Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 7, 2025
Language: Английский
BMEMat, Journal Year: 2024, Volume and Issue: 2(2)
Published: Jan. 12, 2024
Abstract Although immunotherapy has revolutionized cancer therapy by providing efficient tumor growth suppression, long‐term protection from recurrence as well minimized side effects, the low response rate significantly limits clinical application of in board types solid tumors. In order to improve therapeutic efficacy, conventional therapies including radiotherapy, chemotherapy, phototherapy and chemodynamic are employed combine with elicit stronger antitumor immune responses. Polymer nanomedicines frequently utilized synergistic other owing their tunable physiochemical properties, high drug loading capacity, ease modification toxicity. With elaborate design tailored polymer can enhance efficacy enhancing specificity, priming cells amplifying responses However, until now, there is no review solely dedicated comprehensive development polymer‐based platforms for combinational cancers. Herein, this paper summarizes latest advances design, fabrication traditional strategies photothermal therapy, photodynamic therapies. An outlook on trajectory potential challenges bridging gap between also discussed.
Language: Английский
Citations
24
ACS Nano, Journal Year: 2024, Volume and Issue: 18(13), P. 9713 - 9735
Published: March 20, 2024
Cancer-associated fibroblasts (CAFs) assist in breast cancer (BRCA) invasion and immune resistance by overproduction of extracellular matrix (ECM). Herein, we develop FPC@S, a photodynamic immunomodulator that targets the ECM, to improve immunotherapy for fibrotic BRCA. FPC@S combines tumor ECM-targeting peptide, photosensitizer (protoporphyrin IX) an antifibrotic drug (SIS3). After anchoring causes ECM remodeling BRCA cell death generating reactive oxygen species (ROS) situ. Interestingly, ROS-mediated can normalize blood vessel hypoxia turn facilitate more ROS production. Besides, upon acidic microenvironment, will release SIS3 reprograming CAFs reduce their activity but not kill them, thus inhibiting fibrosis while preventing metastasis. The natural physical barrier formed dense is consequently eliminated BRCA, allowing drugs cells penetrate deep into tumors have better efficacy. Furthermore, stimulate system effectively suppress primary, distant metastatic combining with checkpoint blockade therapy. This study provides different insights development targeted delivery systems exploration synergistic immunotherapeutic mechanisms against aggressive
Language: Английский
Citations
22
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 3623 - 3642
Published: March 1, 2025
The treatment of metastatic lung cancer, a common complication many primary cancers, has historically been significant clinical challenge. Once metastasis occurs, patients' survival is often significantly shortened. Therefore, prevention and metastases an important aspect cancer treatment. In this study, simple, low-toxicity, cholesterol-modified cationic cell-penetrating peptide DP7 (DP7-C), in combination with siDR6 was used for intravenous administration the metastases. Initially, databases were analyzed to determine expression levels death receptor 6 (DR6) tumors correlation between DR6 patient times. DP7-C/siDR6 micelles prepared by self-assembly method. By cultivating 293T, B16F10 LL2 cells, vitro experiments performed assess transfection efficiency, safety anti-cancer ability DP7-C/siDR6, while its targeting efficiency lungs investigated mouse experiments. Furthermore, therapeutic efficacy demonstrated model situ, artificial metastasis, 4T1 spontaneous metastasis. data analysis revealed that highly expressed majority patients high exhibited shorter showed it could inhibit tumor cell growth suppressing STAT3 signaling pathway. Subsequent resulted efficient targeting. inhibition on endothelial cells found prevent metastasis-induced necrosis thereby preventing And excellent models. systemic delivery DP7-C carrying provide alternative strategy halt
Language: Английский
Citations
2
Biomaterials Science, Journal Year: 2023, Volume and Issue: 12(1), P. 8 - 56
Published: Oct. 25, 2023
Hydrogels have established their significance as prominent biomaterials within the realm of biomedical research. However, injectable hydrogels garnered greater attention compared with conventional counterparts due to excellent minimally invasive nature and adaptive behavior post-injection. With rapid advancement emerging chemistry deepened understanding biological processes, contemporary been endowed an "intelligent" capacity respond various endogenous/exogenous stimuli (such temperature, pH, light magnetic field). This innovation has spearheaded revolutionary transformations across fields such tissue engineering repair, controlled drug delivery, disease-responsive therapies, beyond. In this review, we comprehensively expound upon raw materials (including natural synthetic materials) principles these advanced hydrogels, concurrently providing a detailed discussion prevalent strategies for conferring stimulus responsiveness. Finally, elucidate latest applications "smart" stimuli-responsive in domain, offering insights into prospects.
Language: Английский
Citations
30
Pharmacological Reviews, Journal Year: 2024, Volume and Issue: 76(5), P. 896 - 914
Published: June 12, 2024
Drug targets are specific molecules in biological tissues and body fluids that interact with drugs. target discovery is a key component of drug essential for the development new drugs areas such as cancer therapy precision medicine. Traditional in vitro or vivo methods time-consuming labour-intensive, limiting pace discovery. With modern methods, application various emerging technologies have greatly improved efficiency discovery, shortened cycle time reduced cost. This review provides comprehensive overview strategies, including computer-assisted approaches, affinity response stability, multiomics analysis, gene editing, NMD, discusses effectiveness limitations well their real cases. Through above related contents, general novel disease treatment strategies will be provided, theoretical basis provided those who engaged pharmaceutical science research. Significance Statement Target-based has been main approach to industry past three decades. based on or validation costly, Therefore, selection process crucial.
Language: Английский
Citations
14
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: July 6, 2024
Abstract Targeted immunomodulation for reactivating innate cells, especially macrophages, holds great promise to complement current adaptive immunotherapy. Nevertheless, there is still a lack of high-performance therapeutics blocking macrophage phagocytosis checkpoint inhibitors in solid tumors. Herein, peptide-antibody combo-supramolecular situ assembled CD47 and CD24 bi-target inhibitor (PAC-SABI) described, which undergoes biomimetic surface propagation on cancer cell membranes through ligand-receptor binding enzyme-triggered reactions. By simultaneously signaling, PAC-SABI enhances the phagocytic ability macrophages vitro vivo, promoting anti-tumor responses breast pancreatic mouse models. Moreover, building foundation PAC-SABI-induced repolarization increased CD8 + T tumor infiltration, sequential anti-PD-1 therapy further suppresses 4T1 progression, prolonging survival rate. The vivo construction PAC-SABI-based nano-architectonics provides an efficient platform bridging immunity maximize therapeutic potency.
Language: Английский
Citations
13
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 366, P. 838 - 848
Published: Feb. 1, 2024
Language: Английский
Citations
12
Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: 45(11)
Published: Feb. 24, 2024
Abstract Hydrogels, key in biomedical research for their hydrophilicity and versatility, have evolved with hydrogel microspheres (HMs) of micron‐scale dimensions, enhancing role minimally invasive therapeutic delivery, tissue repair, regeneration. The recent emergence nanomaterials has ushered a revolutionary transformation the field, which demonstrates tremendous potential targeted therapies, biological imaging, disease diagnostics. Consequently, integration advanced nanotechnology promises to trigger new revolution realm hydrogels. HMs loaded combine advantages both hydrogels nanomaterials, enables multifaceted functionalities such as efficient drug sustained release, therapy, lubrication, biochemical detection, medical biosensing monitoring, micro‐robotics. Here, this review comprehensively expounds upon commonly used classifications. Then, it provides comprehensive insights into raw materials preparation methods HMs. Besides, common strategies employed achieve nano‐micron combinations are summarized, latest applications these combined field elucidated. Finally, valuable future design development provided.
Language: Английский
Citations
11
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 368, P. 97 - 114
Published: Feb. 21, 2024
Language: Английский
Citations
10
ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(4), P. 1103 - 1111
Published: Feb. 26, 2024
Highly proliferative and reactive oxygen species (ROS) overexpression make pancreatic cancer upregulate cysteine (Cys) uptake to maintain redox homeostasis, which indicates that Cys may be a potential target for the treatment of cancer. Herein, polyvinylpyrrolidone (PVP) modified CuO nanoparticles (PVPCuO NPs) are proposed first inducing imbalance initiated by depletion. The PVPCuO NPs not only deplete produce H2O2 but also exhibit peroxidase (POD)-like activity, efficiently converting into hydroxyl radicals (•OH). Simultaneously, depletion induces nicotinamide adenine dinucleotide phosphate (NADPH) consumption thioredoxin (TXN) synthesis trigger ferroptosis. Then remarkable together with mass Cu2+ ions generation further initiate pyroptosis, achieving targeted high-efficiency therapy.
Language: Английский
Citations
9