Noble Metal Nanoparticle-Based Photothermal Therapy: Development and Application in Effective Cancer Therapy

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5632 - 5632

Published: May 22, 2024

Photothermal therapy (PTT) is a promising cancer modality with significant advantages such as precise targeting, convenient drug delivery, better efficacy, and minimal adverse effects. effectively absorbs the photothermal transducers in near-infrared region (NIR), which induces effect to work. Although PTT has role tumor therapy, it also suffers from low conversion efficiency, biosafety, incomplete elimination. Therefore, use of nanomaterials themselves photosensitizers, targeted modification improve targeting or combined other therapies can therapeutic effects reduce side Notably, noble metal have attracted much attention because they strong surface plasmon resonance an effective absorbance light at specific wavelengths. be used excellent photosensitizers mediate its efficiency. This paper provides comprehensive review key played by therapy. It describes major challenges encountered during implementation

Language: Английский

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Boosting Theranostic Performance of AIEgens Using Nanocatalyzer for Robust Cancer Immunotherapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(23)

Published: Feb. 15, 2024

Abstract High‐performance theranostic systems are of paramount importance for achieving precise image‐guided cancer immunotherapy. Here, a novel nanoplatform is presented that integrates aggregation‐induced emission luminogen (AIEgen) with prussian blue (PB) nanocatalyzer robust The AIEgen dimethylamine substitution demonstrates compelling near‐infrared (NIR) light‐induced photothermal conversion and photodynamic therapy (PDT) capabilities. By incorporating into porous PBNPs, further enveloped within M1 macrophage membrane, tumor‐specific nanoagent constructed. This strategic integration effectively constrains the molecular motion AIEgen, leading to amplified NIR‐II fluorescence brightness PDT attributes. Moreover, PBNPs can catalyze tumor‐overexpressed H 2 O generate oxygen boost efficacy, PB's NIR absorption also intensifies photoacoustic imaging effect. provides comprehensive information photoimmunotherapy in orthotopic breast cancer‐bearing mice. Leveraging its potent immunogenic cell death effect, not only significantly inhibits growth, but generates whole‐cell therapeutic vaccine protect mice from tumor rechallenge. In highly malignant post‐surgery models, enables both accurate identification residual tumors efficient inhibition postoperative recurrence pulmonary metastasis. study will offer valuable insights creating efficacious multifaceted protocols.

Language: Английский

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Novel PdPtCu Nanozymes for Reprogramming Tumor Microenvironment to Boost Immunotherapy Through Endoplasmic Reticulum Stress and Blocking IDO‐Mediated Immune Escape

Small, Journal Year: 2023, Volume and Issue: 19(44)

Published: July 2, 2023

Breaking immunosuppressive tumor microenvironment (TME) has unique effects on inhibiting growth and recurrence. Here, an endoplasmic reticulum (ER) targeted PdPtCu nanozyme (PNBCTER ) is prepared to boost immunotherapy. First, PNBCTER three kinds of enzyme activities, including catalase (CAT), glutathione oxidase (GSHOx), peroxidase (POD)-like which can reshape the TME. Second, kills cells by photodynamic therapy (PDT) photothermal (PTT). Third, guided TER , not only realizes combination PDT, PTT chemodynamic (CDT), but also damages ER actives antitumor immune response, breaks through blockade Finally, NLG919 blocks tryptophan/kynurenine escape pathway reverses The strategy that reshaping TME catalysis breaking immunosuppression provides a novel way for application in tumor.

Language: Английский

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Cancer cell membrane–encapsulated biomimetic nanoparticles for tumor immuno-photothermal therapy

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 463, P. 142495 - 142495

Published: March 20, 2023

Language: Английский

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Nanomaterial‐Enabled Photothermal Heating and Its Use for Cancer Therapy via Localized Hyperthermia

Small, Journal Year: 2023, Volume and Issue: 20(7)

Published: Oct. 6, 2023

Abstract Photothermal therapy (PTT), which employs nanoscale transducers delivered into a tumor to locally generate heat upon irradiation with near‐infrared light, shows great potential in killing cancer cells through hyperthermia. The efficacy of such treatment is determined by number factors, including the amount, distribution, and dissipation generated heat, as well type cell involved. amount largely controlled accumulated inside tumor, absorption coefficient photothermal conversion efficiency transducer, irradiance light. depends on distribution penetration depth vascularity tissue thermal conduction both affect thereby temperature. successful implementation PTT clinic setting critically techniques for real‐time monitoring management

Language: Английский

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A Near-Infrared-II Fluorescent Nanocatalyst for Enhanced CAR T Cell Therapy against Solid Tumor by Immune Reprogramming

ACS Nano, Journal Year: 2023, Volume and Issue: 17(12), P. 11749 - 11763

Published: June 15, 2023

Chimeric antigen receptor (CAR) T cell therapy holds great promise in the treatment of hematological malignancies but performs poorly solid tumors due to tumor immunosuppressive microenvironment. Herein, a multifunctional nanocatalyst (APHA@CM) was prepared by encapsulating horseradish peroxidase (HRP)-loaded Au/polydopamine nanoparticles (Au/PDA NPs) and Ag2S quantum dots with CAR membranes improve tumors. The APHA@CM has excellent multimodal imaging capability precisely guide scope time window for nanocatalyst-induced microenvironment regulation therapy. oxidase-like activity Au NPs inhibited glycolytic metabolism cells, reducing lactate efflux, reprogramming immunosuppression, ultimately increasing activation within Additionally, hypoxia environment could be relieved HRP enhance Au/PDA NPs-induced synergistic sonodynamic/photothermal (SDT/PTT), thereby promoting immunogenic death NALM 6 cells enhancing cell-mediated immune reprogramming. When this strategy utilized treat tumors, it not only completely eliminated also formed long-term memory effect inhibit metastasis recurrence. This work offers tumor.

Language: Английский

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ROS Scavenging Nanozyme Modulates Immunosuppression for Sensitized Cancer Immunotherapy

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(21)

Published: April 9, 2023

Myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs), two immunosuppressive myeloid components within the tumor microenvironment (TME), represent fundamental barriers in cancer immunotherapy, whereas current nanomedicines rarely exert dual modulatory roles on these cell types simultaneously. Reactive oxygen species (ROS) not only mediates MDSC-induced immunosuppression but also triggers differentiation polarization of M2-TAMs. Herein, an ROS scavenging nanozyme, Zr-CeO, with enhanced superoxide dismutase- catalase-like activities for renal growth inhibition is reported. Mechanistically, intracellular by Zr-CeO significantly attenuates MDSC via dampening unfolded protein response, hinders M2-TAM through ERK STAT3 pathways, barely affects neoplastic cancer-associated fibroblasts. Furthermore, enhances antitumor effect PD-1 murine breast models, accompanied substantially decreased recruitment reprogrammed phenotype TAMs mass. Upon isolation, reversed phenotypes MDSCs are identified. In addition, alone or combination therapy T lymphocyte infiltration IFN-γ production TME. Collectively, a promising strategy to impair quantity function sensitize immunotherapy both cancers provided.

Language: Английский

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Nanozymes‐Mediated Cascade Reaction System for Tumor‐Specific Diagnosis and Targeted Therapy

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: March 13, 2024

Abstract Cascade reactions are described as efficient and versatile tools, organized catalytic cascades can significantly improve the efficiency of chemical interworking between nanozymes. They have attracted great interest in many fields such chromogenic detection, biosensing, tumor diagnosis, therapy. However, how to selectively kill cells by enzymatic without harming normal cells, well exploring two or more enzyme‐engineered nanoreactors for cascading reactions, remain challenges field targeted specific cancer diagnostics The latest research advances nanozyme‐catalyzed cascade processes diagnosis therapy this article. Here, various sensing strategies summarized, tumor‐specific diagnostics. Targeting mechanisms treatment using nanozymes classified analyzed, “elements” “dimensions” nanozymes, types, designs structure, assembly modes highly active a variety new targeting based on reaction Finally, integrated application systems tumor‐targeted diagnostic is which will lay foundation design rational, efficient, therapeutic modalities future.

Language: Английский

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“Four-in-One” Nanozyme for Amplified Catalytic-Photothermal Therapy

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 665, P. 1 - 9

Published: March 19, 2024

Language: Английский

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Multiple Treatment of Triple‐Negative Breast Cancer Through Gambogic Acid‐Loaded Mesoporous Polydopamine

Small, Journal Year: 2024, Volume and Issue: 20(31)

Published: March 6, 2024

Abstract Triple‐negative breast cancer (TNBC) is a highly heterogeneous subtype of cancer, characterized by aggressiveness and high recurrence rate. As monotherapy provides limited benefit to TNBC patients, combination therapy emerges as promising treatment approach. Gambogic acid (GA) an exceedingly anticancer agent. Nonetheless, its application potential hampered low drug loading efficiency associated toxic side effects. To overcome these limitations, using mesoporous polydopamine (MPDA) endowed with photothermal conversion capabilities considered delivery vehicle for GA. Meanwhile, GA can inhibit the activity heat shock protein 90 (HSP90) enhance effect. Herein, GA‐loaded MPDA nanoparticles (GA@MPDA NPs) are developed rate 75.96% remarkable performance. GA@MPDA NPs combined (PTT) significantly tumor growth, effectively trigger immunogenic cell death (ICD), which thereby increase number activated effector T cells (CD8 + CD4 cells) in tumor, hoist level immune‐inflammatory cytokines (IFN‐ γ , IL‐ 6 TNF‐ α ). The above results suggest that PTT expected activate antitumor immune response, thus potentially enhancing clinical therapeutic effect on TNBC.

Language: Английский

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