Molecules,
Journal Year:
2023,
Volume and Issue:
28(11), P. 4322 - 4322
Published: May 24, 2023
Colorectal
cancer
(CRC)
is
the
third
most
common
worldwide
and
its
incidence
expected
to
increase
by
almost
80%
2030.
CRC
apparition
related
poor
diet,
mainly
due
low
consumption
of
phytochemicals
present
in
fruits
vegetables.
Hence,
this
paper
reviews
promising
literature,
presenting
scientific
evidence
regarding
potential
chemopreventive
effects.
Moreover,
reveals
structure
action
mechanisms
that
these
are
involved
in.
The
review
vegetables
rich
such
as
carrots
green
leafy
vegetables,
well
some
pineapple,
citrus
fruits,
papaya,
mango,
Cape
gooseberry,
have
antioxidant,
anti-inflammatory,
properties
can
promote
a
healthy
colonic
environment.
Fruits
daily
diet
antitumor
regulating
cell
signaling
and/or
proliferation
pathways.
plant
products
recommended
reduce
risk
CRC.
Nutrients,
Journal Year:
2021,
Volume and Issue:
13(1), P. 273 - 273
Published: Jan. 19, 2021
Polyphenols
are
a
group
of
phytochemicals
with
potential
health-promoting
effects.
They
classified
as
flavonoid
(flavonols,
flavanols,
flavones,
flavanones,
isoflavones,
and
anthocyanins)
non-flavonoid
molecules
(phenolic
acids,
hydroxycinnamic
lignans,
stilbenes,
tannins).
Although
an
increasing
number
trials
have
shown
correlation
among
polyphenol
consumption
reduction
in
risk
factors
for
chronic
diseases,
discrepancies
explaining
their
positive
effects
been
found
terms
the
bioavailability.
In
fact,
polyphenols
show
low
bioavailability
due
to
several
factors:
interaction
food
matrix,
metabolic
processes
mediated
by
liver
(phase
I
II
metabolism),
intestine
microbiota.
On
other
hand,
biological
activities
phenol
compounds
may
be
metabolites,
which
produced
vivo,
recent
studies
confirmed
that
these
antioxidant
anti-phlogistic
properties.
This
review
discusses
performed
consider
different
sources.
Factors
influencing
main
classes
also
considered.
Journal of Food Biochemistry,
Journal Year:
2020,
Volume and Issue:
44(9)
Published: July 20, 2020
In
this
review,
the
concept
of
phenolic
antioxidants,
mechanisms
action,
and
applications
have
been
reviewed.
Phenolic
compounds
(PCs)
acts
as
an
antioxidant
by
reacting
with
a
variety
free
radicals.
The
mechanism
actions
involved
either
hydrogen
atom
transfer,
transfer
single
electron,
sequential
proton
loss
electron
chelation
transition
metals.
foods,
PCs
act
antioxidants
which
are
measured
several
in
vitro
spectroscopic
methods.
found
milk
wide
range
dairy
products
sole
purposes
color,
taste,
storage
stability,
quality
enhancement.
role
three
types
food
additives,
that
is,
antimicrobial,
antioxidant,
flavoring
agents
critically
literature
revealed
present
foods
possess
health
benefits
such
antibacterial,
antihyperlipidemic,
anticancer,
cardioprotective,
neuroprotective,
antidiabetic
properties.
Practical
strong
safer
than
synthetic
antioxidants.
occurrence
plant
warranted
continuous
review
applications.
This
therefore,
presented
updated
comprehensive
overview
concept,
mechanism,
foods.
Nutrients,
Journal Year:
2021,
Volume and Issue:
14(1), P. 137 - 137
Published: Dec. 28, 2021
The
present
review
summarizes
the
studies
carried
out
on
this
topic
in
last
five
years.
According
to
new
definitions,
among
all
compounds
included
group
of
prebiotics,
polyphenols
are
probably
most
important
secondary
metabolites
produced
by
plant
kingdom.
Many
these
types
have
low
bioavailability,
therefore
reaching
colon
unaltered
form.
Once
colon,
interact
with
intestinal
microbes
bidirectionally
modulating
them
and,
consequently,
releasing
metabolites.
Despite
much
research
various
metabolites,
little
is
known
about
chemistry
metabolic
routes
used
different
bacteria
species.
In
context,
aims
investigate
prebiotic
effect
preclinical
and
clinical
studies,
highlighting
that
consumption
leads
an
increase
beneficial
bacteria,
as
well
production
valuable
conclusion,
there
evidence
supporting
polyphenols,
but
further
needed
humans.
Antioxidants,
Journal Year:
2019,
Volume and Issue:
8(8), P. 275 - 275
Published: Aug. 4, 2019
Controlling
unwanted
hyperpigmentation
is
a
major
challenge
in
dermatology
and
cosmetology,
safe
efficacious
antimelanogenic
agents
are
deemed
useful
for
this
purpose.
p-Coumaric
acid
natural
metabolite
contained
many
edible
plants,
its
antioxidant
activities
reducing
oxidative
stress
inflammatory
reactions
have
been
demonstrated
various
experimental
models.
has
the
optimal
structure
to
be
competitive
inhibitor
of
tyrosinase
that
catalyzes
key
melanin
biosynthetic
pathway.
Experimental
evidence
supports
notion
as
it
was
found
more
potent
tyrosinase,
especially
toward
human
enzymes,
than
other
well-known
inhibitors
such
arbutin
kojic
acid.
inhibited
synthesis
murine
melanoma
cells,
epidermal
melanocytes,
reconstituted
three-dimensional
skin
Ex-vivo
permeation
experiments
in-vivo
efficacy
tests
p-coumaric
confirmed
efficient
transdermal
delivery
functional
erythema
development
pigmentation
due
ultraviolet
radiation
exposure.
Human
studies
further
supported
effectiveness
hypopigmentation
depigmentation.
These
findings
suggest
good
potential
used
skin-lightening
active
ingredient
cosmetics.
Future
needed
extensively
examine
safety
develop
an
optimized
cosmetic
formulation
best
performance
lightening.
Foods,
Journal Year:
2020,
Volume and Issue:
9(4), P. 534 - 534
Published: April 24, 2020
Nature
has
generously
offered
a
wide
range
of
herbs
(e.g.,
thyme,
oregano,
rosemary,
sage,
mint,
basil)
rich
in
many
polyphenols
and
other
phenolic
compounds
with
strong
antioxidant
biochemical
properties.
This
paper
focuses
on
several
natural
occurring
acids
(caffeic,
carnosic,
ferulic,
gallic,
p-coumaric,
rosmarinic,
vanillic)
first
gives
an
overview
their
most
common
plant
sources.
A
summary
the
recently
reported
activities
o/w
emulsions
is
also
provided
as
vitro
lipid-based
model
system.
Exploring
interfacial
activity
could
help
to
further
elucidate
potential
health
properties
against
oxidative
stress
conditions
biological
membranes
(such
lipoproteins).
Finally,
this
review
reports
latest
literature
evidence
concerning
specific
examined
acids.
Nutrients,
Journal Year:
2020,
Volume and Issue:
12(8), P. 2190 - 2190
Published: July 23, 2020
Hydroxycinnamic
acids
(HCAs)
are
important
natural
phenolic
compounds
present
in
high
concentrations
fruits,
vegetables,
cereals,
coffee,
tea
and
wine.
Many
health
beneficial
effects
have
been
acknowledged
food
products
rich
HCAs;
however,
processing,
dietary
intake,
bioaccessibility
pharmacokinetics
a
impact
on
HCAs
to
reach
the
target
tissue
order
exert
their
biological
activities.
In
particular,
metabolism
is
of
importance
since
HCAs’
metabolites
could
either
lose
activity
or
be
even
more
potent
compared
parent
compounds.
this
review,
sources
pharmacokinetic
properties
esters
presented
discussed.
The
main
focus
along
with
activities
benefits.
Special
emphasis
given
specific
comparison
Innovative Food Science & Emerging Technologies,
Journal Year:
2022,
Volume and Issue:
77, P. 102974 - 102974
Published: March 4, 2022
A
balanced
and
nutritious
diet
is
the
cornerstone
of
good
health.
The
nutritional
pyramid
advises
eating
5
servings
fruit
vegetables
a
day
as
basic
principle
healthy
diet,
they
provide
essential
nutrients
such
vitamins
minerals,
well
fiber
antioxidants.
Consuming
them
in
adequate
quantities
improves
immune
system
helps
prevent
diseases
diabetes,
obesity,
heart
disease
even
certain
types
cancer.
Among
most
nutrient-dense
are
This
context
for
this
review,
which
an
exhaustive
analysis
has
been
carried
out
bioactive
compounds
with
antioxidant
capacity
available
widely
produced
Spain,
considering
not
only
studies
that
identify
these
compounds,
but
also
those
analyze
their
effects
on
human
Furthermore,
it
worth
highlighting
interest
extraction
by-product
streams
from
vegetable
processing
circular
economy.
Therefore,
review
includes
examples
green
technologies
antioxidants
waste
fractions.
In
field,
microwave
ultrasound-assisted
have
found
to
be
efficient,
both
terms
yields,
similar
conventional
technologies,
operating
conditions
required
process.
However,
enzyme
cocktails
or
pulsed
electric
fields
show
promising
results.
Advanced Drug Delivery Reviews,
Journal Year:
2021,
Volume and Issue:
171, P. 289 - 331
Published: Feb. 18, 2021
Although
oral
drug
delivery
is
the
preferred
administration
route
and
has
been
used
for
centuries,
modern
discovery
development
pipelines
challenge
conventional
formulation
approaches
highlight
insufficient
mechanistic
understanding
of
processes
critical
to
absorption.
This
review
presents
opinion
UNGAP
scientists
on
four
key
themes
across
absorption
landscape:
(1)
specific
patient
populations,
(2)
regional
differences
in
gastrointestinal
tract,
(3)
advanced
formulations
(4)
food-drug
interactions.
The
pediatric
geriatric
issues
colonic
absorption,
poorly
water-soluble
(small
molecules)
permeable
(peptides,
RNA
etc.)
drugs,
as
well
vast
realm
food
effects,
are
some
topics
discussed
detail.
identified
controversies
gaps
current
absorption-related
create
a
roadmap
future
research.
Redox Biology,
Journal Year:
2024,
Volume and Issue:
71, P. 103095 - 103095
Published: Feb. 20, 2024
This
systematic
review
provides
an
overview
of
the
available
evidence
on
inter-individual
variability
(IIV)
in
absorption,
distribution,
metabolism,
and
excretion
(ADME)
phenolic
metabolites
its
determinants.
Human
studies
were
included
investigating
metabolism
bioavailability
(poly)phenols
reporting
IIV.
One
hundred
fifty-three
met
inclusion
criteria.
Inter-individual
differences
mainly
related
to
gut
microbiota
composition
activity
but
also
genetic
polymorphisms,
age,
sex,
ethnicity,
BMI,
(patho)physiological
status,
physical
activity,
depending
(poly)phenol
sub-class
considered.
Most
IIV
has
been
poorly
characterised.
Two
major
types
observed.
resulted
metabolite
gradients
that
can
be
further
classified
into
high
low
excretors,
as
seen
for
all
flavonoids,
acids,
prenylflavonoids,
alkylresorcinols,
hydroxytyrosol.
The
other
type
is
based
clusters
individuals
defined
by
qualitative
(producers
vs.
non-producers),
ellagitannins
(urolithins),
isoflavones
(equol
O-DMA),
resveratrol
(lunularin),
preliminarily
avenanthramides
(dihydro-avenanthramides),
or
quali-quantitative
metabotypes
characterized
different
proportions
specific
metabolites,
flavan-3-ols,
flavanones,
even
isoflavones.
Future
works
are
needed
shed
light
current
open
issues
limiting
our
understanding
this
phenomenon
likely
conditions
health
effects
dietary
(poly)phenols.
