Investigating the impact of gut microbiota on venous thromboembolism through a comprehensive Mendelian randomization study DOI Creative Commons
Jia Wang, Bojian Fei, Chao Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 28, 2024

Abstract Background Recent studies have suggested an association between gut microbiota (GM) and venous thromboembolism (VTE). However, observational cannot indicate causality population-level with a higher evidence level for are lacking. Therefore, our study aimed to explore the causal of GM VTE. Methods This utilized summary-level data respective genome-wide 196 microbial taxa Two-sample Mendelian randomization (MR) design was deployed comprehensively sensitive analyses were followed validate robustness results. We used inverse-variance weighted (IVW) method, median mode simple MR-Egger regression, intercept test, Cochrane’s Q-test, outlier leave-one-out analysis as primary analysis. Results identified suggestive associations 17 bacterial traits risk Porphyromonadaceae (IVW odds ratio (OR): 1.3729, p = 0.0035) Cyanobacteria OR: 1.2151, 0.0048) associated increased Three (Eubacteriumrectalegroup 1.0038, 0.0278), Coprococcus2 1.0041, 0.0063), LachnospiraceaeUCG001 0.0009) predicted play role in enhancing encompassing deep vein thrombosis. And three (Christensenellaceae 1.0023, 0.0497), Streptococcaceae 1.0031, 0.0279), Victivallaceae 1.0014, 0.0493) positively pulmonary embolism. Conclusions specific on VTE, which may provide new ideas theoretical basis prevention treatment VTE future.

Language: Английский

Polystyrene microplastics enhance microcystin-LR-induced cardiovascular toxicity and oxidative stress in zebrafish embryos DOI

Yuchun Xiao,

Liwen Hu,

Jiayao Duan

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 352, P. 124022 - 124022

Published: April 26, 2024

Language: Английский

Citations

19

A comprehensive review of the therapeutic potential of cyanobacterial marine bioactives: Unveiling the hidden treasures of the sea DOI Creative Commons
Taufiq Nawaz, Liping Gu, Shah Fahad

et al.

Food and Energy Security, Journal Year: 2023, Volume and Issue: 12(5)

Published: Aug. 14, 2023

Abstract Marine cyanobacterial bioactives, due to their diverse chemistry and promising pharmacological properties, hold significant potential as therapeutic agents. Here, we comprehensively review the scientific state‐of‐the‐art relating marine including bioprospecting, preclinical clinical studies, mechanisms of action, safety toxicity considerations, sustainability, conservation. We discuss challenges in opportunities for developing bioactives therapeutics; underscore treating life‐threatening health ailments, such cancer neurodegenerative, inflammatory viral diseases. further articulate improving human health, identify future research directions underpinning development therapeutics.

Language: Английский

Citations

30

Microcystins Exposure Associated with Blood Lipid Profiles and Dyslipidemia: A Cross-Sectional Study in Hunan Province, China DOI Creative Commons

Shuidong Feng,

Meng-Yue Cao,

Peng Tang

et al.

Toxins, Journal Year: 2023, Volume and Issue: 15(4), P. 293 - 293

Published: April 18, 2023

Increasing evidence from experimental research suggests that exposure to microcystins (MCs) may induce lipid metabolism disorder. However, population-based epidemiological studies of the association between MCs and risk dyslipidemia are lacking. Therefore, we conducted a cross-sectional study involving 720 participants in Hunan Province, China, evaluated effects on blood lipids. After adjusting related metals, used binary logistic regression multiple linear models examine associations among serum concentration, lipids (triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL-C) low-density (LDL-C)). Moreover, additive model was explore interaction metals. Compared lowest quartile exposure, [odds ratios (OR) = 2.27, 95% confidence interval (CI): 1.46, 3.53] hyperTG (OR 3.01, CI: 1.79, 5.05) highest significantly increased, showed dose-response relationships. were positively associated with TG level (percent change, 9.43%; 3.53%, 15.67%) negatively HDL-C -3.53%; -5.70%, -2.10%). In addition, an antagonistic effect Zn also reported [relative excess due (RERI) -1.81 (95% -3.56, -0.05)], attributable proportion reduced antagonism these two exposures 83% -1.66, -0.005). Our first indicated is independent factor for manner.

Language: Английский

Citations

19

A biomarker approach to study the effects of polluted Brazilian urban reservoirs in a native fish DOI
Marcela Muñoz-Peñuela, Fabiana L. Lo Nostro, Aline D. Gomes

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 923, P. 171500 - 171500

Published: March 5, 2024

Language: Английский

Citations

5

Snapshot of cyanobacterial toxins in Pakistani freshwater bodies DOI
Uzma Batool, Nicolas Tromas, Dana F. Simon

et al.

Environmental Science and Pollution Research, Journal Year: 2024, Volume and Issue: 31(16), P. 24648 - 24661

Published: March 6, 2024

Language: Английский

Citations

4

Cyanobacterial Proteomics: Diversity and Dynamics DOI
Rupanshee Srivastava,

Nidhi Singh,

Tripti Kanda

et al.

Journal of Proteome Research, Journal Year: 2024, Volume and Issue: 23(8), P. 2680 - 2699

Published: March 12, 2024

Cyanobacteria (oxygenic photoautrophs) comprise a diverse group holding significance both environmentally and for biotechnological applications. The utilization of proteomic techniques has significantly influenced investigations concerning cyanobacteria. Application proteomics allows large-scale analysis protein expression function within cyanobacterial systems. proteome exhibits tremendous functional, spatial, temporal diversity regulated by multiple factors that continuously modify abundance, post-translational modifications, interactions, localization, activity to meet the dynamic needs these tiny blue greens. Modern mass spectrometry-based enable system-wide examination complexity through global identification high-throughput quantification proteins. These powerful approaches have revolutionized our understanding dynamics promise provide novel insights into integrated cellular behavior at an unprecedented scale. In this Review, we present modern methods cutting-edge technologies employed unraveling spatiotemporal with specific focus on used analyze modifications (PTMs) examples changes in investigated approaches.

Language: Английский

Citations

4

Undibacterium cyanobacteriorum sp. nov., an auxin-producing bacterium isolated from fresh water during cyanobacterial bloom period DOI
Ve Van Le, So-Ra Ko, Loan Thi Thanh Nguyen

et al.

Antonie van Leeuwenhoek, Journal Year: 2024, Volume and Issue: 117(1)

Published: July 10, 2024

Language: Английский

Citations

4

Removal of Cyanobacterial Harmful Algal Blooms (HABs) from Contaminated Local Park Lake using Ganoderma lucidum Mycelial Pellets DOI Creative Commons
Zarimah Mohd Hanafiah, Anggita Rahmi Hafsari,

M. Elango

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 11(1), P. e41205 - e41205

Published: Dec. 15, 2024

Eutrophication and hypereutrophication in lakes foster harmful blue-green algal blooms, which pose a significant threat to the ecological health of freshwater reservoirs. This study investigated effectiveness bio-flocculation approach using Ganoderma lucidum fungus strain BGF4A1 remove these specifically targeting cyanobacterial species like Microcystis PCC-7914. Key flocculation parameters, concentrations, adsorption kinetics, pellet morphology were explored this research. Our results demonstrate that G. can effectively up 93.70 % cyanobacteria (measured as chlorophyll-a absorbance), 75.28 chemical oxygen demand (COD), 92.09 total suspended solids (TSS) under optimal conditions: an initial pH 4, 1 fungal volume (w/v), 48 h contact time, 100 rpm agitation at room temperature. Microscopic examination water samples before after treatment confirmed reduction colonies, indicating death or decline targeted organisms. Morphological analysis field emission scanning electron microscopy (FESEM) revealed cells deposited on hyphae pellets, contrast smooth surface control pellets. These novel culture technologies show great promise bio-flocculating agents for removing algae potentially be adapted microalgae harvesting biodiesel production.

Language: Английский

Citations

3

Visualization of MC-LR in lakes using near-infrared technology DOI

Huiyan Chuan,

Bingyan Li, Zhaomin Wang

et al.

Water Research, Journal Year: 2025, Volume and Issue: unknown, P. 123558 - 123558

Published: March 1, 2025

Language: Английский

Citations

0

From Bloom to Tap: Connecting Harmful Algal Bloom Indicators in Source Water to Cyanotoxin Presence in Treated Drinking Water DOI
Lena Abu-Ali, Ryan Albert, Angela Davis

et al.

Harmful Algae, Journal Year: 2025, Volume and Issue: unknown, P. 102846 - 102846

Published: March 1, 2025

Language: Английский

Citations

0