Translational Selenium Nanoparticles to Attenuate Allergic Dermatitis through Nrf2-Keap1-Driven Activation of Selenoproteins

ACS Nano, Journal Year: 2023, Volume and Issue: 17(14), P. 14053 - 14068

Published: July 10, 2023

Easy recurrence and strong treatment side effects significantly limit the clinical of allergic dermatitis. The human trace element selenium (Se) plays essential roles in redox regulation through incorporation into selenoproteins form 21st necessary amino acid selenocysteine, to participates pathogenesis intervention chronic inflammatory diseases. Therefore, based on safe elemental properties Se, we construct a facile-synthesis strategy for antiallergic nanoparticles (LET-SeNPs), scale up production by employing spray drying method with lactose (Lac-LET-SeNPs) or maltodextrin (Mal-LET-SeNPs) as encapsulation agents realizing larger longer storage time. As expected, these as-prepared LET-SeNPs could effectively activate Nrf2-Keap1 signaling pathway enhance expression antioxidative selenoprotein at mRNA protein levels, then inhibit mast cell activation achieve efficient activity. Interestingly, undergo metabolism seleno-amino acids promote biosynthesis selenoproteins, which suppress ROS-induced cyclooxygenase-2 (COX-2) MAPKs release histamine cytokines. Allergic mouse Macaca fascicularis models further confirm that increase Se content skin, decrease cells infiltration, finally exhibit high therapeutic Taken together, this study not only constructs facile large-scale synthesis translational nanomedicine break bottleneck problem nanomaterials but also sheds light its application allergies.

Language: Английский

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Selenization of Small Molecule Drugs: A New Player on the Board

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(10), P. 7759 - 7787

Published: May 8, 2024

There is an urgent need to develop safer and more effective modalities for the treatment of a wide range pathologies due increasing rates drug resistance, undesired side effects, poor clinical outcomes, etc. Throughout years, selenium (Se) has attracted great deal attention its important role in human health. Besides, growing body work unveiled that inclusion Se motifs into number molecules promising strategy obtaining novel therapeutic agents. In current Perspective, we have gathered most recent literature related incorporation different moieties scaffolds known drugs their feasible pharmaceutical applications. addition, highlight representative examples as well provide our perspective on possible future directions, promises, opportunities, challenges this ground-breaking area research.

Language: Английский

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Clinical Evidence on the Potential Beneficial Effects of Diet and Dietary Supplements against COVID-19 Infection Risk and Symptoms’ Severity

Medical Sciences, Journal Year: 2024, Volume and Issue: 12(1), P. 11 - 11

Published: Feb. 17, 2024

Diet and dietary supplements aim to add trace elements, vitamins, minerals the body improve human health boost immune system. In previous few years, new SARS-CoV-2 coronavirus strain has been threatening of individuals public more broadly, with rates intensive care unit cases on rise, while long-term COVID-19 complications are persisting until today. peculiar circumstances pandemic, in combination disease prevention techniques, strengthening system is considered particularly important enable it effectively respond eliminate viral pathogen event infection. The purpose current literature review thoroughly summarize critically analyze clinical data concerning potential beneficial effects diet against infection risk symptoms' severity. micronutrients/supplements examined this study relation vitamins A, B, C, D, zinc, selenium, magnesium, iron, omega-3 fatty acids, glutamine, resveratrol, beta-glucans, probiotics. patterns such as Mediterranean severity were also analyzed. Our suggests that micro- macronutrient supplementation a healthy lifestyle may provide support function, both before during However, additional studies recommended draw safe conclusions formulate recommendations their possible preventing co-treating disease.

Language: Английский

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Organic selenocompounds: are they the panacea for human illnesses?

New Journal of Chemistry, Journal Year: 2023, Volume and Issue: 47(21), P. 9959 - 9988

Published: Jan. 1, 2023

The pharmacological studies of organoselenium compounds need to be profoundly improved find an actual application this interesting class molecules.

Language: Английский

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Young adults' blood selenium and lung function in Shandong Province, China: A prospective cohort study

The Innovation Medicine, Journal Year: 2023, Volume and Issue: 1(1), P. 100013 - 100013

Published: Jan. 1, 2023

<p>Selenium has been shown a wide range of pleiotropic effects, particularly the antioxidant and anti-inflammatory effects. However, there are limited cohort studies exploring association between blood selenium concentrations lung function in young adults.To explore longitudinal among adults China. A total 1,800 participants were recruited from Chinese undergraduate Shandong province, China during August 2019, followed up September 2020. Socioeconomic demographic information collected for each individual using standard questionnaires. Blood was measured inductively coupled plasma mass spectrometry at baseline. Linear mixed-effects models used to levels indicators forced vital capacity (FVC, ml), expiratory volume 1 second (FEV₁, ml) peak flow (PEF, by stratified analyses regarding sex, respiratory disease history, socioeconomic status physical activities.The median level concentration all 120.9 (25^th: 107.5, 75^th: 137.5) ng/ml. In analysis, 2-fold increase significantly associated with 91.14ml (95%CI: 6.80, 175.48) FEV₁ 270.23ml 53.70, 486.75) PEF, respectively. The beneficial associations stronger women, disease, advantage, those who did not participate activity. High improved function, especially airway obstruction adults. 175ng/ml could possibly be excess up-limit.</p>

Language: Английский

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Redox regulation of the NLRP3-mediated inflammation and pyroptosis

Biomeditsinskaya Khimiya, Journal Year: 2023, Volume and Issue: 69(6), P. 333 - 352

Published: Jan. 1, 2023

The review considers modern data on the mechanisms of activation and redox regulation NLRP3 inflammasome gasdermins, as well role selenium in these processes. Activation pyroptosis represent an evolutionarily conserved mechanism defense against pathogens, described for various types cells tissues (macrophages monocytes, microglial astrocytes, podocytes parenchymal kidneys, periodontal tissues, osteoclasts osteoblasts, digestive urogenital systems, etc.). Depending characteristics regulation, participants inflammation can be subdivided into 2 groups. Members first group block mitochondrial electron transport chain, promote formation reactive oxygen species development oxidative stress. This includes granzymes, antiviral signaling protein MAVS, others. second thioredoxin interacting (TXNIP), erythroid-derived nuclear factor-2 (NRF2), Kelch-like ECH-associated 1 (Keap1), ninjurin (Ninj1), scramblase (TMEM16), regulatory kinase (NEK7), caspase-1, gasdermins GSDM B, D They have redox-sensitive domains and/or cysteine residues subjected to glutathionylation/deglutathionylation or other regulation. Suppression stress depends activity antioxidant enzymes glutathione peroxidase (GPX) reductase (TRXR), containing a selenocysteine residue Sec active site. expression GPX TRXR is regulated by NRF2 concentration blood. Selenium deficiency causes ineffective translation UGA codon, termination, and, consequently, synthesis inactive selenoproteins, which cause programmed cell death: apoptosis nerve sperm, necroptosis erythrocyte precursors, infected myeloid cells, ferroptosis T- B-lymphocytes, kidney pancreatic cells. In addition, suboptimal concentrations blood (0.86 μM 68 μg/l less) significant impact more than two hundred fifty genes compared optimal (1.43 113 μg/l). Based above, we propose consider important parameter homeostasis cell. Suboptimal (or states) should used assessment risk developing inflammatory

Language: Английский

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The Role of Diet and Specific Nutrients during the COVID-19 Pandemic: What Have We Learned over the Last Three Years?

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(7), P. 5400 - 5400

Published: April 4, 2023

Nutrients and diets have an important impact on our immune system infection risk a huge number of papers been published dealing with various aspects nutrition in relation to SARS-CoV-2 or COVID-19 severity. This narrative review aims give update this association tries summarize some the most findings after three years pandemic. The analysis major studies systematic reviews leads conclusion that healthy plant-based diet reduces risks for especially Regarding micronutrients, vitamin D is fore, but also zinc, C and, extent, selenium may play role COVID-19. Furthermore, omega-3-fatty acids their anti-inflammatory effects deserve attention. Therefore, aim societal nutritional efforts future should be foster high quality diet, which not only exerts beneficial non-communicable diseases such as type 2 diabetes obesity are primary factors worse outcomes. Another focus good supply critical immune-effective nutrients, zinc.

Language: Английский

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Selenoprotein S Interacts with the Replication and Transcription Complex of SARS-CoV-2 by Binding nsp7

Journal of Molecular Biology, Journal Year: 2023, Volume and Issue: 435(8), P. 168008 - 168008

Published: Feb. 10, 2023

Language: Английский

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Opportunities and Regulatory Challenges of Functional Foods and Nutraceuticals During COVID-19 Pandemic

Current Nutrition & Food Science, Journal Year: 2024, Volume and Issue: 20(10), P. 1252 - 1271

Published: March 1, 2024

: The novel Coronavirus has brought global mortality, disruption, and a significant loss of life. A compromised immune system is known risk factor for all viral influenza infections. Due to the perceived “immune-boosting” properties nutraceutical products, sales dietary supplements have grown globally. In recent years, consumers increasingly demanded products rather than curative synthetic medicines preventive therapies coronavirus disease outbreak 2019 (COVID-19). Healthy foods nutraceuticals become daily diet plans consumers. Although there been an increase in demand, no such regulation harmonized process, which stands as barrier approval these products. Therefore, many misbranded spurious are entering market, may harm This article focuses on role functional management COVID-19 also different regulations each country compare similarities differences following countries: India, USA (United States America), EU (European Union), China. comparative study USA, Europe, China shows that difference regarding regulations; however, despite differences, it observed same underlying objective, i.e., ensuring safety by maintaining product quality.

Language: Английский

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Optimizing food waste bioconversion with sodium selenite-enhanced Lucilia sericata maggots: a sustainable approach for chicken feed production and heavy metal mitigation

Environmental Geochemistry and Health, Journal Year: 2024, Volume and Issue: 46(12)

Published: Nov. 9, 2024

Language: Английский

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