
crosslinking
plasticization.
These
approaches
have
transformed
not
only
strong,
but
also
elastic
flexible,
making
it
compatible
modern
fabrication
approaches.
significantly
broadened
strategies
include
photolithography,
digital
light
processing,
extrusion-based
3D
printing.
As
result,
now
used
range
applications
including
ocular
prostheses,
bio-adhesives,
tissue
engineering
matrices,
green
biodegradable
LEDs
batteries,
on-skin
implantable
sensors,
bioplastics.
In
this
review,
we
discuss
evolution
materials,
focusing
on
tyrosine-
methacrylate-based
crosslinks,
structural
changes
brough
about
plasticizing
using
glycerol
calcium
ions.
We
describe
how
advances
development
unique
paving
way
for
new
across
multiple
industries,
ushering
era
materials.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(34)
Published: July 7, 2022
Coacervates
droplets
have
long
been
considered
as
potential
protocells
to
mimic
living
cells.
However,
these
lack
a
membrane
and
are
prone
coalescence,
limiting
their
ability
survive,
interact,
organize
into
higher-order
assemblies.
This
work
shows
that
tyrosine-rich
peptide
conjugates
can
undergo
liquid-liquid
phase
separation
in
well-defined
pH
window
transform
stable
membrane-enclosed
by
enzymatic
oxidation
cross-linking
at
the
interface.
The
of
peptides
dityrosine
creates
semipermeable,
flexible
around
coacervates
with
tunable
thickness,
which
displays
strong
intrinsic
fluorescence,
stabilizes
coacervate
against
coalescence.
membranes
an
effective
molecular
weight
cut-off
2.5
kDa,
determined
from
partitioning
small
dyes
labeled
peptides,
RNA,
polymers
protocells.
Flicker
spectroscopy
reveals
bending
rigidity
only
0.1kB
T,
is
substantially
lower
than
phospholipid
bilayers
despite
larger
thickness.
Finally,
it
shown
enzymes
be
stably
encapsulated
inside
supplied
substrates
outside,
opens
way
for
membrane-bound
compartments
used
molecularly
crowded
artificial
cells
capable
communication
or
vehicle
drug
delivery.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(6), P. 3186 - 3219
Published: March 11, 2024
It
is
now
generally
accepted
that
macromolecules
do
not
act
in
isolation
but
"live"
a
crowded
environment,
is,
an
environment
populated
by
numerous
different
molecules.
The
field
of
molecular
crowding
has
its
origins
the
far
80s
became
only
end
90s.
In
present
issue,
we
discuss
various
aspects
are
influenced
and
need
to
consider
effects.
This
Review
meant
as
introduction
theme
analysis
evolution
concept
through
time
from
colloidal
polymer
physics
more
biological
perspective.
We
introduce
themes
will
be
thoroughly
treated
other
Reviews
issue.
our
intentions,
each
may
stand
itself,
complete
collection
aspiration
provide
complementary
perspectives
propose
holistic
view
crowding.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Jan. 11, 2024
Abstract
Targeted
assembly
of
nanoparticles
in
biological
systems
holds
great
promise
for
disease-specific
imaging
and
therapy.
However,
the
current
manipulation
nanoparticle
dynamics
is
primarily
limited
to
organic
pericyclic
reactions,
which
necessitate
introduction
synthetic
functional
groups
as
bioorthogonal
handles
on
nanoparticles,
leading
complex
laborious
design
processes.
Here,
we
report
synthesis
tyrosine
(Tyr)-modified
peptides-capped
iodine
(I)
doped
CuS
(CuS-I@P1
NPs)
self-catalytic
building
blocks
that
undergo
self-propelled
inside
tumour
cells
via
Tyr-Tyr
condensation
reactions
catalyzed
by
themselves.
Upon
cellular
internalization,
CuS-I@P1
NPs
furin-guided
formation
CuS-I
assemblies
through
dityrosine
bond.
The
tumour-specific
furin-instructed
intracellular
exhibits
activatable
dual-modal
capability
enhanced
photothermal
effect,
enabling
highly
efficient
therapy
tumours.
robust
self-catalysis-regulated
situ
assembly,
facilitated
natural
handles,
offers
advantages
convenient
fabrication,
high
reaction
specificity,
biocompatibility,
representing
a
generalizable
strategy
target-specific
biomedical
Advanced Science,
Journal Year:
2018,
Volume and Issue:
6(4)
Published: Nov. 15, 2018
Abstract
The
self‐assembly
of
biomolecules
can
provide
a
new
approach
for
the
design
functional
systems
with
diverse
range
hierarchical
nanoarchitectures
and
atomically
defined
structures.
In
this
regard,
peptides,
particularly
short
are
attractive
building
blocks
because
their
ease
establishing
structure–property
relationships,
productive
synthesis,
possibility
hybridization
other
motifs.
Several
assembling
such
as
ionic‐complementary
cyclic
peptide
amphiphiles,
Fmoc‐peptide,
aromatic
dipeptides,
widely
studied.
Recently,
studies
on
material
synthesis
application
tyrosine‐rich
peptide‐based
have
demonstrated
that
tyrosine
units
serve
not
only
excellent
assembly
motifs
but
also
multifunctional
templates.
Tyrosine
has
phenolic
group
contributes
to
π–π
interactions
conformation
control
efficient
charge
transport
by
proton‐coupled
electron‐transfer
reactions
in
natural
systems.
Here,
critical
roles
motif
respect
its
electrochemical,
chemical,
structural
properties
discussed
recent
discoveries
advances
made
from
self‐assembled
structures
peptide/inorganic
hybrid
materials
highlighted.
A
brief
account
opportunities
optimization
applications
biomimetic
is
included.
Advanced Functional Materials,
Journal Year:
2020,
Volume and Issue:
30(14)
Published: Feb. 16, 2020
Abstract
Synthetic
osteo‐promoting
materials
that
are
able
to
stimulate
and
accelerate
bone
formation
without
the
addition
of
exogenous
cells
or
growth
factors
represent
a
major
opportunity
for
an
aging
world
population.
A
co‐assembling
system
integrates
hyaluronic
acid
tyramine
(
HA‐Tyr
),
bioactive
peptide
amphiphiles
GHK‐Cu
2+
Laponite
Lap
)
engineer
hydrogels
with
physical,
mechanical,
biomolecular
signals
can
be
tuned
enhance
regeneration
is
reported.
The
central
design
element
multicomponent
integration
self‐assembly
enzyme‐mediated
oxidative
coupling
optimize
structure
mechanical
properties
in
combination
incorporation
osteo‐
angio‐promoting
segments
facilitate
signaling.
Spectroscopic
techniques
used
confirm
interplay
orthogonal
covalent
supramolecular
interactions
hydrogel
formation.
Furthermore,
physico‐mechanical
characterizations
reveal
exhibit
improved
compressive
strength,
stress
relaxation
profile,
low
swelling
ratio,
retarded
enzymatic
degradation
compared
single
component
hydrogels.
Applicability
validated
vitro
using
human
mesenchymal
stem
umbilical
vein
endothelial
cells,
vivo
rabbit
maxillary
sinus
floor
reconstruction
model.
Animals
treated
HA‐Tyr‐HA‐Tyr‐GHK‐Cu
significantly
enhanced
relative
controls
including
commercially
available
Bio‐Oss.
Journal of the American Chemical Society,
Journal Year:
2021,
Volume and Issue:
143(13), P. 5127 - 5140
Published: March 25, 2021
Immunotherapy
has
provided
a
promising
strategy
for
the
treatment
of
cancers.
However,
even
in
tumors
with
high
antigen
burdens,
systemic
inhibition
presentation
still
greatly
restricts
application
immunotherapy.
Here,
we
construct
tumor
protein-engineering
system
based
on
functional
tripeptide,
Asp-Phe-Tyr
(DFY),
which
can
automatically
collect
and
deliver
immunogenetic
proteins
from
targeted
cells
to
immune
cells.
Through
tyrosinase-catalyzed
polymerization,
DFY
tripeptide
selectively
accumulates
tyrosinase
high-expressed
melanoma
Then
quinone-rich
intermediates
are
covalently
linked
tumor-specific
by
Michael
addition
form
protein-carried
microfibers
that
could
be
engulfed
antigen-presenting
exhibited
antigenic
properties
boosting
effect.
In
deficient
presentation,
this
successfully
enrich
transport
antigen-containing
Furthermore,
vivo
study
murine
melanoma,
transdermal
delivery
suppressed
growth
postsurgery
recurrence.
Our
findings
provide
an
avenue
regulation
organism
taking
advantage
certain
polymerization
reactions
virtue
chemical
biology.
Theranostics,
Journal Year:
2023,
Volume and Issue:
13(8), P. 2562 - 2587
Published: Jan. 1, 2023
3D
bioprinting
is
a
revolutionary
technology
capable
of
replicating
native
tissue
and
organ
microenvironments
by
precisely
placing
cells
into
structures
using
bioinks.However,
acquiring
the
ideal
bioink
to
manufacture
biomimetic
constructs
challenging.A
natural
extracellular
matrix
(ECM)
an
organ-specific
material
that
provides
physical,
chemical,
biological,
mechanical
cues
are
hard
mimic
small
number
components.Organ-derived
decellularized
ECM
(dECM)
has
optimal
properties.However,
dECM
always
"non-printable"
owing
its
poor
properties.Recent
studies
have
focused
on
strategies
improve
printability
bioink.In
this
review,
we
highlight
decellularization
methods
procedures
used
produce
these
bioinks,
effective
their
printability,
recent
advances
in
regeneration
dECM-based
bioinks.Finally,
discuss
challenges
associated
with
manufacturing
bioinks
potential
large-scale
applications.