Nanoscale Horizons,
Journal Year:
2021,
Volume and Issue:
6(10), P. 766 - 780
Published: Jan. 1, 2021
Biomolecules
play
critical
roles
in
biological
activities
and
are
closely
related
to
various
disease
conditions.
The
reliable,
selective
sensitive
detection
of
biomolecules
holds
much
promise
for
specific
rapid
biosensing.
In
recent
years,
luminescent
lanthanide
probes
have
been
widely
used
monitoring
the
activity
owing
their
long
luminescence
lifetimes
line-like
emission
which
allow
time-resolved
ratiometric
analyses.
this
review
article,
we
concentrate
on
advances
biomolecule
based
systems,
including
upconversion
nanoparticles,
lanthanide-metal
organic
frameworks,
complexes.
We
also
introduce
latest
remarkable
accomplishments
design
principles
sensing
mechanisms,
as
well
forthcoming
challenges
perspectives
practical
achievements.
Chemical Reviews,
Journal Year:
2021,
Volume and Issue:
122(1), P. 209 - 268
Published: Oct. 19, 2021
In
vivo
imaging
in
the
second
near-infrared
window
(NIR-II,
1000-1700
nm),
which
enables
us
to
look
deeply
into
living
subjects,
is
producing
marvelous
opportunities
for
biomedical
research
and
clinical
applications.
Very
recently,
there
has
been
an
upsurge
of
interdisciplinary
studies
focusing
on
developing
versatile
types
inorganic/organic
fluorophores
that
can
be
used
noninvasive
NIR-IIa/IIb
(NIR-IIa,
1300-1400
nm;
NIR-IIb,
1500-1700
nm)
with
near-zero
tissue
autofluorescence
deeper
penetration.
This
review
provides
overview
reports
published
date
design,
properties,
molecular
imaging,
theranostics
fluorophores.
First,
we
summarize
design
concepts
up-to-date
functional
biomaterials,
order
single-walled
carbon
nanotubes
(SWCNTs),
quantum
dots
(QDs),
rare-earth-doped
nanoparticles
(RENPs),
organic
(OFs).
Then,
these
novel
modalities
applications
brought
by
superior
fluorescent
properties
are
reviewed.
Finally,
challenges
perspectives
future
translation,
aiming
at
boosting
application
progress
NIR-IIa
NIR-IIb
technology
highlighted.
Advanced Science,
Journal Year:
2019,
Volume and Issue:
6(22)
Published: Sept. 30, 2019
Abstract
Upconversion
is
a
nonlinear
optical
phenomenon
that
involves
the
emission
of
high‐energy
photons
by
sequential
absorption
two
or
more
low‐energy
excitation
photons.
Due
to
their
excellent
physiochemical
properties
such
as
deep
penetration
depth,
little
damage
samples,
and
high
chemical
stability,
upconversion
nanoparticles
(UCNPs)
are
extensively
applied
in
bioimaging,
biosensing,
theranostic,
photochemical
reactions.
Here,
recent
achievements
synthesis,
optimization,
applications
UCNP‐based
nanomaterials
reviewed.
The
state‐of‐the‐art
approaches
synthesize
UCNPs
past
few
years
introduced
first,
followed
summary
several
strategies
optimize
emissive
various
UCNPs.
Lastly,
challenges
future
perspectives
provided
conclusion.
Advanced Science,
Journal Year:
2018,
Volume and Issue:
5(3)
Published: Jan. 9, 2018
Significant
progress
on
upconversion-nanoparticle
(UCNP)-based
probes
is
witnessed
in
recent
years.
Compared
with
traditional
fluorescent
(e.g.,
organic
dyes,
metal
complexes,
or
inorganic
quantum
dots),
UCNPs
have
many
advantages
such
as
non-autofluorescence,
high
chemical
stability,
large
light-penetration
depth,
long
lifetime,
and
less
damage
to
samples.
This
article
focuses
achievements
the
usage
of
lanthanide-doped
efficient
for
biodetection
since
2014.
The
mechanisms
upconversion
well
luminescence
resonance
energy
transfer
process
introduced
first,
followed
by
a
detailed
summary
researches
UCNP-based
biodetections
including
detection
ions,
gas
molecules,
reactive
oxygen
species,
thiols
hydrogen
sulfide.
ACS Nano,
Journal Year:
2021,
Volume and Issue:
15(2), P. 2005 - 2037
Published: Feb. 10, 2021
Single-atom
catalysts
(SACs)
featuring
the
complete
atomic
utilization
of
metal,
high-efficient
catalytic
activity,
superior
selectivity,
and
excellent
stability
have
been
emerged
as
a
frontier
in
field.
Recently,
increasing
interests
drawn
to
apply
SACs
biomedical
fields
for
enzyme-mimic
catalysis
disease
therapy.
To
fulfill
demand
precision
personalized
medicine,
precisely
engineering
structure
active
site
toward
levels
is
trend
nanomedicines,
promoting
evolution
metal-based
nanomaterials,
particularly
biocatalytic
from
nanoparticles
clusters
now
SACs.
This
review
outlines
syntheses,
characterizations,
mechanisms
metal
SACs,
with
focus
on
their
applications
including
biosensing,
antibacterial
therapy,
cancer
well
an
emphasis
vivo
biological
safeties.
Challenges
future
perspectives
are
ultimately
prospected
diverse
applications.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Nov. 24, 2023
Abstract
Mesoporous
silica
nanoparticles
(MSNs)
are
recognized
as
a
prime
example
of
nanotechnology
applied
in
the
biomedical
field,
due
to
their
easily
tunable
structure
and
composition,
diverse
surface
functionalization
properties,
excellent
biocompatibility.
Over
past
two
decades,
researchers
have
developed
wide
variety
MSNs-based
nanoplatforms
through
careful
design
controlled
preparation
techniques,
demonstrating
adaptability
various
application
scenarios.
With
continuous
breakthroughs
MSNs
fields
biosensing,
disease
diagnosis
treatment,
tissue
engineering,
etc.,
gradually
moving
from
basic
research
clinical
trials.
In
this
review,
we
provide
detailed
summary
beginning
with
comprehensive
overview
development
history.
We
then
discuss
types
nanostructured
architectures,
well
classification
nanocomposites
according
elements
existed
inorganic
functional
components.
Subsequently,
summarize
primary
purposes
surface-functionalized
modifications
MSNs.
following,
applications
MSNs,
highlight
targeted
therapeutic
modalities
currently
developed.
Given
importance
translation,
also
progress
Finally,
take
perspective
on
future
direction
remaining
challenges
field.
ACS Applied Materials & Interfaces,
Journal Year:
2023,
Volume and Issue:
15(2), P. 2499 - 2528
Published: Jan. 5, 2023
Lanthanide-doped
upconversion
nanoparticles
(UCNPs)
possess
the
remarkable
ability
to
convert
multiple
near-infrared
(NIR)
photons
into
higher
energy
ultraviolet-visible
(UV-vis)
photons,
making
them
a
prime
candidate
for
several
advanced
applications
within
realm
of
nanotechnology.
Compared
traditional
organic
fluorophores
and
quantum
dots
(QDs),
UCNPs
narrower
emission
bands
(fwhm
10-50
nm),
large
anti-Stokes
shifts,
low
toxicity,
high
chemical
stability,
resistance
photobleaching
blinking.
In
addition,
unlike
UV-vis
excitation,
NIR
excitation
is
nondestructive
at
lower
power
intensities
has
tissue
penetration
depths
(up
2
mm)
with
autofluorescence
scattering.
Together,
these
properties
make
exceedingly
favored
bioanalytical
theranostic
applications,
where
systems
have
been
well-explored.
are
also
well-suited
bioimaging,
optically
modulating
chemistries,
forensic
science,
other
state-of-the-art
research
applications.
this
review,
an
up-to-date
account
emerging
in
UCNP
research,
beyond
theranostics,
presented
including
optogenetics,
super-resolution
imaging,
encoded
barcodes,
fingerprinting,
vision,
UCNP-assisted
photochemical
manipulations,
optical
tweezers,
3D
printing,
lasing,
NIR-II
UCNP-molecule
nanohybrids,
UCNP-based
persistent
luminescent
nanocrystals.
