Nano Convergence,
Journal Year:
2022,
Volume and Issue:
9(1)
Published: Jan. 8, 2022
Abstract
Cancer
has
been
a
serious
threat
to
human
health.
Among
drug
delivery
carriers,
protein
nanoparticles
are
unique
because
of
their
mild
and
environmentally
friendly
preparation
methods.
They
also
inherit
desired
characteristics
from
natural
proteins,
such
as
biocompatibility
biodegradability.
Therefore,
they
have
solved
some
problems
inherent
inorganic
nanocarriers
poor
biocompatibility.
Also,
the
surface
groups
cavity
allow
for
easy
modification
loading.
Besides,
can
be
combined
with
or
contrast
agents
form
multifunctional
theranostic
platforms.
This
review
introduces
representative
applicable
in
cancer
theranostics,
including
virus-like
particles,
albumin
nanoparticles,
silk
ferritin
nanoparticles.
It
describes
common
methods
preparing
them.
then
critically
analyzes
use
variety
improved
imaging
therapy.
Journal of Hematology & Oncology,
Journal Year:
2022,
Volume and Issue:
15(1)
Published: Sept. 12, 2022
Poor
targeting
of
therapeutics
leading
to
severe
adverse
effects
on
normal
tissues
is
considered
one
the
obstacles
in
cancer
therapy.
To
help
overcome
this,
nanoscale
drug
delivery
systems
have
provided
an
alternative
avenue
for
improving
therapeutic
potential
various
agents
and
bioactive
molecules
through
enhanced
permeability
retention
(EPR)
effect.
Nanosystems
with
cancer-targeted
ligands
can
achieve
effective
tumor
cells
utilizing
cell
surface-specific
receptors,
vasculature
antigens
high
accuracy
affinity.
Additionally,
stimuli-responsive
nanoplatforms
also
been
as
a
promising
strategy
against
tumors,
these
maintain
their
stealth
feature
under
conditions,
but
upon
homing
cancerous
lesions
or
microenvironment,
are
responsive
release
cargoes.
In
this
review,
we
comprehensively
summarize
field
active
number
studies
context
emerging
nanoplatform
development,
discuss
how
knowledge
contribute
further
improvements
clinical
practice.
Small Methods,
Journal Year:
2022,
Volume and Issue:
6(11)
Published: Oct. 6, 2022
Abstract
Nanozymes
refer
to
nanomaterials
that
catalyze
enzyme
substrates
into
products
under
relevant
physiological
conditions
following
kinetics.
Compared
natural
enzymes,
nanozymes
possess
the
characteristics
of
higher
stability,
easier
preparation,
and
lower
cost.
Importantly,
magnetic,
fluorescent,
electrical
properties
nanomaterials,
making
them
promising
replacements
for
enzymes
in
industrial,
biological,
medical
fields.
On
account
rapid
development
recently,
their
application
potentials
regeneration
medicine
are
gradually
being
explored.
To
highlight
achievements
field,
this
review
summarizes
catalytic
mechanism
four
types
representative
nanozymes.
Then,
strategies
improve
biocompatibility
discussed.
covers
recent
advances
tissue
including
wound
healing,
nerve
defect
repair,
bone
regeneration,
cardiovascular
disease
treatment.
In
addition,
challenges
prospects
nanozyme
researches
summarized.
Polymers,
Journal Year:
2023,
Volume and Issue:
15(10), P. 2317 - 2317
Published: May 16, 2023
Hyaluronic
acid
(HA),
a
main
component
of
the
extracellular
matrix,
is
widely
utilized
to
deliver
anticancer
drugs
due
its
biocompatibility,
biodegradability,
non-toxicity,
non-immunogenicity
and
numerous
modification
sites,
such
as
carboxyl
hydroxyl
groups.
Moreover,
HA
serves
natural
ligand
for
tumor-targeted
drug
delivery
systems,
it
contains
endocytic
receptor,
CD44,
which
overexpressed
in
many
cancer
cells.
Therefore,
HA-based
nanocarriers
have
been
developed
improve
efficiency
distinguish
between
healthy
cancerous
tissues,
resulting
reduced
residual
toxicity
off-target
accumulation.
This
article
comprehensively
reviews
fabrication
based
on
context
prodrugs,
organic
carrier
materials
(micelles,
liposomes,
nanoparticles,
microbubbles
hydrogels)
inorganic
composite
(gold
quantum
dots,
carbon
nanotubes
silicon
dioxide).
Additionally,
progress
achieved
design
optimization
these
their
effects
therapy
are
discussed.
Finally,
review
provides
summary
perspectives,
lessons
learned
so
far
outlook
towards
further
developments
this
field.
Asian Journal of Pharmaceutical Sciences,
Journal Year:
2023,
Volume and Issue:
18(1), P. 100775 - 100775
Published: Jan. 1, 2023
Photodynamic
therapy
(PDT)
is
applied
as
a
robust
therapeutic
option
for
tumor,
which
exhibits
some
advantages
of
unique
selectivity
and
irreversible
damage
to
tumor
cells.
Among
which,
photosensitizer
(PS),
appropriate
laser
irradiation
oxygen
(O2)
are
three
essential
components
PDT,
but
the
hypoxic
microenvironment
(TME)
restricts
O2
supply
in
tissues.
Even
worse,
metastasis
drug
resistance
frequently
happen
under
condition,
further
deteriorate
antitumor
effect
PDT.
To
enhance
PDT
efficiency,
critical
attention
has
been
received
by
relieving
hypoxia,
innovative
strategies
on
this
topic
continue
emerge.
Traditionally,
supplement
strategy
considered
direct
effective
relieve
TME,
whereas
it
confronted
with
great
challenges
continuous
supply.
Recently,
O2-independent
provides
brand
new
can
avoid
influence
TME.
In
addition,
synergize
other
strategies,
such
chemotherapy,
immunotherapy,
photothermal
(PTT)
starvation
therapy,
remedy
inadequate
hypoxia
conditions.
paper,
we
summarized
latest
progresses
development
improve
efficacy
against
were
classified
into
O2-dependent
synergistic
therapy.
Furthermore,
deficiencies
various
also
discussed
envisage
prospects
future
study.
