Cancer Letters, Journal Year: 2024, Volume and Issue: unknown, P. 217273 - 217273
Published: Sept. 1, 2024
Language: Английский
Nature Immunology, Journal Year: 2024, Volume and Issue: 25(7), P. 1257 - 1269
Published: May 28, 2024
Language: Английский
Citations
22
Science Advances, Journal Year: 2022, Volume and Issue: 8(32)
Published: Aug. 10, 2022
An alarming rise in young onset colorectal cancer (CRC) has been reported; however, the underlying molecular mechanism remains undefined. Suspected risk factors of CRC include environmental aspects, such as lifestyle and dietary factors, which are known to affect circadian clock. We find that both genetic disruption clock accelerate
Language: Английский
Citations
56
Cancers, Journal Year: 2022, Volume and Issue: 14(20), P. 5071 - 5071
Published: Oct. 17, 2022
Living organisms present rhythmic fluctuations every 24 h in their behavior and metabolism to anticipate changes the environment. These are controlled by a very complex molecular mechanism, circadian clock, that regulates expression of multiple genes ensure right functioning body. An individual’s system is altered during aging, this related numerous age-associated pathologies other alterations could contribute development cancer. Nowadays, there an increasing interest understanding how rhythms be used treatment Chronotherapy aims understand impact biological have on response therapy optimize its action, maximize health benefits minimize possible adverse effects. Clinical trials so far confirmed optimal timing with chemo or immunotherapies decrease drug toxicity increase efficacy. Instead, chronoradiotherapy seems treatment-related symptoms rather than tumor progression patient survival. In addition, potential therapeutic targets within clock also been identified. Therefore, results application chronotherapy cancer until now challenging, feasible, applied clinical practice improve without additional costs. However, different limitations variables such as age, sex, chronotypes, among others, should overcome before can really put into practice.
Language: Английский
Citations
48
Aging Cell, Journal Year: 2022, Volume and Issue: 21(10)
Published: Sept. 3, 2022
Abstract With the aging world population, prevalence of aging‐related disorders is on rise. Diseases such as Alzheimer's, type 2 diabetes mellitus (T2DM), Parkinson's, atherosclerosis, hypertension, and osteoarthritis are age‐related, most these diseases comorbidities or risk factors for AD; however, our understandings molecular events that regulate occurrence still not fully understood. Brain muscle Arnt‐like protein‐1 (Bmal1) an irreplaceable clock gene governs multiple important physiological processes. Continuous research Bmal1 in AD associated ongoing, this review picks relevant studies a detailed account its role mechanisms diseases. Oxidative stress inflammation turned out to be common by which deficiency promotes diseases, other Bmal1‐dependent remain identified. Promising therapeutic strategies involved regulation provided, including melatonin, natural compounds, metformin, d‐Ser2‐oxyntomodulin, interventions, exercise, time‐restricted feeding, adiponectin. The establishment signaling pathway network will lead advances comprehension cellular mechanisms, shedding light novel treatments promoting aging‐associated brain health.
Language: Английский
Citations
38
Cancer Biology and Medicine, Journal Year: 2023, Volume and Issue: 20(1), P. 1 - 24
Published: Jan. 12, 2023
Circadian rhythms are natural that widely exist in all creatures, and regulate the processes physiological functions of various biochemical reactions. The circadian clock is critical for cancer occurrence progression. Its function regulated by metabolic activities, expression transcription genes. This review summarizes composition clock; biological basis its function; relationship with, mechanisms in, cancer; different cancers; effects anti-tumor treatment; potential therapeutic targets. Research this area expected to advance understanding locomotor output cycles kaput (CLOCK) brain muscle ARNT-like protein 1 (BMAL1) tumor diseases, contribute development new treatment strategies.
Language: Английский
Citations
35
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2023, Volume and Issue: 1878(3), P. 188900 - 188900
Published: April 25, 2023
The molecular machinery of the circadian clock regulates expression many genes and processes in organism, allowing adaptation cellular activities to daily light-dark cycles. Disruption rhythm can lead various pathologies, including cancer. Thus, disturbance normal at both genetic environmental levels has been described as an independent risk factor for In addition, researchers have proposed that may a tissue-dependent and/or context-dependent role tumorigenesis function tumor suppressors oncogenes. Finally, core trigger or least be involved different hallmarks Hence, expanding knowledge basis would helpful identify new prognostic markers potential therapeutic targets.
Language: Английский
Citations
25
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Jan. 20, 2024
Language: Английский
Citations
12
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7530 - 7530
Published: July 9, 2024
Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external internal signs of aging manifest various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative cancer. Additionally, cancer, like aging, complex disease that arises from accumulation genetic epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for cancer development. Natural compounds herbal medicines have gained significant attention their potential preventing age-related diseases inhibiting progression. These demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects well circadian regulation. This review explores cancers, specific natural targeting key features these conditions.
Language: Английский
Citations
8
Trends in cancer, Journal Year: 2023, Volume and Issue: 10(3), P. 196 - 207
Published: Nov. 23, 2023
Circadian timekeeping mechanisms and cell cycle regulation share thematic biological principles in responding to signals, repairing cellular damage, coordinating metabolism, allocating resources for optimal function. Recent studies show interactions between regulators circadian clock components, offering insights into potential cancer treatment approaches. Understanding control of metabolism informs timing therapies reduce adverse effects enhance efficacy. adaptability lifestyle factors, such as activity, sleep, nutrition sheds light on their impact cancer. Leveraging regulatory prevention care is vital, most risk stems from modifiable lifestyles. Monitoring factors aids assessment targeted interventions across the continuum.
Language: Английский
Citations
21
Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0
Published: Jan. 1, 2024
Numerous research works have emphasized the critical role that circadian rhythm plays in tumor microenvironment (TME). The goal of clarifying chrono-pharmacological strategies for improving cancer treatment clinical settings is a continuous endeavor. Consequently, to enhance use time-based pharmaceutical therapies oncology, combining existing knowledge on rhythms' roles within TME essential. This perspective elucidates functions rhythms across various stages development, progression, and metastasis. Specifically, aging, angiogenesis, inflammation are implicated modulating TME. Furthermore, exerts profound influence current treatments thereby generates chronotheray manage tumors. From perspective, offers promising opportunities prevention treatment; nevertheless, further study needed address unanswered scientific problems.
Language: Английский
Citations
8