Current potential therapeutic strategies targeting the TGF-β/Smad signaling pathway to attenuate keloid and hypertrophic scar formation

Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 129, P. 110287 - 110287

Published: June 12, 2020

Aberrant scar formation, which includes keloid and hypertrophic scars, is associated with a pathological disorganized wound healing process chronic inflammation. The TGF-β/Smad signaling pathway the most canonical through formation of collagen in fibroblasts myofibroblasts regulated. Sustained activation results long-term overactivation myofibroblasts, necessary for excessive aberrant scars. There are two categories therapeutic strategies that aim to target interfere their cellular functions reduce cell proliferation. first strategy medications, second composed genetic therapeutics. Therefore, focus this review critically evaluate these main attenuate abnormal skin formation.

Language: Английский

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Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics

Journal of Clinical Medicine, Journal Year: 2020, Volume and Issue: 9(4), P. 1061 - 1061

Published: April 8, 2020

Among the major neurodegenerative disorders (NDDs), Alzheimer’s disease (AD) and Parkinson’s (PD), are a huge socioeconomic burden. Over many centuries, people have sought cure for NDDs from natural herbals. Many medicinal plants their secondary metabolites reported with ability to alleviate symptoms of NDDs. The mechanisms identified, through which phytochemicals exert neuroprotective effects potential maintenance neurological health in ageing, include antioxidant, anti-inflammatory, antithrombotic, antiapoptotic, acetylcholinesterase monoamine oxidase inhibition neurotrophic activities. This article reviews action some herbal products treatment according molecular targets, as well regional sources (Asia, America Africa). A number studies demonstrated beneficial properties plant extracts or bioactive compounds against Herbal may potentially offer new options patients NDDs, is cheaper culturally suitable alternative conventional therapies millions world age-related

Language: Английский

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Polyphenols: A first evidence in the synergism and bioactivities

Food Reviews International, Journal Year: 2022, Volume and Issue: 39(7), P. 4419 - 4441

Published: Jan. 24, 2022

Polyphenols are natural compounds and the most plentiful with synergistic properties contributing to potential health benefits. This review describes interactions of polyphenolic compounds; as yet, no literature has been undertaken consider experimental evidence effects polyphenols. The claimed have activities highly effective against oxidation, peptic ulcers, myocardial infarction, tumors, a variety other conditions. In addition, anticancer activity via apoptosis antibacterial, antifungal, anti-inflammatory, estrogenic behaviors also reported. Apart from polyphenols, this illustrates their specific benefits too bioavailability in humans. toxicity some agents, including antinutritional effects, chronic nephrotoxicity, reduction net protein utilization antiluteinizing hormone, tumor development, is evaluated. Synergistic treatment approaches may be many diseases. These findings provide information about polyphenol combination, which could useful for future studies.

Language: Английский

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Neuroprotective and Cognitive Enhancement Potentials of Baicalin: A Review

Brain Sciences, Journal Year: 2018, Volume and Issue: 8(6), P. 104 - 104

Published: June 11, 2018

Neurodegenerative diseases are a heterogeneous group of disorders that characterized by the gradual loss neurons. The development effective neuroprotective agents to prevent and control neurodegenerative is specifically important. Recently, there has been an increasing interest in selecting flavonoid compounds as potential agents, owing their high effectiveness with low side effects. Baicalin one important compounds, which mainly isolated from root Scutellaria baicalensis Georgi (an Chinese medicinal herb). In recent years, number studies have shown baicalin potent effect various vitro vivo models neuronal injury. particular, effectively prevents through pharmacological mechanisms, including antioxidative stress, anti-excitotoxicity, anti-apoptotic, anti-inflammatory, stimulating neurogenesis, promoting expression protective factors, etc. This review focuses on cognitive enhancement effects baicalin. aim present compile all information relation its molecular mechanisms action experimental models.

Language: Английский

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Matrine: A Promising Natural Product With Various Pharmacological Activities

Frontiers in Pharmacology, Journal Year: 2020, Volume and Issue: 11

Published: May 7, 2020

Matrine is an alkaloid isolated from the traditional Chinese medicine Sophora flavescens Aiton. At present, a large number of studies have proved that matrine has anticancer effect can inhibit cancer cell proliferation, arrest cycle, induce apoptosis, and metastasis. It also reversing drug resistance reducing toxicity drugs. In addition, reported therapeutic on Alzheimer's syndrome, encephalomyelitis, asthma, myocardial ischemia, rheumatoid arthritis, osteoporosis, like, its mechanism mainly related to inhibition inflammatory response apoptosis. Its treatable disease spectrum spans multiple systems such as nervous system, circulatory immune system. The antidisease are diverse, so it high research value. This review summarizes recent pharmacological matrine, with view providing reference for subsequent research.

Language: Английский

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Production of plant-specific flavones baicalein and scutellarein in an engineered E. coli from available phenylalanine and tyrosine

Metabolic Engineering, Journal Year: 2018, Volume and Issue: 52, P. 124 - 133

Published: Nov. 26, 2018

Language: Английский

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Control of Reactive Oxygen Species for the Prevention of Parkinson’s Disease: The Possible Application of Flavonoids

Antioxidants, Journal Year: 2020, Volume and Issue: 9(7), P. 583 - 583

Published: July 3, 2020

Oxidative stress reflects an imbalance between the production of reactive oxygen species (ROS) and antioxidant defense systems, it can be associated with pathogenesis progression neurodegenerative diseases such as multiple sclerosis, stroke, Parkinson's disease (PD). The application antioxidants, which defend against oxidative stress, is able to detoxify intermediates prevent neurodegeneration resulting from excessive ROS production. There are many reports showing that numerous flavonoids, a large group natural phenolic compounds, act antioxidants flavonoids has beneficial effects in adult brain. For instance, well known long-term consumption green tea-derived catechin epigallocatechin gallate (EGCG) attenuate onset PD. Also, ampelopsin pinocembrin inhibit mitochondrial dysfunction neuronal death through regulation gene expression nuclear factor erythroid 2-related 2 (Nrf2) pathway. Additionally, established exhibit anti-apoptosis anti-inflammatory cellular signaling pathways, those involving (ERK), glycogen synthase kinase-3β (GSK-3β), (Akt), neuroprotection. In this review article, we have described involved PD explained therapeutic potential protect nigrostriatal DA system, may useful

Language: Английский

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An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways.

PubMed, Journal Year: 2022, Volume and Issue: 25(1), P. 14 - 26

Published: Jan. 1, 2022

The flavonoids, baicalin, and its aglycone baicalein possess multi-fold therapeutic properties are mainly found in the roots of Oroxylum indicum (L.) Kurz Scutellaria baicalensis Georgi. These flavonoids have been reported to various pharmacological properties, including antibacterial, antiviral, anticancer, anticonvulsant, anti-oxidant, hepatoprotective, neuroprotective effects. baicalin due their abilities scavenge reactive oxygen species (ROS) interaction with signaling molecules associated apoptosis, inflammation, autophagy, cell cycle, mitochondrial dynamics, cytoprotection. In this review, we summarized molecular mechanisms underlying chemopreventive chemotherapeutic applications treatment cancer inflammatory diseases. addition, preventive effects on dynamics functions were highlighted a particular emphasis anti-oxidative cytoprotective properties. current review highlights could be useful for future prospective studies further improve baicalin. should define threshold optimal drug exposure, dose optimization focus monitoring, objective disease markers, baicalin/baicalein levels.

Language: Английский

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Baicalein protects against MPP+/MPTP-induced neurotoxicity by ameliorating oxidative stress in SH-SY5Y cells and mouse model of Parkinson’s disease

NeuroToxicology, Journal Year: 2021, Volume and Issue: 87, P. 188 - 194

Published: Oct. 18, 2021

Baicalein, a major bioactive flavone constituent isolated from Scutellaria baicalensis Georgi, has neuroprotective properties in several neurological disorders. Many studies suggest that oxidative stress plays central role the pathogenesis of Parkinson's disease (PD). Baicalein also been shown to have antioxidant effects. Therefore, current study was designed investigate whether baicalein could protect against MPP+/MPTP-induced neurotoxicity via suppressing vitro and vivo. In vitro, our results showed increased cell viability MPP+-treated SH-SY5Y cells. Treatment with reversed MDA ROS levels, decreased GSH levels MPTP-treated mice, ameliorated MPTP-induced motor impairment suppressed accumulation iron lipid peroxides. Besides, improved induced by MPTP as seen significant raise tyrosine hydroxylase (TH) simultaneous decrease monoamine-oxidase-B (MAO-B). The inhibitory effect on probably partially governed inhibition ERK activation. conclusion, prevent stress.

Language: Английский

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Enzymatic Metabolism of Flavonoids by Gut Microbiota and Its Impact on Gastrointestinal Cancer

Cancers, Journal Year: 2021, Volume and Issue: 13(16), P. 3934 - 3934

Published: Aug. 4, 2021

Gastrointestinal (GI) cancer is a prevalent global health disease with massive burden on care providers. Internal and external factors such as obesity, smoking, diet (red meat), low socioeconomic status infection Helicobacter pylori are the critical risk of GI cancers. Flavonoids natural phenolic compounds found abundantly in fruits vegetables. Upon ingestion, 90% flavonoids consumed require further enzymatic metabolism by gut microbiome to enhance their bioavailability absorption. Several epidemiological studies reported that consumption conversion microbes strongly associated reduced development. This review summarizes current knowledge human microbiome. It also addresses underlying anti-GI effects metabolic pathways apoptosis cellular proliferation. Overall, metabolites produced from flavonoid’s illustrate effects, but mechanisms action need clarification.

Language: Английский

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