Therapeutic Advances in Respiratory Disease,
Journal Year:
2023,
Volume and Issue:
17
Published: Jan. 1, 2023
N-acetylcysteine
(NAC)
may
reduce
acute
exacerbations
of
chronic
obstructive
pulmonary
disease
through
an
antioxidant
effect.
Due
to
the
heterogeneity
in
studies,
currently
available
data
do
not
confirm
efficacy
oral
NAC
therapy
patients.
We
hypothesize
that
patients
receiving
regular
achieve
improved
clinical
outcomes.The
purpose
this
meta-analysis
was
determine
long-term
patients.The
literature
search
performed
using
PubMed,
Web
Science,
and
Cochrane
Library
databases
identify
all
included
studies.
Studies
were
eligible
for
inclusion
only
if
they
directly
compared
outcomes
versus
placebo
adults
with
between
1
January
2000
30
May
2022.
All
studies
reported
one
or
more
following
outcomes:
number
no
exacerbations,
forced
expiratory
volume
s
(FEV1),
vital
capacity
(FVC),
St
George's
Respiratory
Questionnaire
score,
glutathione
level,
adverse
events.Nine
randomized
controlled
trials
meta-analysis.
There
1061
group
1076
group.
The
current
provides
evidence
(965
therapy,
979
control
patients),
change
FEV1
(433
447
FVC
(177
180
score
(128
131
levels
(38
40
events
(832
846
patients)
significantly
different
two
groups.NAC
did
risk
exacerbation
ameliorate
decline
lung
Molecules,
Journal Year:
2019,
Volume and Issue:
24(11), P. 2047 - 2047
Published: May 29, 2019
Researchers
are
continuing
to
discover
all
the
properties
of
propolis
due
its
complex
composition
and
associated
broad
spectrum
activities.
This
review
aims
characterize
latest
scientific
reports
in
field
antibacterial
activity
this
substance.
The
results
studies
on
influence
more
than
600
bacterial
strains
were
analyzed.
greater
against
Gram-positive
bacteria
Gram-negative
was
confirmed.
Moreover,
antimicrobial
from
different
regions
world
compared.
As
a
result,
high
Middle
East
found
relation
both,
(Staphylococcus
aureus)
(Escherichia
coli)
strains.
Simultaneously,
lowest
demonstrated
for
samples
Germany,
Ireland
Korea.
Saudi Journal of Biological Sciences,
Journal Year:
2018,
Volume and Issue:
26(7), P. 1695 - 1703
Published: Aug. 17, 2018
Propolis
is
a
natural
substance
collected
by
honey
bees
from
various
plants
such
as,
poplar,
palm,
pine,
conifer
secretions,
gums,
resins,
mucilage
and
leaf
buds.
It
brought
very
painstakingly
to
be
used
for
sealing
cracks
crevices
occurring
in
their
hives.
Originally,
it
as
an
antiseptic
meant
preventing
bee-hive
microbial
infections
along
with
decomposition
of
intruders.
Additionally,
propolis
has
been
folk
medicine
centuries.
The
biological
characteristics
depend
upon
its
chemical
composition,
plant
sources,
geographical
zone
seasons.
More
than
300
compounds
have
identified
phenolic
compounds,
aromatic
acids,
essential
oils,
waxes
amino
acids.
Many
scientific
articles
are
published
every
year
different
international
journals,
several
groups
researchers
focused
attention
on
the
activity
propolis.
Comprehensive Reviews in Food Science and Food Safety,
Journal Year:
2021,
Volume and Issue:
20(2), P. 2106 - 2145
Published: Jan. 23, 2021
Abstract
The
development
of
active
packaging
films
and
edible
coatings
based
on
biopolymers
natural
bioactive
substances
has
received
increasing
attention
in
recent
years.
Propolis,
also
called
bee
glue,
is
a
resin
substance
collected
by
worker‐bees
from
the
mucilage,
gum,
several
plants.
In
food
industry,
propolis
commonly
extracted
solvents
to
afford
polyphenol‐rich
extract
with
potent
antimicrobial
antioxidant
activities.
prepared
can
be
mixed
biopolymers,
plasticizers,
emulsifiers,
reinforcing
agents
develop
coatings.
functionality
closely
related
type,
harvesting
method,
geographic
origin,
extraction
method
conditions
propolis,
content
composition
polyphenolic
compounds
extract,
presence
other
substances.
Active
impact
physical,
biochemical,
sensory
properties
(e.g.,
fruits,
vegetables,
meat,
fish)
during
storage.
This
review
focuses
advances
extract.
structural
characterization,
functionality,
potential
applications
summarized.
Biomedicines,
Journal Year:
2020,
Volume and Issue:
8(10), P. 405 - 405
Published: Oct. 11, 2020
Drug-resistant
bacteria
pose
a
serious
threat
to
human
health
worldwide.
Current
antibiotics
are
losing
efficacy
and
new
antimicrobial
agents
urgently
needed.
Living
organisms
an
invaluable
source
of
compounds.
The
activity
the
most
representative
natural
products
animal,
bacterial,
fungal
plant
origin
reviewed
in
this
paper.
Their
against
drug-resistant
bacteria,
their
mechanisms
action,
possible
development
resistance
them,
role
current
medicine
future
perspectives
discussed.
Electronic
databases
such
as
PubMed,
Scopus
ScienceDirect
were
used
search
scientific
contributions
until
September
2020,
using
relevant
keywords.
Natural
compounds
heterogeneous
origins
have
been
shown
possess
capabilities,
including
antibiotic-resistant
bacteria.
commonly
found
action
related
protein
biosynthesis
alteration
cell
walls
membranes.
Various
compounds,
especially
phytochemicals,
synergistic
capacity
with
antibiotics.
There
is
little
literature
on
specific
New
technologies
-omics,
network
pharmacology
informatics
potential
identify
characterize
future.
This
knowledge
may
be
useful
for
therapeutic
strategies.
Molecules,
Journal Year:
2020,
Volume and Issue:
25(15), P. 3538 - 3538
Published: Aug. 2, 2020
Wood
is
a
renewable,
versatile
material
with
multiple
applications
and
the
largest
terrestrial
pool
of
sequestered
carbon.
However,
it
susceptible
to
degradation,
mainly
caused
by
wood-decaying
fungi.
Since
several
traditional
wood
preservatives
have
been
banned
owing
their
detrimental
effects
on
humans
environment,
extending
lifespan
products
using
new
generation
natural
an
imperative
from
perspectives
human
health
environmental
protection.
Several
compounds
plant
animal
origin
tested
for
fungicidal
properties,
including
essential
oils,
tannins,
extractives,
alkaloids,
propolis
or
chitosan;
enormous
potential
in
protection
has
shown.
Although
they
are
not
free
limitations,
methods
overcome
drawbacks
enhance
bioactivity
already
exist,
such
as
co-impregnation
different
polymers,
cross-linkers,
metal
chelators
antioxidants.
The
presence
discrepancies
between
laboratory
tests
field
performance,
well
legislation-related
problems
resulting
lack
standards
defining
quality
performance
protective
formulations,
however,
create
urgent
need
further
thorough
research
arrangements.
collaboration
other
industries
interested
utilisation
active
will
reduce
associated
costs,
thus,
facilitate
successful
implementation
alternative
antifungal
agents.
Nutrients,
Journal Year:
2021,
Volume and Issue:
13(8), P. 2594 - 2594
Published: July 28, 2021
Propolis
is
a
natural
material
that
honey
bees
(Apis mellifera)
produce
from
various
botanical
sources.
The
therapeutic
activity
of
propolis,
including
antibacterial,
antifungal,
and
anti-inflammatory
effects,
have
been
known
since
antiquity.
Cancer
one
the
major
burdens
disease
worldwide,
therefore,
numerous
studies
are
being
conducted
to
develop
new
chemotherapeutic
agents
treatments
for
cancer.
rich
source
biologically
active
compounds,
which
affect
signaling
pathways
regulating
crucial
cellular
processes.
results
latest
research
show
propolis
can
inhibit
proliferation,
angiogenesis,
metastasis
cancer
cells
stimulate
apoptosis.
Moreover,
it
may
influence
tumor
microenvironment
multidrug
resistance
cancers.
This
review
briefly
summarizes
molecular
mechanisms
anticancer
its
compounds
highlights
potential
benefits
reduce
side
effects
chemotherapy
radiotherapy.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(4), P. 1519 - 1519
Published: Feb. 11, 2025
Propolis
(bee
glue)
is
a
complex
mixture
of
resins,
waxes,
and
gums,
it
resinous
exudate
manufactured
by
honey
bees
to
maintain
the
integrity
hive
defend
against
external
threats.
This
multifunctional
material
exhibits
several
striking
properties.
The
anti-inflammatory
properties
propolis
have
made
subject
traditional
medicine
over
time,
from
ancient
Egyptian
mummification
modern
complementary
medicine.
with
rich
phytochemicals,
such
as
polyphenols
flavonoids,
exhibit
anti-inflammatory,
antioxidant,
anticancer
effects.
review
describes
multiple
uses
propolis,
highlighting
role
an
exceptional
natural
resource
high
therapeutic
potential.
PLoS ONE,
Journal Year:
2019,
Volume and Issue:
14(7), P. e0219063 - e0219063
Published: July 5, 2019
Propolis
is
a
complex
mixture
of
resinous
and
balsamic
material
collected
from
the
exudates
plants,
shoots,
leaves
by
bees.
This
study
evaluated
red
propolis
extracts
obtained
conventional
(ethanolic)
extraction
ultrasound-assisted
six
samples
different
regions
northeastern
Brazil.
The
total
phenolic
compounds
flavonoids,
in
vitro
antioxidant
activity,
concentration
formononetin
kaempferol
cytotoxicity
against
four
human
tumor
cell
lines
were
determined
for
all
twelve
extracts.
Significant
variations
levels
investigated
identified
extracts,
confirming
that
chemical
composition
varied
according
to
sampling
region.
method
used
also
influenced
resulting
compounds.
highest
interest
activity
exhibited
state
Alagoas.
Formononetin
samples.
concentrations
ultrasound,
thus
indicating
greater
selectivity
this
compound
method.
Regarding
cytotoxic
HCT-116
line,
showed
an
inhibition
than
90%,
whereas
HL-60
PC3
lines,
minimum
was
80%.
In
general,
there
no
significant
difference
(p>0.05)
antiproliferative
potential
when
comparing
methods.
results
Brazilian
varies
significantly
depending
on
geographical
origin
influences
are
present
propolis.
However,
regardless
used,
studied
presented
great
biological
high
activity.
Furthermore,
can
be
efficiently
applied
obtain
more
quickly
with
biomarkers
interest.