Micro/nano-plastics impacts in cardiovascular systems across species

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 942, P. 173770 - 173770

Published: June 7, 2024

Language: Английский

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Immunotoxicity of microplastics: Carrying pathogens and destroying the immune system

TrAC Trends in Analytical Chemistry, Journal Year: 2024, Volume and Issue: 177, P. 117817 - 117817

Published: June 13, 2024

Language: Английский

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Detection and quantification of microplastics in various types of human tumor tissues

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 283, P. 116818 - 116818

Published: July 30, 2024

Microplastics (MPs) have been detected in various human tissues. However, whether MPs can accumulate within tumors and how they affect the tumor immune microenvironment (TIME) therapeutic responses remains unclear. This study aimed to determine presence of their potential effects on TIME. Sixty-one samples were collected for analysis. The was qualitatively quantitatively assessed using pyrolysis-gas chromatography-mass spectrometry. 26 examined. Three types identified: polystyrene, polyvinyl chloride, polyethylene. In lung, gastric, colorectal, cervical tumors, MP detection rates 80 %, 40 50 17 % (7.1-545.9 ng/g), respectively. 70 pancreatic (18.4-427.1 ng/g) but not esophageal tumors. cancer, MP-infiltrated TIME exhibited a reduction CD8

Language: Английский

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Microplastics are associated with elevated atherosclerotic risk and increased vascular complexity in acute coronary syndrome patients

Particle and Fibre Toxicology, Journal Year: 2024, Volume and Issue: 21(1)

Published: Aug. 21, 2024

Microplastics, widely present in the environment, are implicated disease pathogenesis through oxidative stress and immune modulation. Prevailing research, primarily based on animal cell studies, falls short elucidating microplastics' impact human cardiovascular health. This cross-sectional study detected blood microplastic concentrations patients presenting with chest pain using pyrolysis-gas chromatography/mass spectrometry evaluating inflammatory markers flow cytometry, to explore potential effects of acute coronary syndrome.

Language: Английский

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Molecular and Cellular Effects of Microplastics and Nanoplastics: Focus on Inflammation and Senescence

Cells, Journal Year: 2024, Volume and Issue: 13(21), P. 1788 - 1788

Published: Oct. 29, 2024

Microplastics and nanoplastics (MNPs) are ubiquitous environmental contaminants. Their prevalence, persistence, increasing industrial production have led to questions about their long-term impact on human animal health. This narrative review describes the effects of MNPs oxidative stress, inflammation, aging. Exposure leads increased reactive oxygen species (ROS) across multiple experimental models, including cell lines, organoids, systems. ROS can cause damage cellular macromolecules such as DNA, proteins, lipids. Direct interaction between immune cells or an indirect result stress-mediated may lead pro-inflammatory cytokines throughout different MNP-exposure conditions. inflammatory response is a common feature in pathogenesis neurodegenerative, cardiovascular, other age-related diseases. also act senescence inducers by promoting mitochondrial dysfunction, impairing autophagy, activating DNA responses, exacerbating aging altogether. Increased reproductive transfer MNPs/induced damages from parents offspring animals further corroborates transgenerational health risks tiny particles. aims provoke deeper investigation into notorious these pervasive particles well-being longevity.

Language: Английский

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Microplastics in the Human Body: Exposure, Detection, and Risk of Carcinogenesis: A State-of-the-Art Review

Cancers, Journal Year: 2024, Volume and Issue: 16(21), P. 3703 - 3703

Published: Nov. 1, 2024

Humans cannot avoid plastic exposure due to its ubiquitous presence in the natural environment. The waste generated is poorly biodegradable and exists form of MPs, which can enter human body primarily through digestive tract, respiratory or damaged skin accumulate various tissues by crossing biological membrane barriers. There an increasing amount research on health effects MPs. Most literature reports focus impact plastics respiratory, digestive, reproductive, hormonal, nervous, immune systems, as well metabolic MPs accumulation leading epidemics obesity, diabetes, hypertension, non-alcoholic fatty liver disease. xenobiotics, undergo ADMET processes body, i.e., absorption, distribution, metabolism, excretion, are not fully understood. Of particular concern carcinogenic chemicals added during manufacturing adsorbed from environment, such chlorinated paraffins, phthalates, phenols, bisphenols, be released when absorbed body. continuous increase NMP has accelerated SARS-CoV-2 pandemic there was a need use single-use products daily life. Therefore, urgent diagnose problems related MP detection.

Language: Английский

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Pollutants, microbiota and immune system: frenemies within the gut

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: May 10, 2024

Pollution is a critical concern of modern society for its heterogeneous effects on human health, despite widespread lack awareness. Environmental pollutants promote several pathologies through different molecular mechanisms. Pollutants can affect the immune system and related pathways, perturbing regulation triggering pro-inflammatory responses. The exposure to also leads alterations in gut microbiota with decreasing abundance beneficial microbes, such as short-chain fatty acid-producing bacteria, an overgrowth species. subsequent intestinal barrier dysfunction, together oxidative stress increased inflammatory responses, plays role pathogenesis gastrointestinal diseases. Moreover, encourage inflammation-dysplasia-carcinoma sequence various mechanisms, stress, dysregulation cellular signalling cell cycle impairment genomic instability. In this narrative review, we will describe interplay between pollutants, microbiota, system, focusing their relationship bowel diseases colorectal cancer. Understanding biological mechanisms underlying health-to-disease transition may allow design public health policies aimed at reducing burden disease pollutants.

Language: Английский

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Effect of micro- and nanoplastic particles on human macrophages

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 471, P. 134253 - 134253

Published: April 11, 2024

Micro- and nanoplastics (MNPs) are ubiquitous in the environment, resulting uptake of MNPs by a variety organisms, including humans, leading to particle-cell interaction. Human macrophages derived from THP-1 cell lines take up Polystyrene (PS), widespread plastic. The question therefore arises whether primary human also PS micro- nanobeads (MNBs) how they react this stimulation. Major aim study is visualize validate isolation peripheral blood mononuclear cells (PBMCs) assess impact on macrophages. Uptake PBMCs was examined transmission electron microscopy (TEM), scanning live imaging. In addition, reaction analyzed terms metabolic activity, cytotoxicity, production reactive oxygen species (ROS) macrophage polarization. This first MNBs using TEM Metabolic activity size- concentration-dependent, necrosis ROS were increased. methods demonstrated outline an approach influence MNP exposure help investigating consequences worldwide plastic pollution. among particles which can be found different ecosystems (1). Because their size, enter food chain accumulate large organisms (2). Previous studies already showed cytotoxic effect murine dTHP-1 (3, 4). However more research needed distribution humans. Studying potential health risks model, supports process political decision-making addressing

Language: Английский

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Harmful effects of true-to-life nanoplastics derived from PET water bottles in human alveolar macrophages.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 348, P. 123823 - 123823

Published: March 19, 2024

The increasing presence of secondary micro/nanoplastics (MNPLs) in the environment requires knowing if they represent a real health concern. To such end, an important point is to test representative MNPLs as denominated true-to-life MNPLs, resulting from degradation plastic goods lab conditions. In this study, we have used polyethylene terephthalate (PET) NPLs PET water bottles. Since inhalation exposure route environmental MNPLS, mouse alveolar macrophages (MH-S) target cell, and study focused only on cells that internalized them. This type approach novel it may capture realistic adverse effects PETNPLs cells, thereby mitigating any biases while assessing risk these MNPLs. Furthermore, utilized set biomarkers including intracellular reactive oxygen species (ROS) levels, variations mitochondrial membrane potential values, macrophage polarization M1 (pro-inflammatory response) M2 (anti-proinflammatory possible cellular due PETNPLs. After exposures lasting for 3 24 h range concentrations (0, 25, 50, 100 μg/mL) results indicate no toxicity was induced despite 100% internalization observed at highest concentration. Significant levels ROS were observed, mainly h, indirect concentration-effect relationship. Interestingly, reduction but without clear Finally, PETNPL shows significant M0 subtypes. Polarization stage) more marked occurred both times. (anti-inflammatory after h. Due relevance described biomarkers, our underscore need further research, better understand implications associated with MNPL exposure.

Language: Английский

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Sonicated polyethylene terephthalate nano- and micro-plastic-induced inflammation, oxidative stress, and autophagy in vitro

Chemosphere, Journal Year: 2024, Volume and Issue: 355, P. 141813 - 141813

Published: April 3, 2024

Language: Английский

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