Molecular Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
20(2), P. 1269 - 1284
Published: Jan. 20, 2023
Diabetes
mellitus
(DM)
is
a
metabolic
disorder
that
one
of
the
most
common
health
problems
in
world,
primarily
type
2
DM
(T2DM).
Metformin
(MTF),
as
first-line
treatment
DMT2,
effective
lowering
glucose
levels,
but
its
oral
administration
causes
problems,
including
gastrointestinal
side
effects,
low
bioavailability,
and
risk
hypoglycemia.
In
this
study,
we
formulated
MTF
into
microparticles
incorporating
glucose-responsive
polymer
(MP–MTF–GR),
which
could
potentially
increase
bioavailability
extend
control
release
according
to
levels.
This
system
was
delivered
by
dissolving
microneedles
(MP–MTF–GR–DMN),
applied
through
skin,
thereby
preventing
effects
orally
administered
MTF.
MP–MTF–GR
using
various
concentrations
gelatin
combined
with
phenylboronic
acid
(PBA)
material.
encapsulated
DMN
polyvinyl
pyrrolidone
(PVP)
alcohol
(PVA)
polymers.
The
physicochemical
evaluation
showed
be
completely
entrapped
MP
percentage
trapped
increasing
concentration
without
changing
chemical
structure
producing
stable
MP.
addition,
results
MP–MTF–GR–DMN
had
adequate
mechanical
strength
properties
penetration
ability
environmental
changes.
vitro
ex
vivo
permeation
study
on
media
from
formula
increased
levels
media.
successfully
skin
at
11.30
±
0.29,
23.31
1.64,
36.12
3.77,
53.09
3.01
μg
PBS,
PBS
+
1%,
2%,
4%,
respectively,
24
h,
indicates
behavior.
developed
also
proven
nontoxic
based
hemolysis
tests.
Importantly,
rat
model
combination
approach
provide
better
reduction
compared
other
routes,
reducing
blood
level
normal
after
3
h
maintaining
for
8
h.
Furthermore,
did
not
change
moisture
rats.
promising
alternative
delivery
overcome
effectiveness
T2DM
therapy.
Nano-Micro Letters,
Journal Year:
2022,
Volume and Issue:
14(1)
Published: April 15, 2022
Abstract
Parkinson’s
disease
(PD),
a
neurodegenerative
that
shows
high
incidence
in
older
individuals,
is
becoming
increasingly
prevalent.
Unfortunately,
there
no
clinical
cure
for
PD,
and
novel
anti-PD
drugs
are
therefore
urgently
required.
However,
the
selective
permeability
of
blood–brain
barrier
(BBB)
poses
huge
challenge
development
such
drugs.
Fortunately,
through
strategies
based
on
physiological
characteristics
BBB
other
modifications,
including
enhancement
permeability,
nanotechnology
can
offer
solution
to
this
problem
facilitate
drug
delivery
across
BBB.
Although
nanomaterials
often
used
as
carriers
PD
treatment,
their
biological
activity
ignored.
Several
studies
recent
years
have
shown
improve
symptoms
via
own
nano-bio
effects.
In
review,
we
first
summarize
features
then
discuss
design
appropriate
brain-targeted
nanoplatforms
treatment.
Subsequently,
highlight
emerging
crossing
with
nano-biological
Finally,
current
challenges
nanomaterial-based
treatment
future
trends
field.
Our
review
emphasizes
value
patents
could
guide
researchers
working
area
future.
Micromachines,
Journal Year:
2022,
Volume and Issue:
13(10), P. 1623 - 1623
Published: Sept. 28, 2022
Although
nanomedicine
has
been
highly
investigated
for
cancer
treatment
over
the
past
decades,
only
a
few
nanomedicines
are
currently
approved
and
in
market;
making
this
field
poorly
represented
clinical
applications.
Key
research
gaps
that
require
optimization
to
successfully
translate
use
of
have
identified,
but
not
addressed;
among
these,
lack
control
release
pattern
therapeutics
is
most
important.
To
solve
these
issues
with
used
(e.g.,
burst
release,
systemic
release),
different
strategies
design
manufacturing
allowing
better
therapeutic
being
investigated.
The
inclusion
stimuli-responsive
properties
prolonged
drug
identified
as
effective
approaches
include
nanomedicine,
discussed
paper.
Recently,
smart
sustained
nanoparticles
designed
safely
efficiently
deliver
kinetic
profiles,
them
promising
many
delivery
applications
specific
treatment.
In
review,
state-of-the-art
discussed,
focusing
on
performances
polymeric
nanotechnologies.
A
complete
list
tested
trials
presented,
critically
discussing
advantages
limitations
respect
newly
developed
nanotechnologies
methods.
By
presented
discussion
highlight
criteria
current
limitations,
review
paper
could
be
high
interest
identify
key
features
release-controlled
Small,
Journal Year:
2022,
Volume and Issue:
18(22)
Published: May 6, 2022
Abstract
Nanoparticle
drug
delivery
is
largely
restricted
by
the
low
loading
capacity
of
nanoparticle
carriers.
To
address
this
critical
challenge
and
maximize
potential
delivery,
a
2D
ultra‐thin
layered
double
hydroxide
(LDH)
nanosheet
with
exceptionally
high
loading,
excellent
colloidal
stability,
prolonged
blood
circulation
for
cancer
treatment
constructed.
The
synthesized
via
biocompatible
polymer‐assisted
bottom‐up
method
exhibits
an
sheet‐like
structure
that
enables
considerable
amount
cargo
anchoring
sites
available
leading
to
extraordinary
734%
(doxorubicin/nanoparticle
mass
ratio)
capacity.
Doxorubicin
delivered
remains
stable
on
carrier
under
physiological
pH
condition,
while
showing
sustained
release
in
tumor
microenvironment
intracellular
environment,
thus
demonstrating
on‐demand
as
result
pH‐responsive
biodegradation
nanosheets.
Using
vitro
vivo
4T1
breast
models,
nanosheet‐based
ultra‐high
drug‐loading
system
demonstrates
even
enhanced
therapeutic
performance
compared
multilayered
LDH‐based
system,
terms
increased
cellular
uptake
efficiency,
circulation,
superior
effect,
reduced
systemic
toxicity.
Journal of Biomaterials Science Polymer Edition,
Journal Year:
2022,
Volume and Issue:
34(7), P. 986 - 1017
Published: Dec. 21, 2022
Microneedle
arrays
are
micron-sized
needles
usually
attached
to
a
supporting
base
or
patch
facilitated
drug
delivery
for
systemic
effects.
Polyvinylpyrrolidone
(PVP)
is
lactam
polymer
containing
an
internal
amide
linkage.
Because
of
its
versatility
and
biocompatibility,
it
has
been
widely
utilized
treat
several
skin,
bone
eye
problems.
Due
specific
unique
properties,
the
researchers
realize
utility
as
tremendous
potential.
PVP-based
dissolvable
microneedles
have
carrier
delivering
DNAs,
proteins,
vitamins,
biological
macromolecules
transdermally.
However,
does
not
get
biodegraded
into
body.
Therefore,
presence
fragments
in
body
post-treatment
needs
proper
justification.
The
adequate
justification
fate
fragment's
end
products
will
allow
even
better
utilization
PVP.
This
review
analyses
illustrates
various
experimental
findings
highlight
most
recent
advancements
applications
PVP
systems
cosmetology
potential
treating
dermal
disorders.
presents
expected
mode
biodegradation
aqueous
soil
environments
waste
material,
inertness,
importance
fabricating
pharmaceutical
uses,
non-toxic
profile.
