Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(11), P. 6891 - 6952

Published: May 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Language: Английский

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Current Advances on the Single‐Atom Nanozyme and Its Bioapplications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Feb. 11, 2023

Nanozymes, a class of nanomaterials mimicking the function enzymes, have aroused much attention as candidate in diverse fields with arbitrarily tunable features owing to diversity crystalline nanostructures, composition, and surface configurations. However, uncertainty their active sites lower intrinsic deficiencies nanomaterial-initiated catalysis compared natural enzymes promote pursuing alternatives by imitating biological centers. Single-atom nanozymes (SAzymes) maximize atom utilization well-defined structure, providing an important bridge investigate mechanism relationship between structure catalytic activity. They risen new burgeoning alternative enzyme from vitro bioanalytical tool vivo therapy flexible atomic engineering structure. Here, focus is mainly on three parts. First, detailed overview single-atom catalyst synthesis strategies including bottom-up top-down approaches given. Then, according structural feature nanocatalysts, influence factors such central metal atom, coordination number, heteroatom doping, metal-support interaction are discussed representative applications (including antibacterial/antiviral performance, cancer therapy, biosensing) highlighted. In end, future perspective challenge facing demonstrated.

Language: Английский

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Recent Progress of Supramolecular Chemotherapy Based on Host–Guest Interactions

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(21)

Published: July 21, 2023

Abstract Chemotherapy is widely recognized as an effective approach for treating cancer due to its ability eliminate cells using chemotherapeutic drugs. However, traditional chemotherapy suffers from various drawbacks, including limited solubility and stability of drugs, severe side effects, low bioavailability, drug resistance, challenges in tracking treatment efficacy. These limitations greatly hinder widespread clinical application. In contrast, supramolecular chemotherapy, which relies on host–guest interactions, presents a promising alternative by offering highly efficient minimally toxic anticancer delivery. this review, overview recent advancements based interactions provided. The significant role it plays guiding therapy emphasized. Drawing wealth cutting‐edge research, herein, timely valuable resource individuals interested the field or therapy, presented. Furthermore, review contributes progression toward

Language: Английский

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Tuning Local Coordination Environments of Manganese Single‐Atom Nanozymes with Multi‐Enzyme Properties for Selective Colorimetric Biosensing

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(15)

Published: Feb. 13, 2023

Single-atom nanozymes (SAzymes) are promising in next-generation nanozymes, nevertheless, how to rationally modulate the microenvironment of SAzymes with controllable multi-enzyme properties is still challenging. Herein, we systematically investigate relationship between atomic configuration and multi-enzymatic performances. The constructed MnSA -N3 -coordinated (MnSA -C) exhibits much more remarkable oxidase-, peroxidase-, glutathione oxidase-like activities than that -N4 -C. Based on experimental theoretical results, these multi-enzyme-like behaviors highly dependent coordination number single Mn sites by local charge polarization. As a consequence, series colorimetric biosensing platforms based -C successfully built for specific recognition biological molecules. These findings provide atomic-level insight into promoting rational design other demanding biocatalysts.

Language: Английский

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Nanoparticle‐Based Photothermal Therapy for Breast Cancer Noninvasive Treatment

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 10, 2023

Rapid advancements in materials science and nanotechnology, intertwined with oncology, have positioned photothermal therapy (PTT) as a promising noninvasive treatment strategy for cancer. The breast's superficial anatomical location aesthetic significance render breast cancer particularly pertinent candidate the clinical application of PTT following melanoma. This review comprehensively explores research conducted on various types nanoparticles employed elaborates their specific roles mechanisms action. integration existing therapies is scrutinized, underscoring its potential synergistic outcomes. Additionally, underlying consequential modifications to tumor microenvironment after are elaborated from medical perspective. Future directions suggested, an emphasis development integrative platforms that combine multiple therapeutic approaches optimization nanoparticle synthesis enhanced efficacy. goal push boundaries toward comprehensive, clinically applicable

Language: Английский

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Spatial Position Regulation of Cu Single Atom Site Realizes Efficient Nanozyme Photocatalytic Bactericidal Activity

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(46)

Published: July 27, 2023

Recently, single-atom nanozymes have made significant progress in the fields of sterilization and treatment, but their catalytic performance as substitutes for natural enzymes drugs is far from satisfactory. Here, a method reported to improve enzyme activity by adjusting spatial position site on nanoplatforms. Two types Cu are synthesized interlayer (CuL /PHI) in-plane (CuP poly (heptazine imide) (PHI) through different synthesis pathways. Experimental theoretical analysis indicates that PHI can effectively adjust coordination number, bond length, electronic structure single atoms compared position, thereby promoting photoinduced electron migration O2 activation, enabling effective generate reactive oxygen species (ROS). Under visible light irradiation, photocatalytic bactericidal CuL /PHI against aureus ≈100%, achieving same antibacterial effect antibiotics, after 10 min low-dose exposure 2 h incubation.

Language: Английский

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Gas‐Mediated Tumor Energy Remodeling for Sensitizing Mild Photothermal Therapy

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(27)

Published: May 4, 2023

Abstract The metabolic reprogramming of tumors requires high levels adenosine triphosphate (ATP) to maintain therapeutic resistance, posing a major challenge for photothermal therapy (PTT). Although raising the temperature helps in tumor ablation, it frequently leads severe side effects. Therefore, improving response and promoting healing are critical considerations development PTT. Here, we proposed gas‐mediated energy remodeling strategy improve mild PTT efficacy while minimizing In proof‐of‐concept study, Food Drug Administration (FDA)‐approved drug‐based hydrogen sulfide (H 2 S) donor was developed provide sustained supply H S sites, serving as an adjuvant This approach proved be highly effective disrupting mitochondrial respiratory chain, inhibiting ATP generation, reducing overexpression heat shock protein 90 (HSP90), which ultimately amplified outcome. With ability reverse thermotolerance, this delivered greatly potent antitumor response, achieving complete ablation single treatment harm healthy tissues. Thus, holds great promise universal solution overcoming limitations may serve valuable paradigm future clinical translation nanoagents.

Language: Английский

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Single‐Atom Nanozymes for Catalytic Therapy: Recent Advances and Challenges

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(16)

Published: Jan. 4, 2024

Abstract As a powerful tool, nanozyme catalysts broaden the avenues to implement bio‐inspired solutions for addressing many important concerns, covering energy, healthcare, environment, and more. Recent endeavors, characterized by atomic precision, have enabled extensive exploration of single‐atom nanozymes (SAzymes) with high catalytic activity, superior substrate selectivity, integrated multifunctionalities, thus becoming an emerging field that bridges nanotechnology biology. This review provides brief outline progress summarizes latest research advances regarding SAzymes in biomedical therapeutics, mainly including tumor therapy, wound antibacterial tissue anti‐inflammatory focus on their prototypical synthesis therapeutic mechanisms. Finally, current challenges future perspectives engineering advanced are also discussed outlooked. It is anticipated this area shall provide useful guidance therapy.

Language: Английский

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Defect-Rich Glassy IrTe₂ with Dual Enzyme-Mimic Activities for Sono-Photosynergistic-Enhanced Oncotherapy

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(7), P. 3952 - 3960

Published: Feb. 9, 2023

The complexity, diversity, and heterogeneity of malignant tumors pose a formidable challenge for antitumor therapy. To achieve the goal significantly enhancing effect, nanomedicine-based synergistic therapy is one important strategies. Herein, we innovatively report defect-rich glassy IrTe2 (G-IrTe2) with weak Ir–Te bond strength sonodynamic (SDT), chemodynamic (CDT), mild photothermal (PTT). G-IrTe2 sonosensitizer under ultrasound (US) stimuli exhibits excellent reactive oxygen species (ROS) production performance. Besides, catalase (CAT)-like activity can provide abundant to enhance SDT effect. Then, theoretical calculation verifies that US easily make irregular be broken in amorphous free electrons will released combine further form singlet (1O2). Meanwhile, peroxidase (POD)-like also catalyze endogenous H2O2 produce more ROS which conducive better tumor ablation. Furthermore, produced by sono-/chemodynamic processes cause mitochondrial dysfunction give rise heat shock protein (HSP) downregulated expression, maximizing efficiency PTT. Therefore, such rich defect could involved oncotherapy then effectively outstanding efficacy. This study provides new research idea expanding application inorganic nanomaterials promoting therapeutic effect tumors.

Language: Английский

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Self‐Driven Electricity Modulates d‐Band Electrons of Copper Single‐Atom Nanozyme for Boosting Cancer Therapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(48)

Published: July 21, 2023

Abstract Single‐atom nanozymes (SAzymes) are considered as the most promising candidates for natural enzymes due to their atomically dispersed active sites that closely resemble metal centers of counterparts. However, a significant challenge still exists improving catalytic activities, retarding practical applications. Herein, this article presents through application human self‐driven triboelectric device impose electrical stimulus, multiple enzyme‐like activities single‐atom copper nanozyme (Cu‐NC) remarkably improved, thereby boosting cancer cell oxidative damage and death realizing improved therapy. Under an stimulus with 20 V voltage, peroxidase, catalase, oxidase, glutathione oxidase like Cu‐NC all boost generation free radicals. Through calculation, work analyzes how modulates activity via decreasing adsorption energy H 2 O on Cu sites, increasing d xy orbital near Fermi level, shifting d‐band center Cu, facilitating reactions. This opens new perspectives nanoenzymes

Language: Английский

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