Per‐ and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research

Environmental Toxicology and Chemistry, Journal Year: 2020, Volume and Issue: 40(3), P. 606 - 630

Published: Oct. 5, 2020

Reports of environmental and human health impacts per- polyfluoroalkyl substances (PFAS) have greatly increased in the peer-reviewed literature. The goals present review are to assess state science regarding toxicological effects PFAS develop strategies for advancing knowledge on this large family chemicals. Currently, much toxicity data available a handful chemicals, primarily legacy such as perfluorooctanoic acid perfluorooctane sulfonate. Epidemiological studies revealed associations between exposure specific variety effects, including altered immune thyroid function, liver disease, lipid insulin dysregulation, kidney adverse reproductive developmental outcomes, cancer. Concordance with experimental animal exists many these effects. However, information modes action outcome pathways must be expanded, profound differences toxicokinetic properties considered understanding responses sexes among species life stages. With noted relatively few example compounds hundreds other commerce lacking data, more contemporary high-throughput approaches read-across, molecular dynamics, protein modeling proposed accelerate development emerging PFAS, individually mixtures. In addition, an appropriate degree precaution, given what is already known from examples noted, may needed protect health. Environ Toxicol Chem 2021;40:606-630. © 2020 SETAC.

Language: Английский

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Water Analysis: Emerging Contaminants and Current Issues

Analytical Chemistry, Journal Year: 2017, Volume and Issue: 90(1), P. 398 - 428

Published: Nov. 7, 2017

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTWater Analysis: Emerging Contaminants and Current IssuesSusan D. Richardson*† Thomas A. Ternes‡View Author Information† Department of Chemistry Biochemistry, University South Carolina, Columbia, Carolina 29205, United States‡ Federal Institute Hydrology, Koblenz, D-56068, Germany*E-mail: [email protected]Cite this: Anal. Chem. 2018, 90, 1, 398–428Publication Date (Web):November 7, 2017Publication History Published online30 November 2017Published inissue 2 January 2018https://doi.org/10.1021/acs.analchem.7b04577Copyright © 2017 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views10421Altmetric-Citations381LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated by Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence for given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InReddit Read OnlinePDF (584 KB) Get e-AlertsSUBJECTS:Anions,Drinking water,Impurities,Pharmaceuticals,Water treatment e-Alerts

Language: Английский

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Early life exposure to per- and polyfluoroalkyl substances (PFAS) and latent health outcomes: A review including the placenta as a target tissue and possible driver of peri- and postnatal effects

Toxicology, Journal Year: 2020, Volume and Issue: 443, P. 152565 - 152565

Published: Aug. 27, 2020

Language: Английский

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A short review on human exposure to and tissue distribution of per- and polyfluoroalkyl substances (PFASs)

The Science of The Total Environment, Journal Year: 2018, Volume and Issue: 636, P. 1058 - 1069

Published: May 3, 2018

Language: Английский

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Albumin is the major carrier protein for PFOS, PFOA, PFHxS, PFNA and PFDA in human plasma

Environment International, Journal Year: 2020, Volume and Issue: 137, P. 105324 - 105324

Published: Feb. 25, 2020

Perfluoroalkyl (PFAS) substances are widespread in the environment and organisms. The fact that exposure to PFAS is associated with elevated cholesterol levels a major concern for human health. Previous investigations, which bovine serum albumin was frequently studied, indicate PFOS, PFOA PFNA bind albumin. However, it critical know whether these other have preference protein or lipid fraction native blood fractions. For this reason, samples from four young healthy volunteers (two women, two men, 23-31 years old) were used size separation fractionation by Cohn method combination serial ultracentrifugation. plasma fractions analyzed 11 using high-performance tandem mass spectrometry (HPLC-MS/MS). Although data based on small sample, they clearly show most important carrier PFOA, PFHxS, PFDA plasma. These five compounds very little no affinity lipoproteins. confirmation of their transport through epidemiology PFAS. present results must be verified examination larger number persons.

Language: Английский

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Legacy and alternative per- and polyfluoroalkyl substances in the U.S. general population: Paired serum-urine data from the 2013–2014 National Health and Nutrition Examination Survey

Environment International, Journal Year: 2019, Volume and Issue: 131, P. 105048 - 105048

Published: July 31, 2019

Concerns are heightened from detecting environmentally persistent man-made per- and polyfluoroalkyl substances (PFAS) in drinking water systems around the world. Many PFAS, including perfluorooctane sulfonate (PFOS) perfluorooctanoate (PFOA), remain human body for years. Since 1999-2000, assessment of exposure to PFOS, PFOA, other select PFAS U.S. general population has relied on measuring serum concentrations participants National Health Nutrition Examination Survey (NHANES). Manufacturers have replaced chemistries ("legacy" PFAS) with shorter biological half-lives (e.g., GenX, perfluorobutanoate [PFBA]) which may efficiently eliminate urine. However, knowledge regarding these compounds is limited. We analyzed 2682 urine samples 17 legacy alternative 2013-2014 NHANES ≥6 years age. Concentrations some measured previously paired same participants, suggested universal PFOS infrequent or no two short-chain perfluorobutane perfluoroheptanoate. Yet, urine, were seldom detected; frequency not having detectable any was 67.5%. Only detected >1.5% population: PFBA (13.3%) perfluorohexanoate (PFHxA, 22.6%); 90th percentile 0.1 μg/L (PFBA), 0.3 (PFHxA). These results suggest that exposures at levels below those would result As such, findings do support biomonitoring fluorinated alternatives using highlight importance selecting adequate matrix.

Language: Английский

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Highly Defective UiO-66 Materials for the Adsorptive Removal of Perfluorooctanesulfonate

ACS Sustainable Chemistry & Engineering, Journal Year: 2019, Volume and Issue: 7(7), P. 6619 - 6628

Published: March 5, 2019

Perfluorooctanesulfonate (PFOS) is a persistent organic pollutant that bioaccumulative and toxic. While its use in most countries has been restricted to certain industrial applications due environmental health concerns, chrome plating semiconductor manufacturing facilities are point sources of PFOS-containing wastewater. Current remediation technologies ineffective at treating these highly concentrated effluents. In this work, UiO-66 metal–organic frameworks (MOFs) several defect concentrations were studied as sorbents for the removal PFOS from aqueous solutions. sorption isotherms indicated defective UiO-66, prepared with HCl modulator, had maximum Langmuir capacity 1.24 mmol/g, which was ∼2× greater than powdered activated carbon (PAC), but less commercial ion-exchange resin. Defective adsorbed 2 orders magnitude faster Large pore defects (∼16 ∼20 Å) within framework critical increased adsorption higher internal surface area an number coordinatively unsaturated Zr sites bind head groups. Of common co-contaminants wastewaters, chloride ions have negligible effect on sorption, while sulfate hexavalent chromium anions compete cationically charged sites. These materials also effective adsorbents shorter-chain homologue, perfluorobutanesulfonate (PFBS). The enhanced PFBS adsorptive properties highlight advantage structurally MOFs water treatment approach toward sustainability.

Language: Английский

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Human biomonitoring of per- and polyfluoroalkyl substances in German blood plasma samples from 1982 to 2019

Environment International, Journal Year: 2020, Volume and Issue: 145, P. 106123 - 106123

Published: Sept. 17, 2020

The findings of per- and polyfluoroalkyl substances (PFAS) in humans the environment all over world have raised concerns public awareness for this group man-made chemicals. In last three decades, led to different regulatory restrictions specific PFAS as well shifts production usage these substances. study, we analyzed levels 100 human blood plasma samples collected from 2009 2019 German Environmental Specimen Bank (ESB) further elucidate time course exposure towards substance shown by Schröter-Kermani et al., (2013) with 1982 2010. A spectrum 37 PFAS, including perfluorocarboxylic (PFCA) –sulfonic acids (PFSA) potential precursors substitutes like ADONA, GenX or F-53B was UHPLC coupled high-resolution mass spectrometry. Validation successful 33 two legacy perfluorooctanoic acid (PFOA) perfluorooctane sulfonic (PFOS) were detected every sample 2009–2019 dataset showed highest concentrations ranges 0.27–14.0 ng/mL 1.21–14.1 ng/mL, respectively. significant portion total PFOS analytes present branched isomers (mean: 34 ± 7%). High detection frequencies 95% 82% also found perfluorohexane (PFHxS) perfluorononanoic (PFNA), respectively, but lower (PFHxS:

Language: Английский

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Immunotoxicity mechanisms of perfluorinated compounds PFOA and PFOS

Chemosphere, Journal Year: 2021, Volume and Issue: 291, P. 132892 - 132892

Published: Nov. 12, 2021

Language: Английский

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The Impact of Environmental Chemicals on the Gut Microbiome

Toxicological Sciences, Journal Year: 2020, Volume and Issue: 176(2), P. 253 - 284

Published: May 5, 2020

Abstract Since the surge of microbiome research in last decade, many studies have provided insight into causes and consequences changes gut microbiota. Among multiple factors involved regulating microbiome, exogenous such as diet environmental chemicals been shown to alter significantly. Although substantially contributes are major contaminants our food often overlooked. Herein, we summarize current knowledge on classes (bisphenols, phthalates, persistent organic pollutants, heavy metals, pesticides) their impact which includes alterations microbial composition, gene expression, function, health effects host. We then discuss health-related implications changes, include metabolism, immunity, neurological function.

Language: Английский

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