Microfluidic technologies for nanoparticle formation DOI
Fei Tian, Lili Cai, Chao Liu

et al.

Lab on a Chip, Journal Year: 2021, Volume and Issue: 22(3), P. 512 - 529

Published: Nov. 1, 2021

Functional nanoparticles (NPs) hold immense promise in diverse fields due to their unique biological, chemical, and physical properties associated with size or morphology. Microfluidic technologies featuring precise fluid manipulation have become versatile toolkits for manufacturing NPs a highly controlled manner low batch-to-batch variability. In this review, we present the fundamentals of microfluidic fabrication strategies, including mixing-, droplet-, multiple field-based methods. We highlight formation functional using these reactors, an emphasis on lipid NPs, polymer lipid-polymer hybrid supramolecular metal metal-oxide metal-organic framework covalent organic quantum dots, perovskite nanocrystals, biomimetic etc. discuss future directions accelerated development such as device parallelization large-scale NP production, efficient optimization formulations, AI-guided design multi-step reactors.

Language: Английский

Lipid nanoparticles for siRNA delivery in cancer treatment DOI
Souhaila H. El Moukhtari, Elisa Garbayo, Ane Amundarain

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 361, P. 130 - 146

Published: Aug. 4, 2023

Language: Английский

Citations

69
A review on microfluidic-assisted nanoparticle synthesis, and their applications using multiscale simulation methods DOI Creative Commons
Abdulrahman Agha, Waqas Waheed, Ion Stiharu

et al.

Discover Nano, Journal Year: 2023, Volume and Issue: 18(1)

Published: Feb. 17, 2023

Abstract Recent years have witnessed an increased interest in the development of nanoparticles (NPs) owing to their potential use a wide variety biomedical applications, including drug delivery, imaging agents, gene therapy, and vaccines, where recently, lipid nanoparticle mRNA-based vaccines were developed prevent SARS-CoV-2 causing COVID-19. NPs typically fall into two broad categories: organic inorganic. Organic mainly include lipid-based polymer-based nanoparticles, such as liposomes, solid polymersomes, dendrimers, polymer micelles. Gold silver NPs, iron oxide quantum dots, carbon silica-based nanomaterials make up bulk inorganic NPs. These are prepared using top-down bottom-up approaches. Microfluidics provide attractive synthesis alternative is advantageous compared conventional methods. The microfluidic mixing-based production methods offer better control achieving desired size, morphology, shape, size distribution, surface properties synthesized technology also exhibits excellent process repeatability, fast handling, less sample usage, yields greater encapsulation efficiencies. In this article, we comprehensive review microfluidic-based passive active mixing techniques for NP synthesis, latest developments. Additionally, summary devices used presented. Nonetheless, despite significant advancements experimental procedures, complete details nanoparticle-based system cannot be deduced from experiments alone, thus, multiscale computer simulations utilized perform systematic investigations. work most common simulation unveiling critical mechanisms involved interaction with other entities, especially therapeutic systems. Finally, analysis provided on challenges microfluidics related future perspectives, large-scale hybrid formulations devices. Graphical abstract

Language: Английский

Citations

66
Lipid-core nanoparticles: Classification, preparation methods, routes of administration and recent advances in cancer treatment DOI Creative Commons
Pablo Graván, Aixa Aguilera-Garrido, Juan Antonio Marchal

et al.

Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 314, P. 102871 - 102871

Published: March 9, 2023

Nanotechnological drug delivery platforms represent a new paradigm for cancer therapeutics as they improve the pharmacokinetic profile and distribution of chemotherapeutic agents over conventional formulations. Among nanoparticles, lipid-based nanoplatforms possessing lipid core, that is, lipid-core nanoparticles (LCNPs), have gained increasing interest due to properties such high solubilizing potential, versatility, biocompatibility, biodegradability. However, wide spectrum morphologies types LCNPs, there is lack consensus regarding their terminology classification. According current state-of-the-art in this critical review, LCNPs are defined classified based on state lipidic components liquid (LLNs). These include nanoemulsions (LNEs) nanocapsules (LNCs), solid (SLNs) nanostructured nanocarriers (NLCs). In addition, we present comprehensive comparative description methods employed preparation, routes administration fundamental role physicochemical efficient antitumoral drug-delivery application. Market available clinical trials preclinical vivo studies promising potential treatments different pathologies summarized.

Language: Английский

Citations

66
Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines DOI Creative Commons
Sarah J. Shepherd, Xuexiang Han,

Alvin J. Mukalel

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(33)

Published: Aug. 9, 2023

Lipid nanoparticles (LNPs) are a potent delivery technology that have made it possible for the recent clinical breakthroughs in mRNA therapeutics and vaccines. A key challenge to broader implementation of vaccines is development produce precisely defined LNP formulations, with throughput can scale from discovery commercial manufacturing meet stringent standards pharmaceutical industry. To address these challenges, we developed microfluidic chip incorporates 1×, 10×, or 256× LNP-generating units achieve scalable production rates up 17 L/h LNPs. Using chips, demonstrate physical properties potency vivo unchanged as scaled. Our chips fabricated out silicon glass substrates, which excellent solvent compatibility, compatibility manufacturing, be fully reset reused. SARS-CoV-2 mRNA-LNP formulated by our triggered antibody responses preclinical study. These results feasibility directly translating microfluidic-generated LNPs necessary production.

Language: Английский

Citations

47
Lipid-based nanoparticles as drug delivery carriers for cancer therapy DOI Creative Commons

Ibtesam Waheed,

Anwar Ali, Huma Tabassum

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: April 10, 2024

Cancer is a severe disease that results in death all countries of the world. A nano-based drug delivery approach best alternative, directly targeting cancer tumor cells with improved cellular uptake. Different types nanoparticle-based carriers are advanced for treatment cancer, and to increase therapeutic effectiveness safety therapy, many substances have been looked into as carriers. Lipid-based nanoparticles (LBNPs) significantly attracted interest recently. These natural biomolecules alternate other polymers frequently recycled medicine due their amphipathic properties. Lipid typically provide variety benefits, including biocompatibility biodegradability. This review covers different classes LBNPs, characterization synthesis technologies. discusses most significant advancements lipid nanoparticle technology use administration. Moreover, also emphasized applications used types.

Language: Английский

Citations

33
Liposomes, transfersomes and niosomes: production methods and their applications in the vaccinal field DOI Creative Commons

Domenico Riccardi,

Lucia Baldino, Ernesto Reverchon

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 9, 2024

Abstract One of the most effective strategies to fight viruses and handle health diseases is vaccination. Recent studies current applications are moving on antigen, DNA RNA-based vaccines overcome limitations related conventional vaccination strategies, such as low safety, necessity multiple injection, side effects. However, due instability pristine RNA molecules, use nanocarriers required. Among different proposed for vaccinal applications, three types nanovesicles were selected analysed in this review: liposomes, transfersomes niosomes. PubMed, Scopus Google Scholar databases used searching recent papers frequently innovative methods production these nanovesicles. Weaknesses (i.e., post-processing, solvent residue, batch-mode processes) can be using methods, particular, ones assisted by supercritical carbon dioxide. SuperSomes process emerged a promising technique solvent-free nanovesicles, since it easily scaled-up, works continuous-mode, does not require further post-processing steps obtain desired products. As result literature analysis, dioxide attracted lot interest field. despite their numerous advantages, processes niosomes with aim reaching well-defined technologies suitable industrial mass vaccines.

Language: Английский

Citations

32
Advances and applications of nanoparticles in cancer therapy DOI Creative Commons

Xianzhou Huang,

Tao He, Xiuqi Liang

et al.

MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(1)

Published: March 1, 2024

Abstract Rapid growth in nanoparticles (NPs) as delivery systems holds vast promise to promote therapeutic approaches for cancer treatment. Presently, a diverse array of NPs with unique properties have been developed overcome different challenges and achieve sophisticated routes enhancement series therapies. Inspiring advances achieved the field therapy using NPs. In this review, we aim summarize up‐to‐date progression addressing various challenges, expect elicit novel potential opportunities alternatively. We first introduce sorts NP technologies, illustrate their mechanisms, present applications. Then, achievements made by break obstacles delivering cargoes specific sites through particular are highlighted, including long‐circulation, tumor targeting, responsive release, subcellular localization. subsequently retrospect recent research treatments from single therapy, like chemotherapy, combination chemoradiotherapy, integrative therapy. Finally, perspectives impact on oncology discussed. believe review can offer deeper understanding

Language: Английский

Citations

31
A comprehensive review on the fundamental principles, innovative designs, and multidisciplinary applications of micromixers DOI
Wenbo Han, Wei Li, Hongpeng Zhang

et al.

Physics of Fluids, Journal Year: 2024, Volume and Issue: 36(10)

Published: Oct. 1, 2024

This paper comprehensively reviews the fundamental principles, innovative designs, and multidisciplinary applications of micromixers. First, it introduces principles fluid mixing in micromixers, including passive active mechanisms, flow characteristics fluids at microscale. Subsequently, focuses on design covering a variety such as obstacle structures, curved serpentine groove separation recombination topology optimization baffle analyzes effects different structures efficiency pressure drop. In addition, also studies magnetic field assistance, electric surface acoustic wave thermal effect driving modes efficiency. Finally, outlines micromixers fields biomedicine, chemical analysis, environmental monitoring control, new energy. review aims to provide comprehensive reference for research application promote their more fields.

Language: Английский

Citations

31
Chemistry and Art of Developing Lipid Nanoparticles for Biologics Delivery: Focus on Development and Scale-Up DOI Creative Commons
Rijo John, Jasmin monpara, Shankar Swaminathan

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(1), P. 131 - 131

Published: Jan. 19, 2024

Lipid nanoparticles (LNPs) have gained prominence as primary carriers for delivering a diverse array of therapeutic agents. Biological products achieved solid presence in clinical settings, and the anticipation creating novel variants is increasing. These predominantly encompass proteins, nucleic acids messenger RNA. The advancement efficient LNP-based delivery systems biologics that can overcome their limitations remains highly favorable formulation strategy. Moreover, given small size, biocompatibility, biodegradation, LNPs proficiently transport moiety into cells without significant toxicity adverse reactions. This especially crucial existing upcoming biopharmaceuticals since large molecules group present several challenges be by LNPs. review describes LNP technology summarizes developments chemistry, manufacturing, characterization lipids used development biologics. Finally, we perspective on potential opportunities current pertaining to technology.

Language: Английский

Citations

29
Microfluidic synthesis of lipid-based nanoparticles for drug delivery: recent advances and opportunities DOI Open Access
Sima Mehraji, Don L. DeVoe

Lab on a Chip, Journal Year: 2024, Volume and Issue: 24(5), P. 1154 - 1174

Published: Jan. 1, 2024

The current landscape of microfluidic technologies for lipid nanoparticle production, size control, scaling, and nanomedicine post-processing is described in a review this evolving field.

Language: Английский

Citations

27