Melatonin/Sericin Wound Healing Patches: Implications for Melanoma Therapy DOI Open Access
Katarzyna Adamiak, Vivian A. Gaida, Jasmin Schäfer

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4858 - 4858

Published: April 29, 2024

Melatonin and sericin exhibit antioxidant properties may be useful in topical wound healing patches by maintaining redox balance, cell integrity, regulating the inflammatory response. In human skin, melatonin suppresses damage caused ultraviolet radiation (UVR) which involves numerous mechanisms associated with reactive oxygen species/reactive nitrogen species (ROS/RNS) generation enhancing apoptosis. Sericin is a protein mainly composed of glycine, serine, aspartic acid, threonine amino acids removed from silkworm cocoon (particularly Bombyx mori other species). It interest because its biodegradability, anti-oxidative, anti-bacterial properties. inhibits tyrosinase activity promotes proliferation that can supportive melanoma treatment. recent years, containing individually have attracted significant attention scientific community. this review, we summarize state innovation such during 2021–2023. To date, melatonin/sericin-polymer for application post-operational treatment has been only sparingly investigated it an imperative to consider these materials as promising approach targeting skin tissue engineering or regenerative dermatology.

Language: Английский

Flexible Accelerated-Wound-Healing Antibacterial Hydrogel-Nanofiber Scaffold for Intelligent Wearable Health Monitoring DOI

Jieyan Xu,

Hui Huang, Cheng Sun

et al.

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 16(5), P. 5438 - 5450

Published: Dec. 19, 2023

Flexible epidermal sensors hold significant potential in personalized healthcare and multifunctional electronic skins. Nonetheless, achieving both robust sensing performance efficient antibacterial protection, especially medical paradigms involving electrophysiological signals for wound healing intelligent health monitoring, remains a substantial challenge. Herein, we introduce novel flexible accelerated-wound-healing biomaterial based on hydrogel-nanofiber scaffold (HNFS) via electrostatic spinning gel cross-linking. We effectively engineer tissue nanoengineered skin treatment monitoring. Key features of HNFS include high tensile strength (24.06 MPa) elasticity (214.67%), flexibility, biodegradability, properties, enabling assembly into versatile monitoring human motion signals. Moreover, vitro vivo experiments demonstrate that significantly enhances cell proliferation healing, provide comprehensive therapeutic strategy smart repair, guide the development high-performance "wound healing-health monitoring" bioelectronic scaffolds. Therefore, this study provides insights crafting repairable sensors, holding diagnostics applications wearable next-generation artificial fields.

Language: Английский

Citations

20
Emerging Smart Micro/Nanofiber‐Based Materials for Next‐Generation Wound Dressings DOI

Yuping Dong,

Shaoju Fu, Jianyong Yu

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(9)

Published: Nov. 20, 2023

Abstract Smart wound dressings capable of detecting, monitoring, and regulating complicated dynamic healing processes hold tremendous potential in tissue reconstruction. Micro/nanofiber‐based materials are regarded as one the most promising candidates to develop smart owing their remarkable features including architectural mimicry extracellular matrix, tunability structural assembly, diversity functionality. Herein, latest progress micro/nanoscale fiber‐based terms composition engineering, design, applications management is comprehensively reviewed. This work begins with advances fibers stimuli‐responsive fibers, shape memory conductive fibers. Then, design from conventional 2D fibrous membrane emerging 3D sponge/hydrogel thoroughly discussed. Furthermore, micro/nanofibrous drug delivery, biomechanical stimulation, electrical monitoring highlighted. Finally, article offers perspectives on existing challenges future directions for management.

Language: Английский

Citations

17
Tailoring the Heterogeneous Structure of Macro‐Fibers Assembled by Bacterial Cellulose Nanofibrils for Tissue Engineering Scaffolds DOI

Nihuan Wu,

Si Meng,

Zhen Li

et al.

Small, Journal Year: 2024, Volume and Issue: 20(23)

Published: Jan. 11, 2024

Abstract Bacterial cellulose/oxidized bacterial cellulose nanofibrils (BC/oxBCNFs) macro‐fibers are developed as a novel scaffold for vascular tissue engineering. Utilizing low‐speed rotary coagulation spinning technique and precise solvent control, with unique heterogeneous structure dense surface porous core created. Enhanced by polydopamine (PDA) coating, these offer robust mechanical integrity, high biocompatibility, excellent cell adhesion. When cultured endothelial cells (ECs) smooth muscle (SMCs), the support healthy proliferation exhibit spiral SMC alignment, demonstrating their suitability. This innovative strategy opens new avenues advances in

Language: Английский

Citations

7
Carboxymethyl chitosan-based hydrogel-Janus nanofiber scaffolds with unidirectional storage-drainage of biofluid for accelerating full-thickness wound healing DOI
Xinhao Chen, Hui Huang, Xinru Song

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: unknown, P. 121870 - 121870

Published: Jan. 1, 2024

Language: Английский

Citations

7
Core‐Shell Gel Nanofiber Scaffolds Constructed by Microfluidic Spinning toward Wound Repair and Tissue Regeneration DOI Creative Commons

Yue Dong,

Zongkun Ding,

Yuting Bai

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(39)

Published: July 15, 2024

Abstract Growing demand for wound care resulting from the increasing chronic diseases and trauma brings intense pressure to global medical health service system. Artificial skin provides mechanical microenvironmental support wound, which is crucial in healing tissue regeneration. However, challenges still remain clinical application of artificial since lack synergy effect necessary performance. In this study, a multi‐functional fabricated through microfluidic spinning technology by using core‐shell gel nanofiber scaffolds (NFSs). This strategy can precisely manipulate microstructure under microscale. The as‐prepared demonstrates superior characteristics including surface wettability, breathability, high strength, strain sensitivity, biocompatibility biodegradability. Notably, has capability deliver medications controlled sustained manner, thereby accelerating process. innovative approach paves way development new generation introduces novel concept structural design unique NFSs.

Language: Английский

Citations

7
Versatile Bioactive Glass/Zeolitic Imidazolate Framework-8-Based Skin Scaffolds toward High-Performance Wound Healing DOI

Yongchun Hou,

Xiaowei Xu,

Yaqin Zhou

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(7), P. 8228 - 8237

Published: Feb. 12, 2024

Designing a novel biomaterial for wound healing is based on biocompatibility and excellent mechanical strength. In this study, bioactive glass (BG) zeolitic imidazolate framework-8 (ZIF-8) have been incorporated into poly(ε-caprolactone)/poly(vinyl alcohol) (PCL/PVA) composite skin scaffolds via microfluidic electrospinning. Interestingly, the addition of ZIF-8 further strengthens BG stability demonstrates better antibacterial effects. Utilizing slow release Zn, Ca, Si ions, it also significantly promotes growth factor expression regeneration. addition, demonstrated by in vitro vivo studies that prepared possess biocompatibility, capabilities, properties. The BG/ZIF-8-loaded scaffold possesses high tensile strength (26 MPa) properties (achieves 89.64 78.8% inhibition E. coli S. aureus, respectively), cell viability increased 51.2%. More importantly, shrinkage than an unloaded scaffold, rates PCL/PVA@BG/ZIF-8(1 wt %) group 95% with 2.2 mm granulation thickness within 12 days. Thus, loaded BG/ZIF-8 electrospinning provides new perspective accelerating potential therapeutic strategy efficient healing.

Language: Английский

Citations

6
Innovations in spider silk‐inspired artificial gel fibers: Methods, properties, strengthening, functionality, and challenges DOI Creative Commons
Abdul Qadeer Khan, Wenjin Guo, Sitong Li

et al.

SusMat, Journal Year: 2024, Volume and Issue: 4(3)

Published: May 27, 2024

Abstract Spider silk, possessing exceptional combination properties, is classified as a bio‐gel fiber. Thereby, it serves valuable origin of inspiration for the advancement various artificial gel fiber materials with distinct functionalities. Gel fibers exhibit promising potential utilization in diverse fields, including smart textiles, muscle, tissue engineering, and strain sensing. However, there are still numerous challenges improving performance functionalizing applications spider silk‐inspired fibers. Thus, to gain penetrating insight into bioinspired fibers, this review provided comprehensive overview encompassing three key aspects: fundamental design concepts implementing strategies properties strengthening functionalities application prospects In particular, multiple toughening mechanisms were introduced at micro, nano, molecular‐level structures Additionally, existing summarized. This aims offer significant guidance development inspire further research field high‐performance

Language: Английский

Citations

6
Expanding the boundaries of silk sericin biomaterials in biomedical applications DOI
Anabela Veiga,

Olivia Foster,

David L. Kaplan

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(29), P. 7020 - 7040

Published: Jan. 1, 2024

Unlock the potential of silk sericin (SS) in bioengineering. From its origins to market evolution, explore diverse applications and future prospects.

Language: Английский

Citations

6
HE@PCL/PCE Gel-Nanofiber Dressing with Robust Self-Adhesion toward High Wound-Healing Rate via Microfluidic Electrospinning Technology DOI

Rong Chen,

Zhiting Liu, Tingting Cui

et al.

ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(39), P. 46322 - 46332

Published: Sept. 25, 2023

Hydrogels have attracted increasing attention in the biomedical field due to their similarity structure and composition natural extracellular matrices. However, they been greatly limited by low mechanical strength self-adhesion for further application. Here, a gel-nanofiber material is designed wound healing, which synergistically combines benefits of hydrogels nanofibers can overcome bottleneck poor inadequate healing environment created nanofibers. First, nanofiber scaffold composed polycaprolactone/poly(citric acid)-ε-lysine (PCL/PCE) fabricated via new strategy microfluidic electrospinning, could provide base hyaluronic acid-polylysine (HE) gel growth on The prepared HE@PCL/PCE possesses high tensile (24.15 ± 1.67 MPa), excellent air permeability (656 m3/m2 h kPa), outstanding property, positive hydrophilicity. More importantly, dressing shows good cytocompatibility antibacterial properties, achieving wound-healing rate (92.48%) 4.685 mm granulation thickness within 12 days. This may open promising avenue accelerating tissue regeneration, providing potential applications clinical medicine.

Language: Английский

Citations

11
Robust Gradient Hydrogel‐Loaded Nanofiber Fleshy Artificial Skin Via A Coupled Microfluidic Electrospinning‐Reactive Coating Strategy DOI
Qing Li,

Rong Chen,

Tingting Cui

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(18)

Published: March 16, 2024

Skin regeneration attracts tremendous interest due to the important role of skin for human protection and beauty. Thus, methods allowing artificial be carried out in a controllable fashion are potentially wound healing, which involves an intersection materials, medicine, biology, other disciplines. Herein, aiming at new general methodology fleshy hydrogel-loaded hydrophobic-hydrophilic nanofiber is designed fabricated. The gradient integrates both advantages hydrogel, exhibiting feature (comparability real terms appearance, texture, function), excellent air permeability, compatibility, good mechanical antibacterial property. Interestingly, efficient transport channels formed throughout structure, beneficial water absorption transfer. These enable establishment moist favorable microenvironment; thus, greatly accelerating healing process. This work couples microfluidic electrospinning with reactive coating technique, favor material design fabrication uniform structures. shows comparability beauty, function, would definitely provide opportunities further optimization upgrading skin.

Language: Английский

Citations

4