Chitosan nanoparticles of imatinib mesylate coated with TPGS for the treatment of colon cancer: In-vivo & in-vitro studies DOI
Darshan Bhirud, Sankha Bhattacharya, Harshvardhan Raval

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 348, P. 122935 - 122935

Published: Nov. 4, 2024

Language: Английский

pH-Responsive Polymer Nanomaterials for Tumor Therapy DOI Creative Commons
Shunli Chu, Xiaolu Shi, Ye Tian

et al.

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: March 22, 2022

The complexity of the tumor microenvironment presents significant challenges to cancer therapy, while providing opportunities for targeted drug delivery. Using characteristic signals microenvironment, various stimuli-responsive delivery systems can be constructed sites. Among these, pH is frequently utilized, owing being lower than that blood and healthy tissues. pH-responsive polymer carriers improve efficiency in vivo , allow delivery, reduce adverse reactions, enabling multifunctional personalized treatment. polymers have gained increasing interest due their advantageous properties potential applicability therapy. In this review, recent advances in, common applications of, nanomaterials therapy are summarized, with a focus on different types polymers. Moreover, future field prospected.

Language: Английский

Citations

108
Advances in Drug Delivery Systems Based on Red Blood Cells and Their Membrane-Derived Nanoparticles DOI
Phuong H. D. Nguyen,

Migara Kavishka Jayasinghe,

Anh Hong Le

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(6), P. 5187 - 5210

Published: March 10, 2023

Red blood cells (RBCs) and RBC membrane-derived nanoparticles have been historically developed as bioinspired drug delivery systems to combat the issues of premature clearance, toxicity, immunogenicity synthetic nanocarriers. RBC-based possess characteristics including biocompatibility, biodegradability, long circulation time, which make them suited for systemic administration. Therefore, they employed in designing optimal formulations various preclinical models clinical trials treat a wide range diseases. In this review, we provide an overview biology, synthesis, characterization based on RBCs their membrane whole RBCs, membrane-camouflaged nanoparticles, RBC-derived extracellular vesicles, hitchhiking. We also highlight conventional latest engineering strategies, along with therapeutic modalities, enhanced precision effectiveness delivery. Additionally, focus current state applications translation carriers, well discussing opportunities challenges associated these systems.

Language: Английский

Citations

98
Advanced strategies to evade the mononuclear phagocyte system clearance of nanomaterials DOI Creative Commons
Junjie Lu,

Xiao Gao,

Siyao Wang

et al.

Exploration, Journal Year: 2023, Volume and Issue: 3(1)

Published: Jan. 5, 2023

Nanomaterials are promising carriers to improve the bioavailability and therapeutic efficiency of drugs by providing preferential drug accumulation at their sites action, but delivery efficacy is severely limited a series biological barriers, especially mononuclear phagocytic system (MPS)-the first major barrier encountered systemically administered nanomaterials. Herein, current strategies for evading MPS clearance nanomaterials summarized. First, engineering methods including surface modification, cell hitchhiking, physiological environment modulation reduce explored. Second, disabling blockade, suppression macrophage phagocytosis, macrophages depletion examined. Last, challenges opportunities in this field further discussed.

Language: Английский

Citations

67
Carrier-Free Nanodrug Based on Co-Assembly of Methylprednisolone Dimer and Rutin for Combined Treatment of Spinal Cord Injury DOI
Hao Wang, Feng Lin,

Yi Wu

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(13), P. 12176 - 12187

Published: June 30, 2023

Spinal cord injury (SCI), which is characterized by excessive inflammatory cell infiltration and accumulation of oxidative substance, would severely impede neurological functional recovery lead to permanent profound neurologic deficits even disability. Methylprednisolone (MP) the most commonly used clinical anti-inflammatory drug for SCI treatment, but high doses are typically required that can cause severe side effects. Here, we developed a carrier-free thioketal linked MP dimer@rutin nanoparticles (MP2-TK@RU NPs) achieve combined treatment coassembling reactive oxygen species (ROS) cleavable dimers rutin. This proposed nanodrug possesses following favorable advantages: (1) system easily accessible has drug-loading capacity, preferred pharmaceutical industry; (2) The ROS-cleavable linker increases efficiency targeted delivery site; (3) Rutin, type plant-derived natural flavonoid with good biocompatibility, anti-inflammatory, antioxidant properties, codelivered enhance therapy outcomes. obtained MP2-TK@RU NPs exhibited potent antioxidative properties both in vitro vivo, demonstrating superior locomotor function neuroprotective efficacy rats SCI. anticipated provide promising therapeutic strategy treatment.

Language: Английский

Citations

47
Polysaccharide-based nanocarriers for efficient transvascular drug delivery DOI
Min Zhang, He Ma, Xijie Wang

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 354, P. 167 - 187

Published: Jan. 9, 2023

Language: Английский

Citations

43
State of the Art in Actuation of Micro/Nanorobots for Biomedical Applications DOI Creative Commons
A. M. El‐naggar, Seungyeop Kang,

Mingzhen Tian

et al.

Small Science, Journal Year: 2024, Volume and Issue: 4(3)

Published: Feb. 2, 2024

The emergence of micro/nanorobotics stands poised to revolutionize various biomedical applications, given its potential offer precision, reduced invasiveness, and enhanced functionality. In the face such potential, understanding mechanisms that drive these tiny robots, especially their actuation techniques, becomes critical. Although there is a surge in research dedicated micro/nanorobotics, exists gap consolidating diverse strategies suitability for applications. This comprehensive review seeks bridge this by providing an in‐depth evaluation current techniques employed micro/nanorobots, particularly emphasizing relevance clinical translation. discussion starts elucidating different strategies, ranging from magnetic, electric, acoustic, light‐based, chemical biological mechanisms. Then, examples meticulous assessment each technique are offered, spotlighting respective merits limitations within context. illuminates transformative capabilities methods medicine. It not only highlights progress made burgeoning field but also underscores areas require further exploration development.

Language: Английский

Citations

22
Engineering cells for precision drug delivery: New advances, clinical translation, and emerging strategies DOI
Chih-Jia Chao, Endong Zhang, Zongmin Zhao

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114840 - 114840

Published: April 22, 2023

Language: Английский

Citations

29
In situ cellular hitchhiking of nanoparticles for drug delivery DOI Creative Commons
Edidiong Udofa, Zongmin Zhao

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 204, P. 115143 - 115143

Published: Nov. 24, 2023

Language: Английский

Citations

28
The interaction between particles and vascular endothelium in blood flow DOI
Xiaotong Li, Jiahui Zou,

Zhongshan He

et al.

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 207, P. 115216 - 115216

Published: Feb. 21, 2024

Language: Английский

Citations

12
Emerging application of nanomedicine-based therapy in acute respiratory distress syndrome DOI

Yitianhe Xu,

Leyao Lv,

Qian Wang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 237, P. 113869 - 113869

Published: March 21, 2024

Language: Английский

Citations

11