Nanomedicine,
Journal Year:
2024,
Volume and Issue:
20(3), P. 305 - 318
Published: Dec. 30, 2024
Colorectal
cancer
(CRC)
is
a
significant
threat
to
human
health.
The
dynamic
equilibrium
between
probiotics
and
pathogenic
bacteria
within
the
gut
microbiota
crucial
in
mitigating
risk
of
CRC.
An
overgrowth
harmful
microorganisms
gastrointestinal
tract
can
result
an
excessive
accumulation
bacterial
toxins
carcinogenic
metabolites,
thereby
disrupting
delicate
balance
microbiota.
This
disruption
may
lead
alterations
microbial
composition,
impairment
mucosal
barrier
function,
potential
promotion
abnormal
cell
proliferation,
ultimately
contribute
progression
Recently,
research
has
indicated
that
intestinal
presence
Fusobacterium
nucleatum
(Fn)
significantly
influences
onset,
progression,
metastasis
Consequently,
interaction
CRC
cells
Fn
presents
promising
strategy
against
Nanomaterials
have
been
extensively
utilized
therapy
infection
control,
demonstrating
substantial
treating
bacteria-associated
tumors.
review
begins
by
elucidating
mechanisms
occurrence
CRC,
with
particular
emphasis
on
clarifying
intricate
relationship
Subsequently,
we
highlight
strategies
utilize
nanomaterials
disrupt
association
Overall,
this
offers
valuable
insight
guidance
for
leveraging
therapy.
International Journal of Oral Science,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: Jan. 2, 2025
Abstract
Oral
squamous
cell
carcinoma
(OSCC)
is
the
most
common
manifestation
of
oral
cancer.
It
has
been
proposed
that
periodontal
pathogens
contribute
to
OSCC
progression,
mainly
by
their
virulence
factors.
However,
main
pathogen
and
its
mechanism
modulate
cells
remains
not
fully
understood.
In
this
study
we
investigate
host-pathogen
pathways
in
computational
proteomics
behind
cancer
progression
microbiome.
The
were
analyzed
secretome
biopsies
from
patients
with
healthy
controls
mass
spectrometry.
Then,
functional
assays
performed
evaluate
highlighted
Host
proteins
associated
LPS
response,
migration/adhesion,
metabolism
amino
acids
significantly
upregulated
human
proteome,
whereas
complement
cascade
was
downregulated
malignant
samples.
microbiome
analysis
revealed
large
number
variety
peptides
Fusobacterium
nucleatum
(
F.
)
samples,
which
several
enzymes
L-glutamate
degradation
pathway
found,
indicating
used
as
an
energy
source,
catabolized
into
butyrate
bacteria.
fact,
observed
modulates
cystine/glutamate
antiporter
line
increasing
SLC7A11
expression,
promoting
efflux
favoring
bacterial
infection.
Finally,
our
results
showed
metabolic
derivates
promote
tumor
spheroids
growth,
spheroids-derived
detachment,
epithelial-mesenchymal
transition
Galectin-9
upregulation.
Altogether,
promotes
pro-tumoral
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(38)
Published: July 26, 2024
Abstract
In
recent
years,
advancements
in
microbial
sequencing
technology
have
sparked
an
increasing
interest
the
bacteria
residing
within
solid
tumors
and
its
distribution
functions
various
tumors.
Intratumoral
critically
modulate
tumor
oncogenesis
development
through
DNA
damage
induction,
chronic
inflammation,
epigenetic
alterations,
metabolic
immune
regulation,
while
also
influencing
cancer
treatment
efficacy
by
affecting
drug
metabolism.
response
to
these
discoveries,
a
variety
of
anti‐cancer
therapies
targeting
microorganisms
emerged.
These
approaches
encompass
oncolytic
therapy
utilizing
tumor‐associated
bacteria,
design
biomaterials
based
on
intratumoral
use
bacterial
components
for
delivery
systems,
comprehensive
strategies
aimed
at
eradication
tumor‐promoting
bacteria.
Herein,
this
review
article
summarizes
patterns
different
tumors,
examines
their
impact
evaluates
current
therapeutic
centered
Furthermore,
challenges
prospects
developing
drugs
that
target
communities
are
explored,
promising
new
directions
treatment.
Artificial Cells Nanomedicine and Biotechnology,
Journal Year:
2024,
Volume and Issue:
52(1), P. 564 - 586
Published: Dec. 5, 2024
Cancer
has
a
high
rate
of
incidence
and
mortality
throughout
the
world.
Although
several
conventional
approaches
have
been
developed
for
treatment
cancer,
such
as
surgery,
chemotherapy,
radiotherapy
thermal
therapy,
they
remarkable
disadvantages
which
result
in
inefficient
cancer.
For
example,
immunogenicity,
prolonged
treatment,
non-specificity,
metastasis
cost
are
considered
major
drawbacks
chemotherapy.
Therefore,
there
is
fundamental
requirement
development
breakthrough
technologies
cancer
suppression.
Polysaccharide-based
drug
delivery
systems
(DDSs)
most
reliable
carriers
therapy.
Polysaccharides,
kind
practical
biomaterials,
divided
into
types,
including
chitosan,
alginates,
dextran,
hyaluronic
acid,
cyclodextrin,
pectin,
etc.
Polysaccharides
extracted
from
different
natural
resources
(like
herbal,
marine,
microorganisms,
etc.).
The
potential
features
polysaccharides
made
them
candidates
therapeutics
to
sites;
simple
purification,
ease
modification
functionalization,
hydrophilicity,
serum
stability,
appropriate
loading
capacity,
biocompatibility,
bioavailability,
biodegradability
stimuli-responsive
sustained
release
manner
considerable
aspects
these
biopolymers.
This
review
highlights
applications
polysaccharides-based
DDSs
pharmaceutical
science
International Journal of Oncology,
Journal Year:
2024,
Volume and Issue:
65(1)
Published: June 6, 2024
Several
studies
have
indicated
that
the
gut
microbiome
and
tumor
microbiota
may
affect
tumors.
Emerging
metabolomics
research
illustrates
need
to
examine
variations
in
microbial
metabolite
composition
between
patients
with
cancer
healthy
individuals.
Microbial
metabolites
can
impact
progression
of
tumors
immune
response
by
influencing
a
number
mechanisms,
including
modulation
system,
or
immune‑related
signaling
pathways,
epigenetic
modification
proteins
DNA
damage.
also
alleviate
side
effects
drug
resistance
during
chemotherapy
immunotherapy,
while
effectively
activating
system
exert
immunotherapy.
Nevertheless,
on
immunity
be
both
beneficial
harmful,
potentially
influenced
concentration
specific
type.
The
present
review
summarizes
roles
various
different
solid
tumors,
alongside
their
influence
treatment.
Additionally,
clinical
trials
evaluating
therapeutic
related
microbes
been
listed.
In
summary,
studying
metabolites,
which
play
crucial
role
interaction
could
lead
identification
new
supplementary
treatments
for
cancer.
This
has
potential
improve
effectiveness
treatment
enhance
patient
prognosis.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 26, 2024
Inflammatory
bowel
disease
(IBD)
is
an
idiopathic
and
persistent
inflammatory
illness
of
the
bowels,
leading
to
a
substantial
burden
on
both
society
patients
due
its
high
incidence
recurrence.
The
pathogenesis
IBD
multifaceted,
partly
attributed
imbalance
immune
responses
toward
gut
microbiota.
There
correlation
between
severity
in
oral
microbiota,
which
has
been
discovered
recent
research
highlighting
role
microbes
development
IBD.
In
addition,
various
conditions,
such
as
angular
cheilitis
periodontitis,
are
common
extraintestinal
manifestations
(EIMs)
associated
with
colonic
inflammation.
However,
it
still
unclear
exactly
how
microbiota
contributes
This
review
sheds
light
probable
causal
involvement
intestinal
inflammation
by
providing
overview
evidence,
developments,
future
directions
regarding
relationship
Changes
can
serve
markers
for
IBD,
aiding
early
diagnosis
predicting
progression.
Promising
advances
probiotic-mediated
microbiome
modification
antibiotic-targeted
eradication
specific
pathogens
hold
potential
prevent
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
12(8), P. 1965 - 1980
Published: Jan. 1, 2024
Recent
progress
in
nanomaterials
for
bacteria-related
tumor
therapy
terms
of
chemotherapy,
immunotherapy
and
synergistic
is
summarized
this
review
order
to
provide
some
insights
into
emerging
rapidly
growing
research
area.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(10), P. e31514 - e31514
Published: May 1, 2024
The
gastrointestinal
tract
is
an
important
part
of
the
human
immune
system.
gut
microbiome,
which
constitutes
a
major
component
tract,
plays
crucial
role
in
maintaining
normal
physiological
functions
and
influences
development,
diagnosis,
immunotherapy
colorectal
cancer
(CRC).
Natural
polysaccharides
can
be
extracted
from
animals,
plants,
traditional
Chinese
medicines.
They
serve
as
essential
energy
source
for
promoting
probiotic
proliferation
regulating
intestinal
microecological
balance.
Moreover,
exhibit
anti-tumor
effects
due
to
their
regulatory
low
toxicity.
This
review
focuses
on
discussing
these
CRC,
along
with
improving
microbiome
dysbiosis
tumor
microenvironment,
providing
evidence
effective
therapeutic
strategies
against
CRC.
