Advances of nanoparticles as drug delivery systems for disease diagnosis and treatment

Chinese Chemical Letters, Journal Year: 2022, Volume and Issue: 34(2), P. 107518 - 107518

Published: May 14, 2022

Language: Английский

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Crossing the Blood-Brain Barrier: Advances in Nanoparticle Technology for Drug Delivery in Neuro-Oncology

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(8), P. 4153 - 4153

Published: April 9, 2022

The blood-brain barrier (BBB) constitutes a microvascular network responsible for excluding most drugs from the brain. Treatment of brain tumors is limited by impermeability BBB and, consequently, survival outcomes malignant remain poor. Nanoparticles (NPs) represent potential solution to improve drug transport tumors, given their small size and capacity target tumor cells. Here, we review unique physical chemical properties NPs that aid in discuss mechanisms NP across BBB, including paracellular transport, carrier-mediated adsorptive- receptor-mediated transcytosis. major types investigated treatment are detailed, polymeric NPs, liposomes, solid lipid dendrimers, metals, quantum dots, nanogels. In addition role delivery, can be used as imaging contrast agents conjugated with probes assist visualizing demarcating lesion boundaries margins, monitoring delivery response. Multifunctional designed capable targeting both therapeutic purposes. Finally, limitations discussed.

Language: Английский

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Ginsenoside Rg1 ameliorates blood–brain barrier disruption and traumatic brain injury via attenuating macrophages derived exosomes miR-21 release

Acta Pharmaceutica Sinica B, Journal Year: 2021, Volume and Issue: 11(11), P. 3493 - 3507

Published: March 20, 2021

During the traumatic brain injury (TBI), improved expression of circulatory miR-21 serves as a diagnostic feature. Low levels exosome-miR-21 in can effectively improve neuroinflammation and blood-brain barrier (BBB) permeability, reduce nerve apoptosis, restore neural function ameliorate TBI. We evaluated role macrophage derived exosomes-miR-21 (M-Exos-miR-21) disrupting BBB, deteriorating TBI, Rg1 interventions. IL-1β-induced macrophages (IIM)-Exos-miR-21 activate NF-κB signaling pathway induce expressions MMP-1, -3 -9 downregulate tight junction proteins (TJPs) BBB. reduced miR-21-5p content IIM-Exos (RIIM-Exos). The interaction NMIIA-HSP90 controlled release Exos-miR-21, this was restricted by Rg1. could inhibit Exos-miR-21 peripheral blood flow to brain, enhancing TIMP3 protein expression, MMPs proteolysis, restricting TJPs degradation thus protected BBB integrity. Conclusively, cerebrovascular endothelial hold therapeutic potential against TBI disease.

Language: Английский

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Brain co‐delivery of first‐line chemotherapy drug and epigenetic bromodomain inhibitor for multidimensional enhanced synergistic glioblastoma therapy

Exploration, Journal Year: 2022, Volume and Issue: 2(4)

Published: April 19, 2022

Glioblastoma (GBM) is a central nervous system tumor with poor prognosis due to the rapid development of resistance mono chemotherapy and brain targeted delivery. Chemoimmunotherapy (CIT) combines drugs activators innate immunity that hold great promise for GBM synergistic therapy. Herein, we chose temozolomide, TMZ, epigenetic bromodomain inhibitor, OTX015, further co-encapsulated them within our well-established erythrocyte membrane camouflaged nanoparticle yield ApoE peptide decorated biomimetic nanomedicine (ABNM@TMZ/OTX). Our nanoplatform successfully addressed limitations in brain-targeted drug co-delivery, simultaneously achieved multidimensional enhanced CIT. In mice bearing orthotopic GL261 GBM, treatment ABNM@TMZ/OTX resulted marked inhibition greatly extended survival time little side effects. The pronounced efficacy can be ascribed three key factors: (i) improved nanoparticle-mediated targeting delivery therapeutic agents by blood circulation blood-brain barrier penetration; (ii) inhibited cellular DNA repair TMZ sensitivity cells; (iii) anti-tumor immune responses inducing immunogenic cell death inhibiting PD-1/PD-L1 conjugation leading expression CD4

Language: Английский

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Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Language: Английский

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A BRD4 PROTAC nanodrug for glioma therapy via the intervention of tumor cells proliferation, apoptosis and M2 macrophages polarization

Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 12(6), P. 2658 - 2671

Published: Feb. 16, 2022

Glioma is a primary aggressive brain tumor with high recurrence rate. The poor efficiency of chemotherapeutic drugs crossing the blood‒brain barrier (BBB) well-known as one main challenges for anti-glioma therapy. Moreover, massive infiltrated tumor-associated macrophages (TAMs) in glioma further thwart drug efficacy. Herein, therapeutic nanosystem (SPP-ARV-825) constructed by incorporating BRD4-degrading proteolytic targeting chimera (PROTAC) ARV-825 into complex micelle (SPP) composed substance P (SP) peptide-modified poly(ethylene glycol)-poly(d,l-lactic acid)(SP-PEG-PDLLA) and methoxy acid) (mPEG-PDLLA, PP), which could penetrate BBB target tumor. Subsequently, released engenders antitumor effect via attenuating cells proliferation, inducing apoptosis suppressing M2 polarization through inhibition IRF4 promoter transcription phosphorylation STAT6, STAT3 AKT. Taken together, our work demonstrates versatile role efficacy SPP-ARV-825 against glioma, may provide novel strategy therapy future.

Language: Английский

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Biogenic Selenium Nanoparticles in Biomedical Sciences: Properties, Current Trends, Novel Opportunities and Emerging Challenges in Theranostic Nanomedicine

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(3), P. 424 - 424

Published: Jan. 19, 2023

Selenium is an important dietary supplement and essential trace element incorporated into selenoproteins with growth-modulating properties cytotoxic mechanisms of action. However, different compounds selenium usually possess a narrow nutritional or therapeutic window low degree absorption delicate safety margins, depending on the dose chemical form in which they are provided to organism. Hence, nanoparticles (SeNPs) emerging as novel diagnostic platform decreased toxicity capacity enhance biological Se-based compounds. Consistent exciting possibilities offered by nanotechnology diagnosis, treatment, prevention diseases, SeNPs useful tools current biomedical research exceptional benefits potential therapeutics, enhanced bioavailability, improved targeting, effectiveness against oxidative stress inflammation-mediated disorders. In view need for developing eco-friendly, inexpensive, simple, high-throughput agents that can also ally theranostic purposes exhibit negligible side effects, biogenic receiving special attention. The present manuscript aims be reference its kind providing readership thorough comprehensive review emphasizes current, yet expanding, field promise hold among selenium-derived products to, eventually, elicit future developments. First, recalls physiological importance oligo-element introduces unique biological, physicochemical, optoelectronic, catalytic Se nanomaterials. Then, it addresses significance nanosizing pharmacological activity (pharmacokinetics pharmacodynamics) cellular interactions SeNPs. Importantly, discusses detail role biosynthesized innovative personalized nanomedicine-based therapies. Finally, this explores ongoing context SARS-CoV-2 pandemic presents key prospects translational nanomedicine.

Language: Английский

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The Gut–Organ-Axis Concept: Advances the Application of Gut-on-Chip Technology

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 4089 - 4089

Published: Feb. 17, 2023

The intestine is considered to be a vital digestive organ absorb nutrients and the largest immune organ, while numerous microorganisms coexist with host. It well known that complex interactions between gut microbiota host’s system inevitably affect function of other organs, creating an “axis” them. During past few years, new technique based mainly on microfluidics cell biology has been developed emulate structure, function, microenvironment human gut, called “gut-on-chip”. This microfluidic chip provides insight into key aspects in health disease, such as gut–brain axis, gut–liver gut–kidney gut–lung axis. In this review, we first describe basic theory axis various composition parameter monitoring microarray systems, summarize development emerging advances gut–organ-on-chip, focus host-gut flora nutrient metabolism, highlight their role pathophysiological studies. addition, paper discusses challenges prospects for current further use gut–organ-on-chip platform.

Language: Английский

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Advances in Nanotechnology for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 1469 - 1495

Published: May 1, 2024

This manuscript offers a comprehensive overview of nanotechnology's impact on the solubility and bioavailability poorly soluble drugs, with focus BCS Class II IV drugs. We explore various nanoscale drug delivery systems (NDDSs), including lipid-based, polymer-based, nanoemulsions, nanogels, inorganic carriers. These offer improved efficacy, targeting, reduced side effects. Emphasizing crucial role nanoparticle size surface modifications, review discusses advancements in NDDSs for enhanced therapeutic outcomes. Challenges such as production cost safety are acknowledged, yet potential transforming methods is highlighted. contribution underscores importance nanotechnology pharmaceutical engineering, suggesting it significant advancement medical applications patient care.

Language: Английский

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Multifunctional Nanotheranostics for Overcoming the Blood–Brain Barrier

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(19)

Published: Jan. 4, 2024

Abstract The blood–brain barrier (BBB) is a tailored system of capillary endothelial cells intermixed with tight junctions and adherent that regulates the transport various materials substances between blood vasculature central nervous (CNS). However, in cases brain diseases, BBB's protective regulatory effects hamper therapeutics from reaching affected sites sufficient quantities. This has so far been leading challenge treating CNS diseases disorders. For this problem to be overcome, recent research sought develop novel modalities achieve efficient therapy alleviate associated symptoms. Therefore, numerous strategies have operated years address limitations traditional invasive methods, including poor penetration serious side effects. As desperately in‐demand technology, nanotheranostics particularly shown promising results. Herein, review reports advancements techniques nanotechnology‐based developed for neurodegenerative study provides comprehensive data on subject used future studies management disorders diseases.

Language: Английский

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