Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2022, Volume and Issue: 1878(1), P. 188848 - 188848
Published: Dec. 9, 2022
Language: Английский
Life Sciences, Journal Year: 2023, Volume and Issue: 334, P. 122223 - 122223
Published: Oct. 29, 2023
Language: Английский
Citations
48
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 171, P. 116115 - 116115
Published: Jan. 5, 2024
Ferroptosis and cuproptosis, regulated forms of cell death resulting from metal ion accumulation, are closely related in terms occurrence, metabolism, signaling pathways, drug resistance. Notably, it is now understood that these processes play crucial roles regulating physiological pathological processes, especially tumor development. Consequently, ferroptosis cuproptosis have gained increasing significance as potential targets for anti-cancer This article systematically outlines the molecular mechanisms cross-talk components both elucidating their impacts on cancer. Furthermore, investigates clinical perspective targeted cancer chemotherapy, immunotherapy, radiotherapy. Our discussion extends to a comparative analysis nanoparticles developed based cancer, contrasting them with current conventional therapies. Opportunities challenges treatment explored, emphasizing therapeutic direction co-targeting cuproptosis. The also attempts analyze applications this approach while summarizing existing barriers require overcoming.
Language: Английский
Citations
48
Advanced Science, Journal Year: 2023, Volume and Issue: 10(26)
Published: July 12, 2023
In recent years, the incidence of gastrointestinal cancers is increasing, particularly in younger population. Effective treatment crucial for improving patients' survival outcomes. Programmed cell death, regulated by various genes, plays a fundamental role growth and development organisms. It also critical maintaining tissue organ homeostasis takes part multiple pathological processes. addition to apoptosis, there are other types programmed such as ferroptosis, necroptosis, pyroptosis, which can induce severe inflammatory responses. Notably, besides pyroptosis contribute occurrence cancers. This review aims provide comprehensive summary on biological roles molecular mechanisms well their regulators hope open up new paths tumor targeted therapy near future.
Language: Английский
Citations
47
Molecules, Journal Year: 2023, Volume and Issue: 28(5), P. 2303 - 2303
Published: March 1, 2023
Copper serves as a vital microelement which is widely present in the biosystem, functioning multi-enzyme active site, including oxidative stress, lipid oxidation and energy metabolism, where reduction characteristics are both beneficial lethal to cells. Since tumor tissue has higher demand for copper more susceptible homeostasis, may modulate cancer cell survival through reactive oxygen species (ROS) excessive accumulation, proteasome inhibition anti-angiogenesis. Therefore, intracellular attracted great interest that multifunctional copper-based nanomaterials can be exploited diagnostics antitumor therapy. this review explains potential mechanisms of copper-associated death investigates effectiveness biomaterials field
Language: Английский
Citations
46
Current Medical Science, Journal Year: 2024, Volume and Issue: 44(1), P. 28 - 50
Published: Feb. 1, 2024
Abstract Copper is an essential trace element, and plays a vital role in numerous physiological processes within the human body. During normal metabolism, body maintains copper homeostasis. deficiency or excess can adversely affect cellular function. Therefore, homeostasis stringently regulated. Recent studies suggest that trigger specific form of cell death, namely, cuproptosis, which triggered by excessive levels intracellular copper. Cuproptosis induces aggregation mitochondrial lipoylated proteins, loss iron-sulfur cluster proteins. In neurodegenerative diseases, pathogenesis progression neurological disorders are linked to This review summarizes advances cuproptosis nervous system diseases. offers research perspectives provide new insights into targeted treatment diseases based on cuproptosis.
Language: Английский
Citations
27
Pharmacological Research, Journal Year: 2024, Volume and Issue: 202, P. 107139 - 107139
Published: March 12, 2024
Chronic kidney disease (CKD) has become a global public health problem with high morbidity and mortality. Renal fibrosis can lead to end-stage renal (ESRD). However, there is still no effective treatment prevent or delay the progression of CKD into ESRD. Therefore, exploring pathogenesis essential for preventing treating CKD. There are variety trace elements in human body that interact each other within complex regulatory network. Iron copper both vital body. They critical maintaining bodily functions, dysregulation their metabolism cause many diseases, including disease. Ferroptosis new form cell death characterized by iron accumulation lipid peroxidation. Studies have shown ferroptosis closely related role abnormal its relationship remains unclear. Here, our current knowledge regarding metabolism, mechanism, diseases summarized. In addition, we discuss between explore possible provide potential therapeutic target
Language: Английский
Citations
23
EBioMedicine, Journal Year: 2024, Volume and Issue: 102, P. 105088 - 105088
Published: March 26, 2024
Metabolic dysfunction-associated steatohepatitis (MASH) is characterised by cell death of parenchymal liver cells which interact with their microenvironment to drive disease activity and fibrosis. The identification the major type could pave way towards pharmacotherapy for MASH. To date, increasing evidence suggest a regulated death, named ferroptosis, occurs through iron-catalysed peroxidation polyunsaturated fatty acids (PUFA) in membrane phospholipids. Lipid enjoys renewed interest light as druggable target This review recapitulates molecular mechanisms ferroptosis physiology, human MASH critically appraises results targeting preclinical models. Rewiring redox, iron PUFA metabolism creates proferroptotic environment involved MASH-related hepatocellular carcinoma (HCC) development. Ferroptosis induction might be promising novel approach eradicate HCC, while its inhibition ameliorate progression.
Language: Английский
Citations
21
Small, Journal Year: 2024, Volume and Issue: 20(25)
Published: Jan. 14, 2024
Abstract Ferroptosis is a new form of regulated cell death featuring iron‐dependent lipid peroxides accumulation to kill tumor cells. A growing body evidence has shown the potential ferroptosis‐based cancer therapy in eradicating refractory malignancies that are resistant apoptosis‐based conventional therapies. In recent years, studies have reported number ferroptosis inducers can increase vulnerability cells by regulating ferroptosis‐related signaling pathways. Encouraged rapid development ferroptosis‐driven therapies, interdisciplinary fields combine ferroptosis, pharmaceutical chemistry, and nanotechnology focused. First, prerequisites metabolic pathways for briefly introduced. Then, detail emerging designed boost ferroptosis‐induced therapy, including metal complexes, metal‐based nanoparticles, metal‐free nanoparticles summarized. Subsequently, application synergistic strategies with apoptosis other emphasis on use both cuproptosis induce redox dysregulation intracellular bimetallic copper/iron metabolism disorders during treatment discussed. Finally, challenges associated clinical translation future directions potentiating therapies highlighted.
Language: Английский
Citations
20
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: May 1, 2024
Copper plays vital roles in numerous cellular processes and its imbalance can lead to oxidative stress dysfunction. Recent research has unveiled a unique form of copper-induced cell death, termed cuproptosis, which differs from known death mechanisms. This process involves the interaction copper with lipoylated tricarboxylic acid cycle enzymes, causing protein aggregation death. Recently, growing number studies have explored link between cuproptosis cancer development. review comprehensively examines systemic metabolism copper, including tumor-related signaling pathways influenced by copper. It delves into discovery mechanisms connection various cancers. Additionally, suggests potential treatments using ionophores that induce combination small molecule drugs, for precision therapy specific types.
Language: Английский
Citations
20
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 8, 2025
Ferroptosis is a newly identified programmed cell death induced by iron-driven lipid peroxidation and implicated as potential approach for tumor treatment. However, emerging evidence indicates that hepatocellular carcinoma (HCC) cells are generally resistant to ferroptosis the underlying molecular mechanism poorly understood. Here, our study confirms S100 calcium binding protein P (S100P), which significantly up-regulated in ferroptosis-resistant HCC cells, efficiently inhibits ferroptosis. Mechanistically, S100P facilitates lysosomal degradation of acetyl-CoA carboxylase alpha (ACC1), indispensable de novo biosynthesis lipids. Loss elevates expression ACC1 promotes ferroptotic sensitivity cells. S100P-mediated relies on RAB5C, directs lysosome via P62-dependent selective autophagy. Knockdown RAB5C or P62 abrogates S100P-induced restores resistance Our work reveals an alternative anti-ferroptosis pathway suggests promising druggable target ferroptosis-related therapy HCC. Resistance remains be authors identify (S100P) suppressor (ACC1) downregulate biosynthesis.
Language: Английский
Citations
4