Polydopamine antibacterial materials

Materials Horizons, Journal Year: 2021, Volume and Issue: 8(6), P. 1618 - 1633

Published: Jan. 1, 2021

This review focuses on the recent progress in polydopamine antibacterial materials, including their structural and functional features, preparation strategies, mechanisms, biomedical applications.

Language: Английский

---

Stimuli-responsive polydopamine-based smart materials

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(14), P. 8319 - 8343

Published: Jan. 1, 2021

This review provides in-depth insight into the structural engineering of PDA-based materials to enhance their responsive feature and use them in construction stimuli-responsive smart materials.

Language: Английский

---

Polydopamine free radical scavengers

Biomaterials Science, Journal Year: 2020, Volume and Issue: 8(18), P. 4940 - 4950

Published: Jan. 1, 2020

This feature article summarizes the recent progress, challenges and future directions of free radical scavengers based on polydopamine, including integrated mechanism, current regulating strategies, kinds biomedical applications.

Language: Английский

---

Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy

Journal of Hematology & Oncology, Journal Year: 2023, Volume and Issue: 16(1)

Published: Nov. 30, 2023

Inflammation is a fundamental defensive response to harmful stimuli, but the overactivation of inflammatory responses associated with most human diseases. Reactive oxygen species (ROS) are class chemicals that generated after incomplete reduction molecular oxygen. At moderate levels, ROS function as critical signaling molecules in modulation various physiological functions, including responses. However, at excessive exert toxic effects and directly oxidize biological macromolecules, such proteins, nucleic acids lipids, further exacerbating development causing Therefore, designing manufacturing biomaterials scavenge has emerged an important approach for restoring homeostasis, limiting protecting host against damage. This review systematically outlines dynamic balance production clearance under conditions. We focus on mechanisms by which regulate cell proteins how these affect inflammation. Furthermore, we discuss use potential currently available-biomaterials ROS, agents were engineered reduce levels blocking generation, chemically reacting or catalytically accelerating clearance, treatment Finally, evaluate challenges prospects controlled material design scavenging biomaterials.

Language: Английский

---

Biocatalytic and Antioxidant Nanostructures for ROS Scavenging and Biotherapeutics

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(31)

Published: May 13, 2021

Abstract In human systems, reactive oxygen species (ROS) significantly affect different physiological activities and play critical roles in diverse living processes. It is widely known that excessive ROS generation inflammatory tissues can further deteriorate the localized tissue injury cause chronic diseases. Though promising for reducing levels, many antioxidant molecules natural enzymes suffer from abundant intrinsic limitations. Recently, a series of biocatalytic or nanostructures have been designed with distinctive scavenging capabilities, which show to overcome these kernel challenges. this timely review, most recent advances engineering are summarized. First, principles corresponding methods testing various enzymatic carefully concluded. Subsequently, rationally high efficiencies comprehensively discussed, especially on catalytic activities, mechanisms, structure‐function relationships. After that, representative applications biotherapeutics summarized detail. At last, primary challenges future perspectives emerging research frontier also outlined. believed progress review will offer cutting‐edge understanding guidance high‐performance broad biotherapeutic applications.

Language: Английский

---

Copper-Based Metal–Organic Framework Overcomes Cancer Chemoresistance through Systemically Disrupting Dynamically Balanced Cellular Redox Homeostasis

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(11), P. 4799 - 4809

Published: Feb. 22, 2022

Chemodrug resistance is a major reason accounting for tumor recurrence. Given the mechanistic complexity of chemodrug resistance, molecular inhibitors and targeting drugs often fail to eliminate drug-resistant cancer cells, sometimes even promote chemoresistance by activating alternative pathways. Here, exploiting biochemical fragility high-level but dynamically balanced cellular redox homeostasis in we design nanosized copper/catechol-based metal-organic framework (CuHPT) that effectively disturbs this tilting balance toward oxidative stress. Within CuHPT starts disassembly triggered persistent consumption glutathione (GSH). simultaneously releases two structural elements: catechol ligands reductive copper ions (Cu+). Both them cooperatively function amplify production intracellular radical species (ROS) via auto-oxidation Fenton-like reactions through exhausting GSH. By drastically heightening stress, exhibits selective potent cytotoxicity multiple cells. Importantly, inhibits vivo growth doubles survival time tumor-bearing mice. Thus, along with CuHPT's good biocompatibility, our biochemical, cell biological, preclinical animal model data provide compelling evidence supporting notion copper-based MOF predesigned smart therapeutic against cancers precisely deconstructing their homeostasis.

Language: Английский

---

Reduced polydopamine nanoparticles incorporated oxidized dextran/chitosan hybrid hydrogels with enhanced antioxidative and antibacterial properties for accelerated wound healing

Carbohydrate Polymers, Journal Year: 2021, Volume and Issue: 257, P. 117598 - 117598

Published: Jan. 11, 2021

Language: Английский

---

Recent Advances in a Polydopamine-Mediated Antimicrobial Adhesion System

Frontiers in Microbiology, Journal Year: 2021, Volume and Issue: 11

Published: Jan. 12, 2021

The drug resistance developed by bacteria during antibiotic treatment has been a call to action for researchers and scientists across the globe, as fungi develop ever increasing current drugs. Innovative antimicrobial/antibacterial materials coatings combat such infections have become priority, many are caused indwelling implants (e.g., catheters) well improving postsurgical function outcomes. Pathogenic microorganisms that can exist either in planktonic form or biofilms water-carrying pipelines one of sources responsible causing water-borne infections. To this, nanotextured surfaces with bactericidal properties mirroring topographical features some natural antibacterial materials. Protein-based adhesives, secreted marine mussels, contain catecholic amino acid, 3,4-dihydroxyphenylalanine (DOPA), which, presence lysine empowers ability anchor them various both wet saline habitats. Inspired these features, novel coating material derived from catechol derivative, dopamine, known polydopamine (PDA), designed adhere almost all kinds substrates. Looking at immense potential PDA, this review article offers an overview recent growth field PDA its derivatives, especially focusing promising applications nanocoatings discussing antimicrobial mechanisms including reactive oxygen species-mediated properties.

Language: Английский

---

Nanomaterials and Their Impact on the Immune System

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2008 - 2008

Published: Jan. 19, 2023

Nanomaterials have been the focus of intensive development and research in medical industrial sectors over past several decades. Some studies found that these compounds can a detrimental impact on living organisms, including their cellular components. Despite obvious advantages using nanomaterials wide range applications, there is sometimes skepticism caused by lack substantial proof evaluates potential toxicities. The interactions nanoparticles (NPs) with cells immune system biomolecule pathways are an area interest for researchers. It possible to modify NPs so they not recognized or suppress stimulate targeted manner. In this review, we look at literature immunostimulation immunosuppression how changing physicochemical features particles could alter better worse (immunotoxicity). We also into whether unique unexpected (but desired) effect system, surface grafting polymers coatings makes stealth cannot find get rid of.

Language: Английский

---

Smart polydopamine-based nanoplatforms for biomedical applications: state-of-art and further perspectives

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 488, P. 215153 - 215153

Published: April 27, 2023

Language: Английский

---