Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(1), P. 209 - 268

Published: Oct. 19, 2021

In vivo imaging in the second near-infrared window (NIR-II, 1000-1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types inorganic/organic fluorophores that can be used noninvasive NIR-IIa/IIb (NIR-IIa, 1300-1400 nm; NIR-IIb, 1500-1700 nm) with near-zero tissue autofluorescence deeper penetration. This review provides overview reports published date design, properties, molecular imaging, theranostics fluorophores. First, we summarize design concepts up-to-date functional biomaterials, order single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), organic (OFs). Then, these novel modalities applications brought by superior fluorescent properties are reviewed. Finally, challenges perspectives future translation, aiming at boosting application progress NIR-IIa NIR-IIb technology highlighted.

Language: Английский

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Achieving Efficient NIR‐II Type‐I Photosensitizers for Photodynamic/Photothermal Therapy upon Regulating Chalcogen Elements

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(7)

Published: Dec. 22, 2021

Second near-infrared (NIR-II) window type-I photosensitizers have intrinsic advantages in photodynamic/photothermal therapy (PDT/PTT) of some malignant tumors with deep infiltration, large size, complicated location, and low possibility surgery/radiotherapy. Herein, three chalcogen-element-based donor-acceptor-type semiconducting polymers (poly[2,2″-((E)-4,4″-bis(2-octyldodecyl)-[6,6″-bithieno[3,2-b]pyrrolylidene]-5,5″(4H,4″H)-dione)-alt-2,5-(thiophene)] (PTS), poly[2,2″-((E)-4,4″-bis(2-octyldodecyl)-[6,6″-bithieno[3,2-b]pyrrolylidene]-5,5″(4H,4″H)-dione)-alt-2,5-(selenophene)] (PTSe), poly[2,2″-((E)-4,4″-bis(2-octyldodecyl)-[6,6″-bithieno[3,2-b]pyrrolylidene]-5,5″(4H,4'H)-dione)-alt-2,5-(tellurophene)] (PTTe)) are synthesized fully characterized, demonstrating strong absorption the NIR-II region. Upon adjusting chalcogen elements, intramolecular charge-transfer characteristics heavy-atom effect tuned to enhance intersystem crossing rate, improving photodynamic effect. Moreover, energy levels Gibbs free energies facilitate process. As a result, PTTe nanoparticles (NPs) produce superoxide anion radicals (O2•- ) more efficiently demonstrate higher photothermal conversion efficiency than PTS PTSe NPs upon (1064 nm) laser irradiation, exhibiting unprecedented PDT/PTT performance vitro vivo. This work provides ideas for achieving high-performance hypoxic oncotherapy.

Language: Английский

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Synergistic Reinforcing of Immunogenic Cell Death and Transforming Tumor‐Associated Macrophages Via a Multifunctional Cascade Bioreactor for Optimizing Cancer Immunotherapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(51)

Published: Oct. 17, 2022

Immunogenic cell death (ICD) has aroused widespread attention because it can reconstruct a tumor microenvironment and activate antitumor immunity. This study proposes two-way enhancement of ICD based on CaO2 @CuS-MnO2 @HA (CCMH) nanocomposite to overcome the insufficient damage-associated molecular patterns (DAMPs) conventional ICD-inducers. The near-infrared (NIR) irradiation (1064 nm) CuS nanoparticles generates 1 O2 through photodynamic therapy (PDT) trigger ICD, also damages Ca2+ buffer function mitochondria. Additionally, react with H2 O produce large amount , which respectively lead enhanced PDT overload during mitochondrial damage, thereby triggering robust activation. Moreover, oxidative-damaged DNA, induced by released from cells, reprograms immunosuppressive transforming tumor-associated macrophages M1 subphenotype. shows that CCMH NIR-II elicit adequate DAMPs an active tumor-immune for both 4T1 CT26 models. Combining this method immune checkpoint blockade realize improved immunotherapy efficacy long-term protection effect body.

Language: Английский

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The Current Status of Photodynamic Therapy in Cancer Treatment

Cancers, Journal Year: 2023, Volume and Issue: 15(3), P. 585 - 585

Published: Jan. 18, 2023

Although we have made great strides in treating deadly diseases over the years, cancer therapy still remains a daunting challenge. Among numerous anticancer methods, photodynamic (PDT), non-invasive therapeutic approach, has attracted much attention. PDT exhibits outstanding performance therapy, but some unavoidable disadvantages, including limited light penetration depth, poor tumor selectivity, as well oxygen dependence, largely limit its efficiency for solid tumors treatment. Thus, strategies gone into overcoming these obstacles, such exploring new photosensitizers with higher conversion efficiency, alleviating hypoxia to fuel generation of reactive species (ROS), designing tumor-targeted PS, and applying PDT-based combination strategies. In this review, briefly summarized related approaches, which are mainly characterized by advanced PSs, PSs excellent additional refreshing features. We also summarize therapies effects.

Language: Английский

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Theranostic Fluorescent Probes

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(5), P. 2699 - 2804

Published: Feb. 29, 2024

The ability to gain spatiotemporal information, and in some cases achieve control, the context of drug delivery makes theranostic fluorescent probes an attractive intensely investigated research topic. This interest is reflected steep rise publications on topic that have appeared over past decade. Theranostic probes, their various incarnations, generally comprise a fluorophore linked masked drug, which released as result certain stimuli, with both intrinsic extrinsic stimuli being reported. release then signaled by emergence signal. Importantly, use appropriate fluorophores has enabled not only this emerging fluorescence marker for but also provided modalities useful photodynamic, photothermal, sonodynamic therapeutic applications. In review we highlight recent work particular focus are activated tumor microenvironments. We summarize efforts develop other applications, such neurodegenerative diseases antibacterials. celebrates diversity designs reported date, from discrete small-molecule systems nanomaterials. Our aim provide insights into potential clinical impact still-emerging direction.

Language: Английский

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AIE-active luminogens as highly efficient free-radical ROS photogenerator for image-guided photodynamic therapy

Chemical Science, Journal Year: 2022, Volume and Issue: 13(12), P. 3599 - 3608

Published: Jan. 1, 2022

Image-guided photodynamic therapy (PDT) can realize highly precise and effective via the integration of imaging therapy, has created high requirements for photosensitizers. However, PDT modality usually utilizes conventional type II photosensitizers, resulting in unsatisfactory therapeutic outcomes due to aggregation-caused quenching (ACQ), "always on" fluorescence strong oxygen dependence. Herein, we report I-based aggregation-induced emission (AIE) photosensitizer TCM-CPS with low dependence, near-infrared (NIR) "off-on" fluorescence; particular, it produces more reactive species (ROS) than commercially available Chlorin e6 Rose Bengal. In rational design AIE-based TCM-CPS, strongly electron-donating carbazole unit π-thiophene bridge distinctly extend wavelength decrease autofluorescence interference bio-imaging, hydrophilic pyridinium salt group guarantees good molecular dispersion maintains fluorescence-off state aqueous system initial background. Moreover, donor-π-acceptor (D-π-A) character greatly separates HOMO-LUMO distribution, enhancing ROS generation, was constructed as a I assistance intramolecular charge transfer electron-rich anion-π+ structure. Based on its favorable hydrophilicity photosensitivity, found be efficient free-radical photogenerator both visualizing cells using light-up NIR efficiently killing cancer upon light irradiation. The positively charged could quickly bind bacteria electrostatic interactions provide signal kill at concentration. treatment bacteria-infected mice, mice exhibited accelerated wound healing infection. Thus, great potential replace photosensitizers image-guided bacterial

Language: Английский

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Efficient NIR-II Type-I AIE Photosensitizer for Mitochondria-Targeted Photodynamic Therapy through Synergistic Apoptosis–Ferroptosis

ACS Nano, Journal Year: 2023, Volume and Issue: 17(10), P. 9110 - 9125

Published: May 5, 2023

Hypoxia, the hallmark of malignant tumors, has been recognized as a major obstacle for photodynamic therapy (PDT). Precisely targeting cancer cells in intricate biological scenarios by hypoxia-resistant photosensitizer (PS) is cornerstone to conquer inevitable tumor recurrence and metastasis. Herein, we describe an organic NIR-II PS (TPEQM-DMA) possessing potent type-I phototherapeutic efficacy overcome intrinsic pitfalls PDT combating hypoxic tumors. TPEQM-DMA exhibited prominent emission (>1000 nm) with aggregation-induced feature efficiently produced superoxide anion hydroxyl radical aggregate state under white light irradiation exclusively through low-O2-dependent photochemical process. The suitable cationic nature assisted accumulate cancerous mitochondria. Meanwhile, impaired cellular redox homeostasis, led mitochondrial dysfunction, raised level lethal peroxidized lipids, which induced apoptosis ferroptosis. This synergistic cell death modality enabled suppress growth cells, multicellular spheroids, To improve pharmacological properties TPEQM-DMA, nanoparticles were prepared encapsulation polymer. In vivo experiments proved appealing fluorescence imaging-guided effect

Language: Английский

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Targeting the Microenvironment of Vulnerable Atherosclerotic Plaques: An Emerging Diagnosis and Therapy Strategy for Atherosclerosis

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(29)

Published: March 3, 2022

Abstract Atherosclerosis is considered one of the primary causes cardiovascular diseases (CVDs). Unpredictable rupture vulnerable atherosclerotic plaques triggers adverse events such as acute myocardial syndrome and even sudden cardiac death. Therefore, assessing vulnerability early intervention are significance in reducing CVD mortality. Nanomedicine possesses tremendous advantages achieving integration diagnosis therapy because its magnetic, optical, thermal, catalytic properties. Based on pathological characteristics plaques, stimuli‐responsive nanoplatforms surface‐functionalized nanoagents designed have drawn great attention for accomplishing precise imaging treatment due to their superior properties, high bioavailability, lesion‐targeting specificity, on‐demand cargo release, low off‐target damage. Here, generalized, some targeted strategies boosting accuracy plaque evaluation by efficacy stabilization (including antioxidant therapy, macrophage depletion regulation lipid metabolism anti‐inflammation etc.) systematically summarized. In addition, existing challenges prospects this field discussed, it believed provide new thinking CVDs near future.

Language: Английский

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Recent advances and trends in nanoparticles based photothermal and photodynamic therapy

Photodiagnosis and Photodynamic Therapy, Journal Year: 2021, Volume and Issue: 37, P. 102697 - 102697

Published: Dec. 20, 2021

Language: Английский

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Antibacterial Carbon Dots: Mechanisms, Design, and Applications

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(23)

Published: May 13, 2023

Abstract The increase in antibiotic resistance promotes the situation of developing new antibiotics at forefront, while development non‐antibiotic pharmaceuticals is equally significant. In post‐antibiotic era, nanomaterials with high antibacterial efficiency and no drug make them attractive candidates for materials. Carbon dots (CDs), as a kind carbon‐based zero‐dimensional nanomaterial, are attracting much attention their multifunctional properties. abundant surface states, tunable photoexcited excellent photo‐electron transfer properties sterilization CDs feasible gradually emerging field. This review provides comprehensive insights into recent topics include mechanisms, design, optimization processes, potential practical applications also highlighted, such treatment bacterial infections, against biofilms, surfaces, food preservation, bacteria imaging detection. Meanwhile, challenges outlook field discussed proposed.

Language: Английский

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