Strategies for enhancing cancer chemodynamic therapy performance

Exploration, Journal Year: 2022, Volume and Issue: 2(2)

Published: March 7, 2022

Chemodynamic therapy (CDT) has emerged to be a frontrunner amongst reactive oxygen species-based cancer treatment modalities. CDT utilizes endogenous H

Language: Английский

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Multifunctional mesoporous silica nanoparticles for biomedical applications

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 24, 2023

Abstract Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, excellent biocompatibility. Over past two decades, researchers have developed wide variety MSNs-based nanoplatforms through careful design controlled preparation techniques, demonstrating adaptability various application scenarios. With continuous breakthroughs MSNs fields biosensing, disease diagnosis treatment, tissue engineering, etc., gradually moving from basic research clinical trials. In this review, we provide detailed summary beginning with comprehensive overview development history. We then discuss types nanostructured architectures, well classification nanocomposites according elements existed inorganic functional components. Subsequently, summarize primary purposes surface-functionalized modifications MSNs. following, applications MSNs, highlight targeted therapeutic modalities currently developed. Given importance translation, also progress Finally, take perspective on future direction remaining challenges field.

Language: Английский

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Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 190, P. 114536 - 114536

Published: Sept. 13, 2022

Language: Английский

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Recent progress in NIR-II fluorescence imaging-guided drug delivery for cancer theranostics

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114821 - 114821

Published: April 9, 2023

Language: Английский

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Potential of Copper and Copper Compounds for Anticancer Applications

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(2), P. 234 - 234

Published: Feb. 3, 2023

Inducing cancer cell death has always been a research hotspot in life sciences. With the continuous deepening and diversification of related research, potential value metal elements inducing explored. Taking iron as an example, ferroptosis, mainly characterized by increasing load driving production large amounts lipid peroxides eventually leading to death, recently attracted great interest community. After iron, copper, trace element, received extensive attention especially tumor death. Copper its complexes can induce autophagy or apoptosis cells through variety different mechanisms action (activation stress pathways, arrest cycle, inhibition angiogenesis, cuproptosis, paraptosis), which are promising therapy have become new hotspots treatment research. This article reviews main applications novel copper compound-induced focusing on compounds their anticancer applications.

Language: Английский

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A Defect‐Engineered Nanozyme for Targeted NIR‐II Photothermal Immunotherapy of Cancer

Advanced Materials, Journal Year: 2022, Volume and Issue: 36(10)

Published: Oct. 10, 2022

Multienzyme-mimicking redox nanozymes, curated by defect engineering, in synergy with immunotherapy offer promising prospects for safe and efficient cancer therapy. However, the spatiotemporally precise immune response often gets challenged off-target adverse effects insufficient therapeutic response. Herein, a tumor cell membrane coated nanozyme (CMO-R@4T1) is reported combinational second near-infrared window (NIR-II) photothermal immunotherapy. CMO-R@4T1 consists of Cu-doped MoO

Language: Английский

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Biocatalytic cascade in tumor microenvironment with a Fe2O3/Au hybrid nanozyme for synergistic treatment of triple negative breast cancer

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 452, P. 138422 - 138422

Published: Aug. 2, 2022

Language: Английский

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An AND Logic Gate for Magnetic‐Resonance‐Imaging‐Guided Ferroptosis Therapy of Tumors

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(45)

Published: Sept. 17, 2023

To improve the magnetic resonance imaging (MRI) efficiency and ferroptosis therapy efficacy of exceedingly small iron oxide nanoparticles (IO, <5 nm) for tumors via enhancing sensitivity tumor microenvironment (TME) responsiveness, inspired by molecular logic gates, a self-assembled IO with an AND gate function is designed constructed. Typically, cystamine (CA) conjugated onto end poly(2-methylthio-ethanol methacrylate) (PMEMA) to generate PMEMA-CA. The PMEMA-CA grafted surface brequinar (BQR)-loaded form IO-BQR@PMEMA. IO-BQR@PMEMA (SA-IO-BQR@PMEMA) obtained due hydrophobicity PMEMA. carbon-sulfur single bond can be oxidized reactive oxygen species (ROS) in TME thio-oxygen double bond, resulting conversion from being hydrophobic hydrophilic. disulfide broken glutathione (GSH) TME, leading shedding PMEMA surface. Under dual actions ROS GSH (i.e., gate), SA-IO-BQR@PMEMA disassembled release IO, Fe2+/3+ , BQR. In vitro vivo results demonstrate mechanism, high T1 MRI performance exceptional tumors, excellent biosafety SA-IO-BQR@PMEMA.

Language: Английский

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Recent design strategies for boosting chemodynamic therapy of bacterial infections

Exploration, Journal Year: 2023, Volume and Issue: 4(2)

Published: Oct. 17, 2023

Abstract The emergence of drug‐resistant bacteria poses a significant threat to people's lives and health as bacterial infections continue persist. Currently, antibiotic therapy remains the primary approach for tackling infections. However, escalating rates drug resistance coupled with lag in development novel drugs have led diminishing effectiveness conventional treatments. Therefore, nonantibiotic‐dependent therapeutic strategies has become imperative impede rise resistance. chemodynamic (CDT) opened up new possibility due CDT can convert H 2 O into •OH via Fenton/Fenton‐like reaction treatment. efficacy is limited by variety practical factors. To overcome this limitation, sterilization efficiency be enhanced introducing therapeutics inherent antimicrobial capability. In addition, researchers explored CDT‐based combined therapies augment its effects mitigate potential toxic side toward normal tissues. This review examines research progress field, explores various enhance presents synergistic combination other modalities. And last, current challenges faced future directions are discussed.

Language: Английский

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Reticular Chemistry‐Enabled Sonodynamic Activity of Covalent Organic Frameworks for Nanodynamic Cancer Therapy

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(20)

Published: March 10, 2023

The development of covalent organic framework (COF) sonosensitizers with intrinsic sonodynamic effects is highly desirable. However, such COFs are generally constructed using small-molecule photosensitizers. Herein, we report that the reticular chemistry-based synthesis from two inert monomers yields a COF-based sonosensitizer (TPE-NN) inherent activity. Subsequently, nanoscale COF TPE-NN fabricated and embedded copper (Cu)-coordinated sites to obtain TPE-NN-Cu. Results show Cu coordination can enhance effect TPE-NN, whereas ultrasound (US) irradiation for therapy augment chemodynamic efficacy Consequently, TPE-NN-Cu upon US shows high-performance anticancer based on mutually reinforced sono-/chemo-nanodynamic therapy. This study reveals backbone-originated activity proposes paradigm nanodynamic

Language: Английский

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