Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 28, 2024
Abstract
Background
Recent
studies
have
suggested
an
association
between
gut
microbiota
(GM)
and
venous
thromboembolism
(VTE).
However,
observational
cannot
indicate
causality
population-level
with
a
higher
evidence
level
for
are
lacking.
Therefore,
our
study
aimed
to
explore
the
causal
of
GM
VTE.
Methods
This
utilized
summary-level
data
respective
genome-wide
196
microbial
taxa
Two-sample
Mendelian
randomization
(MR)
design
was
deployed
comprehensively
sensitive
analyses
were
followed
validate
robustness
results.
We
used
inverse-variance
weighted
(IVW)
method,
median
mode
simple
MR-Egger
regression,
intercept
test,
Cochrane’s
Q-test,
outlier
leave-one-out
analysis
as
primary
analysis.
Results
identified
suggestive
associations
17
bacterial
traits
risk
Porphyromonadaceae
(IVW
odds
ratio
(OR):
1.3729,
p
=
0.0035)
Cyanobacteria
OR:
1.2151,
0.0048)
associated
increased
Three
(Eubacteriumrectalegroup
1.0038,
0.0278),
Coprococcus2
1.0041,
0.0063),
LachnospiraceaeUCG001
0.0009)
predicted
play
role
in
enhancing
encompassing
deep
vein
thrombosis.
And
three
(Christensenellaceae
1.0023,
0.0497),
Streptococcaceae
1.0031,
0.0279),
Victivallaceae
1.0014,
0.0493)
positively
pulmonary
embolism.
Conclusions
specific
on
VTE,
which
may
provide
new
ideas
theoretical
basis
prevention
treatment
VTE
future.
Food and Energy Security,
Journal Year:
2023,
Volume and Issue:
12(5)
Published: Aug. 14, 2023
Abstract
Marine
cyanobacterial
bioactives,
due
to
their
diverse
chemistry
and
promising
pharmacological
properties,
hold
significant
potential
as
therapeutic
agents.
Here,
we
comprehensively
review
the
scientific
state‐of‐the‐art
relating
marine
including
bioprospecting,
preclinical
clinical
studies,
mechanisms
of
action,
safety
toxicity
considerations,
sustainability,
conservation.
We
discuss
challenges
in
opportunities
for
developing
bioactives
therapeutics;
underscore
treating
life‐threatening
health
ailments,
such
cancer
neurodegenerative,
inflammatory
viral
diseases.
further
articulate
improving
human
health,
identify
future
research
directions
underpinning
development
therapeutics.
Toxins,
Journal Year:
2023,
Volume and Issue:
15(4), P. 293 - 293
Published: April 18, 2023
Increasing
evidence
from
experimental
research
suggests
that
exposure
to
microcystins
(MCs)
may
induce
lipid
metabolism
disorder.
However,
population-based
epidemiological
studies
of
the
association
between
MCs
and
risk
dyslipidemia
are
lacking.
Therefore,
we
conducted
a
cross-sectional
study
involving
720
participants
in
Hunan
Province,
China,
evaluated
effects
on
blood
lipids.
After
adjusting
related
metals,
used
binary
logistic
regression
multiple
linear
models
examine
associations
among
serum
concentration,
lipids
(triglyceride
(TG),
total
cholesterol
(TC),
high-density
lipoprotein
(HDL-C)
low-density
(LDL-C)).
Moreover,
additive
model
was
explore
interaction
metals.
Compared
lowest
quartile
exposure,
[odds
ratios
(OR)
=
2.27,
95%
confidence
interval
(CI):
1.46,
3.53]
hyperTG
(OR
3.01,
CI:
1.79,
5.05)
highest
significantly
increased,
showed
dose-response
relationships.
were
positively
associated
with
TG
level
(percent
change,
9.43%;
3.53%,
15.67%)
negatively
HDL-C
-3.53%;
-5.70%,
-2.10%).
In
addition,
an
antagonistic
effect
Zn
also
reported
[relative
excess
due
(RERI)
-1.81
(95%
-3.56,
-0.05)],
attributable
proportion
reduced
antagonism
these
two
exposures
83%
-1.66,
-0.005).
Our
first
indicated
is
independent
factor
for
manner.
Journal of Proteome Research,
Journal Year:
2024,
Volume and Issue:
23(8), P. 2680 - 2699
Published: March 12, 2024
Cyanobacteria
(oxygenic
photoautrophs)
comprise
a
diverse
group
holding
significance
both
environmentally
and
for
biotechnological
applications.
The
utilization
of
proteomic
techniques
has
significantly
influenced
investigations
concerning
cyanobacteria.
Application
proteomics
allows
large-scale
analysis
protein
expression
function
within
cyanobacterial
systems.
proteome
exhibits
tremendous
functional,
spatial,
temporal
diversity
regulated
by
multiple
factors
that
continuously
modify
abundance,
post-translational
modifications,
interactions,
localization,
activity
to
meet
the
dynamic
needs
these
tiny
blue
greens.
Modern
mass
spectrometry-based
enable
system-wide
examination
complexity
through
global
identification
high-throughput
quantification
proteins.
These
powerful
approaches
have
revolutionized
our
understanding
dynamics
promise
provide
novel
insights
into
integrated
cellular
behavior
at
an
unprecedented
scale.
In
this
Review,
we
present
modern
methods
cutting-edge
technologies
employed
unraveling
spatiotemporal
with
specific
focus
on
used
analyze
modifications
(PTMs)
examples
changes
in
investigated
approaches.
Heliyon,
Journal Year:
2024,
Volume and Issue:
11(1), P. e41205 - e41205
Published: Dec. 15, 2024
Eutrophication
and
hypereutrophication
in
lakes
foster
harmful
blue-green
algal
blooms,
which
pose
a
significant
threat
to
the
ecological
health
of
freshwater
reservoirs.
This
study
investigated
effectiveness
bio-flocculation
approach
using
Ganoderma
lucidum
fungus
strain
BGF4A1
remove
these
specifically
targeting
cyanobacterial
species
like
Microcystis
PCC-7914.
Key
flocculation
parameters,
concentrations,
adsorption
kinetics,
pellet
morphology
were
explored
this
research.
Our
results
demonstrate
that
G.
can
effectively
up
93.70
%
cyanobacteria
(measured
as
chlorophyll-a
absorbance),
75.28
chemical
oxygen
demand
(COD),
92.09
total
suspended
solids
(TSS)
under
optimal
conditions:
an
initial
pH
4,
1
fungal
volume
(w/v),
48
h
contact
time,
100
rpm
agitation
at
room
temperature.
Microscopic
examination
water
samples
before
after
treatment
confirmed
reduction
colonies,
indicating
death
or
decline
targeted
organisms.
Morphological
analysis
field
emission
scanning
electron
microscopy
(FESEM)
revealed
cells
deposited
on
hyphae
pellets,
contrast
smooth
surface
control
pellets.
These
novel
culture
technologies
show
great
promise
bio-flocculating
agents
for
removing
algae
potentially
be
adapted
microalgae
harvesting
biodiesel
production.
