Cu Single Atom Nanozyme Based High‐Efficiency Mild Photothermal Therapy through Cellular Metabolic Regulation

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(50)

Published: Oct. 20, 2022

Upregulation of heat shock proteins (HSPs) drastically compromises the treatment effect mild photothermal therapy (PTT). Herein, we designed a polyporous Cu single atom nanozyme (Cu SAzyme) loaded with licogliflozin (LIK066) for HSP-silencing induced PTT. On one hand, LIK066 inhibits glucose uptake by shutting sodium-dependent transporter (SGLT) "valve", effectively blocking energy source adenosine triphosphate (ATP) generation. Without sufficient energy, cancer cells cannot synthesize HSPs. other SAzyme presents extraordinary multienzyme activities to induce reactive oxygen species (ROS) storm formation, which can damage existing HSPs in cells. Through two-pronged strategy SGLT inhibitor and ROS storm, LIK066-loaded shows high efficiency comprehensive removal realize

Language: Английский

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Piezoelectric Metal–Organic Frameworks Based Sonosensitizer for Enhanced Nanozyme Catalytic and Sonodynamic Therapies

ACS Nano, Journal Year: 2023, Volume and Issue: 17(8), P. 7901 - 7910

Published: April 13, 2023

The regulation of electrostatic electric fields through electrical stimulation is an efficient method to increase the catalytic activity nanozymes and improve therapeutic effect nanozyme therapy. Piezoelectric materials, which are capable generating a built-in field under ultrasound (US), not only but also enable piezoelectric sonodynamic therapy (SDT). In this study, sonosensitizer based on Hf-based metal–organic framework (UIO-66) Au nanoparticles (NPs) was produced. Under US irradiation, UIO-66 can generate inside promotes electron–hole separation produces reactive oxygen species (ROS). introduction NPs facilitated electron transfer, inhibited recombination pairs improved properties UIO-66. value constant (d33) increased from 71 122 pmV–1 after deposition NPs. addition, intrinsic catalase peroxidase activities were 2-fold induced exposure. vivo in vitro experiments revealed that proposed kill cancer cells inhibit tumor growth mice enhanced SDT sensitizer work proved be candidate used for multiple modalities

Language: Английский

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Tumor Cell-Targeting and Tumor Microenvironment–Responsive Nanoplatforms for the Multimodal Imaging-Guided Photodynamic/Photothermal/Chemodynamic Treatment of Cervical Cancer

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 5837 - 5858

Published: June 1, 2024

Purpose: Phototherapy, known for its high selectivity, few side effects, strong controllability, and synergistic enhancement of combined treatments, is widely used in treating diseases like cervical cancer. Methods: In this study, hollow mesoporous manganese dioxide was as a carrier to construct positively charged, poly(allylamine hydrochloride)–modified nanoparticles (NPs). The NP efficiently loaded with the photosensitizer indocyanine green (ICG) via addition hydrogen phosphate ions produce counterion aggregation effect. HeLa cell membrane encapsulation performed achieve final M-HMnO 2 @ICG NP. structure, HMnO responsively degrades release ICG tumor microenvironment, self-generates O sensitization ICG-mediated photodynamic therapy (PDT), consumes GSH expand oxidative stress therapeutic effect [chemodynamic (CDT) + PDT]. accumulated tissues exerts PDT/photothermal (PTT) through single laser irradiation, improving efficiency reducing effects. increases nanomedicine accumulation confers an immune evasion ability. addition, local temperatures induced by PTT can enhance CDT. These properties enable full achievement PTT/PDT/CDT targeted Results: Mn 2+ serve magnetic resonance imaging agent guide therapy, be photothermal fluorescence imaging. After intravenous injection, effectively at mouse sites; optimal timing in-vivo treatment could verified near-infrared fluorescence, resonance, NPs had best antitumor effects among groups under light conditions, showed good biocompatibility. Conclusion: we designed nano-biomimetic delivery system that improves hypoxia, responds loads ICG. It provides new economical convenient strategy phototherapy CDT Keywords: phototherapy, reactive oxygen species, hypoxia relief, collaborative

Language: Английский

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Tumor microenvironment-oriented MOFs for chemodynamic therapy

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 484, P. 215098 - 215098

Published: March 14, 2023

Non-invasive tumor therapy via in situ ROS generation is emerging as an appealing treatment modality with the potential for deep-seated tumors without side effects on healthy tissue. Chemodynamic (CDT) based Fenton/Fenton-like reactions a non-invasive cancer treatment, which converts hydrogen peroxide (H2O2) found locally into lethal hydroxyl radicals (OH) through exploitation of transition metal ions catalysts acidic microenvironment (TME) suitable effective oncotherapy. Metal-organic frameworks (MOFs) exhibit great promise CDT account their unique properties. Among them, stimuli-responsive nature and porosity MOFs make them ideal TME-targeted cargo delivery. In addition, ability to select appropriate organic ligands makes it possible prepare intrinsic antitumor activity. This review primarily summarizes latest progress application microenvironment-oriented CDT, including or chemodynamic Furthermore, remaining challenges suggestions future applications are also presented.

Language: Английский

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Fe(III)‐Naphthazarin Metal–Phenolic Networks for Glutathione‐Depleting Enhanced Ferroptosis–Apoptosis Combined Cancer Therapy

Small, Journal Year: 2023, Volume and Issue: 19(19)

Published: Feb. 11, 2023

Abstract Nowadays, Fenton chemistry‐based chemodynamic therapy (CDT) is an emerging approach to killing tumor cells by converting endogenous H 2 O into cytotoxic hydroxyl radicals (·OH). However, the elimination of ·OH intracellular overexpressed glutathione (GSH) results in unsatisfactory antitumor efficiency. In addition, single mode consuming GSH and undesirable drug loading efficiency cannot guarantee efficient cancer effect. Herein, a simple one‐step strategy for construction Fe 3+ ‐naphthazarin metal–phenolic networks (FNP MPNs) with ultrahigh capacity, followed modification NH ‐PEG‐NH , developed. The carrier‐free FNP MPNs can be triggered acid GSH, rapidly release naphthazarin which further reduced 2+ that exerts catalytic activity produce abundant ·OH. Meanwhile, Michael addition between lead depletion thus achieve microenvironment (TME)‐triggered enhanced CDT, activating ferroptosis apoptosis. as T 1 ‐weighted contrast agent endows magnetic resonance imaging (MRI) functionality. Overall, this work debut ligands fabricate functional effectively depleting disrupting redox homeostasis, enhancing CDT effects, opens new perspectives on multifunctional synergistic therapy.

Language: Английский

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Multifunctional nanomedicines-enabled chemodynamic-synergized multimodal tumor therapy via Fenton and Fenton-like reactions

Theranostics, Journal Year: 2023, Volume and Issue: 13(6), P. 1974 - 2014

Published: Jan. 1, 2023

Chemodynamic therapy (CDT) is well-known for using the tumor microenvironment to activate Fenton reaction or Fenton-like generate strong oxidative hydroxyl radicals tumor-specific treatment. It highly selective and safe, without depth limitation of tissue penetration, shows its potential as a new green therapeutic method with great clinical application. However, catalytic efficiency reagents involved in severely affected by inherent microenvironmental limitations tumors strict reaction-dependent conditions. With increasing application nanotechnology medical field, combined therapies based on different types functional nanomaterials have opened up avenues development next-generation CDT-enhanced system. This review will comprehensively exemplify representative results CDT other antitumor such chemotherapy, phototherapy, sonodynamic therapy, radiation magnetic hyperthermia immunotherapy, starvation gas gene oncosis combination thereof improving from hundreds latest literature, introduce strategies ingenious design nanomedicines regulations enhance further summarize challenges future perspective CDT-based multimodal anticancer therapy.

Language: Английский

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Recent Progress in Anti‐Tumor Nanodrugs Based on Tumor Microenvironment Redox Regulation

Small, Journal Year: 2024, Volume and Issue: 20(25)

Published: Jan. 25, 2024

Abstract The growth state of tumor cells is strictly affected by the specific abnormal redox status microenvironment (TME). Moreover, reactions at biological level are also central and fundamental to essential energy metabolism in tumors. Accordingly, anti‐tumor nanodrugs targeting disruption this homeostasis have become one hot spots field research due effectiveness TME modulation efficiency mediated interference. This review discusses latest results therapy, which regulate levels oxidants or reductants through a variety therapeutic strategies, ultimately breaking original “stable” promoting cell death. With gradual deepening study on vigorous development nanomaterials, it expected that more nano drugs based regulation will be designed even applied clinically.

Language: Английский

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Manganese Dioxide Coated Piezoelectric Nanosonosensitizer for Cancer Therapy with Tumor Microenvironment Remodeling and Multienzyme‐Like Catalysis

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: April 1, 2024

Abstract Sonodynamic therapy (SDT) as an emerging method for cancer has encountered difficulty in insufficient production of reactive oxygen species (ROS), especially tumor microenvironment (TME) with elevated antioxidants and hypoxic conditions. In this work, the authors have fabricated heterostructured manganese dioxide (MnO 2 )‐coated BaTiO 3 nanoparticles (BTO@M NPs) a piezoelectric sonosensitizer, which exhibits capacity remodeling TME multienzyme‐like catalysis boosting SDT. Benefitting from piezotronic effect, formation p ‐ n junction between MnO BTO built‐in electric field band bending efficiently promotes separation charge carriers, facilitating generation superoxide anion (•O − ) hydroxyl radical (•OH) under ultrasound (US) stimulation. Moreover, BTO@M NPs can catalyze overexpressed hydrogen peroxide (H O to produce replenishing gas source SDT, also deplete antioxidant glutathione (GSH), realizing remodeling. During process, reduced Mn(II) convert H into •OH, further amplifying cellular oxidative damage. With these combination effects, versatile exhibit prominent cytotoxicity growth inhibition against 4T1 breast cancer. This work provides feasible strategy constructing high‐efficiency sonosensitizers

Language: Английский

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Nanotechnology-enabled sonodynamic therapy against malignant tumors

Nanoscale Advances, Journal Year: 2024, Volume and Issue: 6(8), P. 1974 - 1991

Published: Jan. 1, 2024

This review systematically describes and summarizes the application of nanotechnology-enabled sonodynamic therapy in malignant tumors.

Language: Английский

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Multi‐Enzyme Mimetic MoCu Dual‐Atom Nanozyme Triggering Oxidative Stress Cascade Amplification for High‐Efficiency Synergistic Cancer Therapy

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 64(1)

Published: Aug. 22, 2024

Single-atom nanozymes (SAzymes) with ultrahigh atom utilization efficiency have been extensively applied in reactive oxygen species (ROS)-mediated cancer therapy. However, the high energy barriers of reaction intermediates on single-atom sites and overexpressed antioxidants tumor microenvironment restrict amplification oxidative stress, resulting unsatisfactory therapeutic efficacy. Herein, we report a multi-enzyme mimetic MoCu dual-atom nanozyme (MoCu DAzyme) various catalytic active sites, which exhibits peroxidase, oxidase, glutathione (GSH) nicotinamide adenine dinucleotide phosphate (NADPH) oxidase mimicking activities. Compared Mo SAzyme, introduction Cu atoms, formation synergetic effects among enhance substrate adsorption reduce barrier, thereby endowing DAzyme stronger Benefiting from above enzyme-like activities, can not only generate multiple ROS, but also deplete GSH block its regeneration to trigger cascade stress. Additionally, strong optical absorption near-infrared II bio-window endows remarkable photothermal conversion performance. Consequently, achieves high-efficiency synergistic treatment incorporating collaborative therapy This work will advance applications DAzymes provide valuable insights for nanocatalytic

Language: Английский

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