“Three‐in‐One” Nanozyme Composite for Augmented Cascade Catalytic Tumor Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(8)

Published: Oct. 18, 2023

Abstract Cascade catalytic reaction exhibits simple procedure and high efficiency, such as that from the orderly assembly of different enzymes in biological systems. Mimicking natural cascade becomes critical, but is still challenging. Herein, single Au–Pt nanozyme reported with “three‐in‐one” functions to initiate conversions for O 2 supply mimic catalase, H production its glucose oxidase‐like property, • OH generation peroxidase chemodynamic therapy (CDT). Thus, complex cross‐talk among are avoided. To this end, metastable Cu NPs, scaffolds, used anchor ultrasmall nanozyme, while metal–organic framework (MOF) encapsulate tumor microenvironment response shielding protein adsorption. Pluronic F127 then modified on surface improve hydrophilicity biocompatibility composite. The endogenous acidity glutathione degrade MOF expose CDT. photothermal conversion ability also enhances CDT, 2+ ions consume GSH further CDT efficiency augmented therapy. a new paradigm provided drug‐free improving therapeutic efficacy minimizing side effects.

Language: Английский

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Colorimetric sensor array based on Au2Pt nanozymes for antioxidant nutrition quality evaluation in food

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 236, P. 115417 - 115417

Published: May 22, 2023

Language: Английский

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Defect Engineering in Nanocatalysts: From Design and Synthesis to Applications

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(29)

Published: Feb. 13, 2024

Abstract Defect engineering is an emerging technology for tailoring nanomaterials' characteristics and catalytic performance in various applications. Recently, defect‐engineered nanoparticles have emerged as highly researched materials applications because of their exceptional redox reaction capabilities physicochemical optical properties. The properties nanomaterials can be readily adjusted by controlling the nature concentration defects within nanoparticles, avoiding need intricate design strategies. This review investigates defect nanocatalysts, including design, fabrication, Initially, categories strategies nanomaterial impacts on nanocatalysts' electronic surface properties, activity, selectivity, stability are summarized. Then, processes uses, gas sensing, hydrogen (H 2 ) evolutions, water splitting, reductions carbon dioxide (CO nitrogen to value‐aided products, pollutant degradation, biomedical (oncotherapy, antibacterial wound healing, biomolecular sensing) discussed. Finally, limitations prospective paths allowing logical optimization nanocatalytic long‐term efficient also examined. comprehensive gives unique insights into current state nanocatalysts inspires future research exploiting shortcomings improve customize performance.

Language: Английский

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A Mild Hyperthermia Hollow Carbon Nanozyme as Pyroptosis Inducer for Boosted Antitumor Immunity

ACS Nano, Journal Year: 2023, Volume and Issue: 17(22), P. 22844 - 22858

Published: Nov. 9, 2023

The immune checkpoint blockade (ICB) antibody immunotherapy has demonstrated clinical benefits for multiple cancers. However, the efficacy of in tumors is suppressed by deficient tumor immunogenicity and immunosuppressive microenvironments. Pyroptosis, a form programmed cell death, can release antigens, activate effective immunogenicity, improve efficiency ICB, but efficient pyroptosis treatment currently limited. Herein, we show mild hyperthermia-enhanced pyroptosis-mediated based on hollow carbon nanozyme, which specifically amplify oxidative stress-triggered synchronously magnify anticancer responses microenvironment. sphere modified with iron copper atoms (HCS-FeCu) enzyme-mimicking activities been engineered to induce via radical oxygen species (ROS)-Tom20-Bax-Caspase 3-gasdermin E (GSDME) signaling pathway under light activation. Both vitro vivo antineoplastic results confirm superiority HCS-FeCu nanozyme-induced pyroptosis. Moreover, photothermal-activated combining anti-PD-1 enhance antitumor immunotherapy. Theoretical calculations further indicate that photothermal stimulation generates high-energy electrons enhances interaction between surface adsorbed oxygen, facilitating molecular activation, improves ROS production efficiency. This work presents an approach effectively transforms immunologically "cold" into "hot" ones, significant implications

Language: Английский

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Recent Development of Copper‐Based Nanozymes for Biomedical Applications

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(1)

Published: Sept. 24, 2023

Copper (Cu), an indispensable trace element within the human body, serving as intrinsic constituent of numerous natural enzymes, carrying out vital biological functions. Furthermore, nanomaterials exhibiting enzyme-mimicking properties, commonly known nanozymes, possess distinct advantages over their enzyme counterparts, including cost-effectiveness, enhanced stability, and adjustable performance. These advantageous attributes have captivated attention researchers, inspiring them to devise various Cu-based nanomaterials, such copper oxide, Cu metal-organic framework, CuS, explore potential in enzymatic catalysis. This comprehensive review encapsulates most recent advancements illuminating applications realm biochemistry. Initially, it is delved into emulation typical types achieved by nanomaterials. Subsequently, latest breakthroughs concerning nanozymes biochemical sensing, bacterial inhibition, cancer therapy, neurodegenerative diseases treatment discussed. Within this segment, also explored modulation nanozyme activity. Finally, a visionary outlook for future development presented.

Language: Английский

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Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(13), P. 8307 - 8472

Published: June 26, 2024

Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.

Language: Английский

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Electron Lock Manipulates the Catalytic Selectivity of Nanozyme

ACS Nano, Journal Year: 2024, Volume and Issue: 18(4), P. 3814 - 3825

Published: Jan. 17, 2024

Nanomaterials with enzyme-mimicking functions, termed nanozymes, offer attractive opportunities for biocatalysis and biomedicine. However, manipulating nanozyme selectivity poses an insurmountable hurdle. Here, we propose the concept of energy-governed electron lock that controls transfer between substrates to achieve manipulation enzyme-like catalysis. An can be constructed opened, via modulating nanozyme's energy match barrier enzymatic reactions. iron-doped carbon dot (FeCD) easy-to-regulate is selected as a proof concept. Through regulating conduction band which dominates energy, activatable oxidase selective peroxidase (POD) substrate affinity 123-fold higher than natural horseradish (HRP) achieved. Furthermore, while maintaining selectivity, FeCDs exhibit catalytic kinetics comparable HRP upon transforming photons into electrons. Superior efficient catalysis, undetectable biotoxicity energize potent targeted drugs on antibiotic-resistant bacterial abscesses. provides robust strategy manipulate toward advanced nanozymes.

Language: Английский

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2D Architectures-Transformed Conformational Nanoarchitectonics for Light-Augmented Nanocatalytic Chemodynamic and Photothermal/Photodynamic-Based Trimodal Therapies

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(4), P. 1160 - 1177

Published: Feb. 26, 2024

The complexity of the cancer microenvironment makes it highly challenging for drugs to meet therapeutic requirements, significantly hampering their clinical translation. enormous potential intelligent materials that can act as themselves results in development smart drugless or drug-like architectures, offering synergistic effects. In this study, we demonstrate generation transition metal-based dichalcogenides (TMDCs)-based conformational (flower-like) nanoarchitectonics trimodal therapies against breast carcinoma. Initially, progressive transformation two-dimensional (2D) molybdenum selenide (MoSe2)-based nanosheets into nanoflower-like architectures by thermal injection method is observed with time. Further, these flowers are subsequently decorated an optimal amount platinum (Pt) nanoparticles nanocatalytic efficacy and surface-modified polyethylene glycol (PEG) improved biocompatibility, shortly denoted Pt-MoSe2-PEG light-assisted photothermal (PTT) photodynamic (PDT), well light-augmented chemodynamic (CDT) modalities. A series physicochemical characterizations performance validations successfully demonstrated tumor (pH/GSH)-responsive degradable structures, substantially improving ability reactive oxygen species generation, MoSe2-based PTT/PDT capability, CDT Pt nanoenzymes. Finally, vitro vivo investigations 4T1 cell line its xenograft model BALB/C mice, respectively, validated toward ablating

Language: Английский

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An Enzyme‐Engineered Coppery Nanozyme for High‐Efficiency Mild Photothermal/Chemodynamic/Starvation Therapy Through Self‐Reinforcing Cancer Energy Metabolism Regulation

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(22)

Published: Feb. 5, 2024

Abstract Photothermal therapy (PTT) has a great prospect in further improving tumor therapeutic outcomes, whereas its efficiency is restrained by low light penetration, excessive heat damage to normal tissues, up‐regulated shock proteins (HSPs), and limited effect of single treatment. Herein, an enzyme‐engineered coppery nanozyme based on dendritic mesoporous carbon nanosphere as the cornerstone load with glucose oxidase (GOx) followed modification hyaluronic acid constructed. Density functional theory calculations indicate that obtained exhibits peroxidase glutathione mimicking activities improve hydroxyl radicals (•OH) production. Furthermore, both generation •OH production GOx‐induced energy supply blockade can reduce HSPs expression enhance mild PTT (η = 34.9 %) upon irradiation 1064 nm laser, turn, accelerate catalytic processes for more •OH. Last but not least, introduction copper induce lipoylated protein dihydrolipoamide S‐acetyltransferase aggregation cause cellular cuproptosis. Due synergy multiple therapies, inhibition rate reach 93.4%. Overall, this work provides effective strategy potential treatment basis synergistic therapies.

Language: Английский

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Trisulfide Bond‐Mediated Molecular Phototheranostic Platform for “Activatable” NIR‐II Imaging‐Guided Enhanced Gas/Chemo‐Hypothermal Photothermal Therapy

Advanced Science, Journal Year: 2023, Volume and Issue: 10(36)

Published: Nov. 20, 2023

Abstract Tumor microenvironment (TME)‐triggered phototheranostic platform offers a feasible strategy to improve cancer diagnosis accuracy and minimize treatment side effects. Developing stable biocompatible molecular for TME‐activated second near‐infrared (NIR‐II) fluorescence imaging‐guided multimodal cascade therapy is promising creating desirable anticancer agents. Herein, new NIR‐II activatable (IR‐FEP‐RGD‐S‐S‐S‐Fc) presented actively targeted tumor imaging hydrogen sulfide (H 2 S) gas‐enhanced chemodynamic‐hypothermal photothermal combined (CDT/HPTT). It revealed the first time that coupling distance between IR‐FE ferrocene proportional photoinduced electron transfer (PET), aqueous environment favorable PET generation. The part of Cyclic‐RGDfK (cRGDfk) peptides can target benefit endocytosis nanoparticles. high‐concentration glutathione (GSH) in TME will separate molecule by GSH‐sensitive trisulfide bond, realizing light‐up trimodal synergistic CDT/HPTT/gas (GT). In addition, accumulation hydroxyl radicals (•OH) down‐regulation peroxidase 4 (GPX4) produce excessive harmful lipid hydroperoxides, ultimately leading ferroptosis.

Language: Английский

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