COVID-19 and its long-term sequelae: what do we know in 2023?

Polskie Archiwum Medycyny Wewnętrznej, Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 9, 2023

Post‑viral syndrome is a well‑known medical condition characterized by different levels of physical, cognitive, and emotional impairment that may persist with fluctuating severity after recovering from an acute viral infection. Unsurprisingly, COVID‑19 also be accompanied medium- long‑term clinical sequelae SARS‑CoV‑2 Although many definitions have been provided, "long‑COVID" can defined as occurring in patients history infection, developing 3 months the symptoms onset, persisting for at least 2 months, not explained alternative diagnoses. According to recent global analyses, cumulative prevalence long‑COVID seems range between 9% 63%, up 6‑fold higher than similar postviral infection conditions. Long‑COVID primarily encompasses presence 1 symptom, such fatigue, dyspnea, cognitive / brain fog, postexertional malaise, memory issues, musculoskeletal pain spasms, cough, sleep disturbances, tachycardia palpitations, altered smell taste perception, headache, chest pain, depression. The most important demographic predictors date are female sex, older age, cigarette smoking, pre‑existing conditions, lack vaccination, pre‑Omicron variants, number phase symptoms, load, severe critical illness, well invasive mechanical ventilation. Concerning care patients, greatest challenge fact this cannot considered single entity, thus it needs integrated multidisciplinary management, specifically tailored type symptoms.

Language: Английский

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The displacement of the SARS-CoV-2 variant Delta with Omicron: An investigation of hospital admissions and upper respiratory viral loads

EBioMedicine, Journal Year: 2022, Volume and Issue: 79, P. 104008 - 104008

Published: April 20, 2022

The increase in SARS-CoV-2 infections December 2021 was driven primarily by the Omicron variant, which largely displaced Delta over a three-week span. Outcomes from infection with remain uncertain. We evaluated whether clinical outcomes and viral loads differed between during period when both variants were co-circulating.

Language: Английский

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The relative prevalence of the Omicron variant within SARS-CoV-2 infected cohorts in different countries: A systematic review

Human Vaccines & Immunotherapeutics, Journal Year: 2023, Volume and Issue: 19(1)

Published: Jan. 2, 2023

The Omicron variant of SARS-CoV-2 was detected in October 2021 and exhibited high transmissibility, immune evasion, reduced severity when compared to the earlier variants. lesser vaccine effectiveness against its created vaccination hesitancy among public. This review compiled data reporting relative prevalence as early variants give an insight into existing variants, which may shape decisions regarding targets newly developed vaccines. Complied revealed more than 90% within infected cohorts some countries. BA.1 subvariant predominated over BA.2 during stages wave. Moreover, BA.4/BA.5 subvariants were South Africa, USA Italy between April 2022. It is therefore important develop vaccines that protect well are known cause severe complications.

Language: Английский

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Prevalence and risk factors for long COVID in China: a systematic review and meta-analysis of observational studies

Journal of Infection and Public Health, Journal Year: 2025, Volume and Issue: 18(3), P. 102652 - 102652

Published: Jan. 5, 2025

With the outbreak of COVID-19 in China, a large number patients are at risk long COVID after recovery. The purpose our research is to systematically review existing clinical studies understand current prevalence and related factors China. protocol this systematic was registered on PROSPERO (CRD42024519375). We searched six electronic databases from 1st January 2020-1st March 2024. Literature screening, data extraction, bias assessment were independently carried out by two reviewers. Quality included evaluated AHRQ NOS. meta-analysis performed R software 4.2.3 derive factors. Overall, 50 with 65880 participants included. results showed that (with least one symptom) among approximately % (95 %Confidence Interval (CI) 42-58 %) Although we conducted meta-regression subgroup analysis, heterogeneity study high. But Omicron BA.2 variant had statistically significant effect (P = 0.0004). three most common symptoms fatigue (0.33, 95 %CI 0.28-0.39), cognitive decline (0.30, 0.14-0.46) shortness breath (0.29, 0.15-0.43). Patients severe acute phase (Odds Ratio (OR) 1.57, CI 1.39-1.77), combined 2 comorbidities (OR 1.80, 1.40-2.32), 3 2.13, 1.64-2.77), advanced age 1.02, 1.01-1.04), female 1.58, 1.44-1.73) for prevalence. Current found nearly half may suffering Establishing recovery-support platform regular follow-up would help long-term monitor manage patients, especially those high-risk population.

Language: Английский

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Timeline analysis of clinical severity of COVID-19 in the general population

European Journal of Internal Medicine, Journal Year: 2022, Volume and Issue: 110, P. 97 - 98

Published: Dec. 16, 2022

Language: Английский

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Uncontrolled confounding in COVID-19 epidemiology

Diagnosis, Journal Year: 2022, Volume and Issue: 10(2), P. 200 - 202

Published: Dec. 6, 2022

Language: Английский

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An overview of the most important preanalytical factors influencing the clinical performance of SARS-CoV-2 antigen rapid diagnostic tests (Ag-RDTs)

Clinical Chemistry and Laboratory Medicine (CCLM), Journal Year: 2022, Volume and Issue: 61(2), P. 196 - 204

Published: Nov. 7, 2022

Due to the many technical limitations of molecular biology, possibility sustain enormous volumes severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostic testing relies strongly on use antigen rapid tests (Ag-RDTs). Besides a limited analytical sensitivity, manually intensive test procedures needed for performing these tests, very often performed by unskilled personnel or patients themselves, may contribute considerably impair their accuracy. We provide here an updated overview leading preanalytical drawbacks that SARS-CoV-2 Ag-RDT accuracy, and which encompass lower sensitivity in certain age groups, asymptomatic subjects those with longer time from symptoms onset, vaccine recipients, individuals not appropriately trained usage, recently using oral nasal virucidal agents, oropharyngeal swabs saliva, as well circumstances when instructions provided manufacturers are unclear, incomplete scarcely readable intelligible. Acknowledging important will lead way better, more clinically efficient even safer this technology, represents extremely valuable resource management ongoing pandemic.

Language: Английский

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mRNA-based COVID-19 booster vaccination is highly effective and cost-effective in Australia

Vaccine, Journal Year: 2023, Volume and Issue: 41(15), P. 2439 - 2446

Published: Feb. 3, 2023

Australia implemented an mRNA-based booster vaccination strategy against the COVID-19 Omicron variant in November 2021. We aimed to evaluate effectiveness and cost-effectiveness of over 180 days.We developed a decision-analytic Markov model (administered 3 months after 2nd dose) those aged ≥ 16 years, from healthcare system perspective. The willingness-to-pay threshold was chosen as A$ 50,000.Compared with 2-doses vaccines without booster, Australia's would incur additional cost A$0.88 billion but save A$1.28 direct medical gain 670 quality-adjusted life years (QALYs) days its implementation. This suggested is cost-saving, corresponding benefit-cost ratio 1.45 net monetary benefit A$0.43 billion. prevent 1.32 million new infections, 65,170 hospitalisations, 6,927 ICU admissions 1,348 deaths days. Further, universal having all individuals vaccinated shot immediately once their eligibility met have resulted 1,599 QALYs, A$1.46 1.95 days.The likely be effective cost-effective for epidemic. Universal further improved cost-effectiveness.

Language: Английский

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Diagnostic accuracy of Siemens SARS-CoV-2 Antigen (CoV2Ag) chemiluminescent immunoassay for diagnosing acute SARS-CoV-2 infection: a pooled analysis

Clinical Chemistry and Laboratory Medicine (CCLM), Journal Year: 2023, Volume and Issue: 61(7), P. 1133 - 1139

Published: Jan. 12, 2023

Abstract Background This article provides a critical literature review and pooled analysis of diagnostic accuracy the fully-automated Siemens SARS-CoV-2 Antigen (CoV2Ag) chemiluminescent immunoassay for diagnosis acute infections. Methods An electronic search was conducted in Scopus, PubMed medRxiv using keywords [“Siemens AND CoV2Ag”] OR antigen”] capturing studies that investigated CoV2Ag diagnosing infection against reference molecular test. The retrieved information used constructing 2 × table calculating sensitivity, specificity, Summary Receiver Operating Characteristic Curve (SROC) Agreement. study followed PRISMA (Preferred Reporting Items Systematic Reviews Meta-Analyses) reporting checklist. Results Four totalling 1,310 respiratory samples (612 with high viral load) were finally included our analysis. cumulative area under curve, accuracy, 0.964 (95% CI, 0.957–0.971), 86.9% 84.9–88.7%), 0.79 0.76–0.82) 0.98 0.96–0.99), respectively. negative (NPV) positive (PPV) predictive values 0.77 (0.74–0.79) 0.96–99), sensitivity load (i.e., Ct<29–30) 0.95 0.93–0.97). Conclusions high-throughput approximates minimum performance criteria general antigen testing displays excellent load, thus representing valuable screening solution risk assessment COVID-19 limiting spread.

Language: Английский

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Broadly Reactive SARS-CoV-2-Specific T-Cell Response and Participation of Memory B and T Cells in Patients with Omicron COVID-19 Infection

Journal of Immunology Research, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 19

Published: Oct. 17, 2023

January 2022 onward, India witnessed a sudden increase in Omicron COVID-19 infections, having mild course that prompted us to identify the key host factors/immune molecules modulating disease course/outcomes. The current study evaluated percentages of lymphocyte subsets by flowcytometry, SARS-CoV-2 specific T-cell immune response ELISPOT, estimation plasma cytokine/chemokine levels on Bio-plex Multiplex Immunoassay System and anti-SARS-CoV-2 IgG enzyme-linked immunosorbent assay 19 infected patients, 45 (2020) patients 36 uninfected controls from India. Natural killer cells, B memory cells were high vaccinated total Omicron-infected groups compared patient group, while CD8+ T group control ( p < 0.05 each). had against whole virus, S1 proteins (wild type delta variant) 10 out 17 (59%), 8 (47%), respectively. elucidates broadly reactive antibody, response, participation induced vaccination/natural infection. limited effect Omicron’s mutations is suggestive protection severity. Pro-inflammatory IL-6, IFN-γ, chemokines CCL-2, CCL-3, CCL-4, CCL-5, IL-8 as potential biomarkers infection may have future diagnostic importance. cellular data with parental lineage could serve starting point define readouts protective immunity circulating subvariants.

Language: Английский

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