Polypyrrole Nanoenzymes as Tumor Microenvironment Modulators to Reprogram Macrophage and Potentiate Immunotherapy

Advanced Science, Journal Year: 2022, Volume and Issue: 9(23)

Published: June 9, 2022

Nanozyme-based tumor catalytic therapy has attracted widespread attention in recent years, but its therapeutic outcome is drastically diminished by species of nanozyme, concentration substrate, pH value, and reaction temperature, etc. Herein, a novel Cu-doped polypyrrole nanozyme (CuP) with trienzyme-like activities, including catalase (CAT), glutathione peroxidase (GPx), (POD), first proposed straightforward one-step procedure, which can specifically promote O

Language: Английский

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Self-triggered thermoelectric nanoheterojunction for cancer catalytic and immunotherapy

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 23, 2023

The exogenous excitation requirement and electron-hole recombination are the key elements limiting application of catalytic therapies. Here a tumor microenvironment (TME)-specific self-triggered thermoelectric nanoheterojunction (Bi0.5Sb1.5Te3/CaO2 nanosheets, BST/CaO2 NSs) with self-built-in electric field facilitated charge separation is fabricated. Upon exposure to TME, CaO2 coating undergoes rapid hydrolysis, releasing Ca2+, H2O2, heat. resulting temperature difference on BST NSs initiates effect, driving reactive oxygen species production. H2O2 not only serves as substrate supplement for ROS generation but also dysregulates Ca2+ channels, preventing efflux. This further exacerbates calcium overload-mediated therapy. Additionally, promotes DC maturation antigen presentation, facilitating immunotherapy. It worth noting that NP hydrolyzes very slowly in normal cells, O2 without causing any adverse effects. Tumor-specific combined therapy, ion interference immunotherapy exhibit excellent antitumor performance female mice.

Language: Английский

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Two-dimensional porous vermiculite-based nanocatalysts for synergetic catalytic therapy

Biomaterials, Journal Year: 2023, Volume and Issue: 295, P. 122031 - 122031

Published: Jan. 28, 2023

Language: Английский

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2D Architectures-Transformed Conformational Nanoarchitectonics for Light-Augmented Nanocatalytic Chemodynamic and Photothermal/Photodynamic-Based Trimodal Therapies

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(4), P. 1160 - 1177

Published: Feb. 26, 2024

The complexity of the cancer microenvironment makes it highly challenging for drugs to meet therapeutic requirements, significantly hampering their clinical translation. enormous potential intelligent materials that can act as themselves results in development smart drugless or drug-like architectures, offering synergistic effects. In this study, we demonstrate generation transition metal-based dichalcogenides (TMDCs)-based conformational (flower-like) nanoarchitectonics trimodal therapies against breast carcinoma. Initially, progressive transformation two-dimensional (2D) molybdenum selenide (MoSe2)-based nanosheets into nanoflower-like architectures by thermal injection method is observed with time. Further, these flowers are subsequently decorated an optimal amount platinum (Pt) nanoparticles nanocatalytic efficacy and surface-modified polyethylene glycol (PEG) improved biocompatibility, shortly denoted Pt-MoSe2-PEG light-assisted photothermal (PTT) photodynamic (PDT), well light-augmented chemodynamic (CDT) modalities. A series physicochemical characterizations performance validations successfully demonstrated tumor (pH/GSH)-responsive degradable structures, substantially improving ability reactive oxygen species generation, MoSe2-based PTT/PDT capability, CDT Pt nanoenzymes. Finally, vitro vivo investigations 4T1 cell line its xenograft model BALB/C mice, respectively, validated toward ablating

Language: Английский

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Edge modification facilitated heterogenization and exfoliation of two-dimensional nanomaterials for cancer catalytic therapy

Science Advances, Journal Year: 2022, Volume and Issue: 8(39)

Published: Sept. 30, 2022

The rapid recombination of electron-hole pairs and limited substrates are the most critical factors astricting effect catalytic therapy. Thus, two-dimensional interplanar heterojunction (BiOCl/Bi2O3) that prolongs lifetime excited electrons holes extends selectivity under ultrasound irradiation is prepared to facilitate high-performance cancer An edge modification displacing marginal BiOCl Bi2O3 proposed construct heterojunction, promoting ultrathin nanosheets exfoliation due enhanced affinity with H2O. spontaneously aligning Fermi levels mediate a built-in electric field-guided Z-scheme retard recombination, improve redox potentials. Hence, these high-powered capable catalyzing diverse stable substrates, such as reduction reactions, O2 → ·O2- CO2 CO, oxidation GSH GSSG H2O ·OH. extending completely breaks tumor microenvironment limitation, exhibiting high anticancer activity.

Language: Английский

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Nanoheterojunction‐Mediated Thermoelectric Strategy for Cancer Surgical Adjuvant Treatment and β‐Elemene Combination Therapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(8)

Published: Nov. 9, 2022

As an indispensable strategy for tumor treatment, surgery may cause two major challenges: recurrence and wound infection. Here, a thermoelectric therapeutic is provided as either independent cancer therapy or surgical adjuvant treatment. Bi0.5 Sb1.5 Te3 (BST) Bi2 Te2.8 Se0.2 (BTS) nanoplates composed of Z-scheme heterojunction (BST/BTS) are fabricated via two-step hydrothermal processes. The contact between BST BTS constructs interfacial electric field due to Fermi energy level rearrangement, guiding electrons in the conductive band (CB) combine with holes valance (VB) BST, leaving stronger reduction/oxidation potentials CB VB BTS. Moreover, under mild temperature gradient, another self-built-in formed facilitating migration their surfaces. Based on PEGylated BST/BTS heterojunction, novel platform developed through intravenous injection external cooling tumors. This also proved effective combination β-elemene. hydrogel administrated after surgery, achieving efficient residual treatment antibacterial effects.

Language: Английский

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Copper-Loaded Nanoheterojunction Enables Superb Orthotopic Osteosarcoma Therapy via Oxidative Stress and Cell Cuproptosis

ACS Nano, Journal Year: 2023, Volume and Issue: 17(21), P. 21134 - 21152

Published: Oct. 30, 2023

Catalytic tumor therapy based on two-dimensional (2D) nanomaterials is a burgeoning and promising therapeutic modality. However, the inefficient utilization conversion of exogenous stimulation, single catalytic modality, unsatisfactory efficiency in microenvironment (TME) have seriously restricted their further application therapy. Herein, heterogeneous carbon nitride-based nanoagent named T-HCN@CuMS was successfully developed, which dramatically improved Benefiting from donor–acceptor (triazine-heptazine) structure within nitride nanosheets (HCN) construction interplanar heterostructure with copper loaded metallic molybdenum bisulfide (CuMS), presented favorable photo-induced property to generate abundant reactive oxygen species (ROS) under near-infrared (NIR) light irradiation. Besides, choice CuMS simultaneously enabled this efficiently catalyze Fenton-like reaction trigger cell cuproptosis, recently recognized regulated death mode characterized by imbalanced intracellular homeostasis aggregation lipoylated mitochondrial proteins. Moreover, upon surface modification cRGDfk-PEG2k-DSPE, prepared endowed dispersibility αvβ3 integrins targeting ability. In general, through rational design, facilely had achieved satisfactory antitumor antimetastasis outcomes both vitro high-metastatic orthotopic osteosarcoma model. This strategy could offer an idea treat malignant diseases 2D nanomaterials.

Language: Английский

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Self-generated Schottky barriers in niobium carbide MXene nanocatalysts for theory-oriented sonocatalytic and NIR-II photonic hyperthermia tumor therapy

Nano Today, Journal Year: 2023, Volume and Issue: 48, P. 101750 - 101750

Published: Jan. 5, 2023

Language: Английский

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ROS-responsive self-activatable photosensitizing agent for photodynamic-immunotherapy of cancer

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 164, P. 511 - 521

Published: March 31, 2023

Language: Английский

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Peptide-Hitchhiking for the Development of Nanosystems in Glioblastoma

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 16359 - 16394

Published: June 11, 2024

Glioblastoma (GBM) remains the epitome of aggressiveness and lethality in spectrum brain tumors, primarily due to blood–brain barrier (BBB) that hinders effective treatment delivery, tumor heterogeneity, presence treatment-resistant stem cells contribute recurrence. Nanoparticles (NPs) have been used overcome these obstacles by attaching targeting ligands enhance therapeutic efficacy. Among ligands, peptides stand out their ease synthesis high selectivity. This article aims review single multiligand strategies critically. In addition, it highlights other integrate effects external stimuli, biomimetic approaches, chemical approaches as nanocatalytic medicine, revealing significant potential treating GBM with peptide-functionalized NPs. Alternative routes parenteral administration, specifically nose-to-brain delivery local within resected cavity, are also discussed. Finally, an overview them discussed provide a perspective on this promising field therapy.

Language: Английский

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