Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162723 - 162723
Published: April 1, 2025
Language: Английский
ACS Applied Nano Materials, Journal Year: 2023, Volume and Issue: 6(15), P. 13792 - 13823
Published: July 3, 2023
Nanomaterials that can mimic the activity of various enzymes have been studied extensively in biomedical field recent years. Nanozymes offer better stability and economic value comparison to natural enzymes. Additionally, nanozymes characteristics nanomaterials, such as photothermal properties designability, therefore considerable potential. The cellular microenvironment provides basis for maintaining normal cell growth function. Increasing evidence shows imbalances homeostasis constitute a major factor development many diseases. received attention years regulators microenvironment. In this Review, research on use remodel disease is discussed. First, definition, classification, enzyme-like activities are introduced; several microenvironments summarized including tumor, inflammatory, trauma microenvironments. role main strategies constructing intelligent responsive nanozyme systems specific applications remodeling diseased highlighted. Finally, therapeutic prospected. Nanozyme expected become strategy or an adjunct prevention treatment related
Language: Английский
Citations
17
Chemistry of Materials, Journal Year: 2024, Volume and Issue: 36(3), P. 1088 - 1112
Published: Jan. 29, 2024
Cancer immunotherapy, aimed at reinvigorating the immune system to induce a lasting anticancer response, has emerged as promising approach for counteracting evasive tactics of cancer cells. This study delves into innovative realm stimuli-responsive polymeric nanomedicines in context immunotherapy. By capitalizing on intricate landscape tumor microenvironment (TME), which orchestrates suppression and progression, offer tailored strategy enhance therapeutic interventions. The aberrant features TME, include factors such low pH, inflammation, oxidative stress, enzyme overexpression, serve triggers intelligent delivery systems facilitated by functional polymers. dynamic potential overcome challenges faced traditional nanoparticle-based immunotherapy techniques, presenting platform precisely optimize drug within locale. As synergistic interaction between TME unfolds, novel horizon emerges advance efficacy while mitigating its associated limitations.
Language: Английский
Citations
8
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 665, P. 1065 - 1078
Published: March 29, 2024
Language: Английский
Citations
8
Biomaterials Research, Journal Year: 2024, Volume and Issue: 28
Published: Jan. 1, 2024
It is urgent to develop an alternative dynamic therapy-based method overcome the limited efficacy of traditional therapy methods for bladder cancer and damage caused patients. Sonodynamic (SDT) has advantages high tissue penetration, spatiotemporal selectivity, being non-invasive, representing emerging eradicating deep solid tumors. However, effectiveness SDT often hindered by inefficient production reactive oxygen species nondegradability sonosensitizer. To improve anti-tumor effect on cancer, herein, a BP-based heterojunction sonosensitizer (BFeSe 2 ) was synthesized anchoring FeSe onto BP via P–Se bonding enhance stability SDT. As result, BFeSe showed great cytotoxicity cells under ultrasound (US) irradiation. led notable inhibition tumor growth in subcutaneous models orthotopic US In addition, could also T2-weighted magnetic resonance imaging (MRI) achieve monitoring guide treatment cancer. general, integrates MRI functions precise treatment, promising clinical potential theranostics
Language: Английский
Citations
6
Aggregate, Journal Year: 2024, Volume and Issue: 5(5)
Published: May 10, 2024
Abstract With the development of aggregation‐induced emission (AIE) materials, drawbacks conventional fluorescence materials subjected to aggregation‐caused quenching (ACQ) have been resolved. This has allowed for improvement novel AIE fluorescent that exhibit enhanced photostability, a higher signal‐to‐noise ratio, and better imaging quality. Meanwhile, phototherapeutic effect garnered widespread attention in realm tumor treatment. The distinct physiological anatomical characteristics urinary system make it suitable use materials. Additionally, AIE‐based phototherapy provides superior solution deal with weaknesses treatments urologic neoplasms. In this review, scientific advancement on diseases since emergence concept is reviewed detail. review highlights promise biomarkers detection, (FLI) vivo vitro, phototherapy, synergistic therapy from both diagnostic therapeutic viewpoints. It firmly believed hold immense untapped potential diagnosis treatment disease, as well all human body.
Language: Английский
Citations
6
Nano Today, Journal Year: 2024, Volume and Issue: 57, P. 102386 - 102386
Published: July 13, 2024
Language: Английский
Citations
6
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(10), P. 2490 - 2490
Published: Oct. 19, 2023
Bacteria and bacterial components possess multifunctional properties, making them attractive natural bio-nanocarriers for cancer diagnosis targeted treatment. The inherent tropic motile nature of bacteria allows to grow colonize in hypoxic tumor microenvironments more readily than conventional therapeutic agents other nanomedicines. However, concerns over biosafety, limited antitumor efficiency, unclear tumor-targeting mechanisms have restricted the clinical translation application based on components. Fortunately, therapies combined with engineering strategies nanotechnology may be able reverse a number challenges bacterial/bacterial component-based biotherapies. Meanwhile, tend enhance versatility bionanoplasmic nanoplatforms improve biosafety inhibit tumorigenesis metastasis. This review summarizes advantages therapy, outlines combinatorial nanocarriers components, discusses their applications.
Language: Английский
Citations
16
Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 366, P. 142 - 159
Published: Dec. 30, 2023
Language: Английский
Citations
11
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 663, P. 1064 - 1073
Published: March 4, 2024
Language: Английский
Citations
4
Nanoscale, Journal Year: 2024, Volume and Issue: 16(21), P. 10273 - 10282
Published: Jan. 1, 2024
Intravesical instillation is the common therapeutic strategy for bladder cancer. Besides chemo drugs, nanoparticles are used as intravesical reagents, offering appealing approaches cancer treatment. Metal oxide nanoparticle based chemodynamic therapy (CDT) converts tumor intracellular hydrogen peroxide to ROS with cell-specific toxicity, which makes it a promising approach of However, limited penetration agents into mucosa layer wall poses great challenge clinical application CDT in instillation. Herein, we developed 1064 nm NIR-II light driven hydrogel nanomotor via The was synthesized microfluidics, wrapped lipid bilayer, and encapsulates CuO2 reagent core-shell structured Fe3O4@Cu9S8 fuel asymmetric distribution (LipGel-NM). An irradiation drives active motion LipGel-NMs, thus facilitating their deep wall. After FA-mediated endocytosis cells, released from LipGel-NMs due acidic environment CDT. powered effectively enhances CDT, providing therapy.
Language: Английский
Citations
4