Multi-therapeutic potential of flavonoids as an essential component in nutraceuticals for the treatment and management of human diseases

Phytomedicine Plus, Journal Year: 2024, Volume and Issue: 4(2), P. 100558 - 100558

Published: March 29, 2024

Diseases are one of the factors affecting human and national development in all its ramifications. Some diseases that affect humans usually difficult to manage or treat using conventional medications. Fortunately, nature provides man with many plants endowed medicinal properties. The properties due presence active metabolites, including flavonoids, have been shown multi-therapeutic Therefore, purpose this study was provide information on potencies flavonoids against diseases. Information within scope sourced from scientific databases such as Google Scholar, African Journals Online, Scopus, MEDLINE, PubMed, well non-indexed literature. biological function 27 distinct medical conditions—both communicable non-communicable—was documented. way work 10 different cancer types, 4 neglected tropical 14 health conditions clarified. Flavonoids were also hepatoprotective antioxidant Based findings, therapeutic use treatment and/or management a wide range illnesses, asthma, cancer, dementia, diabetes, glaucoma, hepatitis, malaria, several other conditions. provided paper could help direct future research two more an individual.

Language: Английский

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The Effects of Antioxidant Supplementation on the Pathologic Mechanisms of Metabolic Syndrome and Cardiovascular Disease Development

Nutrients, Journal Year: 2024, Volume and Issue: 16(11), P. 1641 - 1641

Published: May 27, 2024

In people with obesity, diabetes, and hypertension, lipid glucose metabolism oxidative stress generation interact. This condition, known as a “metabolic syndrome” (MetS), presents global challenge appears to be the underlying mechanism for development of cardiovascular diseases (CVDs). review is designed based on evidence indicating pathogenic mechanisms MetS. detail, we will look at induction in MetS, effects elevated levels condition’s pathophysiology, matters related endothelial function. According different components MetS pathophysiological network, antioxidants dysfunction are reviewed. After considering strategic role pathophysiology its associated CVDs, management by antioxidant supplementation seems an appropriate therapeutic approach.

Language: Английский

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Natural products in atherosclerosis therapy by targeting PPARs: a review focusing on lipid metabolism and inflammation

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: April 18, 2024

Inflammation and dyslipidemia are critical inducing factors of atherosclerosis. Peroxisome proliferator-activated receptors (PPARs) ligand-activated transcription control the expression multiple genes that involved in lipid metabolism inflammatory responses. However, synthesized PPAR agonists exhibit contrary therapeutic effects various side atherosclerosis therapy. Natural products structural diversity have a good safety. Recent studies find natural herbs compounds attractive on by alleviating hyperlipidemia inflammation through modulation PPARs. Importantly, preparation generally causes significantly lower environmental pollution compared to chemical compounds. Therefore, it is interesting discover novel modulator develop alternative strategies for therapy based This article reviews recent findings, mainly from year 2020 present, about roles regulation PPARs their provides theoretical basis using targeting PPARs, offers valuable information researchers interested developing modulators.

Language: Английский

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Plant Polyphenols as Heart’s Best Friends: From Health Properties, to Cellular Effects, to Molecular Mechanisms of Action

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 915 - 915

Published: Jan. 22, 2025

Polyphenols are micronutrients found in fruits, vegetables, tea, coffee, cocoa, medicinal herbs, fish, crustaceans, and algae. They can also be synthesized using recombinant microorganisms. Interest plant-derived natural compounds has grown due to their potential therapeutic effects with minimal side effects. This is particularly important as the aging population faces increasing rates of chronic diseases such cancer, diabetes, arthritis, cardiovascular, neurological disorders. Studies have highlighted polyphenols’ capacity reduce risk factors linked onset illnesses. narrative review discusses polyphenol families metabolism, cardioprotective polyphenols evidenced from vitro studies, well vivo on different animal models cardiac disease. study explores molecular mechanisms underlying these benefits. Current research suggests that may protect against ischemia, hypertension, hypertrophy, heart failure, myocardial injury through complex mechanisms, including epigenetic genomic modulation. However, further studies under nutritionally physiologically relevant conditions, untargeted multigenomic approaches, needed more comprehensively elucidate firmly prove polyphenols.

Language: Английский

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Catechins and Proanthocyanidins Involvement in Metabolic Syndrome

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9228 - 9228

Published: May 25, 2023

Recent studies on natural antioxidant compounds have highlighted their potentiality against various pathological conditions. The present review aims to selectively evaluate the benefits of catechins and polymeric structure metabolic syndrome, a common disorder characterized by cluster three main risk factors: obesity, hypertension, hyperglycemia. Patients with syndrome suffer chronic low inflammation state oxidative stress both conditions effectively countered flavanols polymers. mechanism behind activity these molecules has been correlated characteristic features basic flavonoidic skelethon, as well efficient doses needed perform in vitro vivo studies. amount evidence provided this offers starting point for flavanol dietary supplementation potential strategy counteract several targets associated suggests key role albumin flavanol-delivery system different target action inside organism.

Language: Английский

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Proanthocyanidins: Impact on Gut Microbiota and Intestinal Action Mechanisms in the Prevention and Treatment of Metabolic Syndrome

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5369 - 5369

Published: March 10, 2023

The metabolic syndrome (MS) is a cluster of risk factors, such as central obesity, hyperglycemia, dyslipidemia, and arterial hypertension, which increase the probability causing premature mortality. consumption high-fat diets (HFD), normally referred to high-saturated fat diets, major driver rising incidence MS. In fact, altered interplay between HFD, microbiome, intestinal barrier being considered possible origin Consumption proanthocyanidins (PAs) has beneficial effect against disturbances in However, there are no conclusive results literature about efficacy PAs improving This review allows comprehensive validation diverse effects on dysfunction HFD-induced MS, differentiating preventive therapeutic actions. Special emphasis placed impact gut microbiota, providing system facilitate comparison studies. can modulate microbiome toward healthy profile strength integrity. Nevertheless, date, published clinical trials verify preclinical findings scarce. Finally, MS-associated dysbiosis induced by HFD seems more successful than treatment strategy.

Language: Английский

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Coffee, tea, and cocoa in obesity prevention: Mechanisms of action and future prospects

Current Research in Food Science, Journal Year: 2024, Volume and Issue: 8, P. 100741 - 100741

Published: Jan. 1, 2024

Obesity, a major public health problem, causes numerous complications that threaten human and increase the socioeconomic burden. The pathophysiology of obesity is primarily attributed to lipid metabolism disorders. Conventional anti-obesity medications have high abuse potential frequently deliver insufficient efficacy negative side-effects. Hence, functional foods are regarded as effective alternatives address obesity. Coffee, tea, cocoa, three widely consumed beverages, long been considered prevent obesity, several studies focused on their intrinsic molecular mechanisms in past few years. Therefore, this review, we discuss by which bioactive ingredients these beverages counteract from aspects adipogenesis, lipolysis, energy expenditure (thermogenesis). future prospects challenges for coffee, cocoa products treatment also discussed, can be pursued drug development prevention strategies against

Language: Английский

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Dietary polyphenols and the risk of metabolic syndrome: a systematic review and meta-analysis

BMC Endocrine Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: March 1, 2024

Abstract Background Accumulating evidence has suggested that dietary polyphenols may be protective against metabolic syndrome (MetS); however, the available is contradictory. The aim of this meta-analysis was to assess association between intake and odds MetS. Methods PubMed Scopus databases were systematically searched obtain eligible studies. risk MetS for highest versus lowest intakes total, subclasses individual examined by pooling ratios (OR) 95% confidence intervals (95%CI) using random effects model. Results A total 14 studies (6 cohort 8 cross-sectional studies) involving a 50,366 participants with 10,879 cases included. When various polyphenol compounds pooled, they significantly related 22% decreased (([5 studies]; OR: 0.78; 95%CI: 0.72–0.85). Higher flavonoids (([9 0.72–0.85), flavan-3-ols (([2 0.64; 0.43–0.94), isoflavones (([3 0.84; 0.75–0.93), stilbenes (([4 0.86; 0.76–0.97), flavones 0.79; 0.71–0.89), quercetin 0.63; 0.43–0.93) also associated associations not modified age participants. No found polyphenols, phenolic acids, lignans, anthocyanins, flavonols. Conclusion results supported higher can lower

Language: Английский

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Wine Phenolic Compounds: Chemistry, Functionality and Health Benefits

Antioxidants, Journal Year: 2024, Volume and Issue: 13(11), P. 1312 - 1312

Published: Oct. 28, 2024

Wine phenolic compounds, often known as polyphenols, are a diverse group of secondary bioactive compounds derived from grapes. They play crucial role in defining the sensory characteristics, functionality, and health benefits wine. This review explores complex chemistry these focusing on key classes such flavonoids, which include flavanones, flavonols, anthocyanins, flavan-3-ols, non-flavonoids, hydroxycinnamic acids, hydroxybenzoic stilbenes. The wine phenolics, particularly their antioxidant anti-inflammatory properties, also discussed relation to preventing reducing risk non-communicable diseases (NCDs) cardiovascular diseases, cancers, neurodegenerative conditions. Furthermore, this summarized most current data human population-based research that investigated bioactivity red phytochemicals with relevant for NCDs. Finally, proposes some perspectives future better understand bioavailability, metabolism, long-term effects compounds.

Language: Английский

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Selected Seeds as Sources of Bioactive Compounds with Diverse Biological Activities

Nutrients, Journal Year: 2022, Volume and Issue: 15(1), P. 187 - 187

Published: Dec. 30, 2022

Seeds contain a variety of phytochemicals that exhibit wide range biological activities. Plant-derived compounds are often investigated for their antioxidant, anti-inflammatory, immunomodulatory, hypoglycemic, anti-hypercholesterolemic, anti-hypertensive, anti-platelet, anti-apoptotic, anti-nociceptive, antibacterial, antiviral, anticancer, hepatoprotective, or neuroprotective properties. In this review, we have described the chemical content and activity seeds from eight selected plant species—blackberry (Rubus fruticosus L.), black raspberry coreanus Miq.), grape (Vitis vinifera Moringa oleifera Lam., sea buckthorn (Hippophae rhamnoides Gac (Momordica cochinchinensis Sprenger), hemp (Cannabis sativa sacha inchi (Plukenetia volubilis L). This review is based on studies identified in electronic databases, including PubMed, ScienceDirect, SCOPUS. Numerous preclinical, some clinical found extracts, fractions, oil, flour, proteins, polysaccharides, purified isolated these plants display promising, health-promoting effects, could be utilized drug development, to make nutraceuticals functional foods. Despite that, many properties been studied only vitro, it’s unsure if effects would relevant vivo as well, so there need more animal trials help determine they applied disease prevention treatment.

Language: Английский

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