Mechanisms of opioid-induced respiratory depression

Archives of Toxicology, Journal Year: 2022, Volume and Issue: 96(8), P. 2247 - 2260

Published: April 26, 2022

Language: Английский

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The Pharmacological Treatment of Chronic Pain: From Guidelines to Daily Clinical Practice

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(4), P. 1165 - 1165

Published: April 6, 2023

In agreement with the International Association for Study of Pain, chronic pain is an unpleasant sensory and emotional experience associated actual or potential tissue damage. To date, there are several types pain: nociceptive, neuropathic, nociplastic. present narrative review, we evaluated characteristics drugs used each type pain, according to guidelines, their effects in people comorbidity reduce development severe adverse events.

Language: Английский

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Nanotherapeutics for Alleviating Anesthesia‐Associated Complications

Advanced Science, Journal Year: 2024, Volume and Issue: 11(15)

Published: Feb. 11, 2024

Abstract Current management of anesthesia‐associated complications falls short in terms both efficacy and safety. Nanomaterials with versatile properties unique nano‐bio interactions hold substantial promise as therapeutics for addressing these complications. This review conducts a thorough examination the existing nanotherapeutics highlights strategies developing prospective nanomedicines to mitigate anesthetics‐related toxicity. Initially, general, regional, local anesthesia along commonly used anesthetics related prevalent side effects are introduced. Furthermore, employing nanotechnology prevent alleviate is systematically demonstrated from three aspects, that is, 1) safe nano‐formulization anesthetics; 2) nano‐antidotes sequester overdosed alter their pharmacokinetics; 3) pharmacodynamic activities treat Finally, prospects challenges facing clinical translation anesthesia‐related discussed. work provides comprehensive roadmap effective toxicity, which can potentially revolutionize

Language: Английский

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What Causes Premature Coronary Artery Disease?

Current Atherosclerosis Reports, Journal Year: 2024, Volume and Issue: 26(6), P. 189 - 203

Published: April 4, 2024

Language: Английский

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Can Opioid-Free Anaesthesia Be Personalised? A Narrative Review

Journal of Personalized Medicine, Journal Year: 2023, Volume and Issue: 13(3), P. 500 - 500

Published: March 10, 2023

Background: A significant amount of evidence suggests that Opioid-Free Anaesthesia (OFA) may provide better outcomes for patients undergoing surgery, sparing who are particularly vulnerable to adverse side effects opioids. However, what extent personalizing OFA is feasible and beneficial has not been adequately described. Methods: We conducted a narrative literature review aiming comprehensive understanding nociception pain its context within the field OFA. Physiological (including monitoring), pharmacological, procedural (type surgery), genetical phenotypical patients’ conditions) were considered. Results: did find any monitoring robustly associated with improved outcomes. we found supporting particular indications, such as bariatric cancer surgery. benefit more from OFA, an interesting research in suffering vascular disease. variety techniques medications making it impossible consider single technique. Our findings suggest vast remains unexplored. In particular, deeper interest genetic acquired contributors would be excellent starting point paving way personalised Conclusion: Recent developments present holistic approach, challenging use Understanding nociception, given techniques, help maximize their potential different contexts indications.

Language: Английский

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The Effects of Virtual Reality in Maternal Delivery: Systematic Review and Meta-analysis

JMIR Serious Games, Journal Year: 2022, Volume and Issue: 10(4), P. e36695 - e36695

Published: Oct. 12, 2022

Extreme labor pain has negative effects; pharmacologic analgesic modalities are effective but accompanied by adverse effects. Virtual reality (VR) works as a distracting nonpharmacologic intervention for and anxiety relief; however, the effects of VR use in laboring women is unknown.Our study aimed to determine safety effectiveness technology during delivery investigate whether it impacts patient satisfaction.In all, 7 databases (PubMed, Embase, Web Science, Cochrane Library, CINAHL, China National Knowledge Infrastructure, Wan-Fang Database) were systematically searched randomized controlled trials pregnancy childbirth from time database construction until November 24, 2021. Two researchers extracted data evaluated quality using Risk Bias tool 2.0. Outcome measures pain, anxiety, duration, satisfaction, events. Meta-analyses performed where possible.A total 12 studies with 1095 participants included, which 1 11 rated "Low risk" "Some concerns" risk bias, respectively. Of studies, reported 4 duration. Meta-analysis revealed that could relieve (mean difference -1.81, 95% CI -2.04 -1.57; P<.001) active period (standardized mean [SMD] -0.41, -0.68 -0.14; P=.003); reduce (SMD -1.39, -1.99 -0.78; P<.001); improve satisfaction (relative 1.32, 1.10-1.59; P=.003). The on duration first -1.12, -2.38 0.13; P=.08) second -0.22, -0.67 0.24; P=.35) stages not statistically significant.VR safe relieving maternal anxiety; due heterogeneity among conducted date, more rigorous, large-scale, standardized required provide higher-quality evidence base labor, aim improving experience outcomes.PROSPERO CRD42021295410; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=295410.

Language: Английский

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Trastorno por uso de sustancias: epidemiología, complicaciones médicas y tratamiento

Medicina Clínica, Journal Year: 2024, Volume and Issue: 162(9), P. 431 - 438

Published: Jan. 13, 2024

Language: Английский

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MRGPRX2, drug pseudoallergies, inflammatory diseases, mechanisms and distinguishing MRGPRX2‐ and IgE/FcεRI‐mediated events

British Journal of Clinical Pharmacology, Journal Year: 2023, Volume and Issue: 89(11), P. 3232 - 3246

Published: July 11, 2023

MRGPRX2, a novel Gaq -coupled human mast cell receptor, mediates non-immune adverse reactions without the involvement of antibody priming. Constitutively expressed by skin cells, MRGPRX2 modulates degranulation producing pseudoallergies manifesting as itch, inflammation and pain. The term pseudoallergy is defined in relation to drug general immune/non-immune-mediated particular. A list drugs with activity presented, including detailed examination three important widely used approved therapies: neuromuscular blockers, quinolones opioids. For clinician, significance considered an aid distinguishing ultimately identifying specific immune inflammatory reactions. Anaphylactoid/anaphylactic reactions, neurogenic diseases clear or strongly suspected association activation are examined. Inflammatory include chronic urticaria, rosacea, atopic dermatitis, allergic contact mastocytosis, asthma, ulcerative colitis rheumatoid arthritis. MRGPRX2- IgE/FcεRI-mediated may be clinically similar. Importantly, usual testing procedures do not distinguish two mechanisms. Currently, identification diagnosis pseudoallergic generally viewed process exclusion once other processes, particularly ruled out. This does take into account that signals via β-arrestin, which can utilized detect employing transfected cells assess pathways, G-protein-independent β-arrestin pathway G-protein-dependent Ca2+ pathway. Testing procedures, interpretations for mechanisms, patient diagnosis, agonist safety evaluations addressed.

Language: Английский

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Up-regulation of BDNF/TrkB signaling by δ opioid receptor agonist SNC80 modulates depressive-like behaviors in chronic restraint-stressed mice

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 942, P. 175532 - 175532

Published: Jan. 26, 2023

Language: Английский

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Tau protein plays a role in the mechanism of cognitive disorders induced by anesthetic drugs

Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: March 1, 2023

Cognitive disorders are mental health that can affect cognitive ability. Surgery and anesthesia have been proposed to increase the incidence of dysfunction, including declines in memory, learning, attention executive function. Tau protein is a microtubule-associated located axons neurons important for microtubule assembly stability; its biological function mainly regulated by phosphorylation. Phosphorylated tau has associated with dysfunction mediated disrupting stability structure. There an increasing consensus anesthetic drugs cause impairment. Herein, we reviewed latest literature compared relationship between impairment caused different anesthetics. Our results substantiated phosphorylation essential drugs, possible mechanism be summarized as “anesthetic drugs-kinase/phosphatase-p-Tau-cognitive impairment”.

Language: Английский

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