Fiber Derived Microbial Metabolites Prevent Acute Kidney Injury Through G-Protein Coupled Receptors and HDAC Inhibition DOI Creative Commons
Yunzi Liu, Yan Jun Li,

Yik Wen Loh

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 9

Published: April 8, 2021

Short-chain fatty acids (SCFA) derived from gut microbial fermentation of fiber have been shown to exert anti-inflammatory and immune-modulatory properties in acute kidney injury (AKI). However the direct mechanistic link between SCFAs, diet microbiome is yet be established. Using murine model folic-acid nephropathy (FAN), we examined effect dietary on development AKI (day 2) subsequent chronic disease (CKD) 28). FAN was induced wild-type knockout mice lacking G protein–coupled receptors GPR41 , GPR43 or GPR109A . Mice were randomized high-fiber normal-chow diets, SCFAs drinking water. We used 16S rRNA sequencing assess 1 H-NMR spectroscopy for metabolic profiles. fed partially protected against CKD, exhibiting better function throughout, less tubular at day 2 interstitial fibrosis inflammation 28 vs controls. Fiber modified alleviated dysbiosis by AKI, promoting expansion SCFA-producing bacteria Bifidobacterium Prevotella which increased fecal serum SCFA concentrations. treatment achieved similar protection, but not absence GPR109A. Histone deacetylase activity (HDAC) inhibited kidneys mice. conclude that manipulation protects mediated HDAC inhibition activation SCFAs. This study highlights potential as a modifiable target prevention AKI.

Language: Английский

The role of short-chain fatty acids in microbiota–gut–brain communication DOI
Boushra Dalile, Lukas Van Oudenhove, Bram Vervliet

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2019, Volume and Issue: 16(8), P. 461 - 478

Published: May 23, 2019

Language: Английский

Citations

2215
Higher Fecal Short-Chain Fatty Acid Levels Are Associated with Gut Microbiome Dysbiosis, Obesity, Hypertension and Cardiometabolic Disease Risk Factors DOI Open Access
Jacobo de la Cuesta‐Zuluaga, Noel T. Mueller, Rafael Álvarez

et al.

Nutrients, Journal Year: 2018, Volume and Issue: 11(1), P. 51 - 51

Published: Dec. 27, 2018

Fiber fermentation by gut microbiota yields short-chain fatty acids (SCFAs) that are either absorbed the or excreted in feces. Studies conflicting as to whether SCFAs beneficial detrimental cardiometabolic health, and how associated with is unclear. In this study of 441 community-dwelling adults, we examined associations fecal SCFAs, diversity composition, permeability, outcomes, including obesity hypertension. We assessed 16S rRNA gene sequencing, SCFA concentrations gas chromatography/mass spectrometry. Fecal were inversely diversity, 70 unique microbial taxa differentially at least one (acetate, butyrate propionate). Higher a measure markers metabolic dysregulation, Microbial showed association these outcomes opposite direction. Associations significant after adjusting for measured confounders. conclusion, higher excretion was evidence dysbiosis, excess adiposity, risk factors. assessing both circulating needed test hypothesis dysregulation due less efficient absorption.

Language: Английский

Citations

432
Short chain fatty acids: Microbial metabolites for gut-brain axis signalling DOI Creative Commons
Kenneth J. O’Riordan, Michael Collins, Gerard M. Moloney

et al.

Molecular and Cellular Endocrinology, Journal Year: 2022, Volume and Issue: 546, P. 111572 - 111572

Published: Jan. 20, 2022

The role of the intestinal microbiota as a regulator gut-brain axis signalling has risen to prominence in recent years. Understanding relationship between gut microbiota, metabolites it produces, and brain will be critical for subsequent development new therapeutic approaches, including identification novel psychobiotics. A key focus this regard have been short-chain fatty acids (SCFAs) produced by bacterial fermentation dietary fibre, which include butyrate, acetate, propionate. Ongoing research is focused on entry SCFAs into systemic circulation from lumen, their migration cerebral across blood barrier, potential exert acute chronic effects structure function. This review aims discuss our current mechanistic understanding direct indirect influence that function, behaviour physiology, inform future microbiota-targeted interventions disorders.

Language: Английский

Citations

307
Microbiota changes induced by microencapsulated sodium butyrate in patients with inflammatory bowel disease DOI Creative Commons
Sonia Facchin, Nicola Vitulo, Matteo Calgaro

et al.

Neurogastroenterology & Motility, Journal Year: 2020, Volume and Issue: 32(10)

Published: May 31, 2020

Abstract Background Butyrate has shown anti‐inflammatory and regenerative properties, providing symptomatic relief when orally supplemented in patients suffering from various colonic diseases. We investigated the effect of a colonic‐delivery formulation butyrate on fecal microbiota with inflammatory bowel diseases (IBDs). Methods In this double‐blind, placebo‐controlled, pilot study, 49 IBD (n = 19 Crohn's disease, CD n 30 ulcerative colitis, UC) were randomized to oral administration microencapsulated‐sodium‐butyrate (BLM) or placebo for 2 months, addition conventional therapy. Eighteen healthy volunteers (HVs) recruited provide model local people. Fecal stool samples was assessed by 16S sequencing. Clinical disease activity quality life (QoL) evaluated before after treatment. Key Results At baseline, HVs showed different composition compared patients. Sodium‐butyrate altered gut increasing bacteria able produce SCFA UC ( Lachnospiraceae spp.) butyrogenic Butyricicoccus ). patients, QoL positively affected Conclusions Inferences supplementation increases growth potentially action. The clinical impact finding requires further investigation.

Language: Английский

Citations

143
Mechanisms of Short-Chain Fatty Acids Derived from Gut Microbiota in Alzheimer's Disease DOI Creative Commons
Xiaohang Qian,

Ru-yan Xie,

Xiaoli Liu

et al.

Aging and Disease, Journal Year: 2022, Volume and Issue: 13(4), P. 1252 - 1252

Published: Jan. 1, 2022

Short-chain fatty acids (SCFAs) are important metabolites derived from the gut microbiota through fermentation of dietary fiber. SCFAs participate a number physiological and pathological processes in human body, such as host metabolism, immune regulation, appetite regulation. Recent studies on gut-brain interaction have shown that mediators interactions involved occurrence development many neurodegenerative diseases, including Alzheimer's disease. This review summarizes current research potential roles mechanisms AD. First, we introduce metabolic distribution, specific receptors signaling pathways body. The concentration levels AD patient/animal models then summarized. In addition, illustrate effects cognitive level, features (Aβ tau) neuroinflammation Finally, analyze translational value therapeutic targets for treatment

Language: Английский

Citations

83
Neuromicrobiology, an emerging neurometabolic facet of the gut microbiome? DOI Creative Commons
Saba Miri,

JuDong Yeo,

Sarah Abubaker

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Jan. 17, 2023

The concept of the gut microbiome is emerging as a metabolic interactome influenced by diet, xenobiotics, genetics, and other environmental factors that affect host’s absorption nutrients, metabolism, immune system. Beyond nutrient digestion production, also functions personalized polypharmacy, where bioactive metabolites our microbes excrete or conjugate may reach systemic circulation impact all organs, including brain. Appreciable evidence shows microbiota produce diverse neuroactive metabolites, particularly neurotransmitters (and their precursors), stimulating local nervous system (i.e., enteric vagus nerves) affecting brain function cognition. Several studies have demonstrated correlations between central sparking an exciting new research field, neuromicrobiology. Microbiome-targeted interventions are seen promising adjunctive treatments (pre-, pro-, post-, synbiotics), but mechanisms underlying host-microbiome interactions yet to be established, thus preventing informed evidence-based therapeutic applications. In this paper, we review current state knowledge for each major classes microbial emphasizing biological effects on microbiome, environment, Also, discuss biosynthesis, absorption, transport microbiota-derived implication in mental disorders.

Language: Английский

Citations

82
Relative Bioavailability of Trace Minerals in Production Animal Nutrition: A Review DOI Creative Commons
Laurann Byrne, Richard Murphy

Animals, Journal Year: 2022, Volume and Issue: 12(15), P. 1981 - 1981

Published: Aug. 4, 2022

The importance of dietary supplementation animal feeds with trace minerals is irrefutable, various forms both organic and inorganic products commercially available. With advances in research techniques, data obtained from in-vitro in-vivo studies recent years, differences between have become more apparent. Furthermore, specific mineral types can now be identified. Adhering to PRISMA guidelines for systematic reviews, we carried out an extensive literature search on previously published detailing performance responses minerals, addition their corresponding relative bioavailability values. This review covers four the main included feed: copper, iron, manganese zinc, encompasses different Their impact environmental, economic, nutritional perspectives are discussed, along biological availability production animals. Species-specific sections cover ruminants, poultry, swine. Extensive tables values all available, including those not reviewed earlier studies, thereby providing a comprehensive industry reference guide. Additionally, examine reasons variance reported values, emphasis accounting misinterpretation.

Language: Английский

Citations

76
Mechanisms and Therapeutic Potential of Key Anti-inflammatory Metabiotics: Trans-Vaccenic Acid, Indole-3-Lactic Acid, Thiamine, and Butyric Acid DOI

Mnica Cristina,

Elizabeth Bautista, Renju Jose

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Language: Английский

Citations

2
Symposium review: The importance of the ruminal epithelial barrier for a healthy and productive cow DOI Creative Commons
Jörg R. Aschenbach, Qendrim Zebeli, Amlan Kumar Patra

et al.

Journal of Dairy Science, Journal Year: 2018, Volume and Issue: 102(2), P. 1866 - 1882

Published: Dec. 20, 2018

Language: Английский

Citations

126
The gut microbiome and cardiovascular disease: current knowledge and clinical potential DOI Creative Commons
Adilah F. Ahmad, Girish Dwivedi, Fergal O’Gara

et al.

AJP Heart and Circulatory Physiology, Journal Year: 2019, Volume and Issue: 317(5), P. H923 - H938

Published: Aug. 30, 2019

Cardiovascular disease (CVD) is the leading cause of death worldwide. The human body populated by a diverse community microbes, dominated bacteria, but also including viruses and fungi. largest most complex these communities located in gastrointestinal system and, with its associated genome, known as gut microbiome. Gut microbiome perturbations related dysbiosis have been implicated progression pathogenesis CVD, atherosclerosis, hypertension, heart failure. Although there advances characterization analysis microbiota bacterial metabolites, exact mechanisms through which they exert their action are not well understood. This review will focus on role functional components development atherosclerosis. Potential treatments to alter prevent or treat atherosclerosis CVD discussed.

Language: Английский

Citations

119