Revealing the Mutually Enhanced Mechanism of Necroptosis and Immunotherapy Induced by Defect Engineering and Piezoelectric Effect DOI Open Access

Yaqian Du,

Jiani Yang,

Fei He

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(6)

Published: Oct. 12, 2023

Abstract Owing to low immunogenicity‐induced immune escape and short‐term circulating responses, the efficiency of immunotherapy is unsatisfactory. Therefore, triggering immunogenic cell death establishing a long‐term, mutually reinforced treatment modality are urgent challenges. In this study, ultrathin CaBi 2 Nb O 9 nanosheets with tunable oxygen vacancies (abbreviated as CBNO‐OV1) prepared for synergistic necroptosis immunotherapy. The optimized vacancy concentration significantly improves piezoelectric effect under ultrasound irradiation, thereby considerably improving generation reactive species (ROS). Density functional theory shows that can improve electron hole separation by suppressing their recombination, thus resulting in enhanced piezocatalytic activity. Moreover, permeability tumor membranes, Ca 2+ influx. Additionally, CBNO‐OV1 also releases portion , which induces assisted explosive ROS. Ribonucleic acid transcription tests suggest mechanisms associated response activation necroptosis. More importantly, trigger significant vivo, activating macrophage M1 polarization through NF‐kappa B pathway promoting T‐cell differentiation.Tumor Necrosis Factor‐α differentiated from macrophages conversely promotes necroptosis, realizing effect. This study demonstrates feasibility amplifying efficacy.

Language: Английский

Advances and applications of nanoparticles in cancer therapy DOI Creative Commons

Xianzhou Huang,

Tao He, Xiuqi Liang

et al.

MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(1)

Published: March 1, 2024

Abstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed overcome different challenges and achieve sophisticated routes enhancement series therapies. Inspiring advances achieved the field therapy using NPs. In this review, we aim summarize up‐to‐date progression addressing various challenges, expect elicit novel potential opportunities alternatively. We first introduce sorts NP technologies, illustrate their mechanisms, present applications. Then, achievements made by break obstacles delivering cargoes specific sites through particular are highlighted, including long‐circulation, tumor targeting, responsive release, subcellular localization. subsequently retrospect recent research treatments from single therapy, like chemotherapy, combination chemoradiotherapy, integrative therapy. Finally, perspectives impact on oncology discussed. believe review can offer deeper understanding

Language: Английский

Citations

26
Targeted Delivery of Active Sites by Oxygen Vacancy-Engineered Bimetal Silicate Nanozymes for Intratumoral Aggregation-Potentiated Catalytic Therapy DOI
Shuang Liu,

Yu Sun,

Ye Jin

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(2), P. 1516 - 1530

Published: Jan. 3, 2024

Biodegradable silicate nanoconstructs have aroused tremendous interest in cancer therapeutics due to their variable framework composition and versatile functions. Nevertheless, low intratumoral retention still limits practical application. In this study, oxygen vacancy (OV)-enriched bimetallic nanozymes with Fe–Ca dual active sites via modification of oxidized sodium alginate gallic acid (GA) loading (OFeCaSA-V@GA) were developed for targeted aggregation-potentiated therapy. The band gap silica markedly decreased from 2.76 1.81 eV by codoping Fe3+ Ca2+, enabling its excitation a 650 nm laser generate reactive species. OV that occurred the hydrothermal synthetic stage OFeCaSA-V@GA can anchor metal ions form an atomic phase, offering massive fabrication method single-atom nanozymes. Density functional theory results reveal Ca promote adsorption H2O2, Fe accelerate dissociation thereby realizing synergetic catalytic effect. More importantly, delivery induce morphological transformation at tumor sites, leading high (the highest rate is 36.3%) theranostic components cells. Thus, finding may offer ingenious protocol designing engineering highly efficient long-retention nanodrugs.

Language: Английский

Citations

20
Package delivered: folate receptor-mediated transporters in cancer therapy and diagnosis DOI Creative Commons
Mohsen Ahmadi, Christoph A. Ritter, Thomas von Woedtke

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(6), P. 1966 - 2006

Published: Jan. 1, 2024

Neoplasias pose a significant threat to aging society, underscoring the urgent need overcome limitations of traditional chemotherapy through pioneering strategies. Targeted drug delivery is an evolving frontier in cancer therapy, aiming enhance treatment efficacy while mitigating undesirable side effects. One promising avenue utilizes cell membrane receptors like folate receptor guide transporters precisely malignant cells. Based on cellular as hallmark, targeted nanocarriers and small molecule-drug conjugates have been developed that comprise different (bio) chemistries and/or mechanical properties with individual advantages challenges. Such modern folic acid-conjugated stimuli-responsive provide systemic controlled release, enabling reduced dosages, circumvention resistance, diminished adverse Since transporters' structure-based

Language: Английский

Citations

20
Tumor microenvironment responsive nanozymes for multimodal imaging of tumors DOI Creative Commons
Heng Wang, Wenrui Ouyang, Hongxing Liu

et al.

Nano TransMed, Journal Year: 2024, Volume and Issue: 3, P. 100032 - 100032

Published: Jan. 29, 2024

Nanozymes exhibit immense potential and promising prospects in the realm of diagnostic imaging tumor therapy, owing to their inherent physicochemical properties enzymatic activities. With further development application nanotechnology, nanozymes are expected become an important tool field medicine, providing new solutions for disease diagnosis treatment. This review provides overview recent studies over past five years on capable responding microenvironment (TME) multimodal imaging, with a focus hypoxia, acid pH, excess GSH ROS. In addition, we present current status several common related contrast agents, such as MRI/CT, MRI/PET, MRI/SPECT, PET/CT. Moreover, some thoughts challenges, future development, clinical translation microenvironment-responsive shared. aims provide up-to-date theranostic nanomedicine reference those who fields, promote progress this interdisciplinary subject, accelerate translation.

Language: Английский

Citations

20
High Immunogenic Cuproptosis Evoked by In Situ Sulfidation‐Activated Pyroptosis for Tumor‐Targeted Immunotherapy of Colorectal Cancer DOI Creative Commons

Wentao Xiao,

Kuiming Qu,

Wei Zhang

et al.

Small Science, Journal Year: 2024, Volume and Issue: 4(3)

Published: Jan. 17, 2024

Despite the great potential of cuproptosis in tumor therapy, current cuproptosis‐based therapy still suffers from compromised efficiency immune activation. Pyroptosis, a proinflammatory cell death modality, provides good opportunity to induce immunogenic (ICD) and promote systemic response. However, synergistic pyroptosis has not been fully explored. Herein, it is discovered that Cu(II)‐based metal–organic framework (MOF) nanoparticles (NPs) can synergistically evoke ICD for high‐efficiency tumor‐targeted immunotherapy. Although MOF‐199 widely used immunogenicity unclear. Pluronic F127‐modified NPs ( F127 NPs) show dual‐responsiveness glutathione (GSH) hydrogen sulfide (H 2 S). Once entering cancer cells, dissociate GSH‐enriched microenvironment (TME) release copper ion copper‐overload‐mediated cuproptosis. Meanwhile, transform Cu 2− x S by situ sulfidation under H S‐enriched colorectal (CRC) TME. Under photothermal chemodynamic (PTT/CDT) NPs, caspase‐3 activated gasdermin E (GSDME)‐related triggered. The have proved superior antitumor immunity effect both vitro vivo experiments. This work new strategy achieve immunotherapy with high simple NPs.

Language: Английский

Citations

16
Nanosensors Monitor Intracellular GSH Depletion: GSH Triggers Cu(II) for Tumor Imaging and Inhibition DOI
Yihan Wang, Ke Huang,

Tingya Wang

et al.

Small, Journal Year: 2024, Volume and Issue: 20(27)

Published: Feb. 1, 2024

Abstract Glutathione (GSH) is the primary antioxidant in cells, and GSH consumption will break redox balance cells. Based on this, a method that uses high concentrations of tumor microenvironment to trigger reaction Cu(II) generate copper nanoprobes with fluorescence growth inhibition properties proposed. The nanoprobe mainly exists form Cu(I) catalyzes decomposition hydrogen peroxide into hydroxyl radicals. At same time, simple controllable carbon micro‐nano electrode used construct single‐cell sensing platform, which enable detection glutathione content single living cells after treatment, providing an excellent example for detecting biomolecules.

Language: Английский

Citations

16
Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy DOI

Wei Xu,

Guoqiang Guan, Renye Yue

et al.

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Language: Английский

Citations

4
Multifunctional nanoparticles for image-guided drug delivery in nuclear medicine: advancements and applications DOI

Bilal AbdulMajeed Mukhlif,

Muhammad Ikram Ullah, Subasini Uthirapathy

et al.

Journal of Radioanalytical and Nuclear Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Language: Английский

Citations

2
Hollow Nanomaterials in Advanced Drug Delivery Systems: From Single‐ to Multiple Shells DOI
Li Zhao, Ke Xu, Linlin Qin

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(12)

Published: Aug. 23, 2022

Hollow-structured nanomaterials (HSNMs) have attracted increased interest in biomedical fields, owing to their excellent potential as drug delivery systems (DDSs) for clinical applications. Among HSNMs, hollow multi-shelled structures (HoMSs) exhibit properties such high loading capacity, sequential release, and multi-functionalized modification represent a new class of nanoplatforms The remarkable HoMS-based DDS can simultaneously satisfy enhance DDSs delivering small molecular drugs (e.g., antibiotics, chemotherapy drugs, imaging agents) macromolecular protein/peptide- nucleic acid-based drugs). First, the latest research advances are summarized highlight inherent advantages targeting, combining continuous therapeutic theranostics optimize benefit. Meanwhile, initial development stage currently offer limited modes. There is growing need analyze deficiency other HSNMs integrate providing solutions safe, stable, cascade meet vast treatment requirements. Therefore, comprehensively reviewed, mainly focusing on characteristics, progress by category, future prospects.

Language: Английский

Citations

67
Multifunctional Au Modified Ti3C2-MXene for Photothermal/Enzyme Dynamic/Immune Synergistic Therapy DOI
Xin Chang, Qiong Wu,

Yuanyu Wu

et al.

Nano Letters, Journal Year: 2022, Volume and Issue: 22(20), P. 8321 - 8330

Published: Oct. 12, 2022

Ti3C2-MXene-based composites provide multifunctional interfaces in diagnosis and treatment of tumors. Herein, we proposed a nanoplatform based on Ti3C2-MXene–Au nanocomposites, which combines photothermal properties peroxidase-like activity, accomplishing synergistic therapy (PTT) enzyme dynamic (EDT) accompanied by photoacoustic (PA) thermal dual-mode imaging vivo. Furthermore, PTT induces immunogenic cell death, EDT promotes apoptosis, facilitating dendritic (DC) maturation T infiltration into the tumor. On this basis, antibody OX40 (αOX40) was utilized to further contribute immune for reversing immunosuppressive tumor microenvironment activating CD4+ CD8+ cells. In summary, triune PTT/EDT/antitumor is achieved combining nanocomposites αOX40, possesses several strong features good biocompatibility, NIR-controlled targeting, significant cancer killing, satisfactory biosafety vitro Our work might highlight promising application MXene-based nanoplatforms therapy.

Language: Английский

Citations

62