Biomarkers of oxidative stress, inflammation, and genotoxicity to assess exposure to micro- and nanoplastics. A literature review DOI Creative Commons
Marco Panizzolo,

Vitor Hugo da Silva Martins,

Federica Ghelli

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 267, P. 115645 - 115645

Published: Nov. 1, 2023

The increased awareness about possible health effects arising from micro- and nanoplastics (MNPs) pollution is driving a huge amount of studies. Many international efforts are in place to better understand characterize the hazard MNPs present environment. literature search was performed according Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) methodology two different databases (PubMed Embase). selection articles carried out blind, screening titles abstracts inclusion exclusion criteria. In general, these studies rely on already use assessing nanomaterials particles concern. However, only limited number have so far directly measured human exposure examined relationship between such its impact health. This review aims provide an overview current state research biomarkers oxidative stress, inflammation, genotoxicity that been explored relation exposure, using human, cellular, animal, plant models. Both in-vitro in-vivo models suggest level stress inflammation as main mechanism action (MOA) leading adverse chronic immunotoxicity genotoxicity. With identification biological endpoints, representing critical key initiating events (KIEs) towards adaptive or outcomes, it identify panel surrogate be applied validated especially occupational settings, where higher levels may occur.

Language: Английский

Polystyrene micro- and nanoparticles exposure induced anxiety-like behaviors, gut microbiota dysbiosis and metabolism disorder in adult mice DOI Creative Commons
Xuebing Chen,

Luyao Xu,

Qianling Chen

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 259, P. 115000 - 115000

Published: May 19, 2023

Plastics have been proven to be a potential threat the ecosystem, and their toxicity mechanism is still uncertain. In ecological environment, plastics can degraded into microplastics (MPs) nanoplastics (NPs), which contaminated ingested through food chain. MPs NPs are associated with severe intestinal injury, microbiota disorder, neurotoxicity, but it unclear whether MPs- NPs-induced dysbiosis will affect brain gut-brain axis. current study, we determined effects of exposure polystyrene (PS)-MPs PS-NPs on anxiety-like behaviors explored underlying mechanisms. This study behavioral 30-day 60-day PS-MPs using open field test (OFT) elevated plus maze (EPM) test. Behavioral tests showed treatment remarkedly induced compared control group. Using 16 S rRNA gene sequencing untargeted metabolomics analyses, observed that reduced beneficial gut expression level, such as Lachnoclostridium Lactobacillus, increased conditionally pathogenic bacteria expressions Proteobacteria, Actinobacteria, Desulfovibrio. addition, reduce mucus secretion increase permeability. The results serum metabonomics suggested metabolic pathways, ABC transporter aminoacyl-tRNA biosynthesis, biosynthesis amino acids, bile were enriched after treatment. Besides, neurotransmitter metabolites also altered by PS-MPs. It noteworthy correlation analysis disorder was related disorder. regulation may promising strategy for PS-MPs- PS-NPs-induced anxiety

Language: Английский

Citations

38
The Warburg Effect Explained: Integration of Enhanced Glycolysis with Heterogeneous Mitochondria to Promote Cancer Cell Proliferation DOI Open Access
Lilia Alberghina

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15787 - 15787

Published: Oct. 31, 2023

The Warburg effect is the long-standing riddle of cancer biology. How does aerobic glycolysis, inefficient in producing ATP, confer a growth advantage to cells? A new evaluation large set literature findings covering and its yeast counterpart, Crabtree effect, led an innovative working hypothesis presented here. It holds that enhanced glycolysis partially inactivates oxidative phosphorylation induce functional rewiring TCA cycle enzymes generate non-canonical metabolic pathways sustain faster rates. has been structured by constructing two maps, one for metabolism other effect. New lines investigation, suggested these are discussed as instrumental leading toward better understanding biology order allow development more efficient metabolism-targeted anticancer drugs.

Language: Английский

Citations

33
Micro- and nanoplastics (MNPs) and their potential toxicological outcomes: State of science, knowledge gaps and research needs DOI Creative Commons

Zhenning Yang,

Glen M. DeLoid,

Helmut Zarbl

et al.

NanoImpact, Journal Year: 2023, Volume and Issue: 32, P. 100481 - 100481

Published: Sept. 16, 2023

Language: Английский

Citations

30
The detrimental effects of micro-and nano-plastics on digestive system: An overview of oxidative stress-related adverse outcome pathway DOI

Ruiyang Ding,

Yiming Ma, Tianyu Li

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 878, P. 163144 - 163144

Published: March 30, 2023

Language: Английский

Citations

27
Microplastic pollution and associated health hazards: Impact of COVID-19 pandemic DOI Open Access
Bikash R. Tiwari, Joanna Lecka, Rama Pulicharla

et al.

Current Opinion in Environmental Science & Health, Journal Year: 2023, Volume and Issue: 34, P. 100480 - 100480

Published: May 15, 2023

Language: Английский

Citations

24
Cellular and bioenergetic effects of polystyrene microplastic in function of cell type, differentiation status and post-exposure time DOI
Miao Peng, Maaike Vercauteren, Charlotte Grootaert

et al.

Environmental Pollution, Journal Year: 2023, Volume and Issue: 337, P. 122550 - 122550

Published: Sept. 15, 2023

Language: Английский

Citations

23
Molecular and Cellular Effects of Microplastics and Nanoplastics: Focus on Inflammation and Senescence DOI Creative Commons

Faiza Mahmud,

Drishty B. Sarker,

Jonathan A. Jocelyn

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(21), P. 1788 - 1788

Published: Oct. 29, 2024

Microplastics and nanoplastics (MNPs) are ubiquitous environmental contaminants. Their prevalence, persistence, increasing industrial production have led to questions about their long-term impact on human animal health. This narrative review describes the effects of MNPs oxidative stress, inflammation, aging. Exposure leads increased reactive oxygen species (ROS) across multiple experimental models, including cell lines, organoids, systems. ROS can cause damage cellular macromolecules such as DNA, proteins, lipids. Direct interaction between immune cells or an indirect result stress-mediated may lead pro-inflammatory cytokines throughout different MNP-exposure conditions. inflammatory response is a common feature in pathogenesis neurodegenerative, cardiovascular, other age-related diseases. also act senescence inducers by promoting mitochondrial dysfunction, impairing autophagy, activating DNA responses, exacerbating aging altogether. Increased reproductive transfer MNPs/induced damages from parents offspring animals further corroborates transgenerational health risks tiny particles. aims provoke deeper investigation into notorious these pervasive particles well-being longevity.

Language: Английский

Citations

11
Ingested Polystyrene Micro-Nanoplastics Increase the Absorption of Co-Ingested Arsenic and Boscalid in an In Vitro Triculture Small Intestinal Epithelium Model DOI Creative Commons
Davood Kharaghani, Glen M. DeLoid, Trung Huu Bui

et al.

Microplastics, Journal Year: 2025, Volume and Issue: 4(1), P. 4 - 4

Published: Jan. 7, 2025

Micro-nano plastics (MNPs) are emerging environmental and food contaminants that raising serious health concerns. Due to the polycontamination of web with pollutants (EPs), now MNPs, co-ingestion EPs MNPs is likely occur, potential synergistic effects such co-ingestions completely unstudied. In this study, we therefore sought determine two model EPs, arsenic boscalid, on uptake toxicity 25 1000 nm polystyrene (PS-25 PS-1000), vice versa, employing a triculture small intestinal epithelium combined simulated digestion. 24 h exposures, neither nor + caused significant toxicity. The presence PS-25 significantly increased (from 0.0 5.8%, p < 0.001) translocation 5.2 9.8%, 0.05) but had no effect boscalid or translocation, whereas PS-1000 either EP. both PS was also by rising from 10.6 19.5% (p 0.01) for 4.8 8.5% PS-1000. These findings highlight need further studies assess MNP-EP interactions possible adverse impacts.

Language: Английский

Citations

1
Microplastic Contamination of Chicken Meat and Fish through Plastic Cutting Boards DOI Open Access

Rana Zeeshan Habib,

Ruwaya Al Kindi,

Feras Al Salem

et al.

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(20), P. 13442 - 13442

Published: Oct. 18, 2022

Microplastic contamination was found in fish and chicken bought on the market, food stores chain supermarkets Middle East with ranging from 0.03 ± 0.04 to 1.19 0.72 particles per gram of meat 0.014 0.024 2.6 2.8 fish. Only one be free microplastic. The source microplastic established polythene-based plastic cutting board cut on. More bone than fillets when themselves were prepared surfaces other plastic. Washing before preparation decreased but did not completely remove contamination. fate grilled studied. mechanical properties typical boards commercially used markets investigated form tensile, hardness, wear tests. Overall, showed similar rates.

Language: Английский

Citations

36
Efficient removal of polyamide particles from wastewater by electrocoagulation DOI
Yu Hu, Li Zhou, Jia Zhu

et al.

Journal of Water Process Engineering, Journal Year: 2022, Volume and Issue: 51, P. 103417 - 103417

Published: Dec. 14, 2022

Language: Английский

Citations

34