Dual Nanozyme-Driven PtSn Bimetallic Nanoclusters for Metal-Enhanced Tumor Photothermal and Catalytic Therapy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(7), P. 6833 - 6848

Published: March 28, 2023

Specific generation of reactive oxygen species (ROS) within tumors in situ catalyzed by nanozymes is a promising strategy for cancer therapeutics. However, it remains significant challenge to fabricate highly efficient acting the tumor microenvironment. Herein, we develop bimetallic nanozyme (Pt50Sn50) with photothermal enhancement dual enzymatic activities catalytic therapy. The structures and PtSn nanoclusters (BNCs) different Sn content are explored evaluated systematically. Experimental comparisons show that Pt50Sn50 BNCs exhibit highest among all those investigated, including activity property, due SnO2–x vacancy (Ovac) sites on surface BNCs. Specifically, photothermal-enhanced peroxidase-like catalase-like activities, as well significantly enhanced anticancer efficacy both multicellular spheroids vivo experiments. Due high X-ray attenuation coefficient excellent light absorption also dual-mode imaging capacity computed tomography photoacoustic imaging, which could achieve real-time monitoring therapeutic process. Therefore, this work will advance development noble-metal optimal composition

Language: Английский

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Stimuli-Responsive Gene Delivery Nanocarriers for Cancer Therapy

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 15(1)

Published: Feb. 8, 2023

Gene therapy provides a promising approach in treating cancers with high efficacy and selectivity few adverse effects. Currently, the development of functional vectors safety effectiveness is intense focus for improving delivery nucleic acid drugs gene therapy. For this purpose, stimuli-responsive nanocarriers displayed strong potential overall efficiencies reducing effects via effective protection, prolonged blood circulation, specific tumor accumulation, controlled release profile drugs. Besides, synergistic could be achieved when combined other therapeutic regimens. This review summarizes recent advances various delivery. Particularly, responding to endogenous stimuli including pH, reactive oxygen species, glutathione, enzyme, etc., exogenous light, thermo, ultrasound, magnetic field, are introduced. Finally, future challenges prospects toward clinical translation well discussed. The major objective present biomedical cancer provide guidance developing novel nanoplatforms that clinically applicable.

Language: Английский

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A Dual‐Responsive STAT3 Inhibitor Nanoprodrug Combined with Oncolytic Virus Elicits Synergistic Antitumor Immune Responses by Igniting Pyroptosis

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(11)

Published: Dec. 22, 2022

Immune checkpoint blockade (ICB) therapy shows excellent efficacy against malignancies; however, insufficient tumor immunogenicity and the immunosuppressive microenvironment (TME) are considered as two major stumbling blocks to a broad ICB response. Here, combinational therapeutic strategy is reported, wherein TME-reactive oxygen species/pH dual-responsive signal transducers activators of transcription 3 inhibitor nanoprodrugs MPNPs combined with oncolytic herpes simplex virus 1 virotherapy synergistically ignite pyroptosis for enhancing immunotherapy. exhibit certain level accumulation, reduce cell stemness, enhance antitumor immune responses. Furthermore, simultaneous application viruses (OVs) confers higher penetration capacity remarkable gasdermin-E-mediated pyroptosis, thereby reshaping TME transforming "cold" tumors into "hot" ones. This "fire immunity" successfully activates robust T-cell-dependent responses, potentiating effects local recurrence pulmonary metastasis in preclinical murine triple-negative breast cancer syngeneic oral models. Collectively, this work may pave new way offer an unprecedented opportunity combination OVs nanomedicine

Language: Английский

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Polysaccharide-based tumor microenvironment-responsive drug delivery systems for cancer therapy

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 362, P. 19 - 43

Published: Aug. 24, 2023

Language: Английский

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Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 181 - 207

Published: Feb. 2, 2024

Peptide molecules have design flexibility, self-assembly ability, high biocompatibility, good biodegradability, and easy functionalization, which promote their applications as versatile biomaterials for tissue engineering biomedicine. In addition, the functionalization of self-assembled peptide nanomaterials with other additive components enhances stimuli-responsive functions, promoting function-specific that induced by both internal external stimulations. this review, we demonstrate recent advance in molecular design, self-assembly, functional tailoring, biomedical peptide-based nanomaterials. The strategies on synthesis single, dual, multiple various dimensions are analyzed, regulation active such metal/metal oxide, DNA/RNA, polysaccharides, photosensitizers, 2D materials, others discussed. designed temperature-, pH-, ion-, light-, enzyme-, ROS-responsive abilities drug delivery, bioimaging, cancer therapy, gene antibacterial, well wound healing dressing presented This comprehensive review provides detailed methodologies advanced techniques from biology, materials science, nanotechnology, will guide inspire level peptides specific functions applications.

Language: Английский

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Microenvironment-responsive nanocarriers for targeted bone disease therapy

Nano Today, Journal Year: 2023, Volume and Issue: 50, P. 101838 - 101838

Published: March 29, 2023

Language: Английский

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Enzyme Core Spherical Nucleic Acid That Enables Enhanced Cuproptosis and Antitumor Immune Response through Alleviating Tumor Hypoxia

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(20), P. 13805 - 13816

Published: March 29, 2024

Cuproptosis, a copper-dependent cell death process, has been confirmed to further activate the immune response and mediate resistance. However, hypoxic tumor microenvironment hampers cuproptosis sensitivity suppresses body's antitumor response. Herein, we have successfully immobilized functionalized catalase (CAT) with long single-stranded DNA containing polyvalent CpG sequences through rolling circle amplification (RCA) techniques, obtaining an enzyme-cored spherical nucleic acid nanoplatform (CAT-ecSNA-Cu) deliver copper ions for cuproptosis. The presence of long-stranded DNA-protected CAT enhances mitochondrial respiration by catalyzing conversion H2O2 O2, thereby sensitizing Meanwhile, increased oxygenation expression hypoxia-inducible factor-1 (HIF-1) protein, resulting in alleviation immunosuppressive microenvironment. Of note, induces immunogenic (ICD), which facilitates dendritic (DC) maturation antigen presentation polyCpG-supported Toll-like receptor 9 (TLR9) activation. Furthermore, cuproptosis-induced PD-L1 upregulation cells complements checkpoint blockers (αPD-L1), enhancing immunity. strategy cuproptosis-mediated responses alleviating hypoxia effectively promotes activation proliferation effector T cells, ultimately leading long-term immunity against cancer.

Language: Английский

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Smart Nanoassembly Enabling Activatable NIR Fluorescence and ROS Generation with Enhanced Tumor Penetration for Imaging‐Guided Photodynamic Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(28)

Published: April 30, 2024

Abstract Fluorescence imaging‐guided photodynamic therapy (FIG‐PDT) holds promise for cancer treatment, yet challenges persist in poor imaging quality, phototoxicity, and insufficient anti‐tumor effect. Herein, a novel nanoplatform, LipoHPM, designed to address these challenges, is reported. This approach employs an acid‐sensitive amine linker connect biotin‐modified hydrophilic polymer ( Biotin PEG) with new hydrophobic photosensitizer (MBA), forming OFF‐state P EG‐ M BA (PM) micelles via aggregation‐caused quenching (ACQ) These are then co‐loaded the tumor penetration enhancer hydralazine H DZ) into pH‐sensitive liposomes (Lipo HPM ). Leveraging ACQ effect, LipoHPM silent both fluorescence reactive oxygen species (ROS) generation during blood circulation but restores properties upon disassembly. Following intravenous injection tumor‐bearing mice, actively targets cells overexpressing biotin‐receptors, contributing enhanced accumulation. Upon cellular internalization, disassembles within lysosomes, releasing HDZ enhance inhibit metastasis. Concurrently, activate boost production of type‐I type‐II ROS eradication. Therefore, smart synergistically integrates near‐infrared emission, activatable imaging, robust generation, efficient anti‐metastasis activity, successfully overcoming limitations conventional photosensitizers establishing itself as promising nanoplatform potent FIG‐PDT applications.

Language: Английский

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An insight into the dual role of MoS2-based nanocarriers in anticancer drug delivery and therapy

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 179, P. 36 - 60

Published: March 27, 2024

Language: Английский

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Two-Dimensional Nanomaterial-based catalytic Medicine: Theories, advanced catalyst and system design

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 184, P. 114241 - 114241

Published: March 31, 2022

Language: Английский

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