Fluorescent dyes based on rhodamine derivatives for bioimaging and therapeutics: recent progress, challenges, and prospects

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(16), P. 5607 - 5651

Published: Jan. 1, 2023

Since their inception, rhodamine dyes have been extensively applied in biotechnology as fluorescent markers or for the detection of biomolecules owing to good optical physical properties. Accordingly, they emerged a powerful tool visualization living systems. In addition fluorescence bioimaging, molecular design derivatives with disease therapeutic functions (e.g., cancer and bacterial infection) has recently attracted increased research attention, which is significantly important construction libraries diagnostic integration. However, reviews focusing on integrated strategies dye-based diagnosis treatment wide application are extremely rare. this review, first, brief history development dyes, transformation from bioimaging therapy, concept optics-based integration its significance human presented. Next, systematic review several excellent rhodamine-based well treatment, Finally, challenges practical future outlook clinical translation also discussed.

Language: Английский

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Molecular Engineering of pH-Responsive NIR Oxazine Assemblies for Evoking Tumor Ferroptosis via Triggering Lysosomal Dysfunction

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(6), P. 3736 - 3747

Published: Feb. 2, 2023

Ferroptosis, a newly discovered form of regulated cell death, is emerging as promising approach to tumor therapy. However, the spatiotemporal control cell-intrinsic Fenton chemistry modulate ferroptosis remains challenging. Here, we report an oxazine-based activatable molecular assembly (PTO-Biotin Nps), which capable triggering lysosomal dysfunction-mediated pathway with excellent resolution via near-infrared (NIR) light evoke ferroptosis. In this system, pH-responsive NIR photothermal oxazine molecule was designed and functionalized tumor-targeting hydrophilic biotin-poly(ethylene glycol) (PEG) chain engineer well-defined nanostructured assemblies within single-molecular framework. PTO-Biotin Nps possesses selective tropism lysosome accumulation inside cells, accommodated by its enhanced activity in acidic microenvironment. Upon activation, promoted dysfunction induced cytosolic acidification impaired autophagy. More importantly, photoactivation-mediated found markedly enhance cellular reactions ferroptosis, thereby improving antitumor efficacy mitigating systemic side effects. Overall, our study demonstrates that engineering enables modulation intrinsic mechanism, offering novel strategy for development metal-free inducers

Language: Английский

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A photo-triggered self-accelerated nanoplatform for multifunctional image-guided combination cancer immunotherapy

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 25, 2023

Precise and efficient image-guided immunotherapy holds great promise for cancer treatment. Here, we report a self-accelerated nanoplatform combining an aggregation-induced emission luminogen (AIEgen) hypoxia-responsive prodrug multifunctional combination immunotherapy. The near-infrared AIEgen with methoxy substitution simultaneously possesses boosted fluorescence photoacoustic (PA) brightness the strong light absorption ability, as well amplified type I II photodynamic therapy (PDT) properties via enhanced intersystem crossing process. By formulating high-performance paclitaxel (PTX) into nanoparticles, further camouflaging macrophage cell membrane, tumor-targeting theranostic agent is built. integration of PA imaging helps to delineate tumor site sensitively, providing accurate guidance light-induced PDT effect could consume local oxygen lead severer hypoxia, accelerating release PTX drug. As result, chemotherapy induces immunogenic death, which not only elicit antitumor immunity suppress primary tumor, but also inhibit growth distant in 4T1 tumor-bearing female mice. strategy develop agents rational molecular design boosting

Language: Английский

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Chlorination‐Mediated π–π Stacking Enhances the Photodynamic Properties of a NIR‐II Emitting Photosensitizer with Extended Conjugation

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(25)

Published: April 20, 2023

NIR-II-emitting photosensitizers (PSs) have attracted great research interest due to their promising clinical applications in imaging-guided photodynamic therapy (PDT). However, it is still challenging realize highly efficient PDT on NIR-II PSs. In this work, we develop a chlorination-mediated π-π organizing strategy improve the of PS with conjugation-extended A-D-A architecture. The significant dipole moment carbon-chlorine bond and strong intermolecular interactions chlorine atoms bring compact stacking chlorine-substituted PS, which facilitates energy/charge transfer promotes photochemical reactions PDT. Consequently, resultant emitting exhibits leading performance yield reactive oxygen species higher than that previously reported long-wavelength These findings will enlighten future design PSs enhanced efficiency.

Language: Английский

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Crucial Breakthrough of BODIPY‐Based NIR‐II Fluorescent Emitters for Advanced Biomedical Theranostics

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(36)

Published: March 29, 2024

Abstract Fluorescence imaging in the second near‐infrared window (NIR‐II, 1000–1700 nm) has aroused immense attention for biomedical applications, offering exceptional advantages such as ultra‐low photon scattering and increased tissue penetration. Among NIR‐II‐emitted organic dyes, Boron dipyrromethene (BODIPY), emerged a noteworthy candidate. BODIPY, distinguished by its controllable molecular structure optical properties, outstanding fluorescence quantum yields, high molar absorption coefficients, remarkable chemical stability, undergone comprehensive investigation extensive exploration within realm of biological theranostics. This work aims to provide summary advancements development design strategies NIR‐II BODIPY fluorophores tailored advanced phototheranostics. Initially, elucidates several representative strategies, concluding electron‐programming strategy, extension conjugated backbone, J‐aggregation strategic establishment activatable fluorophores, which enhance skeletons. Subsequently, developments fluorescent BODIPY‐based nanoplatforms applications are intricately elaborated. In conclusion, this outlines future efforts directions refining meet evolving clinical demands. It is anticipated that contribution may feasible reference thereby advancing their potential practices.

Language: Английский

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Photodynamic therapy for cancer: mechanisms, photosensitizers, nanocarriers, and clinical studies

MedComm, Journal Year: 2024, Volume and Issue: 5(7)

Published: June 22, 2024

Photodynamic therapy (PDT) is a temporally and spatially precisely controllable, noninvasive, potentially highly efficient method of phototherapy. The three components PDT primarily include photosensitizers, oxygen, light. employs specific wavelengths light to active photosensitizers at the tumor site, generating reactive oxygen species that are fatal cells. Nevertheless, traditional have disadvantages such as poor water solubility, severe oxygen-dependency, low targetability, difficult penetrate deep tissue, which remains toughest task in application clinic. Here, we systematically summarize development molecular mechanisms challenges management, highlighting advantages nanocarriers-based against cancer. third generation has opened up new horizons PDT, cooperation between nanocarriers attained satisfactory achievements. Finally, clinical studies discussed. Overall, present an overview our perspective field believe this work will provide insight into tumor-based PDT.

Language: Английский

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Boosting Theranostic Performance of AIEgens Using Nanocatalyzer for Robust Cancer Immunotherapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(23)

Published: Feb. 15, 2024

Abstract High‐performance theranostic systems are of paramount importance for achieving precise image‐guided cancer immunotherapy. Here, a novel nanoplatform is presented that integrates aggregation‐induced emission luminogen (AIEgen) with prussian blue (PB) nanocatalyzer robust The AIEgen dimethylamine substitution demonstrates compelling near‐infrared (NIR) light‐induced photothermal conversion and photodynamic therapy (PDT) capabilities. By incorporating into porous PBNPs, further enveloped within M1 macrophage membrane, tumor‐specific nanoagent constructed. This strategic integration effectively constrains the molecular motion AIEgen, leading to amplified NIR‐II fluorescence brightness PDT attributes. Moreover, PBNPs can catalyze tumor‐overexpressed H 2 O generate oxygen boost efficacy, PB's NIR absorption also intensifies photoacoustic imaging effect. provides comprehensive information photoimmunotherapy in orthotopic breast cancer‐bearing mice. Leveraging its potent immunogenic cell death effect, not only significantly inhibits growth, but generates whole‐cell therapeutic vaccine protect mice from tumor rechallenge. In highly malignant post‐surgery models, enables both accurate identification residual tumors efficient inhibition postoperative recurrence pulmonary metastasis. study will offer valuable insights creating efficacious multifaceted protocols.

Language: Английский

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Prodrug Integrated Envelope on Probiotics to Enhance Target Therapy for Ulcerative Colitis

Advanced Science, Journal Year: 2022, Volume and Issue: 10(4)

Published: Dec. 11, 2022

Abstract Ulcerative colitis (UC), affecting millions of patients worldwide, is associated with disorders the gut microbiota. Probiotics‐based therapy positively regulating community structure microbiota regarded as an efficient intervention for UC. However, oral probiotics delivery restricted by limited bioactivity, short retention time, complex pathological condition, and single therapeutic efficacy. Here, a bioengineered probiotic decorated multifunctional prodrug coating constructed to ameliorate aforementioned shortcomings. The results UC mice induced dextran sulfate sodium demonstrate that intrinsic features fabricated integrate microbes protection, colon‐targeted drug release, prolonged retention, inflammation regulation. In parallel, Lactobacillus rhamnosus GG (LGG) could regulate composition improve epithelial barrier function, thereby synergistically ameliorating These provide ample shreds evidence effect on UC, therefore, great promise potential strategy treatment.

Language: Английский

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Molecular imaging: design mechanism and bioapplications

Science China Chemistry, Journal Year: 2023, Volume and Issue: 66(5), P. 1336 - 1383

Published: March 3, 2023

Language: Английский

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Carrier‐Free ATP‐Activated Nanoparticles for Combined Photodynamic Therapy and Chemotherapy under Near‐Infrared Light

Small, Journal Year: 2023, Volume and Issue: 19(11)

Published: Jan. 1, 2023

Abstract The combination of photodynamic therapy (PDT) and chemotherapy (chemo‐photodynamic therapy) for enhancing cancer therapeutic efficiency has attracted tremendous attention in the recent years. However, limitations, such as low local concentration, non‐suitable treatment light source, uncontrollable release agents, result reduced combined efficacy. This study considered adenosine triphosphate (ATP), which is highly upregulated tumor cells, a biomarker developed ingenious ATP‐activated nanoparticles (CDNPs) that are directly self‐assembled from near‐infrared photosensitizer (Cy‐I) amphiphilic Cd(II) complex (DPA‐Cd). After selective entry into positively charged CDNPs would escape lysosomes be disintegrated by high ATP concentration cytoplasm. released Cy‐I capable producing single oxygen ( 1 O 2 ) PDT with 808 nm irradiation DPA‐Cd can concurrently function chemotherapy. Irradiation lead to ablation tumor‐bearing mice after intravenous injection CDNPs. carrier‐free nanoparticle offers new platform chemo‐photodynamic therapy.

Language: Английский

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