Journal of Affective Disorders Reports,
Journal Year:
2023,
Volume and Issue:
13, P. 100607 - 100607
Published: June 7, 2023
This
narrative
review
summarizes
key
aspects
of
vagus
nerve
function
as
a
main
player
in
the
microbiota-gut-brain
axis
depression.
Gut
microbes
well
their
metabolites
signal
directly
to
via
specialized
enteroendocrine
cells
called
"neuropods".
Some
gut
microbes,
such
Lactobacillus
rhamnosus,
do
not
exhibit
anti-anxiety
effects
animal
models
when
is
cut.
Furthermore,
correlates
with
microbiota
diversity,
and
short-chain
fatty
acid
producers,
Lactobacillales
Ruminococcaceae,
are
more
abundant
individuals
better
function.
The
activated
by
several
neurotransmitters
produced
regulates
cholinergic
anti-inflammatory
pathway
(CAIP),
which
attenuates
inflammation
decreases
intestinal
permeability,
may
be
relevant
inflammatory
subtype
Psychobiotics,
pre-,
pro
synbiotics,
on
behavior,
work
nerve,
could
used
enhance
its
More
research
microbiome
interactions
necessary
develop
targeted
psychobiotics
improve
for
optimal
mental
health.
Journal of Child Psychology and Psychiatry,
Journal Year:
2019,
Volume and Issue:
61(3), P. 353 - 371
Published: Nov. 26, 2019
The
gut
microbiota
is
a
vast,
complex,
and
fascinating
ecosystem
of
microorganisms
that
resides
in
the
human
gastrointestinal
tract.
As
an
integral
part
microbiota–gut–brain
axis,
it
now
being
recognized
modulator
brain
behavior,
across
species.
Intriguingly,
periods
change
coincide
with
development
other
body
systems
particularly
brain.
We
hypothesize
these
times
parallel
are
biologically
relevant,
corresponding
to
‘sensitive
periods’
or
‘critical
windows’
axis.
Specifically,
signals
from
during
hypothesized
be
crucial
for
establishing
appropriate
communication
along
axis
throughout
life
span.
In
words,
act
like
expected
input
calibrate
absence
disruption
specific
developmental
windows
would
therefore
have
disproportionate
effect
on
functions
potentially
regulation
system
as
whole.
Evidence
microbial
modulation
neurocognitive
neurodevelopmental
risk
discussed
light
this
hypothesis,
finishing
focus
challenges
lay
ahead
future
study
development.
Phytomedicine,
Journal Year:
2021,
Volume and Issue:
88, P. 153606 - 153606
Published: May 24, 2021
Depressive
symptoms
are
thought
to
promote
cancer
development
and
depressive
remission
has
been
reported
be
effective
for
defeating
cancer.
The
herbal
formula
Xiao-Chai-Hu-Tang
(XCHT),
that
an
anti-depressive
efficacy,
widely
utilized
in
China.
However,
its
anti-cancer
effect
underlying
mechanisms
remain
unclear.
Proceedings of the National Academy of Sciences,
Journal Year:
2023,
Volume and Issue:
120(30)
Published: July 18, 2023
Adversity
exposures
in
the
prenatal
and
postnatal
period
are
associated
with
an
increased
risk
for
psychopathology,
which
can
be
perpetuated
across
generations.
Nonhuman
animal
research
highlights
gut
microbiome
as
a
putative
biological
mechanism
underlying
such
generational
risks.
In
sample
of
450
mother–child
dyads
living
Singapore,
we
examined
associations
between
three
distinct
adversity
experienced
two
generations—maternal
childhood
maltreatment,
maternal
anxiety,
second-generation
children’s
exposure
to
stressful
life
events—and
composition
children
at
2
y
age.
We
found
differences
profiles
linked
each
exposure,
well
some
nonaffected
features
(e.g.,
beta
diversity).
Remarkably,
microbial
taxa
concurrent
prospective
child
socioemotional
functioning
shared
overlapping
functions
those
affected
by
adversity,
suggesting
that
intergenerational
transmission
may
have
lasting
impact
on
mental
health
via
alterations
functions.
Our
findings
open
up
new
avenue
into
mechanisms
risks
potential
target
intervention.
Stress,
Journal Year:
2024,
Volume and Issue:
27(1)
Published: Feb. 29, 2024
Despite
decades
of
stress
research,
there
still
exist
substantial
gaps
in
our
understanding
how
social,
environmental,
and
biological
factors
interact
combine
with
developmental
stressor
exposures,
cognitive
appraisals
stressors,
psychosocial
coping
processes
to
shape
individuals'
reactivity,
health,
disease
risk.
Relatively
new
profiling
approaches,
called
multi-omics,
are
helping
address
these
issues
by
enabling
researchers
quantify
thousands
molecules
from
a
single
blood
or
tissue
sample,
thus
providing
panoramic
snapshot
the
molecular
occurring
an
organism
systems
perspective.
In
this
review,
we
summarize
two
types
research
designs
for
which
multi-omics
approaches
best
suited,
describe
can
help
advance
development,
prevention,
treatment
stress-related
pathologies.
We
first
discuss
incorporating
into
theory-rich,
intensive
longitudinal
study
characterize,
high-resolution,
transition
multisystem
dysfunction
throughout
development.
Next,
should
be
incorporated
intervention
better
understand
back
inform
novel
precision
medicine
managing
fostering
biopsychosocial
resilience.
Throughout,
provide
concrete
recommendations
studies
that
will
translate
data
health
care.
Life,
Journal Year:
2024,
Volume and Issue:
14(10), P. 1234 - 1234
Published: Sept. 26, 2024
Microbes
have
inhabited
the
earth
for
hundreds
of
millions
years
longer
than
humans.
The
microbiota-gut-brain
axis
(MGBA)
represents
a
bidirectional
communication
pathway.
These
communications
occur
between
central
nervous
system
(CNS),
enteric
(ENS),
and
emotional
cognitive
centres
brain.
field
research
on
gut-brain
has
grown
significantly
during
past
two
decades.
Signalling
occurs
gut
microbiota
brain
through
neural,
endocrine,
immune,
humoral
pathways.
A
substantial
body
evidence
indicates
that
MGBA
plays
pivotal
role
in
various
neurological
diseases.
include
Alzheimer's
disease
(AD),
autism
spectrum
disorder
(ASD),
Rett
syndrome,
attention
deficit
hyperactivity
(ADHD),
non-Alzheimer's
neurodegeneration
dementias,
fronto-temporal
lobe
dementia
(FTLD),
Wilson-Konovalov
(WD),
multisystem
atrophy
(MSA),
Huntington's
chorea
(HC),
Parkinson's
(PD),
multiple
sclerosis
(MS),
amyotrophic
lateral
(ALS),
temporal
epilepsy
(TLE),
depression,
schizophrenia
(SCZ).
Furthermore,
correlation
therapeutics
will
be
discussed.
Conversely,
mood
delivery,
exercise,
psychotropic
agents,
stress,
neurologic
drugs
can
influence
MGBA.
By
understanding
MGBA,
it
may
possible
to
facilitate
into
microbial-based
interventions
therapeutic
strategies
