Dietary trends and the decline in male reproductive health

HORMONES, Journal Year: 2023, Volume and Issue: 22(2), P. 165 - 197

Published: Feb. 2, 2023

Language: Английский

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Lack of association between endocrine disrupting chemicals and male fertility: A systematic review and meta-analysis

Environmental Research, Journal Year: 2022, Volume and Issue: 217, P. 114942 - 114942

Published: Nov. 24, 2022

The incidence of infertility currently affects about 15% the world's population. Male factors are estimated to be responsible for up 40–50% these cases. While cause reproductive disorders is still unclear, exposure a family ubiquitous compounds in our daily life, named endocrine disrupting chemicals (EDCs) could involved. This paper was aimed at performing systematic review and meta-analysis population studies exploring whether human male EDCs fertility. Clinical observational assessing along with sperm quality, most common disorders, DNA damage, oxidative stress, fertilization rate, implantation clinical pregnancy live birth miscarriage rate were included. quality assessment tool from NHLBI-NIH used assure that met standardized criteria. Sensitivity analysis heterogeneity among assessed. Overall, 32 selected articles, including 7825 individuals review, explored 12 families EDCs. results revealed high relation association between endpoints analyzed. Meta-analyses performed data 7 articles 479 individuals, 4 BPA urine 3 evaluating PCB153 serum quality. In meta-analysis, we identified an unpredicted significant positive concentration. However, it would not clinically relevant. No or inverse associations found neither BPA, nor rest parameters disparity made difficult draw conclusions on potential harmful effects Consequently, delineate relationship can have fertility, important condition stressing health system, further investigations required.

Language: Английский

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Androgens and erectile dysfunction: from androgen deficiency to treatment

Sexual Medicine Reviews, Journal Year: 2024, Volume and Issue: 12(3), P. 458 - 468

Published: May 8, 2024

Abstract Introduction Androgens play important roles in regulating the growth and development of male reproductive system maintaining libido erectile function. The specific mechanisms by which androgen deficiency leads to dysfunction (ED) are not yet fully understood. Objectives To understand treatment deficiency–related ED. Methods A literature search past 10 years was conducted PubMed Google Scholar determine effects on function deficiency. Results Androgen can be caused hypothalamic-pituitary lesions injuries, testicular-related diseases endocrine metabolic disorders, side medication, age. lead ED inhibiting NOS/NO/cGMP pathway (nitric oxide synthase/nitric oxide/cyclic guanosine monophosphate) altering expression ion channel proteins, as well inducing oxidative stress, death, fibrosis penile corpus cavernosum cells. Testosterone replacement therapy is effective at improving serum testosterone levels patients with For who need maintain a low androgenic state, improved lifestyle changes, phosphodiesterase type 5 inhibitors, low-intensity extracorporeal shock wave therapy, stem cell therapy. Conclusions affect structure cavernosum, leading Areas further study include how improve maintenance hypoandrogenic status.

Language: Английский

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Low-fat diets and testosterone in men: Systematic review and meta-analysis of intervention studies

The Journal of Steroid Biochemistry and Molecular Biology, Journal Year: 2021, Volume and Issue: 210, P. 105878 - 105878

Published: March 18, 2021

Language: Английский

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Association of sleep duration and quality with serum testosterone concentrations among men and women: NHANES 2011–2016

Andrology, Journal Year: 2023, Volume and Issue: 12(3), P. 518 - 526

Published: July 15, 2023

The association between testosterone concentrations and sleep duration is poorly understood.

Language: Английский

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Cholesterol intake and serum total cholesterol levels are not associated with total testosterone levels in men: a cross-sectional study from NHANES 2013–2014

Lipids in Health and Disease, Journal Year: 2023, Volume and Issue: 22(1)

Published: Oct. 5, 2023

Abstract Background Testosterone (T) is an anabolic hormone crucial to the structure and function of skeletal muscle. partially synthesized from cholesterol, but little known about relationship cholesterol intake serum with T levels. Aim To investigate whether total (TC) levels are associated testosterone (TT) in men. Methods A cross-sectional study enrolling 1996 men aged 20 80 years National Health Nutrition Examination Survey (NHANES) 2013–2014 was carried out. Diet assessment performed using two 24-h food recalls, TT were measured by liquid chromatography coupled tandem mass spectrometry. Regression analyses evaluate TC Results Neither nor unadjusted adjusted (adjustment for energy, fat alcohol intake, smoking, age, physical activity, family income, marital status, race, educational level, diabetes, hypertension, body index). Conclusion Dietary not USA.

Language: Английский

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The relationship between remnant cholesterol and the risk of testosterone deficiency in US adults: a cross-sectional study based on the NHANES database

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 24, 2024

Testosterone deficiency (TD) is an urgent health issue that requires attention, associated with various adverse outcomes including cardiovascular diseases (CVD) and metabolic syndrome. Remnant cholesterol (RC) has emerged as a potential biomarker for risk, but its relationship testosterone levels TD not been thoroughly investigated. This study aims to explore the association between RC in adult American males using data from National Health Nutrition Examination Survey (NHANES).

Language: Английский

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Association between comorbidities and longitudinal changes in total testosterone among men from the Baltimore Longitudinal Study of Aging

The Journal of Sexual Medicine, Journal Year: 2023, Volume and Issue: 20(5), P. 605 - 611

Published: March 10, 2023

Language: Английский

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Biomarkers of Iron Are Associated with Anterior-Pituitary-Produced Reproductive Hormones in Men with Infertility

Nutrients, Journal Year: 2024, Volume and Issue: 16(2), P. 290 - 290

Published: Jan. 18, 2024

Approximately 16% of North American couples are affected by infertility, with 30% cases being attributable to male factor infertility. The regulation reproductive hormones via the hypothalamic–pituitary–gonadal axis is important for spermatogenesis and subsequently fertility. Maintaining iron homeostasis critical normal physiological function. This cross-sectional study’s objective was determine association between serum biomarkers hormones. Men experiencing infertility (n = 303) were recruited from Mount Sinai Hospital, Toronto. Serum analyzed ferritin as status (follicle-stimulating hormone, luteinizing testosterone, estradiol, prolactin), which primary outcome. Associations determined using non-parametric Spearman’s rank correlation coefficient, linear regressions, logistic regressions. A significant independent monotonic inverse relationship prolactin (p 0.0002) found. In regression analyses, inversely associated hormone (unadjusted p 0.03, adjusted 0.03) 0.001 0.003). both gonadotropins, follicle-stimulating (adjusted 0.03), 0.02). These findings suggest that pituitary-produced hormones, play a role in signaling pathway involved spermatogenesis, testicular testosterone production,

Language: Английский

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Association between weight-adjusted waist index and serum total testosterone in males aged 6–19 years in the United States: Data from NHANES 2013–2016

Heliyon, Journal Year: 2024, Volume and Issue: 10(6), P. e27520 - e27520

Published: March 1, 2024

This study aimed to estimate the association between weight-adjusted waist index and serum total testosterone (sTT) in males aged 6-19 years United States.

Language: Английский

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