Fe(III)-Chelated Polydopamine Nanoparticles for Synergistic Tumor Therapies of Enhanced Photothermal Ablation and Antitumor Immune Activation

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(14), P. 15894 - 15910

Published: March 31, 2022

Both the low energy density of near-infrared (NIR) photothermal conversion during treatment and recurrence metastasis after local have been main obstacles conundrums in polydopamine-mediated tumor therapy (PTT). Herein, On basis enhancement NIR absorption by ligand to metal charge transfer (LMCT) transition-metal complexes activation antitumor immunity an appropriate concentration Fe(III) ions, Fe(III)-chelated PDA nanoparticles (Fe-PDA NPs) with high loading responsive release iron ions were synthesized through a prechelation-polymerization method. First, chelated catechol groups DA form mono-dopa-Fe(III) chelate, then polymerization dopamine was initiated under alkaline conditions. The results revealed that chelate still Fe ion existing Fe-PDA able greatly enhance light behaviors NIR, resulting superior ability (η = 55.5%). Moreover, existence also gave T1-weighted MRI contrast-enhancement performance (r1 7.668 mM-1 s-1) it would enable accurate ablation primary tumors vivo irradiation means guidance thermal imaging. Furthermore, exhibited better H2O2-responsive biodegradability comparison easily released tumors, which could effectively promote tumor-associated macrophage (TAM) repolarization M1 mode. TAM combined immunogenic cell death (ICD) induced PTT efficacy immunotherapy, preventing metastasis. design should provide more inspiration for structural functional improvements melanin-based materials suppression.

Language: Английский

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Enhancement of antitumor immunotherapy using mitochondria-targeted cancer cell membrane-biomimetic MOF-mediated sonodynamic therapy and checkpoint blockade immunotherapy

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: May 14, 2022

Immunotherapeutic interventions represent a promising approach to treating cancer, with strategies such as immune checkpoint blockade (ICB), immunogenic sonodynamic therapy (SDT), and adjuvant T cell delivery having exhibited clinical promise. In this report, we describe the use of cancer membrane-coated triphenylphosphonium (TPP) decorated nano-metal-organic framework (nMOF) constructs [Zr-TCPP(TPP)/R837@M] that were used generate homologous, mitochondria-targeted platforms high rate sonosensitizer loading. This construct was utilized simultaneously promote tumor antigen presentation via enhancing SDT while synergistically promoting dendritic (DC) maturation through Toll-like receptor agonist R837. vitro, these functionalized nMOFs readily internalized by homologous cells in which they efficiently targeted mitochondria, DC activation induction death (ICD) following ultrasound exposure. Moreover, nanoplatform able achieve vivo synergy anti-CTLA-4 ICB reverse immunosuppression microenvironment (TME), thus achieving more robust antitumor efficacy capable suppressing metastatic disease progression facilitating development durable memory responses. Together, results highlight enhanced activity overcoming an immunosuppressive TME, thereby immunity.

Language: Английский

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Biomedical applications of PLGA nanoparticles in nanomedicine: advances in drug delivery systems and cancer therapy

Expert Opinion on Drug Delivery, Journal Year: 2023, Volume and Issue: 20(7), P. 937 - 954

Published: June 9, 2023

During the last decades, ever-increasing proportion of patients with cancer has been led to serious concerns worldwide. Therefore, development and use novel pharmaceuticals, like nanoparticles (NPs)-based drug delivery systems (DDSs), can be potentially effective in therapy.Poly lactic-co-glycolic acid (PLGA) NPs, as a kind bioavailable, biocompatible, biodegradable polymers, have approved by Food Drug Administration (FDA) for some biomedical pharmaceutical applications. PLGA is comprised lactic (LA) glycolic (GA) their ratio could controlled during various syntheses preparation approaches. LA/GA determines stability degradation time PLGA; lower content GA results fast degradation. There are several approaches preparing NPs that affect aspects, such size, solubility, stability, loading, pharmacokinetics, pharmacodynamics, so on.These indicated sustained release site passive active (via surface modification) DDSs. This review aims provide an overview approach physicochemical mechanism cellular fate, DDSs efficient therapy, status industry nanomedicine.

Language: Английский

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Advances and Prospects in Integrated Nano-oncology

Nano Biomedicine and Engineering, Journal Year: 2024, Volume and Issue: 16(2), P. 152 - 187

Published: Feb. 5, 2024

In recent years, the deep integration of basic research and clinical translational nanotechnology oncology has led to emergence a new branch, namely integrated nano-oncology. This is an emerging important interdisciplinary field, which plays irreplaceable role in diagnosis, treatment, early warning, monitoring prevention tumors, become frontier. Here main advances nano-oncology was reviewed, mainly included controlled preparation nanomaterials, ultra-sensitive detection tumor biomarkers, multi-functional nanoimaging probes diagnosis treatment technology, innovative nano drugs drug delivery system, DNA nanotechnology, RNA self-assembly nanosensors, intelligent nanorobots, nanotherapeutic machines. The terms, concepts, trends challenges are also discussed with aim promoting application solving scientific key technical problems cancer.

Language: Английский

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From structural design to delivery: mRNA therapeutics for cancer immunotherapy

Exploration, Journal Year: 2023, Volume and Issue: 4(2)

Published: Nov. 17, 2023

Abstract mRNA therapeutics have emerged as powerful tools for cancer immunotherapy in accordance with their superiority expressing all sequence‐known proteins vivo. In particular, a small dosage of delivered mRNA, antigen‐presenting cells (APCs) can synthesize mutant neo‐antigens and multi‐antigens present epitopes to T lymphocytes elicit antitumor effects. addition, receptors like chimeric antigen receptor (CAR), T‐cell (TCR), CD134, immune‐modulating factors including cytokines, interferons, antibodies specific enhance immunological response against tumors. With the maturation vitro transcription (IVT) technology, large‐scale pure encoding be synthesized quickly. However, clinical translation mRNA‐based anticancer strategies is restricted by delivering into target organs or inadequate endosomal escape efficiency mRNA. Recently, there been some advances immunotherapy, which roughly classified modifications structure development delivery systems, especially lipid nanoparticle platforms. this review, latest overcoming limitations immunotherapies recent are summarized. Challenges opportunities applications also discussed.

Language: Английский

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Ultrasound-responsive catalytic microbubbles enhance biofilm elimination and immune activation to treat chronic lung infections

Science Advances, Journal Year: 2023, Volume and Issue: 9(4)

Published: Jan. 25, 2023

Efficient treatment of chronic lung infections caused by Pseudomonas aeruginosa biofilms is a great challenge because drug tolerance and immune evasion issues. Here, we develop ultrasound-responsive catalytic microbubbles with biofilm elimination activation properties to combat infection induced P. biofilms. In these microbubbles, piperacillin Fe3O4 nanoparticles form drug-loaded shell surrounding the air core. Under ultrasound stimulation, can physically disrupt structure enhance penetration both into biofilm. Then, chemically degrade matrix kill bacteria assistance piperacillin. activate response for polarizing macrophages pro-inflammatory phenotype. These efficiently treat in mouse model combining physical/chemical/antibiotic activation, thus providing promising strategy combating bacterial infections.

Language: Английский

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A Hierarchical Structured Fiber Device Remodeling the Acidic Tumor Microenvironment for Enhanced Cancer Immunotherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(21)

Published: March 13, 2023

Abstract The acidic microenvironment of tumors significantly reduces the anti‐tumor effect immunotherapy. Herein, a hierarchically structured fiber device is developed as local drug delivery system for remodeling tumor (TME) to improve therapeutic Proton pump inhibitors in matrix can be sustainedly released inhibit efflux intracellular H + from cells, resulting TME. targeted micelles and M1 macrophage membrane‐coated nanoparticles internal cavities induce immunogenic cell death (ICD) cells phenotypic transformation tumor‐associated macrophages (TAMs), respectively. relief acidity TME further promotes ICD polarization TAMs, alleviating immunosuppressive synergistically enhancing antitumor immune response. In vivo results reveal this restores pH value 6.8 7.2 exhibit an excellent immunotherapeutic effect.

Language: Английский

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Metal‐based smart nanosystems in cancer immunotherapy

Exploration, Journal Year: 2024, Volume and Issue: 4(6)

Published: March 22, 2024

Abstract Metals are an emerging topic in cancer immunotherapy that have shown great potential modulating immunity cycle and promoting antitumor by activating the intrinsic immunostimulatory mechanisms which been identified recent years. The main challenge of metal‐assisted lies fact free metals as ion forms easily cleared during circulation, even cause systemic metal toxicity due to off‐target effects. With rapid development nanomedicine, metal‐based smart nanosystems (MSNs) with unique controllable structure become one most promising delivery carriers solve issue, owing their various endogenous/external stimuli‐responsiveness release ions for metalloimmunotherapy. In this review, state‐of‐the‐art research progress metal‐related is comprehensively summarized. First, mainstream MSNs‐assisted will be delineated. immunological effects certain categorization MSNs different characters compositions then provided, followed representative exemplar applications treatment, synergistic combination immunotherapy. Finally, we conclude review a summary remaining challenges associated provide authors' perspective on further advances.

Language: Английский

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NF-κB: Governing Macrophages in Cancer

Genes, Journal Year: 2024, Volume and Issue: 15(2), P. 197 - 197

Published: Jan. 31, 2024

Tumor-associated macrophages (TAMs) are the major component of tumor microenvironment (TME), where they sustain progression and or-tumor immunity. Due to their plasticity, can exhibit anti- or pro-tumor functions through expression different gene sets leading distinct macrophage phenotypes: M1-like pro-inflammatory M2-like anti-inflammatory. NF-κB transcription factors central regulators TAMs in cancers, often drive polarization toward an phenotype. Therefore, pathway is attractive therapeutic target for cancer immunotherapy a wide range human tumors. Hence, targeting myeloid compartment potential clinical strategy overcome microenvironment-induced immunosuppression increase anti-tumor In this review, we discuss role as key driver tumors well principal strategies by pathway.

Language: Английский

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Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: March 7, 2025

Abstract Macrophages are immune cells belonging to the mononuclear phagocyte system. They play crucial roles in defense, surveillance, and homeostasis. This review systematically discusses types of hematopoietic progenitors that give rise macrophages, including primitive progenitors, erythro-myeloid stem cells. These have distinct genetic backgrounds developmental processes. Accordingly, macrophages exhibit complex diverse functions body, phagocytosis clearance cellular debris, antigen presentation, response, regulation inflammation cytokine production, tissue remodeling repair, multi-level regulatory signaling pathways/crosstalk involved homeostasis physiology. Besides, tumor-associated a key component TME, exhibiting both anti-tumor pro-tumor properties. Furthermore, functional status is closely linked development various diseases, cancer, autoimmune disorders, cardiovascular disease, neurodegenerative metabolic conditions, trauma. Targeting has emerged as promising therapeutic strategy these contexts. Clinical trials macrophage-based targeted drugs, immunotherapies, nanoparticle-based therapy were comprehensively summarized. Potential challenges future directions targeting also been discussed. Overall, our highlights significance this versatile cell human health which expected inform research clinical practice.

Language: Английский

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