Performance and Mechanism of Self-Oxygenated Perfluorohexane Nanosystem for Combined Photothermal/Photodynamic Bacterial Inhibition DOI

Linrui Dong,

Weihao Jin,

Guoliang Zhang

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(6), P. 6214 - 6228

Published: March 4, 2024

Biofilms are responsible for most bacterial infections and significantly threaten human health. Designing effective less harmful materials to inhibit remove biofilms remains a significant challenge. Complex biofilm structures make conventional antibiotic treatments ineffective, in recent years, photothermal therapy (PTT) photodynamic (PDT) have attracted attention their ability treat drug-resistant effectively. Therefore, synergistic nanoantimicrobial system (PFH/TCPP@SL@PDA) enhances the effect through PTT PDT. It is synthesized by loading meso-tetra(4-carboxyphenyl) porphine (TCPP) on soybean lecithin (SL), further coating perfluorohexane (PFH) finally polydopamine (PDA) outer layer. The designed alleviates hypoxic properties of microenvironment oxygen PDT generate more reactive species. enhanced permeability improved antimicrobial properties, with over 95% inhibition multidrug-resistant (MDR) Escherichia coli MDR Staphylococcus aureus while inhibiting removing 90% biofilms. PDA not only acts as good nanoshell but also induces relatively mild can facilitate reaction PFH/TCPP@SL@PDA has biocompatibility, hemolysis test showed than 5% erythrocytes, effectively relieving inflammatory symptoms accelerating wound healing mice model. In conclusion, this study provides an efficient safe combined therapeutic strategy inhibition, suppression, removal

Language: Английский

Photothermal antibacterial materials to promote wound healing DOI

Luning He,

Donghua Di,

Xinhui Chu

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 363, P. 180 - 200

Published: Sept. 27, 2023

Language: Английский

Citations

127
Recent progress in MOFs-based nanozymes for biosensing DOI

Imamdin Chandio,

Yongjian Ai, Lei Wu

et al.

Nano Research, Journal Year: 2023, Volume and Issue: 17(1), P. 39 - 64

Published: July 6, 2023

Language: Английский

Citations

46
Nanomaterials in Antibacterial Photodynamic Therapy and Antibacterial Sonodynamic Therapy DOI

Chaonan He,

Peipei Feng, Mingming Hao

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 27, 2024

Abstract Antibacterial photodynamic therapy (aPDT) and antibacterial sonodynamic (aSDT) utilize sensitizers (photosensitizers/sonosensitizers) to produce reactive oxygen species (ROS) for treatment under the stimulation of light/ultrasound, which have characteristics broad‐spectrum properties, low drug‐resistance, effective targeting infected tissues. Nanomaterials in aPDT/aSDT are primarily used as nano‐sensitizers or nano‐carriers sensitizers. They enhance stability permeability sensitizers, improve strengthen photodynamic/sonodynamic properties (modification absorption efficiency light/ultrasonic response stress by modulation nanoparticle shape, size, structure). Also, they modifiability (controlling release rate time sensitizer needed optimize therapeutic effect), programmability multifunctionality (flexible application nanotechnology designing with multiple functions, such drug delivery, targeted therapy, monitoring), expand possibilities combination therapies (the can be loaded other agents, enabling therapies). expected further promote development achieve improved effects. This review summarizes progress nanomaterials recent years based on current strategies provide a theoretical reference aPDT/aSDT.

Language: Английский

Citations

44
Type I photodynamic antimicrobial therapy: Principles, progress, and future perspectives DOI Open Access

Jingai Jiang,

Xinyi Lv,

Huijuan Cheng

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 177, P. 1 - 19

Published: Feb. 7, 2024

Language: Английский

Citations

34
Ultrasound-Based Micro-/Nanosystems for Biomedical Applications DOI
Hui Huang,

Yi Zheng,

Meiqi Chang

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(13), P. 8307 - 8472

Published: June 26, 2024

Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.

Language: Английский

Citations

32
Black Titania Janus Mesoporous Nanomotor for Enhanced Tumor Penetration and Near-Infrared Light-Triggered Photodynamic Therapy DOI

Kexin Lv,

Mengmeng Hou, Yufang Kou

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(21), P. 13910 - 13923

Published: May 16, 2024

Thanks to their excellent photoelectric characteristics generate cytotoxic reactive oxygen species (ROS) under the light-activation process, TiO2 nanomaterials have shown significant potential in photodynamic therapy (PDT) for solid tumors. Nevertheless, limited penetration depth of TiO2-based photosensitizers and excitation sources (UV/visible light) PDT remains a formidable challenge when confronted with complex tumor microenvironments (TMEs). Here, we present H2O2-driven black mesoporous nanomotor near-infrared (NIR) light absorption capability autonomous navigation ability, which effectively enhances NIR light-triggered PDT. The was rationally designed fabricated based on Janus nanostructure, consists light-responsive nanosphere an enzyme-modified periodic organosilica (PMO) nanorod that wraps around nanosphere. overexpressed H2O2 can drive TME catalysis catalase PMO domain. By precisely controlling ratio compartments TiO2&PMO nanomotors achieve optimal self-propulsive directionality velocity, enhancing cellular uptake facilitating deep penetration. Additionally, by decomposition endogenous within tumors, these continuously supply enable highly efficient ROS production photocatalysis TiO2, leading intensified effects effective inhibition.

Language: Английский

Citations

24
Phototherapy-based multifunctional nanoplatform for synergistic therapy against drug resistance bacteria: Progress, advances and challenges DOI

Bingqian Yu,

Qirui Liu,

Jiadi Sun

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150705 - 150705

Published: March 25, 2024

Language: Английский

Citations

19
Gold core@CeO2 halfshell Janus nanocomposites catalyze targeted sulfate radical for periodontitis therapy DOI
Sijia Li, Qihang Ding, Lingling Zhang

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 370, P. 600 - 613

Published: May 14, 2024

Language: Английский

Citations

16
Silver/jellyfish-like mesoporous polydopamine nanomotor with concentration-dependent synergistic antibacterial activity DOI
Xiujuan Li, Hong Shang,

Yue Xiong

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159367 - 159367

Published: Jan. 1, 2025

Language: Английский

Citations

2
Recent advances on nanomaterials for antibacterial treatment of oral diseases DOI Creative Commons

Zetong Chen,

Zhaoyou Chu,

Yechun Jiang

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 20, P. 100635 - 100635

Published: April 15, 2023

An imbalance of bacteria in oral environment can lead to a variety diseases, such as periodontal disease, dental caries, and peri-implant inflammation. In the long term, view increasing bacterial resistance, finding suitable alternatives traditional antibacterial methods is an important research today. With development nanotechnology, agents based on nanomaterials have attracted much attention field due their low cost, stable structures, excellent properties broad spectrum. Multifunctional break through limitations single therapy functions remineralization osteogenesis basis antibacterial, which has made significant progress long-term prevention treatment diseases. this review, we summarized applications metal oxides, organic composite recent five years. These not only inactivate bacteria, but also achieve more efficient diseases by improving materials themselves, enhancing precision targeted delivery drugs imparting richer functions. Finally, future challenges untapped potential are elaborated demonstrate prospects field.

Language: Английский

Citations

35