Super‐Elastic Carbonized Mushroom Aerogel for Management of Uncontrolled Hemorrhage

Advanced Science, Journal Year: 2023, Volume and Issue: 10(16)

Published: April 10, 2023

Abstract Uncontrolled hemorrhage is still the most common cause of potentially preventable death after trauma in prehospital settings. However, there rarely are hemostatic materials that can achieve safely and efficiently rapid hemostasis simultaneously. Here, new carbonized cellulose‐based aerogel material developed for management noncompressible torso hemorrhage, intractable issue uncontrolled hemorrhage. The cellulose derived from Agaricus bisporus a series processing, including cutting, carbonization, purification, freeze‐drying. In vitro, aerogels with porous structure show improved hydrophilicity, good blood absorption, coagulation ability, shape recoverable ability under wet conditions. And vivo, effective both small big animal serious models. amount loss time all better than positive control group. Moreover, mechanism studies reveal associated high hemoglobin binding efficiency, red cell platelets absorption activation. Together, this study could be promising

Language: Английский

---

The production of pH indicator Ca and Cu alginate ((1,4)- β -d-mannuronic acid and α -l-guluronic acid) cryogels containing anthocyanin obtained via red cabbage extraction for monitoring chicken fillet freshness

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 231, P. 123304 - 123304

Published: Jan. 19, 2023

Language: Английский

---

A self-healing hydrogel wound dressing based on oxidized Bletilla striata polysaccharide and cationic gelatin for skin trauma treatment

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 127189 - 127189

Published: Sept. 30, 2023

Language: Английский

---

Enhanced physiochemical, antibacterial, and hemostatic performance of collagen-quaternized chitosan-graphene oxide sponges for promoting infectious wound healing

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 131277 - 131277

Published: March 31, 2024

Bacteria-infected wound healing has attracted widespread attention in biomedical engineering. Wound dressing is a potential strategy for repairing infectious wounds. However, the development of with appropriate physiochemical, antibacterial, and hemostatic properties, remains challenging. Hence, there motivation to develop new synthetic dressings improve bacteria-infected healing. Here, we fabricate biocompatible sponge through covalent crosslinking collagen (Col), quaternized chitosan (QCS), graphene oxide (GO). The resulting Col-QCS-GO shows an elastic modulus 1.93-fold higher than Col due enhanced degree by GO incorporation. Moreover, fabricated favorable porosity (84.30 ± 3.12 %), water absorption/retention (2658.0 113.4 %/1114.0 65.7 hemostasis capacities (blood loss <50.0 mg). Furthermore, antibacterial property under near-infrared (NIR) irradiation significantly (the inhibition rates are 99.9 % S. aureus E. coli) inherent properties QCS photothermal capabilities GO. Finally, Col-QCS-GO+NIR exhibits lowest percentage area (9.05 1.42 %) at day 14 compared control group (31.61 1.76 %). This study provides insights developing innovative sponges

Language: Английский

---

The study of double-network carboxymethyl chitosan/sodium alginate based cryogels for rapid hemostasis in noncompressible hemorrhage

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 131399 - 131399

Published: April 18, 2024

Language: Английский

---

Robust 3D‐Printable, Injectable, and Adhesive Hydrogels with Stepwise‐Triggered Dual Reversible/Irreversible Covalent Linkages for Wound Healing

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Abstract The development of 3D‐printable and injectable biocompatible hydrogels with robust mechanical adhesive properties useful for biomedical applications remains a great challenge. Herein, stepwise‐triggered dual reversible/irreversible covalent linkages are engineered between two functionalized polymers, glycidyl methacrylate‐modified polyvinyl alcohol (PVA‐GMA) oxidized sodium alginate tailed 3‐aminophenylboronic acid (OSA‐PBA), allowing the availability PVA‐GMA/OSA‐PBA (PGOP) versatile functions. PGOP have excellent injectability, processability, strength (39.5 ± 2.3 kPa), self‐healing, elasticity toughness (80% compressive strain at 84.5 kPa stress), bioadhesion (34.2 2.7 to fresh pig skin, vs 7.3–15.38 commercial fibrin glue adhesives), degradability, antibacterial property, biocompatibility (265% cell survival fibroblasts co‐culture 5 d). With these merits, pregel can be applied as 3D‐printing construct materials produce diverse 3D hierarchical architectures high shape fidelity, good properties, active materials‐laden capacity. mouse liver hemorrhage model full‐thickness skin defect demonstrate that hemostatic ability accelerated wound healing Therefore, this work provides hydrogel adhesives favorable various such tissue engineering healing.

Language: Английский

---

A highly stretchable, adhesive, and antibacterial hydrogel with chitosan and tobramycin as dynamic cross-linkers for treating the infected diabetic wound

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 324, P. 121543 - 121543

Published: Nov. 2, 2023

Language: Английский

---

Multifunctional Regeneration Silicon‐Loaded Chitosan Hydrogels for MRSA‐Infected Diabetic Wound Healing

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 13(10)

Published: Nov. 13, 2023

Abstract Repeated microbial infection, excess reactive oxygen species (ROS) accumulation, cell dysfunction, and impaired angiogenesis under hyperglycemia severely inhibit diabetic wound healing. Therefore, developing multifunctional dressings accommodating the complex microenvironment of wounds is great significance. Here, a hydrogel (Regesi‐CS) prepared by loading regeneration silicon (Regesi) in non‐crosslinked chitosan (CS) solution, followed freeze‐drying hydration. As expected, blank CS (1%) shows antibacterial activity against Escherichia coli , Staphylococcus aureus methicillin‐resistant S. (MRSA), improves fibroblast migration, scavenges intracellular ROS. Interestingly, after 1% Regesi, Regesi‐CS (1%‐1%) greater activity, significantly promotes fibroblasts proliferation much more ROS, substantially protects oxidative stress, yet Regesi alone has no or even negative effects. In MRSA‐infected model, effectively healing eliminating bacterial enhancing granulation tissue formation, promoting collagen deposition, improving angiogenesis. conclusion, may be potential dressing for effective treatment management chronic wounds.

Language: Английский

---

Gallic acid-modified bioglass with combined photothermal and antibacterial effects for the regeneration of infected diabetic wound

Composites Part B Engineering, Journal Year: 2023, Volume and Issue: 257, P. 110668 - 110668

Published: March 20, 2023

Language: Английский

---

Sodium hyaluronate hydrogel for wound healing and human health monitoring based on deep eutectic solvent

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 257, P. 128801 - 128801

Published: Dec. 13, 2023

Language: Английский

---