Circadian Effects of Drug Responses DOI Creative Commons
Yaakov Nahmias, Ioannis P. Androulakis

Annual Review of Biomedical Engineering, Journal Year: 2021, Volume and Issue: 23(1), P. 203 - 224

Published: March 31, 2021

Circadian rhythms describe physiological systems that repeat themselves with a cycle of approximately 24 h. Our understanding the cellular and molecular origins these oscillations has improved dramatically, allowing us to appreciate significant role play in maintaining homeostasis. allow living organisms predict efficiently respond dynamically changing environment, set by repetitive day/night cycles. Since circadian underlie almost every aspect human physiology, it is unsurprising they also influence response organism disease, stress, therapeutics. Therefore, not only do mechanisms maintain health disrupt homeostasis depend on our internal clock, but way drugs are perceived function depends rhythms. We present holistic view therapeutic process, discussing components such as disease state, pharmacokinetics, pharmacodynamics, well adverse reactions critically affected outline challenges opportunities moving toward personalized medicine approaches explore capitalize for benefit patient.

Language: Английский

Circadian rhythms: influence on physiology, pharmacology, and therapeutic interventions DOI Open Access

Vivaswath S. Ayyar,

Siddharth Sukumaran

Journal of Pharmacokinetics and Pharmacodynamics, Journal Year: 2021, Volume and Issue: 48(3), P. 321 - 338

Published: April 1, 2021

Language: Английский

Citations

119
Circadian rhythms and cancers: the intrinsic links and therapeutic potentials DOI Creative Commons
Li Zhou, Zhe Zhang, Edouard C. Nice

et al.

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: March 4, 2022

The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a wide variety of processes including sleep-wake cycles, eating-fasting and activity-rest coordinating the behavior physiology all organs for whole-body homeostasis. Acute disruption may lead to transient discomfort, whereas long-term irregular will result in dysfunction organism, therefore increasing risks numerous diseases especially cancers. Indeed, both epidemiological experimental evidence has demonstrated intrinsic link between dysregulated cancer. Accordingly, rapidly understanding molecular mechanisms rhythms opening new options cancer therapy, possibly by modulating clock. In this review, we first describe general regulators their functions on addition, provide insights into underlying how several types (including sleep-wake, eating-fasting, activity-rest) can drive progression, which expand our development from clock perspective. Moreover, also summarize potential applications treatment, optional therapeutic strategy patients.

Language: Английский

Citations

91
Dietary gallic acid as an antioxidant: A review of its food industry applications, health benefits, bioavailability, nano-delivery systems, and drug interactions DOI

Zedong Xiang,

Huida Guan, Xiang Zhao

et al.

Food Research International, Journal Year: 2024, Volume and Issue: 180, P. 114068 - 114068

Published: Jan. 29, 2024

Language: Английский

Citations

45
Shikonin, a naphthalene ingredient: Therapeutic actions, pharmacokinetics, toxicology, clinical trials and pharmaceutical researches DOI
Qiang Sun, Ting Gong,

Maolun Liu

et al.

Phytomedicine, Journal Year: 2021, Volume and Issue: 94, P. 153805 - 153805

Published: Oct. 25, 2021

Language: Английский

Citations

102
Circadian Rhythm, Clock Genes, and Hypertension: Recent Advances in Hypertension DOI Open Access
Hannah M. Costello, Michelle L. Gumz

Hypertension, Journal Year: 2021, Volume and Issue: 78(5), P. 1185 - 1196

Published: Oct. 4, 2021

Accumulating evidence suggests that the molecular circadian clock is crucial in blood pressure (BP) control. Circadian rhythms are controlled by central clock, which resides suprachiasmatic nucleus of hypothalamus and peripheral clocks throughout body. Both light food cues entrain these but whether important for rhythm BP a growing area interest. The smooth muscle, perivascular adipose tissue, liver, adrenal gland, kidney have been recently implicated regulation rhythm. Dysregulation associated with adverse cardiorenal outcomes increased risk cardiovascular mortality. In this review, we summarize most recent advances as regulators, highlight disrupted hypertension, provide insight into potential future work areas exploring control chronotherapy. A better understanding function regulating will help pave way targeted therapeutics treatment dysregulation hypertension.

Language: Английский

Citations

83
Chronotherapy: Circadian Rhythms and Their Influence in Cancer Therapy DOI Open Access
Ana Amiama-Roig, Eva M. Verdugo‐Sivianes, Amancio Carnero

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(20), P. 5071 - 5071

Published: Oct. 17, 2022

Living organisms present rhythmic fluctuations every 24 h in their behavior and metabolism to anticipate changes the environment. These are controlled by a very complex molecular mechanism, circadian clock, that regulates expression of multiple genes ensure right functioning body. An individual’s system is altered during aging, this related numerous age-associated pathologies other alterations could contribute development cancer. Nowadays, there an increasing interest understanding how rhythms be used treatment Chronotherapy aims understand impact biological have on response therapy optimize its action, maximize health benefits minimize possible adverse effects. Clinical trials so far confirmed optimal timing with chemo or immunotherapies decrease drug toxicity increase efficacy. Instead, chronoradiotherapy seems treatment-related symptoms rather than tumor progression patient survival. In addition, potential therapeutic targets within clock also been identified. Therefore, results application chronotherapy cancer until now challenging, feasible, applied clinical practice improve without additional costs. However, different limitations variables such as age, sex, chronotypes, among others, should overcome before can really put into practice.

Language: Английский

Citations

48
Updates in IDH-Wildtype Glioblastoma DOI Creative Commons
Jawad Melhem, Jay Detsky, Mary Jane Lim-Fat

et al.

Neurotherapeutics, Journal Year: 2022, Volume and Issue: 19(6), P. 1705 - 1723

Published: May 31, 2022

Language: Английский

Citations

47
Circadian rhythms in the blood–brain barrier: impact on neurological disorders and stress responses DOI Creative Commons
Nicolette Schurhoff, Michał Toborek

Molecular Brain, Journal Year: 2023, Volume and Issue: 16(1)

Published: Jan. 12, 2023

Circadian disruption has become more prevalent in society due to the increase shift work, sleep disruption, blue light exposure, and travel via different time zones. The circadian rhythm is a timed transcription-translation feedback loop with positive regulators, BMAL1 CLOCK, that interact negative CRY PER, regulate both central peripheral clocks. This review highlights functions of rhythm, specifically blood-brain barrier (BBB), during healthy pathological states. BBB highly selective dynamic interface composed CNS endothelial cells, astrocytes, pericytes, neurons, microglia form neurovascular unit (NVU). rhythms modulate integrity through regulating oscillations tight junction proteins, assisting NVU, modulating transporter functions. disruptions within have been observed stress responses several neurological disorders, including brain metastasis, epilepsy, Alzheimer's disease, Parkinson's disease. Further understanding these interactions may facilitate development improved treatment options preventative measures.

Language: Английский

Citations

40
“Time” for obesity-related cancer: The role of the circadian rhythm in cancer pathogenesis and treatment DOI Creative Commons
Caterina Miro, Annamaria Docimo, Luigi Barrea

et al.

Seminars in Cancer Biology, Journal Year: 2023, Volume and Issue: 91, P. 99 - 109

Published: March 7, 2023

The circadian rhythm is regulated by an intrinsic time-tracking system, composed both of a central and peripheral clock, which influences the cycles activities sleep individual over 24 h. At molecular level, begins when two basic helix-loop-helix/Per-ARNT-SIM (bHLH-PAS) proteins, BMAL-1 CLOCK, interact with each other to produce BMAL-1/CLOCK heterodimers in cytoplasm. target genes encode for repressor components cryptochrome (Cry1 Cry2) Period proteins (Per1, Per2 Per3). It has been recently demonstrated that disruption associated increased risk developing obesity obesity-related diseases. In addition, it plays key role tumorigenesis. Further, association between disruptions incidence progression several types cancer (e.g., breast, prostate, colorectal thyroid cancer) found. As perturbation adverse metabolic consequences obesity) at same time tumor promoter functions, this manuscript aim report how aberrant rhythms affect development prognosis different cancers (breast, colon rectal focusing on human studies aspects.

Language: Английский

Citations

34
Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy DOI Creative Commons
Françis Lévi, Alper Okyar, Éva Hadadi

et al.

The Annual Review of Pharmacology and Toxicology, Journal Year: 2023, Volume and Issue: 64(1), P. 89 - 114

Published: Sept. 19, 2023

Today's challenge for precision medicine involves the integration of impact molecular clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy. Meaningful improvements tolerability and/or medications through proper administration timing have been confirmed over past decade immunotherapy chemotherapy against cancer, as well commonly used pharmacological agents in cardiovascular, metabolic, inflammatory, neurological conditions. Experimental human studies recently revealed sexually dimorphic circadian responses. Dedicated randomized clinical trials should now aim to issue recommendations daily medical practice, integrating innovative technologies remote longitudinal monitoring metrics, statistical prediction clock function from single-timepoint biopsies, multiscale biorhythmic mathematical modelling. Importantly, chronofit patients with a robust function, who would benefit most chronotherapy, need be identified. Conversely, nonchronofit could emerging class chronobiotics targeting clock.

Language: Английский

Citations

32