Engineered Multifunctional Zinc–Organic Framework-Based Aggregation-Induced Emission Nanozyme for Accelerating Spinal Cord Injury Recovery

ACS Nano, Journal Year: 2024, Volume and Issue: 18(3), P. 2355 - 2369

Published: Jan. 10, 2024

Functional recovery following a spinal cord injury (SCI) is challenging. Traditional drug therapies focus on the suppression of immune responses; however, strategies for alleviating oxidative stress are lacking. Herein, we developed zinc–organic framework (Zn@MOF)-based aggregation-induced emission–active nanozymes accelerating SCI. A multifunctional Zn@MOF was modified with molecule 2-(4-azidobutyl)-6-(phenyl(4-(1,2,2-triphenylvinyl)phenyl)amino)-1H-phenalene-1,3-dione via bioorthogonal reaction, and resulting were denoted as Zn@MOF-TPD. These gradually released gallic acid zinc ions (Zn2+) at SCI site. The acid, scavenger reactive oxygen species (ROS), promoted antioxidation alleviated inflammation, re-establishing balance between ROS production antioxidant defense system. Zn2+ inhibited activity matrix metalloproteinase 9 (MMP-9) to facilitate regeneration neurons ROS-mediated NF-κB pathway secondary In addition, Zn@MOF-TPD protected myelin sheaths against trauma, glial scar formation, proliferation differentiation neural stem cells, thereby facilitating repair injured tissue promoting functional in rats contusive Altogether, this study suggests that possess potential stress-mediated pathophysiological damage motor

Language: Английский

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Multifunctional Integrated Nanozymes Facilitate Spinal Cord Regeneration by Remodeling the Extrinsic Neural Environment

Advanced Science, Journal Year: 2023, Volume and Issue: 10(7)

Published: Jan. 16, 2023

High levels of reactive oxygen species (ROS) and inflammation create a complicated extrinsic neural environment that dominates the initial post-injury period after spinal cord injury (SCI). The compensatory pathways between ROS limited efficacy modulating above single treatment regimen SCI. Here, novel "nanoflower" Mn

Language: Английский

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Single-Atom-Based Nanoenzyme in Tissue Repair

ACS Nano, Journal Year: 2024, Volume and Issue: 18(20), P. 12639 - 12671

Published: May 8, 2024

Since the discovery of ferromagnetic nanoparticles Fe3O4 that exhibit enzyme-like activity in 2007, research on nanoenzymes has made significant progress. With in-depth study various and rapid development related nanotechnology, have emerged as a promising alternative to natural enzymes. Within nanozymes, there is category metal-based single-atom nanozymes been rapidly developed due low cast, convenient preparation, long storage, less immunogenicity, especially higher efficiency. More importantly, possess capacity scavenge reactive oxygen species through mechanisms, which beneficial tissue repair process. Herein, this paper systemically highlights types metal their catalytic recent applications repair. The existing challenges are identified prospects future composed metallic nanomaterials proposed. We hope review will illuminate potential repair, encouraging sequential clinical translation.

Language: Английский

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Sequential Targeting Chondroitin Sulfate‐Bilirubin Nanomedicine Attenuates Osteoarthritis via Reprogramming Lipid Metabolism in M1 Macrophages

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract The infiltration and excessive polarization of M1 macrophages contribute to the induction persistence low‐grade inflammation in joint‐related degenerative diseases such as osteoarthritis (OA). lipid metabolism dysregulation promotes macrophage by coordinating compensatory pathways inflammatory oxidative stress responses. Here, a self‐assembling, licofelone‐loaded nanoparticle (termed LCF‐CSBN), comprising chondroitin sulfate bilirubin joined an ethylenediamine linker, is developed selectively reprogram activation. LCF‐CSBN internalized via CD44‐mediated endocytosis targets Golgi apparatus accompanied with reactive oxygen species‐responsive release licofelone (LCF, dual inhibitor arachidonic acid metabolism). effectively M2 transition reprogramming apparatus‐related sphingolipid metabolism. Intra‐articularly injected retains joint for up 28 days accumulates into macrophages. Moreover, can attenuate inflammation, stress, cartilage degeneration OA model rats. These findings indicate promising potential lipid‐metabolism‐reprogramming targeted therapy OA.

Language: Английский

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High rapamycin-loaded hollow mesoporous Prussian blue nanozyme targets lesion area of spinal cord injury to recover locomotor function

Biomaterials, Journal Year: 2023, Volume and Issue: 303, P. 122358 - 122358

Published: Oct. 31, 2023

Language: Английский

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Nanozymes: Potential Therapies for Reactive Oxygen Species Overproduction and Inflammation in Ischemic Stroke and Traumatic Brain Injury

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 16450 - 16467

Published: June 19, 2024

Nanozymes, which can selectively scavenge reactive oxygen species (ROS), have recently emerged as promising candidates for treating ischemic stroke and traumatic brain injury (TBI) in preclinical models. ROS overproduction during the early phase of these diseases leads to oxidative damage, has been a major cause mortality worldwide. However, clinical application ROS-scavenging enzymes is limited by their short vivo half-life inability cross blood-brain barrier. mimic catalytic function natural enzymes, several advantages, including cost-effectiveness, high stability, easy storage. These advantages render them superior disease diagnosis therapeutic interventions. This review highlights recent advancements nanozyme applications TBI, emphasizing potential mitigate detrimental effect overproduction, inflammation, barrier compromise. Therefore, nanozymes represent treatment modality conditions future medical practices.

Language: Английский

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Electrospun Composite PLLA‐PPSB Nanofiber Nerve Conduits for Peripheral Nerve Defects Repair and Regeneration

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(10)

Published: Jan. 18, 2024

Peripheral nerve injury (PNI) is a common clinical problem and regenerating peripheral defects remain significant challenge. Poly(polyol sebacate) (PPS) polymers are developed as promising materials for biomedical applications due to their biodegradability, biocompatibility, elastomeric properties, ease of production. However, the application PPS-based biomaterials in tissue engineering, especially PNI repair, limited. In this study, composite nanofibers poly(l-lactic acid)-poly(polycaprolactone triol-co-sebacic acid-co-N,N-bis(2-hydroxyethyl)-2-aminoethanesulfonic acid sodium salt) (PLLA-PPSB) aimed construct through electrospinning assess vitro biocompatibility with Schwann cells (SCs) vivo repair capabilities defects. For first time, bioactivity nanomaterial examined at molecular, cellular, animal levels repair. Electrospun PLLA-PPSB display favorable physicochemical properties providing an effective interface proliferation, glial expression, adhesion SCs vitro. experiments using 10-mm rat sciatic defect model show that nanofiber conduits enhance myelin formation, axonal regeneration, angiogenesis, functional recovery. Transcriptome analysis biological validation indicate may promote SC proliferation by activating PI3K/Akt signaling pathway. This suggests potential

Language: Английский

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Multistructured hydrogel promotes nerve regeneration

Materials Today Advances, Journal Year: 2024, Volume and Issue: 21, P. 100465 - 100465

Published: Feb. 7, 2024

Hydrogels have emerged as promising biomaterials for nerve regeneration due to their adjustable properties, structural resemblance the extracellular matrix, and ability promote cell adhesion proliferation. This comprehensive review discusses advantages, challenges, future directions of various functional hydrogels. Advanced technologies fabricating Multistructured hydrogel, including injectable hydrogels, hydrogel microspheres, fibrous 3D printing nanogels, stem cell-loaded electrical ultrasound magnetic been developed studied regeneration. These demonstrate versatility hydrogels in neural tissue repair. However, challenges such biocompatibility, degradation rates, scaffold design need be addressed. Interdisciplinary research is necessary develop innovative systems that overcome these realize potential provides valuable insights into advanced highlights regenerative medicine, particularly Researchers can use this knowledge refine therapeutic approaches involving enhancing

Language: Английский

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Application and progress of nanozymes in antitumor therapy

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 130960 - 130960

Published: March 20, 2024

Tumors remain one of the major threats to public health and there is an urgent need design new pharmaceutical agents for their diagnosis treatment. In recent years, due rapid development nanotechnology, biotechnology, catalytic science, theoretical computing, subtlety has gradually made great progress in research related tumor Compared conventional drugs, enzymes can improve drug distribution enhance enrichment at site, thereby reducing side effects enhancing efficacy. Nanozymes also be used as tracking imaging reshape microenvironment, providing a versatile platform treatment malignancies. this paper, we review current status on oncology analyze novel therapeutic approaches mechanisms. To date, large number nanomaterials, such noble metal nonmetallic carbon-based have been shown able function like natural enzymes, particularly with significant advantages therapy. light this, authors systematically summarized evaluated construction, enzymatic activity, characteristics nanozymes respect modalities addition, application different types nicknames features years are detail. We conclude summary outlook study It hoped that will inspire researchers fields chemistry, biology, materials science contribute nano-enzymology.

Language: Английский

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Nanomedicine-enabled next-generation therapeutics for spinal cord injury

Materials Today, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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